PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35185356-8 2022 The availability of FDA-approved anti-RdRp drugs (Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir) as potent drugs against SARS-CoV-2 that tightly bind to its RdRp may aid in the treatment of patients and reduce the risk of the mysterious new form of COVID-19 viral infection. Ribavirin 50-59 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 38-42 33766591-6 2021 Afterwards, the clinical development of some NAs including Favipiravir, Sofosbuvir, Ribavirin, Tenofovir, and Remdesivir as potential inhibitors of RdRp, were surveyed. Ribavirin 84-93 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 148-152 35510477-3 2022 The results reveal a comparable binding affinity of sofosbuvir, galidesivir, ribavirin and remdesivir compared with the physiological nucleotide triphosphates against R. oryzae RdRp as well as the SARS-CoV-2 RdRp as reported before. Ribavirin 77-86 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 177-181 35510477-3 2022 The results reveal a comparable binding affinity of sofosbuvir, galidesivir, ribavirin and remdesivir compared with the physiological nucleotide triphosphates against R. oryzae RdRp as well as the SARS-CoV-2 RdRp as reported before. Ribavirin 77-86 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 208-212 35185356-8 2022 The availability of FDA-approved anti-RdRp drugs (Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir) as potent drugs against SARS-CoV-2 that tightly bind to its RdRp may aid in the treatment of patients and reduce the risk of the mysterious new form of COVID-19 viral infection. Ribavirin 50-59 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 173-177 32338164-6 2021 The results show the effectiveness of Sofosbuvir, Ribavirin, Galidesivir, Remdesivir, Favipiravir, Cefuroxime, Tenofovir, and Hydroxychloroquine, in binding to SARS-CoV-2 RdRp. Ribavirin 50-59 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 171-175 33556871-4 2021 The present article provides an overview of these small-molecule therapeutics based on insights from medicinal chemistry research and focuses on RNA-dependent RNA polymerase (RdRp) inhibitors, such as the nucleoside analogues remdesivir, favipiravir and ribavirin. Ribavirin 254-263 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 175-179 33347311-5 2021 The inhibitors of the virus entry to cells and RdRp, such as Arbidol, remdesivir, favipiravir, EIDD-2081, and ribavirin, are in clinical trials, while most of the protease inhibitors are mainly calculated by molecular docking technology, which needs in vivo and in vitro experiments to prove the effect for SARS-CoV-2. Ribavirin 110-119 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 47-51 33421473-6 2021 In-silico screening, molecular mechanics, molecular dynamics simulation (MDS) analysis suggest ribavirin, and remdesivir have good interaction with the binding site of the RdRp protein as compared to other antiviral investigated. Ribavirin 95-104 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 172-176 32222463-0 2020 Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir against SARS-CoV-2 RNA dependent RNA polymerase (RdRp): A molecular docking study. Ribavirin 0-9 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 111-115 32222463-6 2020 KEY FINDINGS: The results suggest the effectiveness of Ribavirin, Remdesivir, Sofosbuvir, Galidesivir, and Tenofovir as potent drugs against SARS-CoV-2 since they tightly bind to its RdRp. Ribavirin 55-64 ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2 183-187