PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8894667-6 1996 Thus we studied the response of the renin-angiotensin-aldosterone system to sodium depletion using a single dose of furosemide. Furosemide 116-126 renin Homo sapiens 36-41 8928409-3 1996 During dynamic testing of the response of plasma renin activity and aldosterone to the administration of furosemide and a vertical position in diabetics a significantly reduced response was recorded as compared with non-diabetic hypertonic subjects. Furosemide 105-115 renin Homo sapiens 49-54 8894667-13 1996 During sodium depletion with furosemide, renin as well as aldosterone levels rose significantly in 1 parent and a sibling, respectively. Furosemide 29-39 renin Homo sapiens 41-46 8033511-3 1994 The aim of this study was to determine whether the plasma active renin concentration could be stimulated in women with pre-eclampsia by intravenous frusemide, which stimulates renin acutely through a prostacyclin-mediated mechanism. Furosemide 148-157 renin Homo sapiens 65-70 7752314-5 1995 Five years postoperatively, ambulation and furosemide administration under low sodium diet stimuli remarkably enhanced plasma renin activity and plasma aldosterone concentration in the aldosterone-producing adenoma enucleation group (p < 0.001), almost similar to that of normal subjects but increment magnitudes were slight (p < 0.05 to < 0.01) in the adrenalectomy group. Furosemide 43-53 renin Homo sapiens 126-131 7584692-10 1995 After the administration of furosemide 4 patients in Group I were unable to increase aldosterone (2.8 +/- 0.9 ng/dl) secretion in spite of marked elevation of plasma renin activity (28 +/- 7 ng/ml/h), suggesting an impairment of 11-hydroxylase in the zona glomerulosa. Furosemide 28-38 renin Homo sapiens 166-171 8054254-6 1994 The frusemide-induced rise in plasma renin activity was significantly less with paracetamol than placebo at 60 min (4.3 +/- 2.9 vs 2.7 +/- 1.9 ng ml-1 h-1, P < 0.01; 95% confidence interval of the difference 0.4 to 2.7). Furosemide 4-13 renin Homo sapiens 37-42 8586834-2 1995 METHODS: We artificially activated the renin-angiotensin-aldosterone system by two means: by pretreatment with frusemide (40 mg/day orally for 2 days) and by administering exogenous angiotensin II (1 ng/kg per min intravenously). Furosemide 111-120 renin Homo sapiens 39-44 7758515-9 1995 Furosemide-induced diuresis resulted in normal rises of plasma renin activity in both patients; however, plasma aldosterone levels increased only in the boy and not in his sister. Furosemide 0-10 renin Homo sapiens 63-68 7599693-3 1995 Oral administration of furosemide, 40 mg for 2 days, under mild salt restriction (50 mEq NaCl/day) for 6 days stimulated the renin-angiotensin system resulting in significant increases in plasma renin activity (PRA) (1.84 +/- 0.12 vs. 1.05 +/- 0.17 ng/l/s; P < 0.01), plasma angiotensin II concentration, and plasma aldosterone concentration (PAC). Furosemide 23-33 renin Homo sapiens 125-130 7599693-3 1995 Oral administration of furosemide, 40 mg for 2 days, under mild salt restriction (50 mEq NaCl/day) for 6 days stimulated the renin-angiotensin system resulting in significant increases in plasma renin activity (PRA) (1.84 +/- 0.12 vs. 1.05 +/- 0.17 ng/l/s; P < 0.01), plasma angiotensin II concentration, and plasma aldosterone concentration (PAC). Furosemide 23-33 renin Homo sapiens 195-200 7900569-8 1995 A case with a high level of plasma renin and aldosterone activity temporarily induced by furosemide was reported. Furosemide 89-99 renin Homo sapiens 35-40 8038908-4 1994 Postural stimulation with or without furosemide administration increased 18-oxoF, 18-OH-F, aldosterone and plasma renin activity (PRA). Furosemide 37-47 renin Homo sapiens 114-119 8033511-3 1994 The aim of this study was to determine whether the plasma active renin concentration could be stimulated in women with pre-eclampsia by intravenous frusemide, which stimulates renin acutely through a prostacyclin-mediated mechanism. Furosemide 148-157 renin Homo sapiens 176-181 8033511-11 1994 After frusemide, plasma active renin concentration rose significantly in non-pregnant (P = 0.002) and normal pregnant (P = 0.008) women, but not in women with pre-eclampsia. Furosemide 6-15 renin Homo sapiens 31-36 8179835-3 1993 Also, the renin-aldosterone stimulation testing on