PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16314406-6	2006	Similarly, B-Raf phosphorylation of MEK-coated microarrays was inhibited in the nanoliter reactions by GW5074 at the expected IC50 of 9 nM.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	103-109	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	11-16	
18194435-0	2008	Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	79-85	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	34-39	
18194435-2	2008	Using low potassium (LK) induced apoptosis of cerebellar granule neurons, we report here that the protective action of GW5074 is mediated through the activation of B-Raf.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	119-125	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	164-169	
18194435-3	2008	Over-expression of a kinase-dead form of B-Raf blocks the ability of GW5074 to neuroprotect, whereas over-expression of active forms of B-Raf protect even in the absence of GW5074.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	69-75	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	41-46	
15255937-4	2004	In contrast to its effect in vitro, treatment of neurons with GW5074 causes c-Raf activation (when measured in vitro in the absence of the drug) and stimulates the Raf-MEK-ERK pathway.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	62-68	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	78-81	
15255937-5	2004	Treatment of neurons with GW5074 also leads to an increase in the activity of B-Raf, which is not inhibited by GW5074 in vitro at concentrations at which the drug exerts its neuroprotective effect.	5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone	26-32	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	78-83