PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3326401-8 1987 In DI rats was found a paradoxical antidiuretic effect of furanthril after either an acute or chronic treatment, which was attributed to the per se stimulated renin-angiotensin system and suppressed PG-synthesis typical for these rats. Furosemide 58-68 renin Rattus norvegicus 159-164 2677316-0 1989 Caffeine potentiates the renin response to furosemide in rats. Furosemide 43-53 renin Rattus norvegicus 25-30 2677316-6 1989 We therefore wanted to determine if: 1) adenosine modulates furosemide-induced renin release and 2) sodium-chloride reabsorption at the macula densa is essential for adenosine actions. Furosemide 60-70 renin Rattus norvegicus 79-84 2677316-9 1989 In the vehicle group, furosemide increased urinary volume, sodium and potassium excretion and increased plasma renin activity from 6 +/- 1 to 45 +/- 11 ngAl/ml/hr. Furosemide 22-32 renin Rattus norvegicus 111-116 2677316-10 1989 Caffeine and 1,3-dipropyl-8-(p-sulfophenyl)xanthine potentiated the increase in plasma renin activity produced by furosemide (to 120 +/- 15 and 147 +/- 21 ng Al/ml/hr, respectively), whereas having no significant effects on urinary volume, sodium excretion or blood pressure. Furosemide 114-124 renin Rattus norvegicus 87-92 2677316-11 1989 These results suggest that furosemide-induced renin release in vivo is restrained by endogenous adenosine. Furosemide 27-37 renin Rattus norvegicus 46-51 3032710-1 1987 Renin secretion was stimulated in rats by adrenalectomy (ADX), by treatment with the converting enzyme inhibitor enalapril (MK 421), or by feeding a low salt diet plus furosemide treatment (FUR). Furosemide 168-178 renin Rattus norvegicus 0-5 3296006-2 1987 PGI2 may mediate, in part, the early increment in plasma renin activity (PRA) after furosemide. Furosemide 84-94 renin Rattus norvegicus 57-62 3296006-3 1987 We hypothesized that thromboxane synthetase inhibition should direct prostaglandin endoperoxide metabolism toward PGI2, thereby enhancing the effects of furosemide on renin release. Furosemide 153-163 renin Rattus norvegicus 167-172 3105853-0 1987 Effect of cyclooxygenase and thromboxane synthetase inhibition on furosemide-stimulated plasma renin activity. Furosemide 66-76 renin Rattus norvegicus 95-100 3105853-1 1987 We studied the effects of a specific thromboxane (TX) synthetase inhibitor (U-63,557A) and a cyclooxygenase inhibitor on furosemide-induced renin release. Furosemide 121-131 renin Rattus norvegicus 140-145 3105853-5 1987 Plasma renin activity was measured in blood samples collected 0, 10, 20, and 40 min after the injection of furosemide. Furosemide 107-117 renin Rattus norvegicus 7-12 3105853-7 1987 The results demonstrated that plasma renin activity rose with time following furosemide in the various groups of rats; indomethacin suppressed the furosemide-induced increments in plasma renin activity, while U-63,557A at doses of 4-8 mg X kg-1 augmented it. Furosemide 77-87 renin Rattus norvegicus 37-42 3105853-7 1987 The results demonstrated that plasma renin activity rose with time following furosemide in the various groups of rats; indomethacin suppressed the furosemide-induced increments in plasma renin activity, while U-63,557A at doses of 4-8 mg X kg-1 augmented it. Furosemide 147-157 renin Rattus norvegicus 37-42 3105853-7 1987 The results demonstrated that plasma renin activity rose with time following furosemide in the various groups of rats; indomethacin suppressed the furosemide-induced increments in plasma renin activity, while U-63,557A at doses of 4-8 mg X kg-1 augmented it. Furosemide 147-157 renin Rattus norvegicus 187-192 3105853-10 1987 Thus, these experiments suggest that thromboxane synthetase inhibition, within a