this patient performed by sodium restricted diet and furosemide, upright position and by angiotensin converting enzyme inhibition (captopril, 50 mg) showed the blunted renin and aldosterone responses to each of these stimuli, almost no changes from baseline renin and aldosterone levels, it was concluded that the underlying defect responsible for hyperkalemia in this case was hyporeninemic hypoaldosteronism and this was aggravated by other factors or drugs affecting potassium homeostasis. Furosemide 104-114 renin Homo sapiens 10-15 8011564-4 1993 The transient systemic arterial constriction and small increase in systemic blood pressure that follows intravenous furosemide probably results from the release of renin and subsequent activation of angiotensin. Furosemide 116-126 renin Homo sapiens 164-169 8179835-3 1993 Also, the renin-aldosterone stimulation testing on this patient performed by sodium restricted diet and furosemide, upright position and by angiotensin converting enzyme inhibition (captopril, 50 mg) showed the blunted renin and aldosterone responses to each of these stimuli, almost no changes from baseline renin and aldosterone levels, it was concluded that the underlying defect responsible for hyperkalemia in this case was hyporeninemic hypoaldosteronism and this was aggravated by other factors or drugs affecting potassium homeostasis. Furosemide 104-114 renin Homo sapiens 219-224 8179835-3 1993 Also, the renin-aldosterone stimulation testing on this patient performed by sodium restricted diet and furosemide, upright position and by angiotensin converting enzyme inhibition (captopril, 50 mg) showed the blunted renin and aldosterone responses to each of these stimuli, almost no changes from baseline renin and aldosterone levels, it was concluded that the underlying defect responsible for hyperkalemia in this case was hyporeninemic hypoaldosteronism and this was aggravated by other factors or drugs affecting potassium homeostasis. Furosemide 104-114 renin Homo sapiens 219-224 1924052-6 1991 The increase in plasma renin activity after frusemide was inhibited by ketoprofen on both Day 1 and Day 5. Furosemide 44-53 renin Homo sapiens 23-28 7910062-0 1993 Correlation between renin responsiveness to furosemide and antihypertensive effect of captopril in patients with normal-renin essential hypertension. Furosemide 44-54 renin Homo sapiens 20-25 7910062-1 1993 The relationship between renin responsiveness to furosemide and the antihypertensive effect of captopril in patients with normal-renin essential hypertension were studied in 23 patients including nine men (mean age, 41 years) and 14 women (mean age, 40 years). Furosemide 49-59 renin Homo sapiens 25-30 7910062-6 1993 These data suggest that renin responsiveness to a single intravenous dose of furosemide can be a useful test for predicting the therapeutic response to captopril in patients with normal-renin essential hypertension. Furosemide 77-87 renin Homo sapiens 24-29 7910062-6 1993 These data suggest that renin responsiveness to a single intravenous dose of furosemide can be a useful test for predicting the therapeutic response to captopril in patients with normal-renin essential hypertension. Furosemide 77-87 renin Homo sapiens 186-191 8466703-8 1993 The renin response to sodium and volume depletion induced by the low sodium diet and furosemide correlated significantly (P < .001) with the subsequent blood pressure response to the low sodium diet. Furosemide 85-95 renin Homo sapiens 4-9 8471406-1 1993 A combination of dietary sodium restriction (40 mmol day-1) and frusemide pretreatment has been used to activate the renin angiotensin system (RAS) in order to characterise the haemodynamic and hormonal responses to enalapril in young normotensives. Furosemide 64-73 renin Homo sapiens 117-122 7506186-5 1993 Furosemide-induced increases in plasma renin activity and aldosterone levels were blunted, and urinary excretion of prostaglandin E2 was markedly reduced by nimesulide. Furosemide 0-10 renin Homo sapiens 39-44 1623899-5 1992 Metamizole significantly reduced furosemide clearance (175 vs 141 ml.min-1), furosemide-stimulated plasma renin activity (1.42 vs 0.79 ng AI.ml-1.h-1) and the urinary excretion of prostacyclin metabolites and of prostaglandin F2 alpha (by 70-81%). Furosemide 77-87 renin Homo sapiens 106-111 1655330-5 1991 Frusemide