PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26304989-4 2015 Interestingly, although treated CD40 KO mice remained healed, developed long-term immunity, and were resistant to secondary L. major challenge, treated CD40L KO reactivated their lesion after cessation of rIL-12 treatment. ril-12 205-211 CD40 ligand Mus musculus 152-157 16920960-4 2006 This defect is probably due to impaired CD40-dependent IL-12 production in vivo, because administration of anti-CD40 Ab, or rIL-12, restored IFN-gamma production by sdLN cells from CD154-/- mice. ril-12 124-130 CD40 ligand Mus musculus 181-186 17485453-7 2007 However, the treatment of CD154(-/-) mice with rIL-12 did not restore protection. ril-12 47-53 CD40 ligand Mus musculus 26-31 26304989-6 2015 We show that IL-12 production by dendritic cells and macrophages via CD40L-macrophage Ag 1 (Mac-1) interaction is responsible for the sustained resistance in CD40 KO mice after cessation of rIL-12 treatment. ril-12 190-196 CD40 ligand Mus musculus 69-74