PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19423711-0 2009 ZAC1 is up-regulated by hypertonicity and decreases sorbitol dehydrogenase expression, allowing accumulation of sorbitol in kidney cells. Sorbitol 52-60 pleiomorphic adenoma gene-like 1 Mus musculus 0-4 19423711-9 2009 Taken together, these data strongly suggest that ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of SDH, allowing for accumulation of sorbitol as a compatible organic osmolyte. Sorbitol 167-175 pleiomorphic adenoma gene-like 1 Mus musculus 49-53