PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8535074-1 1995 The polyol pathway comprises the enzymes aldose reductase and sorbitol dehydrogenase, which convert glucose to sorbitol and sorbitol to fructose, respectively, particularly in hyperglycemic states. Sorbitol 111-119 sorbitol dehydrogenase Homo sapiens 62-84 15128296-3 2004 The resulting enzyme preparation catalyzed the oxidation of pentitols (L-arabinitol) and hexitols (D-allitol, D-sorbitol, L-iditol, L-mannitol) to the same corresponding ketoses as mammalian sorbitol dehydrogenase (SDH), albeit with different catalytic efficacies, showing highest k(cat)/K(m) for L-arabinitol. Sorbitol 112-120 sorbitol dehydrogenase Homo sapiens 191-213 15128296-3 2004 The resulting enzyme preparation catalyzed the oxidation of pentitols (L-arabinitol) and hexitols (D-allitol, D-sorbitol, L-iditol, L-mannitol) to the same corresponding ketoses as mammalian sorbitol dehydrogenase (SDH), albeit with different catalytic efficacies, showing highest k(cat)/K(m) for L-arabinitol. Sorbitol 112-120 sorbitol dehydrogenase Homo sapiens 215-218 15128296-6 2004 Juxtapositioning of the Lad1 3D structure over that of SDH revealed major amino acid exchanges at topologies flanking the binding pocket for d-sorbitol. Sorbitol 141-151 sorbitol dehydrogenase Homo sapiens 55-58 12615520-1 2003 The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. Sorbitol 69-77 sorbitol dehydrogenase Homo sapiens 93-96 12615520-1 2003 The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. Sorbitol 196-204 sorbitol dehydrogenase Homo sapiens 69-91 12615520-1 2003 The polyol pathway consists of two enzymes aldose reductase (AR) and sorbitol dehydrogenase (SDH); the former is the first enzyme in the polyol pathway, that catalyzes the reduction of glucose to sorbitol, the latter is the second one, that converts sorbitol to fructose using by NAD(+) as a cofactor. Sorbitol 196-204 sorbitol dehydrogenase Homo sapiens 93-96 23850972-2 2013 Hyperglycemia increases glucose flux through the polyol pathway, in which aldose reductase converts glucose into intracellular sorbitol, which is subsequently converted to fructose by sorbitol dehydrogenase (SDH). Sorbitol 127-135 sorbitol dehydrogenase Homo sapiens 184-206 23850972-2 2013 Hyperglycemia increases glucose flux through the polyol pathway, in which aldose reductase converts glucose into intracellular sorbitol, which is subsequently converted to fructose by sorbitol dehydrogenase (SDH). Sorbitol 127-135 sorbitol dehydrogenase Homo sapiens 208-211 20372835-1 2010 Sorbitol is an intermediate in the polyol pathway, which converts from glucose to fructose by sorbitol dehydrogenase (SORD). Sorbitol 0-8 sorbitol dehydrogenase Homo sapiens 94-116 20372835-1 2010 Sorbitol is an intermediate in the polyol pathway, which converts from glucose to fructose by sorbitol dehydrogenase (SORD). Sorbitol 0-8 sorbitol dehydrogenase Homo sapiens 118-122 17508915-2 2007 Our studies suggest that cytosolic NADH reductive stress under high glucose is largely caused by increased flux of glucose through polyol (sorbitol) pathway consisting of aldose reductase and sorbitol dehydrogenase. Sorbitol 139-147 sorbitol dehydrogenase Homo sapiens 192-214 16596633-5 2006 The observations are consistent with diffusion of circulating glucose into the lumen, its conversion via AR to sorbitol which accumulates in the lumen and the action of SDH on sorbitol to produce fructose. Sorbitol 176-184 sorbitol dehydrogenase Homo sapiens 169-172 14965227-1 2004 Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. Sorbitol 174-182 sorbitol dehydrogenase Homo sapiens 0-22 14965227-1 2004 Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. Sorbitol 174-182 sorbitol