narrow dosage range, potentiates furosemide-induced renin release while cyclooxygenase inhibition suppresses it. Furosemide 114-124 renin Rattus norvegicus 133-138 6375797-0 1984 Frusemide releases renin in the rat kidney when prostacyclin synthesis is suppressed. Furosemide 0-9 renin Rattus norvegicus 19-24 3928488-4 1985 In furosemide-treated marmosets, CGP 29 287 lowered blood pressure and inhibited plasma renin activity during intravenous infusion and after intravenous bolus injection. Furosemide 3-13 renin Rattus norvegicus 88-93 3161339-7 1985 6-Aminonicotinamide also completely blocked furosemide-stimulated renin release without having any effect on glomerular filtration rate or furosemide-induced natriuresis. Furosemide 44-54 renin Rattus norvegicus 66-71 3161339-9 1985 We conclude that 6-aminonicotinamide interferes with renin release by nonfiltering kidneys and also inhibits furosemide-stimulated renin release but does not affect beta-adrenergic-stimulated renin secretion. Furosemide 109-119 renin Rattus norvegicus 131-136 3161339-9 1985 We conclude that 6-aminonicotinamide interferes with renin release by nonfiltering kidneys and also inhibits furosemide-stimulated renin release but does not affect beta-adrenergic-stimulated renin secretion. Furosemide 109-119 renin Rattus norvegicus 131-136 3893163-0 1985 Renin release in turtles: effects of volume depletion and furosemide administration. Furosemide 58-68 renin Rattus norvegicus 0-5 3893163-6 1985 In other studies 48 h of furosemide administration in awake turtles increased renin more than threefold (P less than 0.05) and were accompanied by concomitant reductions in plasma sodium and potassium (P less than 0.05). Furosemide 25-35 renin Rattus norvegicus 78-83 3903651-3 1985 With a normal perfusate chloride the addition of furosemide 10(-4) M to the perfusate also led to an increase in renin and a reduction in tubule chloride reabsorption. Furosemide 49-59 renin Rattus norvegicus 113-118 6375797-1 1984 The effect of inhibiting prostaglandin (PG) synthesis on basal and frusemide-stimulated renin secretion was examined in the rat isolated perfused kidney. Furosemide 67-76 renin Rattus norvegicus 88-93 6375797-7 1984 Although renin secretion was increased during frusemide infusion, there was no significant difference between control (1,806 +/- 384 ng angiotensin I (AI) min-1) and treated (2,310 +/- 554 ng AI min-1) rats (P greater than 0.05). Furosemide 46-55 renin Rattus norvegicus 9-14 6375797-9 1984 These results demonstrate that frusemide-stimulated renin secretion in the rat kidney does not require intact renal PGI2 synthesis and is independent of beta-adrenergic mechanisms. Furosemide 31-40 renin Rattus norvegicus 52-57 6461704-5 1982 Continuous intravenous loading with saline and furosemide, although increasing renal renin levels, afforded as much protection as saline loading alone. Furosemide 47-57 renin Rattus norvegicus 85-90 6187220-3 1983 Plasma renin activity (PRA) was increased by furosemide and also by the low-sodium diet. Furosemide 45-55 renin Rattus norvegicus 7-12 6187220-6 1983 These results suggest that furosemide and low-sodium diet act on the kidney to release renin via protease production. Furosemide 27-37 renin Rattus norvegicus 87-92 6187220-7 1983 Because SBTI affected neither PRA nor urinary kallikrein excretion stimulated by these sodium depletions, it is suggested that renal kallikrein may play an important role in the control of renin release stimulated by furosemide and by low-sodium diet. Furosemide 217-227 renin Rattus norvegicus 189-194 6188888-4 1983 Plasma renin concentration (PRC) prior to the administration of captopril was highest in the furosemide group, followed by the HCTZ, TCTZ, and control groups, in