PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12115730-0 2002 Stress kinase p38 mediates EGFR transactivation by hyperosmolar concentrations of sorbitol. Sorbitol 82-90 mitogen-activated protein kinase 14 Homo sapiens 14-17 12115730-5 2002 Furthermore, sorbitol treatment results in a strong activation of stress kinase p38. Sorbitol 13-21 mitogen-activated protein kinase 14 Homo sapiens 80-83 11710946-8 2001 We have demonstrated that the p38 mitogen activated protein kinase was strongly activated by 200 mM and 300 mM sorbitol. Sorbitol 111-119 mitogen-activated protein kinase 14 Homo sapiens 30-33 11710946-9 2001 The specific p38 mitogen activated protein kinase inhibitor PD169316 almost completely blocked heat shock protein 70 mRNA induction by 200 mM and 300 mM sorbitol and completely suppressed heat shock protein 27 mRNA induction with 200 mM sorbitol. Sorbitol 153-161 mitogen-activated protein kinase 14 Homo sapiens 13-16 11710946-9 2001 The specific p38 mitogen activated protein kinase inhibitor PD169316 almost completely blocked heat shock protein 70 mRNA induction by 200 mM and 300 mM sorbitol and completely suppressed heat shock protein 27 mRNA induction with 200 mM sorbitol. Sorbitol 237-245 mitogen-activated protein kinase 14 Homo sapiens 13-16 11078444-6 2000 Phosphorylation of p38 MAPK was stimulated strongly by sorbitol (22-fold) but weakly by insulin (2.7-fold). Sorbitol 55-63 mitogen-activated protein kinase 14 Homo sapiens 19-22 11279172-4 2001 Similar effects were elicited by chronic (24 h) exposure to tumor necrosis factor alpha, interleukin-1beta, or 200 mm sorbitol, all activate the MKK6/3-p38 MAPK pathway. Sorbitol 118-126 mitogen-activated protein kinase 14 Homo sapiens 152-155 11506188-5 2001 p38-MAPK was phosphorylated by sorbitol (almost 12-fold, maximal within 10-15 min) and JNKs were phosphorylated and activated by sorbitol or anoxia/reoxygenation (approximately 4- and 2.5-fold, respectively). Sorbitol 31-39 mitogen-activated protein kinase 14 Homo sapiens 0-3 11506188-5 2001 p38-MAPK was phosphorylated by sorbitol (almost 12-fold, maximal within 10-15 min) and JNKs were phosphorylated and activated by sorbitol or anoxia/reoxygenation (approximately 4- and 2.5-fold, respectively). Sorbitol 129-137 mitogen-activated protein kinase 14 Homo sapiens 0-3 11506188-6 2001 SB203580 completely blocked the activation of p38-MAPK by sorbitol. Sorbitol 58-66 mitogen-activated protein kinase 14 Homo sapiens 46-49 11078444-8 2000 JNK and p38 MAPK were activated only significantly by sorbitol. Sorbitol 54-62 mitogen-activated protein kinase 14 Homo sapiens 8-11 10816593-7 2000 Initially, exposure of cells to the hyperosmotic stressor, sorbitol, stimulated MKK6, p38, and MAPKAP-K2 and increased phosphorylation of alphaB-crystallin on serine 59. Sorbitol 59-67 mitogen-activated protein kinase 14 Homo sapiens 86-89 10816593-10 2000 Thus, under these conditions, the activation of MKK6, p38, and MAPKAP-K2 by sorbitol can provide a degree of protection against stress-induced apoptosis. Sorbitol 76-84 mitogen-activated protein kinase 14 Homo sapiens 54-57 10816593-9 2000 This sorbitol-induced apoptosis was increased when p38 was inhibited in a manner that would block alphaB-crystallin induction and phosphorylation. Sorbitol 5-13 mitogen-activated protein kinase 14 Homo sapiens 51-54 9545260-7 1998 However other stresses such as heat shock, sorbitol, and H2O2, which also stimulate p38 MAP kinase and increase Mnk1 activity, do not increase phosphorylation of eIF4E. Sorbitol 43-51 mitogen-activated protein kinase 14 Homo sapiens 84-87 10567216-7 1999 A high osmolarity solution of sorbitol induced comparatively small activation of SAPK2a and MAPKAP-K2. Sorbitol 30-38 mitogen-activated protein kinase 14 Homo sapiens 81-87 10082138-4 1999 Activation of JNK or p38 MAPK by NaSal (or aspirin) was not due to a nonspecific hyperosmotic effect because much higher molar concentrations of sorbitol or NaCl were required to produce a similar activation. Sorbitol 145-153 mitogen-activated protein kinase 14 Homo sapiens 21-24 22154358-7 2012 Stress stimuli (sorbitol, hydrogen peroxide, and UV irradiation) were used to active p38, which was measured by phospho-antibody. Sorbitol 16-24 mitogen-activated protein kinase 14 Homo sapiens 85-88 8972182-6 1997 Intriguingly, p38 activation by sorbitol and etoposide was resistant to YVAD-CMK and Z-VAD-FMK, suggesting the existence of an additional mechanism(s) of p38 regulation. Sorbitol 32-40 mitogen-activated