increased plasma pre-kallikrein, angiotensin II and aldosterone concentrations and plasma renin activity, whereas the plasma level of tissue kallikrein remained unchanged. Furosemide 0-9 renin Homo sapiens 100-105 8498970-11 1993 The vascular renin-angiotensin system is subject to the action of a number of drugs and chemicals, most notably specific inhibitors of the angiotensin-converging enzyme and drugs affecting kidney function (furosemide) and/or vessel tone (propranolol). Furosemide 206-216 renin Homo sapiens 13-18 1572111-1 1992 Furosemide causes not only natriuresis, but a rapid (5-10 min) increase in plasma renin activity. Furosemide 0-10 renin Homo sapiens 82-87 1572111-3 1992 Drugs like indomethacin abolish the renin increment and could potentially affect both mechanisms: they inhibit cyclooxygenase but could also compete with furosemide for transport into the tubular lumen, reducing furosemide concentration at its site of action. Furosemide 154-164 renin Homo sapiens 36-41 1572111-3 1992 Drugs like indomethacin abolish the renin increment and could potentially affect both mechanisms: they inhibit cyclooxygenase but could also compete with furosemide for transport into the tubular lumen, reducing furosemide concentration at its site of action. Furosemide 212-222 renin Homo sapiens 36-41 1853956-11 1991 At the doses studied, hydrochlorothiazide was also more potent than furosemide in increasing plasma renin activity, increasing sodium excretion, and decreasing lithium excretion. Furosemide 68-78 renin Homo sapiens 100-105 1924052-7 1991 These results suggest that ketoprofen reduces the diuresis and renin release induced by frusemide, but that the reduction in diuretic response may become less important after their repeated coadministration. Furosemide 88-97 renin Homo sapiens 63-68 2160342-4 1990 Renin was responsive to posture, low sodium diet, saline infusion and frusemide, but relatively unresponsive to raising or lowering circulating levels of angiotensin II. Furosemide 70-79 renin Homo sapiens 0-5 1864454-2 1991 Prostaglandin E1 also increased the total serum protein and serum albumin concentrations, and reduced creatinine clearance and plasma renin activity following frusemide loading. Furosemide 159-168 renin Homo sapiens 134-139 1832596-4 1991 After upright posture and furosemide administration plasma ANP was decreased (p less than 0.01) in patients with low renin and, less markedly, with normal renin essential hypertension, however not in IHA and APA. Furosemide 26-36 renin Homo sapiens 117-122 2087934-0 1990 Plasma renin activity and urinary kallikrein excretion in response to intravenous furosemide in diabetic patients. Furosemide 82-92 renin Homo sapiens 7-12 2087934-1 1990 The responsiveness of renin-angiotensin and kallikrein-kinin systems to furosemide challenge has been investigated in forty-six diabetic patients (34 NIDDM/12 IDDM), subdivided into Group I (uncomplicated DM), Group II (DM with hypertension), Group III (DM with nephropathy), Group IV (DM with hypertension and nephropathy) and a control group of 10 healthy volunteers. Furosemide 72-82 renin Homo sapiens 22-27 2087934-2 1990 Plasma renin activity (PRA) was estimated by radioimmunoassay in blood samples drawn before and 10 min after furosemide administration (0.5 mg/kg i.v.). Furosemide 109-119 renin Homo sapiens 7-12 2178660-9 1990 Both nonsteroidal agents inhibited equally the rise in renin activity seen after frusemide. Furosemide 81-90 renin Homo sapiens 55-60 2855542-2 1988 Each measurement was repeated before and after stimulation of renin activity induced by furosemide. Furosemide 88-98 renin Homo sapiens 62-67 2655691-9 1989 Significant increments in plasma renin activity, which were suppressed by all treatments, were observed after frusemide. Furosemide 110-119 renin Homo sapiens 33-38 2655691-13 1989 In the presence of frusemide, indomethacin had more anti-natriuretic and renin-suppressing effect than ibuprofen. Furosemide 19-28 renin Homo sapiens 73-78 2655681-8 1989 Plasma renin activity was increased acutely by both doses of frusemide and by bumetanide (2.5 mg) compared with placebo and to bumetanide (250 micrograms). Furosemide 61-70 renin Homo sapiens 7-12 2655681-14 1989 Frusemide 100 mg and bumetanide 2.5 mg have the same effects on the renal vasculature and the renin-angiotensin-prostaglandin