PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33980604-5 2021 Mizoribine and ribavirin mapped to the ENT1 substrate pharmacophore and proved to be substrates of the ENTs. Ribavirin 15-24 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 39-43 33980604-7 2021 NBMPR also decreased ribavirin accumulation in ENT1 and ENT2 cells (ENT1: ~50% decrease p = 0.0498; ENT2: ~30% decrease p = 0.0125). Ribavirin 21-30 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 47-51 28417642-0 2017 Equilibrative nucleoside transporter 1 expression in primary human hepatocytes is highly variable and determines uptake of ribavirin. Ribavirin 123-132 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 0-38 32864162-6 2020 We found several drug-gene variant pairs that may alter the pharmacokinetics of hydroxychloroquine/chloroquine (CYP2C8, CYP2D6, SLCO1A2, and SLCO1B1); azithromycin (ABCB1); ribavirin (SLC29A1, SLC28A2, and SLC28A3); and lopinavir/ritonavir (SLCO1B1, ABCC2, CYP3A). Ribavirin 173-182 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 184-191 32635975-6 2020 Ribavirin uptake was inhibited by nucleosides such as adenosine and uridine, and by inhibitors of equilibrative nucleoside transporter 1 (ENT1) such as S-(4-nitrobenzyl)-6-thioinosine and dipyridamole in a concentration-dependent manner. Ribavirin 0-9 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 98-136 32635975-6 2020 Ribavirin uptake was inhibited by nucleosides such as adenosine and uridine, and by inhibitors of equilibrative nucleoside transporter 1 (ENT1) such as S-(4-nitrobenzyl)-6-thioinosine and dipyridamole in a concentration-dependent manner. Ribavirin 0-9 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 138-142 32635975-8 2020 On the other hand, Na+-dependence of ribavirin uptake was not observed, suggesting the involvement of ENT1, but not Na+-dependent concentrative nucleoside transporters, in ribavirin uptake in K562 cells. Ribavirin 172-181 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 102-106 32635975-10 2020 These results suggest that ribavirin uptake into K562 cells is mainly mediated by ENT1, which may have a pivotal role in anticancer effect of ribavirin. Ribavirin 27-36 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 82-86 32635975-10 2020 These results suggest that ribavirin uptake into K562 cells is mainly mediated by ENT1, which may have a pivotal role in anticancer effect of ribavirin. Ribavirin 142-151 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 82-86 30716294-4 2019 Our data indicate that ENT1 participates in uptake of ribavirin by BeWo cells, fresh human placental villous fragments and microvillous plasma membrane (MVM) vesicles while activity of CNTs (probably CNT2) was only observed in BeWo cells. Ribavirin 54-63 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 23-27 30716294-7 2019 In summary, our data show that ribavirin placental pharmacokinetics are largely controlled by ENT1 activity and independent of ABCB1, ABCG2, and ABCC2 efflux pumps. Ribavirin 31-40 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 94-98 28417642-9 2017 Results There was a strong direct correlation between expression of ENT1 in primary hepatocytes and ribavirin uptake at 24 hr. Ribavirin 100-109 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 68-72 28417642-12 2017 Conclusions In this study, we clearly demonstrate that ribavirin uptake in primary human hepatocytes is variable and correlates with ENT1 expression. Ribavirin 55-64 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 133-137 28417642-13 2017 This variation in ENT1 expression may account for differences in response rate in patients receiving ribavirin-based anti-hepatitis C virus therapy. Ribavirin 101-110 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 18-22 26750805-7 2016 RBV-induced anemia was independently correlated with SLC29A1 rs760370 AA genotype (OR, 2.90; 95% CI, 1.29-6.54, P = 0.010), and the severity of IFN-induced thrombocytopenia was related to GG genotype (OR, 4.98; 95% CI, 1.27-19.61; P = 0.021); the detected effects held true for HCV-2a patients but weakened in HCV-1b patients. Ribavirin 0-3 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 53-60 28207300-2 2017 The equilibrative nucleoside transporter-1 codified by SLC29A1 gene has been associated with ribavirin