PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22496496-9 2012 CONCLUSION: The IGF-I-mediated and PTH-independent increase in calcitriol synthesis in acromegaly is responsible for both absorptive hypercalciuria and increased fasting plasma calcium linked to enhanced distal tubular calcium reabsorption, as shown by the selectively diminished calciuric response to furosemide. Furosemide 302-312 insulin like growth factor 1 Homo sapiens 16-21