PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11840340-2	2002	When subjected to a hyperosmolar concentration of sorbitol, HaCaT/E5 cells respond with cytochrome c release, activation of caspase-3, -8, and -9, and PARP-cleavage, showing that the mitochondria and death-receptor mediated apoptotic pathways are involved in subsequent cell death.	Sorbitol	50-58	poly(ADP-ribose) polymerase 1	Homo sapiens	151-155	
10982349-8	2000	(iii) Poly(ADP-ribose) polymerase was cleaved in mock-infected cells exposed to sorbitol or dexamethasone and in cells infected with the d120 mutant but not in either untreated cells infected with wild-type virus or cells exposed to sorbitol and then infected with wild-type virus.	Sorbitol	80-88	poly(ADP-ribose) polymerase 1	Homo sapiens	6-33	
10982349-8	2000	(iii) Poly(ADP-ribose) polymerase was cleaved in mock-infected cells exposed to sorbitol or dexamethasone and in cells infected with the d120 mutant but not in either untreated cells infected with wild-type virus or cells exposed to sorbitol and then infected with wild-type virus.	Sorbitol	233-241	poly(ADP-ribose) polymerase 1	Homo sapiens	6-33	
24932277-6	2014	Following treatment with sorbitol for 3 h, western blotting demonstrated cleavage of the caspase-3 zymogen protein and a cleavage product of poly (ADP-ribose) polymerase (PARP), a known substrate of caspase-3, was also evident.	Sorbitol	25-33	poly(ADP-ribose) polymerase 1	Homo sapiens	141-169	
24932277-6	2014	Following treatment with sorbitol for 3 h, western blotting demonstrated cleavage of the caspase-3 zymogen protein and a cleavage product of poly (ADP-ribose) polymerase (PARP), a known substrate of caspase-3, was also evident.	Sorbitol	25-33	poly(ADP-ribose) polymerase 1	Homo sapiens	171-175	
16356118-5	2005	Others put forward a so-called "unifying hypothesis" suggesting that activation of several major pathways implicated in diabetic complications (e.g., sorbitol pathway) occurs due to increased production of superoxide anion radicals in mitochondria and resulting poly(ADP-ribose) polymerase activation.	Sorbitol	150-158	poly(ADP-ribose) polymerase 1	Homo sapiens	262-289