system. Furosemide 0-9 renin Homo sapiens 94-99 2655681-15 1989 Under the conditions of this study, frusemide 10 mg had different effects on plasma renin activity than bumetanide 250 micrograms. Furosemide 36-45 renin Homo sapiens 84-89 2543544-2 1989 Hyporeninemic hypoaldosteronism was disclosed on the basis of a lack of response of plasma renin activity to furosemide administration or tilting with marked hypotension and a subnormal response of aldosterone to furosemide stimulation, tilting, angiotensin II infusion and ACTH administration, as well as increased vascular responsiveness to angiotensin II infusion. Furosemide 109-119 renin Homo sapiens 4-9 2543544-2 1989 Hyporeninemic hypoaldosteronism was disclosed on the basis of a lack of response of plasma renin activity to furosemide administration or tilting with marked hypotension and a subnormal response of aldosterone to furosemide stimulation, tilting, angiotensin II infusion and ACTH administration, as well as increased vascular responsiveness to angiotensin II infusion. Furosemide 213-223 renin Homo sapiens 4-9 2521333-0 1989 Atrial natriuretic factor inhibits isoproterenol- and furosemide-stimulated renin release in humans. Furosemide 54-64 renin Homo sapiens 76-81 2521333-4 1989 Atrial natriuretic factor abolished the rise in plasma renin activity caused by isoproterenol (p = 0.003) and significantly (p = 0.048) attenuated the rise in plasma renin activity after a bolus injection of furosemide. Furosemide 208-218 renin Homo sapiens 55-60 2521333-4 1989 Atrial natriuretic factor abolished the rise in plasma renin activity caused by isoproterenol (p = 0.003) and significantly (p = 0.048) attenuated the rise in plasma renin activity after a bolus injection of furosemide. Furosemide 208-218 renin Homo sapiens 166-171 3061717-0 1988 Effects of frusemide and captopril on the relationship between biologically and immunologically active renin in human plasma. Furosemide 11-20 renin Homo sapiens 103-108 3220046-5 1988 However, plasma renin activity (PRA) was normal or slightly high, and responded normally to furosemide-upright stimulation and fluorohydrocortisone suppression. Furosemide 92-102 renin Homo sapiens 16-21 2266774-0 1990 Disproportional release of differently glycosylated forms of human renin by furosemide. Furosemide 76-86 renin Homo sapiens 67-72 2266774-7 1990 These results provide evidence for the presence of differently glycosylated forms of AR and PR in human plasma and suggest the preferential release of AR-III with the acute stimulation of renin, by furosemide. Furosemide 198-208 renin Homo sapiens 188-193 2645910-3 1989 Reduction of renal perfusion pressure, intravenous infusion of furosemide, and captopril administration cause a greater increase in renin release from innervated kidneys than from denervated kidneys. Furosemide 63-73 renin Homo sapiens 132-137 2792172-2 1989 Decreased renal sensitivity to frusemide was found in only one patient, who also had hypovolaemia and an activated renin-angiotensin-aldosterone system. Furosemide 31-40 renin Homo sapiens 115-120 3064599-12 1988 In conclusion, furosemide modulates coronary reserve, and it is likely that this is because furosemide mediates activation of renin-angiotensin system, thus reducing the vasodilatory capacity of the coronary arteries. Furosemide 15-25 renin Homo sapiens 126-131 3064599-12 1988 In conclusion, furosemide modulates coronary reserve, and it is likely that this is because furosemide mediates activation of renin-angiotensin system, thus reducing the vasodilatory capacity of the coronary arteries. Furosemide 92-102 renin Homo sapiens 126-131 3555065-4 1987 Renin/aldosterone stimulation testing was performed by intravenous injection of 80 mg of furosemide followed by four hours of upright posture. Furosemide 89-99 renin Homo sapiens 0-5 3277563-3 1988 We studied the renin-aldosterone response to intravenous furosemide (60 mg) and upright posture and the renin response to converting enzyme inhibition (captopril, 50 mg) and upright posture in five patients with SLE and hyperkalemia (group 1) and five normokalemic patients with SLE (group 2). Furosemide 57-67 renin Homo sapiens 15-20 3276725-4 1988 Four of the 5 diabetic patients whose PRA failed to rise to the usual level after furosemide treatment attained a plasma prorenin level higher than any