dehydrogenase Homo sapiens 24-27 14525943-1 2003 Sorbitol dehydrogenase (SDH) is a polyol pathway enzyme that catalyzes conversion of sorbitol to fructose. Sorbitol 85-93 sorbitol dehydrogenase Homo sapiens 0-22 14525943-1 2003 Sorbitol dehydrogenase (SDH) is a polyol pathway enzyme that catalyzes conversion of sorbitol to fructose. Sorbitol 85-93 sorbitol dehydrogenase Homo sapiens 24-27 10209867-1 1998 The carbohydrate specificity of the two enzymes that catalyze the metabolic interconversions in the sorbitol pathway, aldose reductase and sorbitol dehydrogenase, has been examined through the use of fluoro- and deoxy-substrate analogs. Sorbitol 100-108 sorbitol dehydrogenase Homo sapiens 139-161 8535074-3 1995 Inappropriate sorbitol accumulation in some patients may be the result of polymorphic variation in the human sorbitol dehydrogenase gene, causing reduced expression levels or enzymatic activity. Sorbitol 14-22 sorbitol dehydrogenase Homo sapiens 109-131 34517598-5 2021 The concentration of cofactors (NADH, NAD+) and substrates (fructose, sorbitol) for SDH determination at a strip was optimized via internally-calibrated amperometric assays at a chitosan/nitrogen-doped carbon nanotube electrode. Sorbitol 70-78 sorbitol dehydrogenase Homo sapiens 84-87 8236522-3 1993 A decrease of enzyme activity at the sorbitol way of glucose exchange (sorbitol-dehydrogenase and aldose reductase) in placenta reflects accumulation of sorbitol in tissue, which intensifies the damage of membrane structures in placenta. Sorbitol 37-45 sorbitol dehydrogenase Homo sapiens 71-93 8330752-1 1993 Conversion of glucose to fructose via sorbitol depends upon the enzymes aldose reductase and sorbitol dehydrogenase and is called the polyol pathway. Sorbitol 38-46 sorbitol dehydrogenase Homo sapiens 93-115 8487505-5 1993 In SORD-deficient patients, the enzymatic deficiency was observed in both crude haemolysate and SORD-M preparations with sorbitol, galactitol, xylitol or ribitol as substrates. Sorbitol 121-129 sorbitol dehydrogenase Homo sapiens 3-7 34517598-7 2021 The assays yielded kinetic parameters Km and kcat and demonstrated higher apparent affinity of SDH for NADH and fructose than NAD+ and sorbitol. Sorbitol 135-143 sorbitol dehydrogenase Homo sapiens 95-98 34827446-10 2021 Further approaches are aimed at correcting metabolic abnormalities, including the accumulation of sorbitol caused by biallelic mutations in the sorbitol dehydrogenase (SORD) gene and of neurotoxic glycosphingolipids in HSN1. Sorbitol 98-106 sorbitol dehydrogenase Homo sapiens 144-166 34827446-10 2021 Further approaches are aimed at correcting metabolic abnormalities, including the accumulation of sorbitol caused by biallelic mutations in the sorbitol dehydrogenase (SORD) gene and of neurotoxic glycosphingolipids in HSN1. Sorbitol 98-106 sorbitol dehydrogenase Homo sapiens 168-172 6412013-4 1983 Sorbitol does not accumulate either in control or in G6PD deficient fibroblasts incubated in high glucose medium, most likely because of the action of sorbitol dehydrogenase, and the presence of a carrier-mediated glucose transport system in the cell membrane which limits the concentration of glucose that can accumulate in these cells. Sorbitol 0-8 sorbitol dehydrogenase Homo sapiens 151-173 35224818-9 2022 UPLC-tandem mass spectrometry confirmed that the patient had elevated serum sorbitol levels (12.0 mg/L) consistent with levels previously observed in patients with biallelic SORD mutations. Sorbitol 76-84 sorbitol dehydrogenase Homo sapiens 174-178 32367058-3 2020 SORD is an enzyme that converts sorbitol into fructose in the two-step polyol pathway previously implicated in diabetic neuropathy. Sorbitol 32-40 sorbitol dehydrogenase Homo sapiens 0-4