this order. Furosemide 93-103 renin Rattus norvegicus 7-12 6399315-5 1984 Renin secretion and renal inner medullary blood flow (tissue clearance of 133Xe) were simultaneously measured before and after frusemide-induced renin release. Furosemide 127-136 renin Rattus norvegicus 145-150 7042955-9 1982 injection of furosemide, by decreasing cardiac preload, mainly due to venodilation, reduces cardiac output of renin-dependent hypertensive animals, whereas mean arterial blood pressure and heart rate remain unaltered. Furosemide 13-23 renin Rattus norvegicus 110-115 7028226-1 1981 Dose-response relationships of furosemide to its diuretic and cardiovascular actions and its effects on plasma renin activity (PRA) were evaluated in unanesthetized rats. Furosemide 31-41 renin Rattus norvegicus 111-116 7028226-7 1981 Furosemide did not induce significant changes in blood pressure and heart rate, but it did alter the renin dependency of the blood pressure as assessed by Saralasin. Furosemide 0-10 renin Rattus norvegicus 101-106 732253-3 1978 of colchicine or vinblastine to furosemide treated rats on a low salt diet resulted in a decrease of plasma renin as well as plasma angiotensinogen concentration during a 5 h observation period. Furosemide 32-42 renin Rattus norvegicus 108-113 581995-15 1978 It is concluded that the decrease in renal medullary hemodynamics of furosemide-treated rats is due to a stimulation of the renin-angiotensin system. Furosemide 69-79 renin Rattus norvegicus 124-129 7018800-9 1981 In contrast, indomethacin pretreatment caused renin to rise in response to frusemide in spontaneously hypertensive rats (4.7 +/- 0.8 to 27.1 +/- 1.8 ng h-1 ml-1). Furosemide 75-84 renin Rattus norvegicus 46-51 7018800-11 1981 These findings suggest that a prostaglandin normally inhibits the renin response of spontaneously hypertensive rats to frusemide-induced volume contraction. Furosemide 119-128 renin Rattus norvegicus 66-71 479736-2 1979 The diuretic drug frusemide brought about a rapid increase in plasma renin activity and aldosterone concentration in serum. Furosemide 18-27 renin Rattus norvegicus 69-74 760897-0 1979 A comparative study of the action of frusemide and methyclothiazide on renin release by rat kidney slices and the interaction with indomethacin. Furosemide 37-46 renin Rattus norvegicus 71-76 760897-2 1979 2 Frusemide at concentrations of 1.5 and 7.5 mmol/l produced significant increases in renin release but had no effect at 0.15 mmol/l. Furosemide 2-11 renin Rattus norvegicus 86-91 1071628-10 1976 The diuresis and natriuresis induced by frusemide in rats was associated with increased urinary kallikrein excretion and acute rises in plasma renin. Furosemide 40-49 renin Rattus norvegicus 143-148 1071582-0 1976 Stimulation of renin secretion by frusemide and diazoxide in the isolated rat kidney. Furosemide 34-43 renin Rattus norvegicus 15-20 1071582-2 1976 The effect of diazoxide (17-3 micronmol min-1 g-1) and frusemide (0-12 micronmol min-1 g-1) on renin secretion was examined in the isolated perfused rat kidney. Furosemide 55-64 renin Rattus norvegicus 95-100 1071582-10 1976 These observations identify an intrarenal site of action for diazoxide and frusemide on renin secretion. Furosemide 75-84 renin Rattus norvegicus 88-93 1071587-8 1976 Frusemide effectively reduced blood pressure and renin at all phases. Furosemide 0-9 renin Rattus norvegicus 49-54 884392-0 1977 Intrarenal stimulation of renin secretion by frusemide in the isolated kidney of the rat. Furosemide 45-54 renin Rattus norvegicus 26-31 884392-2 1977 Intrarenal infusion of frusemide markedly stimulated renin secretion in the isolated perfused kidney of the rat. Furosemide 23-32 renin Rattus norvegicus 53-58 884392-4 1977 Renin vales