normal subject, suggesting that furosemide stimulated synthesis and secretion of prorenin, but that conversion of prorenin to active renin was impaired. Furosemide 184-194 renin Homo sapiens 124-129 3060993-8 1988 It is proposed that activation of the sympathetic nervous system and/or the renin-angiotensin-aldosterone system may play a role in mediating the acute tolerance to furosemide diuresis. Furosemide 165-175 renin Homo sapiens 76-81 3506626-1 1987 Changes in plasma active and inactive renin and angiotensin II in response to tilt and intravenous frusemide were assessed in ten patients with essential hypertension, before treatment and again during chronic therapy with the alpha 1-adrenoceptor antagonist prazosin. Furosemide 99-108 renin Homo sapiens 38-43 3506626-3 1987 Both before and during prazosin, tilt and frusemide each led to significant elevation of plasma active renin (P less than 0.001) and angiotensin II (P less than 0.05). Furosemide 42-51 renin Homo sapiens 103-108 3506626-4 1987 Inactive renin tended to fall with tilt, and fell significantly following frusemide (P less than 0.05). Furosemide 74-83 renin Homo sapiens 9-14 3652622-7 1987 Indomethacin attenuated the natriuretic and renin responses to frusemide, but did not alter urine dopamine output. Furosemide 63-72 renin Homo sapiens 44-49 2853446-2 1988 The role of the renin-angiotensin-aldosterone system in the development of tolerance to the diuretic effect of furosemide was investigated in 12 healthy male volunteers. Furosemide 111-121 renin Homo sapiens 16-21 3549504-5 1987 Serum renin and serum aldosterone correlated mutually before and after intravenous furosemide. Furosemide 83-93 renin Homo sapiens 6-11 3549322-6 1987 These results suggest that urinary PGE2 excretion after frusemide administration may be reduced by propranolol and that the mechanism responsible for the effect of propranolol on the frusemide-induced renal PGE2 production may be, at least in part, secondary to inhibition of the renin-angiotensin system. Furosemide 183-192 renin Homo sapiens 280-285 3600908-4 1987 In the biopsy carried out after the cessation of furosemide intake, these morphological changes were markedly improved with a reduced activity of the renin-angiotensin system. Furosemide 49-59 renin Homo sapiens 150-155 3553421-0 1987 System dynamics modeling of renin aldosterone and electrolyte changes induced by furosemide in hypertensive patients. Furosemide 81-91 renin Homo sapiens 28-33 3528445-3 1986 Twenty children with chronic renal failure never had hyperkalemia, and both renin and aldosterone were normally stimulated by intravenous administration of furosemide, whereas three patients had moderate hyperkalemia (serum potassium concentration between 5.3 and 5.6 mEq/L) and failed to raise plasma renin activity and aldosterone values in response to furosemide. Furosemide 156-166 renin Homo sapiens 76-81 2944248-6 1986 In patients with RVH, inactive renin was markedly decreased by furosemide but unchanged by captopril, in spite of significant increase in active renin. Furosemide 63-73 renin Homo sapiens 31-36 3023151-5 1986 In 27 DP, plasma renin activity (PRA) increased from 0.8 +/- 0.6 SD to 2.4 +/- 2.2 ng/ml/h (normal: 1.2 +/- 0.7 to 3.2 +/- 1.7 ng/ml/h) 2 hours after intravenous administration of furosemide (1 mg/kg) and assumption of the upright posture. Furosemide 180-190 renin Homo sapiens 17-22 2944248-8 1986 These data support the idea that in patients with RVH, the increase in active renin by furosemide is at least partly due to the activation of inactive renin. Furosemide 87-97 renin Homo sapiens 78-83 2944248-8 1986 These data support the idea that in patients with RVH, the increase in active renin by furosemide is at least partly due to the activation of inactive renin. Furosemide 87-97 renin Homo sapiens 151-156 3518770-7 1986 Plasma aldosterone concentrations were unchanged after either drug but plasma renin activity (PRA) was increased after frusemide 10 mg (4.42 +/- 1.01----8.50 +/- 1.90 ng A I ml-1 h-1 P less than 0.01) and 20 mg (4.01 +/- 0.72----7.81 +/- 2.27 ng A I ml-1 h-1 P less than 0.05). Furosemide 119-128 renin Homo sapiens 78-83 3529267-6 1986 TGF responses are inhibitable by furosemide, and the renin secretion produced by furosemide seems to be in part macula densa dependent. Furosemide 81-91 renin Homo sapiens 