uptake into hepatocytes and erythrocytes. Ribavirin 93-102 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 55-62 28207300-3 2017 rs760370A>G single nucleotide polymorphism (SNP) at the SLC29A1 gene may have a role in ribavirin-based regimen treatment response. Ribavirin 91-100 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 59-66 25661337-1 2015 Ribavirin is phosphorylated by adenosine kinase 1 (AK1) and cytosolic 5"-nucleotidase 2 and it is transported into cells by concentrative nucleoside transporters (CNT) 2/3, coded by SLC28A2/3 genes, and equilibrative nucleoside transporters (ENT) 1/2, coded by SLC29A1/2 genes. Ribavirin 0-9 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 261-268 25583751-1 2015 OBJECTIVES: The equilibrative nucleoside transporter 1 (ENT1) is the main protein involved in ribavirin cellular uptake. Ribavirin 94-103 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 16-54 25583751-1 2015 OBJECTIVES: The equilibrative nucleoside transporter 1 (ENT1) is the main protein involved in ribavirin cellular uptake. Ribavirin 94-103 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 56-60 25583751-2 2015 Polymorphisms at the SLC29A1 gene, encoding ENT1, may influence ribavirin-associated anaemia, which is observed at a higher incidence with telaprevir in combination with pegylated-IFNalpha and ribavirin than with pegylated-IFNalpha and ribavirin alone. Ribavirin 64-73 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 21-28 25583751-2 2015 Polymorphisms at the SLC29A1 gene, encoding ENT1, may influence ribavirin-associated anaemia, which is observed at a higher incidence with telaprevir in combination with pegylated-IFNalpha and ribavirin than with pegylated-IFNalpha and ribavirin alone. Ribavirin 64-73 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 44-48 25583751-2 2015 Polymorphisms at the SLC29A1 gene, encoding ENT1, may influence ribavirin-associated anaemia, which is observed at a higher incidence with telaprevir in combination with pegylated-IFNalpha and ribavirin than with pegylated-IFNalpha and ribavirin alone. Ribavirin 193-202 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 21-28 25583751-2 2015 Polymorphisms at the SLC29A1 gene, encoding ENT1, may influence ribavirin-associated anaemia, which is observed at a higher incidence with telaprevir in combination with pegylated-IFNalpha and ribavirin than with pegylated-IFNalpha and ribavirin alone. Ribavirin 193-202 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 44-48 25583751-2 2015 Polymorphisms at the SLC29A1 gene, encoding ENT1, may influence ribavirin-associated anaemia, which is observed at a higher incidence with telaprevir in combination with pegylated-IFNalpha and ribavirin than with pegylated-IFNalpha and ribavirin alone. Ribavirin 193-202 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 21-28 25583751-2 2015 Polymorphisms at the SLC29A1 gene, encoding ENT1, may influence ribavirin-associated anaemia, which is observed at a higher incidence with telaprevir in combination with pegylated-IFNalpha and ribavirin than with pegylated-IFNalpha and ribavirin alone. Ribavirin 193-202 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 44-48 25583751-3 2015 In this study, we investigated the role of the rs760370 SLC29A1 variant in ribavirin-induced anaemia in chronic hepatitis C patients treated with telaprevir-based triple therapy. Ribavirin 75-84 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 56-63 25583751-8 2015 CONCLUSIONS: In patients with chronic hepatitis C receiving telaprevir-based therapy, SNP rs760370A>G at the SLC29A1 gene influences the severity of ribavirin-induced anaemia, possibly mirroring the erythrocyte uptake of ribavirin. Ribavirin 152-161 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 112-119 25583751-8 2015 CONCLUSIONS: In patients with chronic hepatitis C receiving telaprevir-based therapy, SNP rs760370A>G at the SLC29A1 gene influences the severity of ribavirin-induced anaemia, possibly mirroring the erythrocyte uptake of ribavirin. Ribavirin 224-233 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 112-119 25661339-3 2015 The aim of this retrospective study was the evaluation of the influence of some single nucleotide polymorphisms (SNPs) of genes (ABCB1, SLC28A2/3, SLC29A1) involved in TLV and RBV