increased from 24+/-6 to 195+/-34 units of secretion rate (renin concentration (nmol angiotensin I/h per litre) X flow rate (ml/min)) following administration of frusemide for 8 min, compared with corresponding control values of 13 +/- 2 (P greater than 0.05) and 47 +/-18 (P less than 0.001). Furosemide 174-183 renin Rattus norvegicus 0-5 884392-4 1977 Renin vales increased from 24+/-6 to 195+/-34 units of secretion rate (renin concentration (nmol angiotensin I/h per litre) X flow rate (ml/min)) following administration of frusemide for 8 min, compared with corresponding control values of 13 +/- 2 (P greater than 0.05) and 47 +/-18 (P less than 0.001). Furosemide 174-183 renin Rattus norvegicus 71-76 884392-9 1977 These findings indicate the existence of an intrarenal site of action for frusemide on renin secretion. Furosemide 74-83 renin Rattus norvegicus 87-92 884392-12 1977 A direct effect of frusemide on the renin secreting cell is therefore suggested. Furosemide 19-28 renin Rattus norvegicus 36-41 1155613-5 1975 The addition of furosemide (from 10 minus 5 to 10 minus 3 M) stimulated renin secretion. Furosemide 16-26 renin Rattus norvegicus 72-77 18179782-13 2008 Furosemide significantly elevated plasma renin activity and aldosterone concentration. Furosemide 0-10 renin Rattus norvegicus 41-46 20660105-8 2010 Likewise, cinacalcet decreased furosemide-stimulated renin from 30.6 +- 2.3 to 21.3 +- 2.3 ng ANG I ml(-1) h(-1) (P < 0.001). Furosemide 31-41 renin Rattus norvegicus 53-58 15149320-7 2004 Basal as well as furosemide-induced stimulation of plasma renin activity (PRA) and of renal renin mRNA was further enhanced by CsA. Furosemide 17-27 renin Rattus norvegicus 58-63 16011733-7 2005 In treated group: cardiac dimensions were reduced with left ventricular fractional shortening significantly increased in combination group (from 22.4 to 28%); captopril + furosemide animals had highest heart rate and lowest systolic and diastolic blood pressures; body and heart weight were reduced, but kidney weight was significantly increased with furosemide (1.7 g in control vs. 2 g in capto + furo); plasma renin activity and angiotensin 1 were greatly increased, and moderately stimulated in control. Furosemide 171-181 renin Rattus norvegicus 413-418 15149320-8 2004 In contrast, rofecoxib attenuated the furosemide-induced rise of PRA and of renin mRNA, both in the absence and in the presence of CsA. Furosemide 38-48 renin Rattus norvegicus 76-81 15149320-11 2004 Since the furosemide-induced stimulation of the renin system is not attenuated by CsA but by COX-2 inhibition, we speculate that extrarenal COX-2-derived prostanoids may be involved in the stimulation of the renin system by CsA and by loop diuretics. Furosemide 10-20 renin Rattus norvegicus 48-53 15149320-11 2004 Since the furosemide-induced stimulation of the renin system is not attenuated by CsA but by COX-2 inhibition, we speculate that extrarenal COX-2-derived prostanoids may be involved in the stimulation of the renin system by CsA and by loop diuretics. Furosemide 10-20 renin Rattus norvegicus 208-213 15180925-8 2004 Renin mRNA expression was regulated strictly in parallel in both kidneys, a low-salt diet or furosemide treatment stimulating and a high-salt diet suppressing it. Furosemide 93-103 renin Rattus norvegicus 0-5 15149320-7 2004 Basal as well as furosemide-induced stimulation of plasma renin activity (PRA) and of renal renin mRNA was further enhanced by CsA. Furosemide 17-27 renin Rattus norvegicus 92-97 11135058-8 2001 Furosemide led to a fivefold and threefold increase of plasma renin activity and renocortical renin mRNA level, respectively. Furosemide 0-10 renin Rattus norvegicus 62-67 12798820-10 2003 Plasma renin activity was upregulated