PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34631154-1	2022	We describe the total flow synthesis of the widely prescribed anti-inflammatory COX-2 inhibitor Celecoxib from 2-bromo-3,3,3-trifluoropropene, as a convenient and available trifluoromethyl building block, to generate trifluoropropynyl lithium and to trap it immediately with an aldehyde.	Aldehydes	278-286	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85	
34352174-2	2021	Herein an unprecedented cobalt-catalyzed highly site-, diastereo-, and enantioselective protocol for stereoselective formation of nucleophilic allyl-Co(II) complexes followed by addition to aldehydes is presented.	Aldehydes	190-199	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	149-155	
25071929-0	2014	Selective Radical Amination of Aldehydic C(sp2)-H Bonds with Fluoroaryl Azides via Co(II)-Based Metalloradical Catalysis: Synthesis of N-Fluoroaryl Amides from Aldehydes under Neutral and Nonoxidative Conditions.	Aldehydes	160-169	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	83-88	
164901-10	1975	The role of the catalytic Co(II) thus appears to be the activation of a hydroxyl or water ligand which polarizes the aldehyde carbonyl group by hydrogen bonding.	Aldehydes	117-125	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	26-32	
30844097-2	2019	Building on the recently reported synthesis of five-membered N-heterocyclic pyrrolidines catalyzed by CoII porphyrins, the [Co(TPP)]-catalyzed formation of useful six-membered N-heterocyclic piperidines directly from linear aldehydes is presented herein.	Aldehydes	224-233	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	102-106	
30226522-2	2018	Herein, two hydroxy-rich hydrazone-based COFs are synthesized in pure water and postsynthetically incorporated with CoII, exhibiting Lewis acid catalytic activity towards cyanosilylation of various aldehydes with size selectivity.	Aldehydes	198-207	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	116-120	
28812076-2	2017	The combination of [WZn3(H2O)2(ZnW9O34)2]12- and Co(ii) provides a synergistical catalytic way to promote oximation of aldehyde/ketone with in situ generated hydroxylamine that initially produces an oxime, which further either dehydrates into a nitrile or undergoes a Beckmann rearrangement to form an amide.	Aldehydes	119-127	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	49-55	
25071929-1	2014	The Co(II) complex of the D2h-symmetric amidoporphyrin 3,5-Di t Bu-IbuPhyrin, [Co(P1)], has proven to be an effective metalloradical catalyst for intermolecular amination of C(sp2)-H bonds of aldehydes with fluoroaryl azides.	Aldehydes	192-201	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9	
21932236-4	2011	In situ chelation of CoCl(2) and proline (1:2) is proposed to promote the reaction through a six-membered Zimmermann-Traxler type transition state involving the positioning of proline-enamine and the aldehyde through chelation to Co(II).	Aldehydes	200-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	230-236	
15355999-3	2004	COX-2 was found to colocalize with 4-hydroxy-2-nonenal (HNE), a major lipid peroxidation-derived aldehyde, in foamy macrophages within human atheromatous lesions, suggesting that COX-2 expression may be associated with the accumulation of lipid peroxidation products within macrophages.	Aldehydes	97-105	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5	
19553698-0	2009	Convergence of the 5-LOX and COX-2 pathways: heme-catalyzed cleavage of the 5S-HETE-derived di-endoperoxide into aldehyde fragments.	Aldehydes	113-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34	
11950315-2	2002	The oxidation of N-alkylamides by O(2), catalyzed by N-hydroxyphthalimide (NHPI) and Co(II) salt, leads under mild conditions to carbonyl derivatives (aldehydes, ketones, carboxylic acids, imides) whose distribution depends on the nature of the alkyl group and on the reaction conditions.	Aldehydes	151-160	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91