transport and their correlation with plasma TLV drug exposure at 1 month of therapy. Ribavirin 176-179 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 147-154 25011570-3 2015 The CNT1- and ENT1-mediated ribavirin uptake showed concentration dependency with the following kinetics parameters: Km 26.3 muM and Vmax 426.2 fmol/min/oocyte for CNT1; Km 70.5 muM and Vmax 134.3 fmol/min/oocyte for ENT1. Ribavirin 28-37 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 217-221 25011570-0 2015 Contribution of CNT1 and ENT1 to ribavirin uptake in human hepatocytes. Ribavirin 33-42 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 25-29 25011570-2 2015 The initial studies in oocytes expressing CNT1 and ENT1 showed increases in ribavirin uptake, indicating that ribavirin was a substrate for both CNT1 and ENT1. Ribavirin 76-85 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 51-55 25011570-2 2015 The initial studies in oocytes expressing CNT1 and ENT1 showed increases in ribavirin uptake, indicating that ribavirin was a substrate for both CNT1 and ENT1. Ribavirin 76-85 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 154-158 25011570-2 2015 The initial studies in oocytes expressing CNT1 and ENT1 showed increases in ribavirin uptake, indicating that ribavirin was a substrate for both CNT1 and ENT1. Ribavirin 110-119 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 51-55 25011570-2 2015 The initial studies in oocytes expressing CNT1 and ENT1 showed increases in ribavirin uptake, indicating that ribavirin was a substrate for both CNT1 and ENT1. Ribavirin 110-119 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 154-158 25011570-3 2015 The CNT1- and ENT1-mediated ribavirin uptake showed concentration dependency with the following kinetics parameters: Km 26.3 muM and Vmax 426.2 fmol/min/oocyte for CNT1; Km 70.5 muM and Vmax 134.3 fmol/min/oocyte for ENT1. Ribavirin 28-37 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 14-18 25011570-5 2015 Estimation of the contributions of CNT1 and ENT1 to the hepatic uptake of ribavirin by using a relative activity factor method indicated that the relative contribution of ENT1 to the ribavirin uptake was 82.8 +- 3.9%. Ribavirin 74-83 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 44-48 25011570-5 2015 Estimation of the contributions of CNT1 and ENT1 to the hepatic uptake of ribavirin by using a relative activity factor method indicated that the relative contribution of ENT1 to the ribavirin uptake was 82.8 +- 3.9%. Ribavirin 74-83 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 171-175 25011570-5 2015 Estimation of the contributions of CNT1 and ENT1 to the hepatic uptake of ribavirin by using a relative activity factor method indicated that the relative contribution of ENT1 to the ribavirin uptake was 82.8 +- 3.9%. Ribavirin 183-192 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 171-175 25011570-6 2015 Real-time polymerase chain reaction analysis of CNT1 and ENT1 expressions in the hepatocytes showed that ENT1 mRNA expression was closely correlated with ribavirin uptake (R = 0.95, P = 0.003) while CNT1 was not. Ribavirin 154-163 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 105-109 25011570-7 2015 The findings indicated that ENT1 was the major transporter controlling the hepatic uptake of ribavirin. Ribavirin 93-102 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 28-32 25339775-4 2015 We found that HCV replication in persistently infected cultures induces an autophagy response that impairs RBV uptake by preventing the expression of equilibrative nucleoside transporter 1 (ENT1). Ribavirin 107-110 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 190-194 26279293-0 2015 ITPA and SLC29A1 Genotyping for the Prediction of Ribavirin Dose Reduction in Anti-HCV Triple Therapy with Protease Inhibitors. Ribavirin 50-59 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 9-16 26279293-5 2015 Here, we investigated haemoglobin levels and the best-known functional SNPs in ITPA and SLC29A1 genes in 22 patients treated with triple therapy with BOC/Peg-IFN/RBV. Ribavirin 162-165 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 88-95 26279293-6 2015 The identification of ITPA protective and SLC29A1 risk genotypes still appears to be a current methodology in RBV dosing during hepatitis C virus