protein kinase 14 Homo sapiens 14-17 8972182-6 1997 Intriguingly, p38 activation by sorbitol and etoposide was resistant to YVAD-CMK and Z-VAD-FMK, suggesting the existence of an additional mechanism(s) of p38 regulation. Sorbitol 32-40 mitogen-activated protein kinase 14 Homo sapiens 154-157 24932277-8 2014 The investigation for the downstream signal pathway revealed that sorbitol-induced apoptosis was mediated by an increase in phosphorylated p38 MAPK expression. Sorbitol 66-74 mitogen-activated protein kinase 14 Homo sapiens 139-142 24932277-0 2014 Sorbitol induces apoptosis of human colorectal cancer cells via p38 MAPK signal transduction. Sorbitol 0-8 mitogen-activated protein kinase 14 Homo sapiens 64-67 24932277-9 2014 Overall, the observations from the present study imply that sorbitol causes increased levels of Bax in response to p38 MAPK signaling, which results in the initiation of the mitochondrial death cascade. Sorbitol 60-68 mitogen-activated protein kinase 14 Homo sapiens 115-118 8626550-5 1996 Treatment of HeLa cells with sorbitol or TNF resulted in activation of CSBP and MAPKAP kinase-3 and activation of MAPKAP kinase-3 could be blocked by preincubation of cells with SB203580, a specific inhibitor of CSBP kinase activity. Sorbitol 29-37 mitogen-activated protein kinase 14 Homo sapiens 71-75 8626550-5 1996 Treatment of HeLa cells with sorbitol or TNF resulted in activation of CSBP and MAPKAP kinase-3 and activation of MAPKAP kinase-3 could be blocked by preincubation of cells with SB203580, a specific inhibitor of CSBP kinase activity. Sorbitol 29-37 mitogen-activated protein kinase 14 Homo sapiens 212-216 20798394-11 2010 Activation of p38 MAPK in cells by sorbitol-induced hyperosmotic stress increased phosphorylation of S-tag-tensin1, which reduced binding to deleted in liver cancer-1 and increased binding to endogenous pTyr proteins, including p130Cas and focal adhesion kinase. Sorbitol 35-43 mitogen-activated protein kinase 14 Homo sapiens 14-17 23552557-4 2012 Our results show that MLK4beta inhibits sorbitol- and tumor necrosis factor-induced activation of p38. Sorbitol 40-48 mitogen-activated protein kinase 14 Homo sapiens 98-101 16762846-4 2006 The phosphorylation of ATF2 was detected to assay the effect of His-TAT-p38 on endogeneious p38 activity after the cells were stimulated by sorbitol. Sorbitol 140-148 mitogen-activated protein kinase 14 Homo sapiens 72-75 17875425-8 2007 Suppression of the expression of OSM or MEKK3 by RNA interference strongly inhibits the sorbitol-dependent activation of p38. Sorbitol 88-96 mitogen-activated protein kinase 14 Homo sapiens 121-124 19435873-5 2009 Activation of p38 MAPK by sorbitol pretreatment resembled the sensitization effects, whereas inhibition of p38 MAPK activation by its inhibitor SB202190 counteracted the sensitization effects induced by TCTP. Sorbitol 26-34 mitogen-activated protein kinase 14 Homo sapiens 14-17 18456458-6 2008 Overexpression of DMKP-4 inhibited the activation of ERK, JNK and p38 by H(2)O(2), sorbitol and heat shock in HEK293-T cells, and JNK activation in Drosophila S2 cells under PGN stimuli. Sorbitol 83-91 mitogen-activated protein kinase 14 Homo sapiens 66-69 16762846-4 2006 The phosphorylation of ATF2 was detected to assay the effect of His-TAT-p38 on endogeneious p38 activity after the cells were stimulated by sorbitol. Sorbitol 140-148 mitogen-activated protein kinase 14 Homo sapiens 92-95 14634666-5 2003 RNA interference (RNAi) demonstrates that MEKK3 and the scaffold protein are required for p38 activation in response to sorbitol-induced hyperosmolarity. Sorbitol 120-128 mitogen-activated protein kinase 14 Homo sapiens 90-93 16352664-2 2006 Here we identify a new nuclear protein, NP60, which regulates the activation of p38alpha in response to sorbitol treatment. Sorbitol 104-112 mitogen-activated protein kinase 14 Homo sapiens 80-88 16165096-2 2005 CHO-K1 cells stably express green fluorescent protein-5-lipoxygenase fusion protein (GFP-5LO), which is located predominantly in the nucleus, and is exported by anisomycin, hydrogen peroxide, and sorbitol, with activation of p38 MAPK. Sorbitol 196-204 mitogen-activated protein kinase 14 Homo sapiens 225-228 14634666-7 2003 Through its ability to bind actin, relocalize to Rac-containing membrane ruffles and its obligate requirement for p38 activation in response to sorbitol, we have termed this protein osmosensing scaffold for MEKK3 (OSM). Sorbitol 144-152 mitogen-activated protein kinase 14 Homo sapiens 114-117