PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32622469-5	2020	Inhaled furosemide, a small molecule capable of inhibiting IL-6 and TNFalpha, may be an agent capable of treating the Coronavirus Disease 2019 cytokine storm in both resource-rich and developing countries.	Furosemide	8-18	interleukin 6	Homo sapiens	59-63	
33225679-7	2020	Our data demonstrate that furosemide inhibits the secretion of proinflammatory TNF-alpha, IL-6, and nitric oxide; downregulates the mRNA level of Cd86 and the protein expression of COX-2, iNOS; promotes phagocytic activity; and enhances the expression of anti-inflammatory IL-1RA and arginase.	Furosemide	26-36	interleukin 6	Homo sapiens	90-94	
19086502-11	2007	Furosemide caused a dose dependent decrease in IL-6 (421 +/- 31, 534 +/- 33 vs. 662 +/- 41 pg mL(-1) p < 0.05).	Furosemide	0-10	interleukin 6	Homo sapiens	47-51	
32704455-10	2020	Upon treatment with furosemide, LPS-induced production of pro-inflammatory cytokines was reduced, indicating that furosemide suppresses the M1 polarization, including IL-6 and TNF-alpha release.	Furosemide	20-30	interleukin 6	Homo sapiens	167-171	
32704455-10	2020	Upon treatment with furosemide, LPS-induced production of pro-inflammatory cytokines was reduced, indicating that furosemide suppresses the M1 polarization, including IL-6 and TNF-alpha release.	Furosemide	114-124	interleukin 6	Homo sapiens	167-171	
32704455-12	2020	Accordingly, we conclude that furosemide is a reasonably potent inhibitor of IL-6 and TNF-alpha that is also safe, inexpensive and well-studied.	Furosemide	30-40	interleukin 6	Homo sapiens	77-81	
17710582-9	2007	IL-10, TNF-alpha, and IL-6 production from preeclamptic placenta and PBMCs were inhibited by diazoxide and furosemide.	Furosemide	107-117	interleukin 6	Homo sapiens	22-26	
16612254-8	2006	There was a stepwise reduction in production of TNF-alpha and IL-6 with increasing doses of diazoxide, hydralazine and furosemide by placentas and PBMCs from these women with normal pregnancies.	Furosemide	119-129	interleukin 6	Homo sapiens	62-66	
16612254-9	2006	CONCLUSION: Our data suggest that the antihypertensive drugs clonidine and hydralazine can stimulate production of the circulating anti-inflammatory cytokine IL-10, whereas furosemide and diazoxide inhibit the production of this cytokine and the proinflammatory cytokines TNF-alpha and IL-6 by placentas and PBMCs.	Furosemide	173-183	interleukin 6	Homo sapiens	286-290	
10619350-9	1999	RESULTS: There was a significant reduction in levels of TNF-alpha and IL-6 at a furosemide concentration of 0.5 x 10(-2) M and a reduction in IL-8 levels at 10(-2) M. This inhibition was comparable to that found with equivalent molar concentrations of hydrocortisone.	Furosemide	80-90	interleukin 6	Homo sapiens	70-74	
34288546-6	2021	Patients treated with furosemide plus HSS compared with controls treated with furosemide alone showed a comparable degree of reduction in the serum levels of interleukin (IL)-6, soluble suppression of tumorigenicity 2 (sST2), and N-terminal pro-brain natriuretic peptide (NT-proBNP) in the "between-group" analysis.	Furosemide	78-88	interleukin 6	Homo sapiens	158-176