PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2319462-10 1990 This blunted response presumably occurs because of a reduction in the amount of pharmacologically active drug due to albumin-furosemide binding. Furosemide 125-135 albumin Rattus norvegicus 117-124 2319462-0 1990 Intratubular albumin blunts the response to furosemide-A mechanism for diuretic resistance in the nephrotic syndrome. Furosemide 44-54 albumin Rattus norvegicus 13-20 2319462-4 1990 After addition of albumin to furosemide perfusate, fractional loop chloride reabsorption was 45 +/- 1%; a value greater (P less than .01) than that observed in furosemide perfused loop segments, but less (P less than .05) than that observed in control loop segments. Furosemide 160-170 albumin Rattus norvegicus 18-25 2319462-9 1990 Thus, albumin in renal tubule fluid attenuates the effect of furosemide on loop segment chloride reabsorption in the rat. Furosemide 61-71 albumin Rattus norvegicus 6-13 2319462-11 1990 Consequently, albumin-furosemide binding in the renal tubule may contribute to the diuretic resistance in nephrotic syndrome. Furosemide 22-32 albumin Rattus norvegicus 14-21 6085642-2 1984 When applied to digitoxin and frusemide, two drugs highly bound to bovine serum albumin, the fraction of drug unbound could be continuously varied over approximately a 30-fold range. Furosemide 30-39 albumin Rattus norvegicus 74-87