PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23402912-2	2013	Biochemical fractionation and indirect immunofluorescence demonstrated that sorbitol induced hyperosmotic stress stimulated expression and triggered the localization of endogenous Sgk-1 into the mitochondria of NMuMG mammary epithelial cells.	Sorbitol	76-84	serum/glucocorticoid regulated kinase 1	Mus musculus	180-185	
12488318-1	2003	The effects of multiple stress stimuli on the cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) were examined in NMuMg mammary epithelial cells exposed to hyperosmotic stress induced by the organic osmolyte sorbitol, heat shock, ultraviolet irradiation, oxidative stress induced by hydrogen peroxide, or to dexamethasone, a synthetic glucocorticoid that represents a general class of physiological stress hormones.	Sorbitol	242-250	serum/glucocorticoid regulated kinase 1	Mus musculus	126-129	
10842172-2	2000	Treatment of NMuMg mammary epithelial cells with the organic osmolyte, sorbitol, caused the stable accumulation of Sgk transcripts and protein after an approximately 4-h lag.	Sorbitol	71-79	serum/glucocorticoid regulated kinase 1	Mus musculus	115-118	
10842172-3	2000	Transient transfection of a series of sgk-CAT reporter plasmids containing either 5" deletions or continuous 6-base pair substitutions identified a hyperosmotic stress-regulated element that is GC-rich and is necessary for the sorbitol stimulation of sgk gene promoter activity.	Sorbitol	227-235	serum/glucocorticoid regulated kinase 1	Mus musculus	38-41	
10842172-3	2000	Transient transfection of a series of sgk-CAT reporter plasmids containing either 5" deletions or continuous 6-base pair substitutions identified a hyperosmotic stress-regulated element that is GC-rich and is necessary for the sorbitol stimulation of sgk gene promoter activity.	Sorbitol	227-235	serum/glucocorticoid regulated kinase 1	Mus musculus	251-254	
10842172-6	2000	Treatment with pharmacological inhibitors of p38 MAPK or with a dominant negative form of MKK3, an upstream regulator of p38 MAPK, significantly reduced or ablated the sorbitol induction of sgk promoter activity or protein production.	Sorbitol	168-176	serum/glucocorticoid regulated kinase 1	Mus musculus	190-193	
10842172-7	2000	Using an in vitro peptide transphosphorylation assay, sorbitol treatment activates either endogenous or exogenous Sgk that is localized to the cytoplasmic compartment.	Sorbitol	54-62	serum/glucocorticoid regulated kinase 1	Mus musculus	114-117	
10842172-8	2000	Thus, we propose that the stimulated expression of enzymatically active Sgk after sorbitol treatment is a newly defined component of the p38 MAPK-mediated response to hyperosmotic stress.	Sorbitol	82-90	serum/glucocorticoid regulated kinase 1	Mus musculus	72-75