therapy with DAAs. Ribavirin 110-113 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 42-49 23459628-1 2013 Ribavirin (RBV), a guanosine analog for treatment of hepatitis C, is a substrate of a nucleoside transporter, solute carrier family 29 member 1 (SLC29A1). Ribavirin 0-9 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 145-152 23459628-1 2013 Ribavirin (RBV), a guanosine analog for treatment of hepatitis C, is a substrate of a nucleoside transporter, solute carrier family 29 member 1 (SLC29A1). Ribavirin 11-14 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 145-152 23459628-9 2013 These results suggest that RBV/DP coadministration reduces the concentration of RBV in blood by inhibiting an important role of SLC29A1 in gastrointestinal absorption of RBV. Ribavirin 27-30 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 128-135 23459628-9 2013 These results suggest that RBV/DP coadministration reduces the concentration of RBV in blood by inhibiting an important role of SLC29A1 in gastrointestinal absorption of RBV. Ribavirin 80-83 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 128-135 23459628-9 2013 These results suggest that RBV/DP coadministration reduces the concentration of RBV in blood by inhibiting an important role of SLC29A1 in gastrointestinal absorption of RBV. Ribavirin 80-83 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 128-135 22212648-2 2012 Equilibrative nucleoside transporter 1 (ENT1), encoded by SLC29A1 gene, is the main transporter that imports ribavirin into human hepatocytes. Ribavirin 109-118 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 0-38 22212648-2 2012 Equilibrative nucleoside transporter 1 (ENT1), encoded by SLC29A1 gene, is the main transporter that imports ribavirin into human hepatocytes. Ribavirin 109-118 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 40-44 22212648-2 2012 Equilibrative nucleoside transporter 1 (ENT1), encoded by SLC29A1 gene, is the main transporter that imports ribavirin into human hepatocytes. Ribavirin 109-118 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 58-65 21543469-6 2011 When Huh7.5 cells were exposed to RBV, resistance developed through reduced RBV uptake via the ENT1 nucleoside transporter and antiviral efficacy was reduced. Ribavirin 34-37 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 95-99 22232287-0 2012 ENT1, a ribavirin transporter, plays a pivotal role in antiviral efficacy of ribavirin in a hepatitis C virus replication cell system. Ribavirin 8-17 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 0-4 22232287-2 2012 However, because the role of this transporter in the antiviral mechanism of the drug remains unclear, the present study aimed to elucidate the role of ENT1 in ribavirin antiviral action. Ribavirin 159-168 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 151-155 22232287-5 2012 Nitrobenzylmercaptopurine riboside (NBMPR) and micro-RNA targeted to ENT1 mRNA (miR-ENT1) were used to reduce the ribavirin uptake level in OR6 cells. Ribavirin 114-123 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 69-73 22232287-5 2012 Nitrobenzylmercaptopurine riboside (NBMPR) and micro-RNA targeted to ENT1 mRNA (miR-ENT1) were used to reduce the ribavirin uptake level in OR6 cells. Ribavirin 114-123 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 84-88 22232287-7 2012 It was found that the primary ribavirin transporter in OR6 cells was ENT1 and that inhibition of ENT1-mediated ribavirin uptake by NBMPR significantly attenuated the antiviral activity of the drug as well as its accumulation in OR6 cells. Ribavirin 30-39 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 69-73 22232287-7 2012 It was found that the primary ribavirin transporter in OR6 cells was ENT1 and that inhibition of ENT1-mediated ribavirin uptake by NBMPR significantly attenuated the antiviral activity of the drug as well as its accumulation in OR6 cells. Ribavirin 30-39 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 97-101 22232287-8 2012 The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. Ribavirin 73-82 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 59-63 22232287-8 2012 The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. Ribavirin 73-82 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 123-127 22232287-8 2012 