PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23798702-2	2013	S-Oxidation of RyR1 is coupled to muscle oxygen tension (pO2) through O2-dependent production of hydrogen peroxide by SR-resident NADPH oxidase 4.	PO-2	57-60	NADPH oxidase 4	Homo sapiens	130-145	
25062272-8	2014	This allows Nox4 to generate H2O2 as a function of oxygen concentration throughout a physiological range of pO2 values and to respond rapidly to changes in pO2.	PO-2	108-111	NADPH oxidase 4	Homo sapiens	12-16	
25062272-8	2014	This allows Nox4 to generate H2O2 as a function of oxygen concentration throughout a physiological range of pO2 values and to respond rapidly to changes in pO2.	PO-2	156-159	NADPH oxidase 4	Homo sapiens	12-16	
23798702-5	2013	Eight additional Cys residues are oxidized at high versus low pO2 only when NADPH levels are supplemented to enhance NADPH oxidase 4 activity.	PO-2	62-65	NADPH oxidase 4	Homo sapiens	117-132	
21896730-3	2011	Reactive oxygen species are generated in proportion to pO(2) by NADPH oxidase 4 (Nox4) in the sarcoplasmic reticulum, and the consequent oxidation of a small set of RyR1 cysteine thiols results in increased RyR1 activity and Ca(2+) release in isolated sarcoplasmic reticulum and in cultured myofibers and enhanced contractility of intact muscle.	PO-2	55-60	NADPH oxidase 4	Homo sapiens	64-79	
21896730-3	2011	Reactive oxygen species are generated in proportion to pO(2) by NADPH oxidase 4 (Nox4) in the sarcoplasmic reticulum, and the consequent oxidation of a small set of RyR1 cysteine thiols results in increased RyR1 activity and Ca(2+) release in isolated sarcoplasmic reticulum and in cultured myofibers and enhanced contractility of intact muscle.	PO-2	55-60	NADPH oxidase 4	Homo sapiens	81-85