PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7981013-2	1994	The primary metabolism of diazepam was studied in human liver microsomes in order to investigate the kinetics and to identify the cytochrome P450 (CYP) isoforms responsible for the formation of the main diazepam metabolites, temazepam and N-desmethyldiazepam.	Temazepam	225-234	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	130-145	
7704038-1	1994	Metabolism of diazepam was studied in vitro to identify the forms of cytochrome P450 (CYP) responsible for N-demethylation (nordazepam formation) and 3-hydroxylation (temazepam formation), using liver microsomes obtained from extensive (EM) and poor metabolizers (PM) for S-mephenytoin 4"-hydroxylation.	Temazepam	167-176	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	69-84	
7704038-1	1994	Metabolism of diazepam was studied in vitro to identify the forms of cytochrome P450 (CYP) responsible for N-demethylation (nordazepam formation) and 3-hydroxylation (temazepam formation), using liver microsomes obtained from extensive (EM) and poor metabolizers (PM) for S-mephenytoin 4"-hydroxylation.	Temazepam	167-176	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	86-89	
7981013-2	1994	The primary metabolism of diazepam was studied in human liver microsomes in order to investigate the kinetics and to identify the cytochrome P450 (CYP) isoforms responsible for the formation of the main diazepam metabolites, temazepam and N-desmethyldiazepam.	Temazepam	225-234	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	147-150	
7981013-11	1994	Studies with a series of CYP isoform selective inhibitors and with an inhibitory anti-CYP2C antibody indicated that temazepam formation was carried out mainly by CYP3A isoforms, whereas the formation of N-desmethyldiazepam was mediated by both CYP3A isoforms and S-mephenytoin hydroxylase.	Temazepam	116-125	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	25-28