PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26550796-10 2016 The alterations in furosemide pharmacokinetics and pharmacodynamics were explained by changes in the expression of renal organic anion transporters 1 and 3, and sodium-potassium-chloride cotransporter-2. Furosemide 19-29 solute carrier family 22 member 6 Rattus norvegicus 115-155 30120768-2 2018 Simultaneously, drug-drug interactions (DDIs) mediated by OAT1 occur at high altitude, severely affecting furosemide pharmacokinetics. Furosemide 106-116 solute carrier family 22 member 6 Rattus norvegicus 58-62 27282888-0 2017 Impact of the induced organic anion transporter 1 (Oat1) renal expression by furosemide on the pharmacokinetics of organic anions. Furosemide 77-87 solute carrier family 22 member 6 Rattus norvegicus 22-49 27282888-0 2017 Impact of the induced organic anion transporter 1 (Oat1) renal expression by furosemide on the pharmacokinetics of organic anions. Furosemide 77-87 solute carrier family 22 member 6 Rattus norvegicus 51-55 27282888-3 2017 This study was undertaken to simultaneously evaluate the effects of furosemide pretreatment on organic anion transporter 1 (Oat1) and multidrug resistance protein 2 (Mrp2) renal expressions, on p-aminohippurate (PAH) pharmacokinetics and on renal and urinary PAH levels in rats. Furosemide 68-78 solute carrier family 22 member 6 Rattus norvegicus 95-122 27282888-3 2017 This study was undertaken to simultaneously evaluate the effects of furosemide pretreatment on organic anion transporter 1 (Oat1) and multidrug resistance protein 2 (Mrp2) renal expressions, on p-aminohippurate (PAH) pharmacokinetics and on renal and urinary PAH levels in rats. Furosemide 68-78 solute carrier family 22 member 6 Rattus norvegicus 124-128 27282888-8 2017 RESULTS: Furosemide pretreatment increased both the expression of Oat1 and Mrp2. Furosemide 9-19 solute carrier family 22 member 6 Rattus norvegicus 66-70 12897087-0 2003 Up-regulation of organic anion transporter 1 protein is induced by chronic furosemide or hydrochlorothiazide infusion in rat kidney. Furosemide 75-85 solute carrier family 22 member 6 Rattus norvegicus 17-44 16628676-2 2006 The objective of this work was to study, in rats with acute extrahepatic cholestasis, the cortical renal expression of the organic anion transporter 1 (OAT1) and the organic anion transporter 3 (OAT3), in association with the pharmacokinetics and renal excretion of furosemide (FS). Furosemide 278-280 solute carrier family 22 member 6 Rattus norvegicus 123-150 16628676-2 2006 The objective of this work was to study, in rats with acute extrahepatic cholestasis, the cortical renal expression of the organic anion transporter 1 (OAT1) and the organic anion transporter 3 (OAT3), in association with the pharmacokinetics and renal excretion of furosemide (FS). Furosemide 278-280 solute carrier family 22 member 6 Rattus norvegicus 152-156 16628676-12 2006 In conclusion, acute obstructive jaundice is associated with an upregulation of OAT1 and OAT3, which might explain, at least in part, the increased systemic and renal elimination of FS. Furosemide 182-184 solute carrier family 22 member 6 Rattus norvegicus 80-84 12897087-9 2003 Although OAT1 protein abundance in cortical homogenates was increased by furosemide infusion (271 +/- 35 vs 100 +/- 15%, P < 0.05), Na-K-ATPase alpha1 subunit protein abundance was not affected (113 +/- 14 vs 100 +/- 8%, P = 0.42). Furosemide 73-83 solute carrier family 22 member 6 Rattus norvegicus 9-13 12897087-12 2003 CONCLUSION: Chronic furosemide or hydrochlorothiazide infusion caused increases in OAT1 protein abundance in rat kidney. Furosemide 20-30 solute carrier family 22 member 6 Rattus norvegicus 83-87 10991988-4 2000 p-[(14)C]Aminohippurate (PAH) uptake by rOAT1-expressing oocytes was inhibited in the presence of a thiazide (chlorothiazide, cyclothiazide, hydrochlorothiazide), a loop diuretic (bumetanide, ethacrynic acid, furosemide), or a carbonic anhydrase inhibitor (acetazolamide, ethoxzolamide, methazolamide). Furosemide 209-219 solute carrier family 22 member 6 Rattus norvegicus 40-45 10991988-10 2000 Although the loop diuretics had little trans-stimulation effect on [(14)C]PAH efflux via rOAT1, the rOAT1-mediated furosemide uptake was observed. Furosemide 115-125 solute carrier family 22 member 6 Rattus norvegicus 100-105