PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26301821-10	2015	Based on these results we propose that the anticonvulsant action of furosemide in the Cs(+)-model is exerted through blockade of the neuronal KCC2 and Na(+)-independent Cl(-)/HCO3(-)-exchanger (AE3) leading to stabilization of the activity-induced intracellular acidification in CA1 pyramidal neurons.	Furosemide	68-78	solute carrier family 12 member 5	Rattus norvegicus	142-146	
22441041-7	2012	We then measured KCC2 activity by monitoring both the rate and relative amount of furosemide-sensitive NH(4)(+) influx through the co-transporter using an intracellular pH-sensitive fluorescent indicator.	Furosemide	82-92	solute carrier family 12 member 5	Rattus norvegicus	17-21	
23847084-5	2013	Microinjection of brain-derived neurotrophic factor (BDNF) into the NRM inhibited the KCC2 protein level in the NRM, and both BDNF administration and KCC2 inhibition by furosemide mimicked the pain-induced effects on EIPSC and excitability in MOR-expressing neurons.	Furosemide	169-179	solute carrier family 12 member 5	Rattus norvegicus	150-154	
23847084-6	2013	Furthermore, inhibiting BDNF signaling by NRM infusion of tyrosine receptor kinase B-IgG or blocking KCC2 with furosemide prevented these pain effects in MOR-expressing neurons.	Furosemide	111-121	solute carrier family 12 member 5	Rattus norvegicus	101-105	
18094240-10	2007	Application of the KCC2 blocker, furosemide, to control neurons mimicked E(GABA) shifts evident in granule cells post-STEP.	Furosemide	33-43	solute carrier family 12 member 5	Rattus norvegicus	19-23	
19428648-4	2009	The impairment of LTP maintenance was significantly reversed by picrotoxinin, a specific GABA(A) receptor-chloride channel blocker and furosemide, a K+-Cl- cotransporter 2 (KCC2) blocker, respectively.	Furosemide	135-145	solute carrier family 12 member 5	Rattus norvegicus	149-171	
19428648-4	2009	The impairment of LTP maintenance was significantly reversed by picrotoxinin, a specific GABA(A) receptor-chloride channel blocker and furosemide, a K+-Cl- cotransporter 2 (KCC2) blocker, respectively.	Furosemide	135-145	solute carrier family 12 member 5	Rattus norvegicus	173-177	
16581019-7	2006	Furthermore, the inhibition of KCC2 function with furosemide directly induced EPSP-spike (E-S) potentiation, an important component of LTP in hippocampus.	Furosemide	50-60	solute carrier family 12 member 5	Rattus norvegicus	31-35	
10793196-1	2000	The purpose of this study was to determine whether the loop diuretics furosemide, bumetanide and ethacrynic acid, which block the KCC1 potassium-chloride transporter in the kidney loop of Henle and the KCC2 potassium-chloride transporter in neuronal membranes, would prevent sound-triggered seizures in post-ischemic audiogenic seizure-prone rats.	Furosemide	70-80	solute carrier family 12 member 5	Rattus norvegicus	202-206	
16239278-7	2005	Furosemide (100 microm), a pharmacological compound known to block the activity of the neurone-specific K(+)-Cl- cotransporter, KCC2, reversed IPSC polarity and shifted E(IPSC) towards its theoretical value.	Furosemide	0-10	solute carrier family 12 member 5	Rattus norvegicus	128-132	
11050128-9	2000	KCC2 inhibition by furosemide caused a change in the intracellular Cl(-) concentration that depended on the concentration of pipette Cl(-); in recordings with low pipette Cl(-), furosemide lowered intracellular Cl(-), whereas in recordings with elevated pipette Cl(-), furosemide raised intracellular Cl(-).	Furosemide	19-29	solute carrier family 12 member 5	Rattus norvegicus	0-4	
11050128-9	2000	KCC2 inhibition by furosemide caused a change in the intracellular Cl(-) concentration that depended on the concentration of pipette Cl(-); in recordings with low pipette Cl(-), furosemide lowered intracellular Cl(-), whereas in recordings with elevated pipette Cl(-), furosemide raised intracellular Cl(-).	Furosemide	178-188	solute carrier family 12 member 5	Rattus norvegicus	0-4	
11050128-9	2000	KCC2 inhibition by furosemide caused a change in the intracellular Cl(-) concentration that depended on the concentration of pipette Cl(-); in recordings with low pipette Cl(-), furosemide lowered intracellular Cl(-), whereas in recordings with elevated pipette Cl(-), furosemide raised intracellular Cl(-).	Furosemide	178-188	solute carrier family 12 member 5	Rattus norvegicus	0-4