PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20293-4 1977 The qualitative difference in response to CO exposure in the two groups of animals may be due to differences in the sensitivity of cytochrome P-450 and cytochrome P-448 with respect to complexing with CO or to lowered intracellular PO2; or to differences in the dependency on blood flow of the rate of in vivo metabolism of zoxazolamine. PO-2 232-235 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 131-147 11678630-1 2001 This study determined the contribution of cytochrome P450 (CP450) 4A enzyme metabolites of arachidonic acid in mediating the constriction of isolated rat skeletal muscle resistance arteries in response to elevated PO2. PO-2 214-217 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 42-57 11678630-1 2001 This study determined the contribution of cytochrome P450 (CP450) 4A enzyme metabolites of arachidonic acid in mediating the constriction of isolated rat skeletal muscle resistance arteries in response to elevated PO2. PO-2 214-217 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 59-64 11071299-9 2000 Cytochrome P450 4A blockers also attenuate the vasoconstrictor response to elevations in tissue PO2, suggesting that this system may serve as a vascular oxygen sensor. PO-2 96-99 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 0-15 2609348-7 1989 These results suggest that the reductive activation to free radicals, catalyzed by cytochrome P-450, and thus the induction of lipid peroxidation at low but physiological PO2 are characteristic not only of CCl4 but also of other polyhalogenated methanes, especially CBrCl3, CBr4, CHI3, CHBr3, and CHBr2Cl. PO-2 171-174 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 83-99