PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11840340-2 2002 When subjected to a hyperosmolar concentration of sorbitol, HaCaT/E5 cells respond with cytochrome c release, activation of caspase-3, -8, and -9, and PARP-cleavage, showing that the mitochondria and death-receptor mediated apoptotic pathways are involved in subsequent cell death. Sorbitol 50-58 poly(ADP-ribose) polymerase 1 Homo sapiens 151-155 10982349-8 2000 (iii) Poly(ADP-ribose) polymerase was cleaved in mock-infected cells exposed to sorbitol or dexamethasone and in cells infected with the d120 mutant but not in either untreated cells infected with wild-type virus or cells exposed to sorbitol and then infected with wild-type virus. Sorbitol 80-88 poly(ADP-ribose) polymerase 1 Homo sapiens 6-33 10982349-8 2000 (iii) Poly(ADP-ribose) polymerase was cleaved in mock-infected cells exposed to sorbitol or dexamethasone and in cells infected with the d120 mutant but not in either untreated cells infected with wild-type virus or cells exposed to sorbitol and then infected with wild-type virus. Sorbitol 233-241 poly(ADP-ribose) polymerase 1 Homo sapiens 6-33 24932277-6 2014 Following treatment with sorbitol for 3 h, western blotting demonstrated cleavage of the caspase-3 zymogen protein and a cleavage product of poly (ADP-ribose) polymerase (PARP), a known substrate of caspase-3, was also evident. Sorbitol 25-33 poly(ADP-ribose) polymerase 1 Homo sapiens 141-169 24932277-6 2014 Following treatment with sorbitol for 3 h, western blotting demonstrated cleavage of the caspase-3 zymogen protein and a cleavage product of poly (ADP-ribose) polymerase (PARP), a known substrate of caspase-3, was also evident. Sorbitol 25-33 poly(ADP-ribose) polymerase 1 Homo sapiens 171-175 16356118-5 2005 Others put forward a so-called "unifying hypothesis" suggesting that activation of several major pathways implicated in diabetic complications (e.g., sorbitol pathway) occurs due to increased production of superoxide anion radicals in mitochondria and resulting poly(ADP-ribose) polymerase activation. Sorbitol 150-158 poly(ADP-ribose) polymerase 1 Homo sapiens 262-289