by ramipril or ramipril plus furosemide but not influenced by infarction or furosemide alone. Furosemide 67-77 renin Rattus norvegicus 7-12 12798820-10 2003 Plasma renin activity was upregulated by ramipril or ramipril plus furosemide but not influenced by infarction or furosemide alone. Furosemide 114-124 renin Rattus norvegicus 7-12 11703585-9 2001 Moreover, the COX-2 inhibitor rofecoxib dose-dependently attenuated diuresis and saluresis, as well as the stimulation of the renin system induced by furosemide. Furosemide 150-160 renin Rattus norvegicus 126-131 11135058-8 2001 Furosemide led to a fivefold and threefold increase of plasma renin activity and renocortical renin mRNA level, respectively. Furosemide 0-10 renin Rattus norvegicus 94-99 10604960-7 2000 The high dose of furosemide (100 mg/kg) significantly elevated serum renin activity and aldosterone concentration, indicating that furosemide activated the renin-angiotensin-aldosterone system (RAA-system). Furosemide 17-27 renin Rattus norvegicus 69-74 10604960-7 2000 The high dose of furosemide (100 mg/kg) significantly elevated serum renin activity and aldosterone concentration, indicating that furosemide activated the renin-angiotensin-aldosterone system (RAA-system). Furosemide 17-27 renin Rattus norvegicus 156-161 10604960-7 2000 The high dose of furosemide (100 mg/kg) significantly elevated serum renin activity and aldosterone concentration, indicating that furosemide activated the renin-angiotensin-aldosterone system (RAA-system). Furosemide 131-141 renin Rattus norvegicus 69-74 10604960-7 2000 The high dose of furosemide (100 mg/kg) significantly elevated serum renin activity and aldosterone concentration, indicating that furosemide activated the renin-angiotensin-aldosterone system (RAA-system). Furosemide 131-141 renin Rattus norvegicus 156-161 9186867-7 1997 In other animals furosemide, a diuretic acting on macula densa cells, activated renin synthesis to a level similar to that found in the ramipril-treated group. Furosemide 17-27 renin Rattus norvegicus 80-85 10233039-6 1999 Plasma levels of aldosterone and plasma renin activity are substantially increased 3 h after furosemide treatment, and so the NaCl appetite cannot result simply from progressively increasing levels of these hormones. Furosemide 93-103 renin Rattus norvegicus 40-45 9683914-8 1998 In order to differentiate the potential role of elevated renin in the down-regulation of pulmonary ACE, additional rats (n = 12) were treated with furosemide that resulted in a 8-fold rise in plasma renin activity, but only in a marginal decrease of pulmonary ACE mRNA levels and activity (-10% vs. sham (n = 8), P-value n.s.). Furosemide 147-157 renin Rattus norvegicus 199-204 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. Furosemide 26-36 renin Rattus norvegicus 78-83 9136670-2 1997 To this end the renin system in male Sprague Dawley rats was stimulated by unilateral renal artery clipping (0.2 mm clip), by furosemide (60 mg/kg per diem) or isoproterenol (160 microg/kg per diem), and by ingestion of a low-salt diet (0.02%), or was suppressed by setting a contralateral renal artery clip (0.2-mm clip) or by ingestion of a high-salt diet (4%). Furosemide 126-136 renin Rattus norvegicus 16-21 9136670-4 1997 Renin gene expression was stimulated four- to fivefold by renal artery clipping and isoproterenol infusion, two- to three-fold by furosemide and a low-salt diet, and about four-fold by losartan. Furosemide 130-140 renin Rattus norvegicus 0-5 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. Furosemide 26-36 renin Rattus norvegicus 103-108 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. Furosemide 26-36 renin Rattus norvegicus 103-108 9186867-8 1997 Addition of L-NAME