PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32964723-10	2020	Since fibroblasts play a major role in the production and maintenance of extracellular matrix in emphysema, primary lung fibroblasts were treated with the ERK inhibitor LY3214996 or the c-RAF inhibitor GW5074, resulting in less S100A9-induced MMP-3, MMP-9, MCP-1, IL-6, and IL-8.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	202-208	v-raf-leukemia viral oncogene 1	Mus musculus	186-191	
34947972-5	2021	Here, we targeted KRAS, through inhibition of downstream c-RAF with GW5074, and MYC expression via difluoromethylornithine (DFMO).	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	68-74	v-raf-leukemia viral oncogene 1	Mus musculus	57-62	
32636458-5	2020	C-Raf inhibitor GW5074 was able to reverse the EMT in cells effectively, and was found to be dependent on Twist1 expression.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	16-22	v-raf-leukemia viral oncogene 1	Mus musculus	0-5	
32636458-7	2020	Conclusively, these results demonstrate that C-Raf inhibitor GW5074 inhibits high-dose small-volume radiation-induced EMT via the C-Raf/Twist1 signalling pathway in mice.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	61-67	v-raf-leukemia viral oncogene 1	Mus musculus	45-50	
32636458-7	2020	Conclusively, these results demonstrate that C-Raf inhibitor GW5074 inhibits high-dose small-volume radiation-induced EMT via the C-Raf/Twist1 signalling pathway in mice.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	61-67	v-raf-leukemia viral oncogene 1	Mus musculus	130-135	
27213581-4	2016	Furthermore, we have shown that overexpression and knockdown of ARF1 produce opposing effects on prostate cancer cell proliferation, anchorage-independent growth and tumor growth in mouse xenograft models and that ARF1-mediated cell proliferation can be abolished by the Raf1 inhibitor GW5074 and the MEK inhibitors U0126 and PD98059.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	286-292	v-raf-leukemia viral oncogene 1	Mus musculus	271-275	
29207116-12	2018	Additionally, the inductive effect of melatonin on the expression of insulin mRNA was attenuated when the activities of Raf-1 or ERK were blocked using the chemical inhibitors GW5074 and U0126, respectively.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	176-182	v-raf-leukemia viral oncogene 1	Mus musculus	120-125	
27803850-7	2016	However, the expression of p-Raf-1 was apparently declined after treated with GW5074 or Laminarin compared with Aspergillus fumigatus group.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	78-84	v-raf-leukemia viral oncogene 1	Mus musculus	29-34	
18976506-0	2008	The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	20-26	v-raf-leukemia viral oncogene 1	Mus musculus	4-9	
18976506-2	2008	The present study was designed to investigate if the Raf-1 inhibitor GW5074 and the anti-inflammatory drug dexamethasone suppress airway hyperreactivity in a mouse model of sidestream smoke exposure.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	69-75	v-raf-leukemia viral oncogene 1	Mus musculus	53-58	
22619359-6	2012	Raf-1 antagonist GW5074 decreased attachment to PMC and trans-mesothelial invasion by primary EEC and ESC.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	17-23	v-raf-leukemia viral oncogene 1	Mus musculus	0-5