The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. Ribavirin 73-82 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 123-127 22232287-8 2012 The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. Ribavirin 225-234 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 59-63 22232287-8 2012 The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. Ribavirin 225-234 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 123-127 22232287-8 2012 The results also showed that even a small reduction in the ENT1-mediated ribavirin uptake, achieved in this case using miR-ENT1, caused a significant decrease in its antiviral activity, thus indicating that the ENT1-mediated ribavirin uptake level determined its antiviral activity level in OR6 cells. Ribavirin 225-234 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 123-127 22232287-9 2012 In conclusion, our results show that by facilitating its uptake and accumulation in OR6 cells, ENT1 plays a pivotal role in the antiviral effectiveness of ribavirin and therefore provides an important insight into the efficacy of the drug in anti-HCV therapy. Ribavirin 155-164 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 95-99 21543469-6 2011 When Huh7.5 cells were exposed to RBV, resistance developed through reduced RBV uptake via the ENT1 nucleoside transporter and antiviral efficacy was reduced. Ribavirin 76-79 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 95-99 21543469-7 2011 The uptake defect in RBV-resistant cells was specific to RBV, since transport of another ENT1 substrate, cytidine, was unaffected. Ribavirin 21-24 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 89-93 20096989-0 2010 Kinetic study of anti-viral ribavirin uptake mediated by hCNT3 and hENT1 in Xenopus laevis oocytes. Ribavirin 28-37 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 67-72 20814156-5 2010 The trans-stimulated uptake of [3H]uridine at ICT was inhibited by ENT1 inhibitors/substrates such as NBMPR, dipyridamole, adenosine, and ribavirin in a concentration-dependent manner. Ribavirin 138-147 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 67-71 17140564-4 2007 In Xenopus oocytes, influxes of ribavirin mediated by hCNT2 (concentrative nucleoside transporter 2), hCNT3 (concentrative nucleoside transporter 3), hENT1 (equilibrative nucleoside transporter 1) and hENT2 (equilibrative nucleoside transporter 2) were saturable, and apparent K(m) values were 18.0 microM, 14.2 microM, 3.46 mM and 3.71 mM, respectively. Ribavirin 32-41 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 150-155 17140564-7 2007 These results suggest that ribavirin is taken up by BeWo cells via both the high-affinity Na(+)-dependent transporter hCNT3 and the low-affinity Na(+)-independent transporters hENT1 and hENT2. Ribavirin 27-36 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 176-181 20812847-1 2010 The equilibrative nucleoside transporter 1 (ENT1) is the main protein involved in ribavirin cellular uptake. Ribavirin 82-91 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 4-42 20812847-1 2010 The equilibrative nucleoside transporter 1 (ENT1) is the main protein involved in ribavirin cellular uptake. Ribavirin 82-91 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 44-48 20812847-2 2010 Polymorphisms at the ENT1 gene may influence ribavirin activity as part of hepatitis C virus (HCV) therapy. Ribavirin 45-54 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 21-25 20812847-9 2010 In summary, a SNP rs760370A G at the ENT1 gene influences the chance of rapid virological response to pegIFN-ribavirin therapy in HIV-infected patients with chronic HCV infection due to HCV genotypes 1 or 4, most likely modulating intracellular ribavirin exposure within hepatocytes. Ribavirin 109-118 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 37-41 20812847-9 2010 In summary, a SNP rs760370A G at the ENT1 gene influences the chance of rapid virological response to pegIFN-ribavirin therapy in HIV-infected patients with chronic HCV infection due to HCV genotypes 1 or 4, most likely modulating intracellular ribavirin exposure within hepatocytes. Ribavirin 245-254 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 37-41 20185188-5 2010 RESULTS: Equilibrative nucleoside transporter 1 (ENT1)-mediated uptake was exclusively involved in ribavirin uptake