to the furosemide-treated rats suppressed the increases in renin mRNA levels, total renin content and renin secretion, suggesting that NO acts on renin activation by a mechanism independent of angiotensin II. Furosemide 26-36 renin Rattus norvegicus 103-108 8594873-5 1995 Furosemide treatment resulted in a marked increase of both NOS and renin levels compared with controls (P < 0.05). Furosemide 0-10 renin Rattus norvegicus 67-72 8648902-4 1996 Renin secretion was increased in isolated afferent arterioles after in vivo treatment with the diuretic furosemide (+300%) or in vitro treatment with the adenylyl cyclase activator forskolin (+50%), indicating that this vascular preparation responds appropriately to regulators of the renin-angiotensin system. Furosemide 104-114 renin Rattus norvegicus 0-5 8594876-4 1995 Furosemide infusion increased plasma renin activity (PRA) from 8.8 +/- 1.4 to 41 +/- 5.2 ng angiotensin I (ANG I).h-1.ml-1 and renin mRNA levels from 112 +/- 8 of standard to 249 +/- 18% of standard. Furosemide 0-10 renin Rattus norvegicus 37-42 8594876-4 1995 Furosemide infusion increased plasma renin activity (PRA) from 8.8 +/- 1.4 to 41 +/- 5.2 ng angiotensin I (ANG I).h-1.ml-1 and renin mRNA levels from 112 +/- 8 of standard to 249 +/- 18% of standard. Furosemide 0-10 renin Rattus norvegicus 127-132 8594876-5 1995 After treatment with indomethacin, the furosemide-induced increases in renin mRNA levels was attenuated to 190 +/- 11% of standard. Furosemide 39-49 renin Rattus norvegicus 71-76 8594876-6 1995 After injections of L-NAME, both the furosemide-induced increases of renin mRNA levels and of PRA were reduced to 126 +/- 14% of standard and 22 +/- 5 ng ANG I.h-1.ml-1, respectively. Furosemide 37-47 renin Rattus norvegicus 69-74 8765998-2 1996 Stimulation of the renin system was achieved by unilateral renal artery clipping (2-kidney/1-clip rats), treatment with the angiotensin II (ANG II) antagonist losartan (40 mg/kg), application of furosemide (12 mg x kg-1 x day-1) and a low-sodium diet (0.02% w/w Na+), which increased renin mRNA levels to 464%, 495%, 309% and 219% of those of control animals, respectively. Furosemide 195-205 renin Rattus norvegicus 19-24 8058474-4 1994 In non-clipped animals furosemide increased PRA from 10 to 47 ng angiotensin I.h-1.ml-1 and raised renin mRNA levels in both kidneys 2.5-fold. Furosemide 23-33 renin Rattus norvegicus 99-104 7977842-3 1994 Rats treated jointly with furosemide and low-dose captopril had exaggerated increases in plasma renin activity and angiotensin I but equivalent increases in plasma aldosterone compared with rats treated with either agent alone. Furosemide 26-36 renin Rattus norvegicus 96-101 7977842-5 1994 The administration of a higher dose of captopril (100 mg/kg) with furosemide, a combination of drugs that does not stimulate fluid intake (29), further increased plasma renin activity and angiotensin I but prevented the rise in plasma vasopressin. Furosemide 66-76 renin Rattus norvegicus 169-174 7543251-0 1995 Selective neuronal nitric oxide synthase inhibition blocks furosemide-stimulated renin secretion in vivo. Furosemide 59-69 renin Rattus norvegicus 81-86 7543251-3 1995 To test whether neuronal NOS mediates renin secretion, renin was stimulated by either the renal baroreceptor or the diuretic furosemide (acting through the macula densa pathway). Furosemide 125-135 renin Rattus norvegicus 55-60 7651759-4 1995 Plasma renin activity was elevated by furosemide treatment. Furosemide 38-48 renin Rattus norvegicus 7-12 8271212-3 1993 To this end we investigated the effects of frusemide and bumetanide, two different inhibitors of the macula densa Na(+)-K(+)-2Cl- cotransport, on pressure-dependent renin release from isolated perfused rat