PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16434701-1 2006 The main regulator of the human tumor suppresser gene p21(waf1/cip1) is the transcription factor p53, but more recently it has been suggested to be a primary anti-proliferative target for the nuclear receptor VDR in the presence of its ligand 1alpha,25-dihydroxyvitamin D3 (1alpha,25(OH)2D3). 25-dihydroxyvitamin d3 250-272 tumor protein p53 Homo sapiens 97-100 10786699-6 2000 1alpha,25-Dihydroxyvitamin D3 and EB1089 induced p53-independent apoptosis in adenoma and carcinoma cell lines in a dose-dependent manner between 10(-10) and 10(-6) M. EB1089, as well as inducing apoptosis, increased the proportion of cells in the G1 phase, particularly in the adenoma cell lines. 25-dihydroxyvitamin d3 7-29 tumor protein p53 Homo sapiens 49-52