in HH268 and HH283 and was responsible for the largest ribavirin uptake fraction in HH291. Ribavirin 99-108 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 9-47 20185188-5 2010 RESULTS: Equilibrative nucleoside transporter 1 (ENT1)-mediated uptake was exclusively involved in ribavirin uptake in HH268 and HH283 and was responsible for the largest ribavirin uptake fraction in HH291. Ribavirin 99-108 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 49-53 20185188-5 2010 RESULTS: Equilibrative nucleoside transporter 1 (ENT1)-mediated uptake was exclusively involved in ribavirin uptake in HH268 and HH283 and was responsible for the largest ribavirin uptake fraction in HH291. Ribavirin 171-180 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 9-47 20185188-5 2010 RESULTS: Equilibrative nucleoside transporter 1 (ENT1)-mediated uptake was exclusively involved in ribavirin uptake in HH268 and HH283 and was responsible for the largest ribavirin uptake fraction in HH291. Ribavirin 171-180 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 49-53 20185188-10 2010 CONCLUSIONS: ENT1, but not ENT2 or CNTs, is a major ribavirin uptake transporter in human hepatocytes. Ribavirin 52-61 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 13-17 20185188-11 2010 The different ENT1-mediated ribavirin uptake levels in different hepatocyte lines are associated with different expression levels of specific isoforms of ENT1 mRNAs. Ribavirin 28-37 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 14-18 20185188-11 2010 The different ENT1-mediated ribavirin uptake levels in different hepatocyte lines are associated with different expression levels of specific isoforms of ENT1 mRNAs. Ribavirin 28-37 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 154-158 19244331-6 2009 Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. Ribavirin 123-126 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 18-56 19244331-6 2009 Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. Ribavirin 123-126 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 58-62 19244331-6 2009 Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. Ribavirin 137-140 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 18-56 19244331-6 2009 Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. Ribavirin 137-140 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 58-62 19244331-6 2009 Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. Ribavirin 137-140 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 18-56 19244331-6 2009 Overexpression of equilibrative nucleoside transporter 1 (ENT1) or concentrative nucleoside transporter 3 (CNT3) increased RBV uptake in RBV-sensitive cell lines and restored the uptake defect in most RBV-resistant cell lines. Ribavirin 137-140 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 58-62 19244331-9 2009 Taken together, these results indicate that RBV uptake is restricted primarily to ENT1 in the cell lines examined. Ribavirin 44-47 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 82-86 19244331-10 2009 Interestingly, some RBV-resistant cell lines may compensate for reduced ENT1-mediated nucleoside uptake by increasing the activity of an alternative nucleoside transporter, ENT2. Ribavirin 20-23 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 72-76 19164463-0 2009 The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes. Ribavirin 93-102 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 16-54 19164463-0 2009 The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes. Ribavirin 93-102 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 56-60 19164463-0 2009 The role of the equilibrative nucleoside transporter 1 (ENT1) in transport and metabolism of ribavirin by human and wild-type or Ent1-/- mouse erythrocytes. Ribavirin 93-102 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 129-133 19164463-2 2009 The human equilibrative nucleoside transporter (ENT) 1 transports ribavirin into erythrocytes where it is phosphorylated. Ribavirin 66-75 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 10-54 19164463-4 2009 Here, we examined the in vitro and ex vivo transport and metabolism of ribavirin by erythrocytes isolated from humans and Ent1-null mice. Ribavirin 71-80 solute carrier family 29 member 1 (Augustine blood group) Homo sapiens 122-126