kidneys. Furosemide 43-52 renin Rattus norvegicus 165-170 8141403-5 1994 It is concluded that the integrity of renin-angiotensin mechanisms is necessary for the rapid ingestion of water and saline after furosemide and captopril and that arterial pressure modulates the behavioral responses. Furosemide 130-140 renin Rattus norvegicus 38-43 7954537-4 1994 Both torasemide and furosemide increased plasma renin activity and aldosterone concentration, but only torasemide significantly inhibited aldosterone-receptor binding in rat kidney. Furosemide 20-30 renin Rattus norvegicus 48-53 8271212-10 1993 The vasorelaxant effects of frusemide and bumetanide were paralleled by an increase of renin secretion to a maximum of 21 +/- 4 (ng Ang I h-1) min-1 g-1 (n = 10). Furosemide 28-37 renin Rattus norvegicus 87-92 8271212-11 1993 On a molar basis bumetanide was twice as potent as frusemide in stimulating renin secretion. Furosemide 51-60 renin Rattus norvegicus 76-81 1812004-5 1991 Higher doses of torasemide (10 mg/kg) and furosemide (100 mg/kg) increased both plasma renin activity and aldosterone concentration in normotensive rats in a similar manner. Furosemide 42-52 renin Rattus norvegicus 87-92 8255723-0 1993 Furosemide stimulates renin expression in the kidneys of salt-supplemented rats. Furosemide 0-10 renin Rattus norvegicus 22-27 8255723-5 1993 Plasma renin activities increased from 2.9 +/- 0.5 ng angiotensin I h-1 ml-1 in controls to 10.6 +/- 2.2 ng angiotensin I h-1 ml-1 in furosemide-treated rats. Furosemide 134-144 renin Rattus norvegicus 7-12 8255723-6 1993 In parallel, kidney areas immunoreactive for renin increased by 80% and the renal content of renin mRNA increased by 120% in the animals receiving furosemide. Furosemide 147-157 renin Rattus norvegicus 45-50 8255723-6 1993 In parallel, kidney areas immunoreactive for renin increased by 80% and the renal content of renin mRNA increased by 120% in the animals receiving furosemide. Furosemide 147-157 renin Rattus norvegicus 93-98 8255723-7 1993 Under the assumption that the effects seen on renal renin expression were primarily due to the inhibition of TALH and macula densa function by furosemide, our findings suggest that salt transport across the TALH and macula densa exerts a negative control function not only on the secretion but also on the expression of renin in the kidney. Furosemide 143-153 renin Rattus norvegicus 52-57 8418022-0 1993 Time course of stimulation of renal renin messenger RNA by furosemide. Furosemide 59-69 renin Rattus norvegicus 36-41 2203682-5 1990 Renin release in intact hydropenic rats was not altered by diuretic therapy, but furosemide increased plasma renin activity in hydropenic as well as in volume-expanded rats. Furosemide 81-91 renin Rattus norvegicus 109-114 2203682-6 1990 This demonstrates the importance of furosemide inhibition of transport in the macula densa for its renin secretory action. Furosemide 36-46 renin Rattus norvegicus 99-104 2118863-13 1990 Furosemide (50 micrograms/ml) stimulated the release of active and inactive renins significantly at 20 and 40 min (p less than 0.05 vs. control) but did not affect the release of either renin at 60 min. Furosemide 0-10 renin Rattus norvegicus 76-81 8418022-3 1993 In the first series, Sprague-Dawley rats received furosemide (10 mg/kg) intraperitoneally and a low sodium diet (0.05% sodium); renin secretion was significantly stimulated at 8 or 16 hours after treatment, but renin mRNA levels did not change. Furosemide 50-60 renin Rattus norvegicus 128-133 8418022-6 1993 In additional animals, the response of renin mRNA 4 hours after furosemide was found not to be potentiated by the converting enzyme inhibitor quinapril (5 mg/kg). Furosemide 64-74 renin Rattus norvegicus 39-44