PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10975299-5	2000	Baseline renin production was elevated, although the renin response to furosemide was similar in chronic furosemide-treated and vehicle-treated lambs.	Furosemide	71-81	renin	Ovis aries	53-58	
14756687-9	2004	After high-dose furosemide, plasma renin activity increased in both groups of lambs, although the effects were greater in 1-week-old lambs.	Furosemide	16-26	renin	Ovis aries	35-40	
7600440-0	1995	Renal and renin responses to furosemide in conscious lambs during postnatal maturation.	Furosemide	29-39	renin	Ovis aries	10-15	
9365820-2	1997	injection of 2 mg/kg of furosemide resulted in a sustained increase in heart rate and an age-dependent increase in plasma renin activity.	Furosemide	24-34	renin	Ovis aries	122-127	
7600440-2	1995	To test the hypothesis that the renal and renin responses to furosemide are altered during postnatal maturation, experiments were carried out in conscious chronically instrumented newborn lambs (11 +/- 3 days, n = 7) and older lambs (28 +/- 3 days, n = 6), at least 5 days after surgery under halothane anesthesia for placement of catheters.	Furosemide	61-71	renin	Ovis aries	42-47	
6350561-6	1983	Furosemide (10 mg/kg) in anaesthetized animals produced a similar diuresis and natriuresis response to conscious sheep, but plasma active renin increased by 270% and inactive renin decreased to zero.	Furosemide	0-10	renin	Ovis aries	138-143	
6350561-6	1983	Furosemide (10 mg/kg) in anaesthetized animals produced a similar diuresis and natriuresis response to conscious sheep, but plasma active renin increased by 270% and inactive renin decreased to zero.	Furosemide	0-10	renin	Ovis aries	175-180	
6350561-7	1983	In conscious sheep given an infusion of papaverine, furosemide also produced an increase in plasma active renin and a concurrent decrease in the inactive form.	Furosemide	52-62	renin	Ovis aries	106-111	
6997818-1	1980	Circulating arginine vasopressin (AVP) and plasma renin activity responses to furosemide (2 mg/kg) and acute hypertonic saline (10 mEq/kg) were studied in the fetal lamb from 100 days gestation to term.	Furosemide	78-88	renin	Ovis aries	50-55	
6997818-6	1980	The fetal lamb also manifests a hypothalamus-posterior pituitary AVP response to furosemide that is proportional to the maturing renal renin response.	Furosemide	81-91	renin	Ovis aries	135-140	
429554-4	1979	Plasma renin activity increased from a mean (+/-SEM) of 21.3+/-3.4 ng/ml per h in the 10 control lambs to 39.4+/-8.2 ng/ml per h at 8 min (P < 0.001) and remained high through 120 min after furosemide.	Furosemide	193-203	renin	Ovis aries	7-12	
471592-3	1979	Plasma renin activity (PRA) increases from 23 +/- 2.7 ng/ml/hr (M and SE) to 85.8 +/- 16.5 (P less than 0.05) during infusion of saralasin alone and remained at this level after injection of furosemide.	Furosemide	191-201	renin	Ovis aries	7-12	
6987603-2	1980	The baseline to peak plasma renin activity (PRA) response to furosemide increased from delta 3.0 +/- 1.3 ng/ml/hr (M and SEM) and 95--106 days of gestation to delta 18.4 +/- 4.0 (P less than 0.01) at 123--142 days and delta 33.6 +/- 6.5 (P less than 0.001) in the newborn.	Furosemide	61-71	renin	Ovis aries	28-33	
6987603-4	1980	The newborn plasma aldosterone response to furosemide via the endogenous renin-angiotensin was delta 17.1 +/- 4.2 ng/dl (P less than 0.01); the fetal lamb plasma aldosterone level did not increase.	Furosemide	43-53	renin	Ovis aries	73-78	
429554-11	1979	These data support the view that the observed AVP response to furosemide in the newborn lamb was mediated through the renin-angiotensin system.	Furosemide	62-72	renin	Ovis aries	118-123	
19919977-7	2009	In contrast to the increase in plasma renin activity elicited by furosemide alone, Ucn2 and Ucn2+furosemide markedly reduced plasma renin activity.	Furosemide	65-75	renin	Ovis aries	38-43	
657458-10	1978	Renin secretion was 118 +/- 62 ng/min during the control period and averaged 240 +/- 67 ng/min after ouabain plus furosemide.	Furosemide	114-124	renin	Ovis aries	0-5	
657458-13	1978	Ouabain also blocks the normal stimulatory effects of furosemide on renin secretion.	Furosemide	54-64	renin	Ovis aries	68-73	
19919977-0	2009	Urocortin 2 inhibits furosemide-induced activation of renin and enhances renal function and diuretic responsiveness in experimental heart failure.	Furosemide	21-31	renin	Ovis aries	54-59	
876706-0	1977	The renin-angiotensin-aldosterone system in the newborn lamb: response to furosemide.	Furosemide	74-84	renin	Ovis aries	4-9	
876706-2	1977	Plasma renin activity (PRA) increased within 8 min after furosemide from a baseline value of 12.6 +/- 3.5 ng/ml/hr (mean and SEM) to a level of 24.1 +/- 8.6 ng/ml/hr (P less than 0.05), and peaked 20 mins after the furosemide infusion at a level of 33.1 +/- 8.0 ng/ml/hr.	Furosemide	57-67	renin	Ovis aries	7-12	
876706-2	1977	Plasma renin activity (PRA) increased within 8 min after furosemide from a baseline value of 12.6 +/- 3.5 ng/ml/hr (mean and SEM) to a level of 24.1 +/- 8.6 ng/ml/hr (P less than 0.05), and peaked 20 mins after the furosemide infusion at a level of 33.1 +/- 8.0 ng/ml/hr.	Furosemide	215-225	renin	Ovis aries	7-12	
876706-5	1977	The results indicate that the renin-angiotensin-aldosterone system responds promptly to furosemide stimulation despite initially high PRA and aldosterone levels.	Furosemide	88-98	renin	Ovis aries	30-35	
840860-0	1977	Renin secretion after papaverine and furosemide in conscious sheep.	Furosemide	37-47	renin	Ovis aries	0-5	
19919977-7	2009	In contrast to the increase in plasma renin activity elicited by furosemide alone, Ucn2 and Ucn2+furosemide markedly reduced plasma renin activity.	Furosemide	97-107	renin	Ovis aries	132-137	
19919977-10	2009	Furthermore, Ucn2 reversed furosemide-induced increases in plasma renin activity and induced greater decreases in plasma aldosterone and vasopressin.	Furosemide	27-37	renin	Ovis aries	66-71