53-58 3519847-0 1986 [Furosemide stimulation of renin-secretion in essential hypertension]. Furosemide 1-11 renin Homo sapiens 27-32 3512619-9 1986 The brisk increment in plasma renin activity seen ten minutes after furosemide, as well as later values (30 and 240 min) were not changed by aspirin. Furosemide 68-78 renin Homo sapiens 30-35 2425102-2 1986 Recently, we have shown that aprotinin, a kallikrein inhibitor, inhibits the stimulation of plasma renin activity (PRA) by either furosemide or a low sodium diet. Furosemide 130-140 renin Homo sapiens 99-104 3896657-6 1985 Piretanide and furosemide both induced a short-term increase in plasma renin activity with a maximum about 4 hours after dosing which returned to initial levels after approximately 12 hours regardless of whether a single or twice daily dose had been given. Furosemide 15-25 renin Homo sapiens 71-76 3891172-3 1985 The daily maintenance dose of frusemide correlated closely and in a positive fashion with plasma levels of renin activity, angiotensin II and aldosterone (P less than 0.001), and to a lesser extent with plasma noradrenaline. Furosemide 30-39 renin Homo sapiens 107-112 3881208-1 1985 Prostaglandin-dependent, frusemide-induced changes in renal plasma flow, glomerular filtration rate and plasma renin activity were measured in 14 patients with mild essential hypertension. Furosemide 25-34 renin Homo sapiens 111-116 3881302-4 1985 furosemide, which stimulates renal prostaglandin (PG) synthesis and renin release, to compare these vasoactive systems in 14 diabetic and 23 normal control subjects. Furosemide 0-10 renin Homo sapiens 68-73 3888240-1 1985 To examine the importance of acute frusemide-induced renin release in the production of the acute peripheral venous and arterial responses to frusemide in man, the effects of two drugs, previously described as inhibitors of acute frusemide-induced renin release, propranolol and digoxin, were examined. Furosemide 35-44 renin Homo sapiens 53-58 3888240-5 1985 The study provides further evidence of a relationship between acute frusemide-induced renin release and the acute peripheral vascular effects of frusemide in man. Furosemide 68-77 renin Homo sapiens 86-91 3888240-5 1985 The study provides further evidence of a relationship between acute frusemide-induced renin release and the acute peripheral vascular effects of frusemide in man. Furosemide 145-154 renin Homo sapiens 86-91 3903529-6 1985 Mean plasma renin activity levels in the 4 h after furosemide increased significantly at all time points in comparison to basal values, but were significantly less for ibuprofen and sulindac groups in the first hour. Furosemide 51-61 renin Homo sapiens 12-17 3903529-0 1985 Sulindac and ibuprofen inhibit furosemide-stimulated renin release but not natriuresis in men on a normal sodium diet. Furosemide 31-41 renin Homo sapiens 53-58 3903529-5 1985 Mean basal plasma renin activity levels prior to furosemide administration on day 6 were significantly lower in the presence of ibuprofen (1.5 +/- 2.0 ng/ml/h;p less than 0.01) and sulindac (2,3 +/- 0.9 ng/ml/h; p less than 0.05), compared with placebo (3.3 +/- 1.1 ng/ml/h); the difference between the two NSAIDs was also significant (p less than 0.05). Furosemide 49-59 renin Homo sapiens 18-23 3895336-3 1985 Captopril test, upright posture, and furosemide administration provoked in our patients changes of renin and prorenin similar to those found in normal and hypertensive subjects. Furosemide 37-47 renin Homo sapiens 99-104 6384651-4 1984 Patients with low-renin essential hypertension (LREH) had a significantly reduced excretion of both PGE2 and PGF2 alpha before and after administration of furosemide as compared to controls. Furosemide 155-165 renin Homo sapiens 18-23 6389735-9 1984 In normal participants, plasma renin concentration determined by direct radioimmunoassay was increased by standing and furosemide injection. Furosemide 119-129 renin Homo sapiens 31-36 3890391-9 1985 A significant increase of plasma renin activity was observed after furosemide. Furosemide 67-77 renin Homo sapiens 33-38 6090761-7 1984 Plasma renin activity was tripled and rose after furosemide. Furosemide 49-59 renin Homo sapiens 7-12 6428443-3 1984 The early increase in plasma renin activity after frusemide was inhibited by indomethacin. Furosemide 50-59 renin Homo sapiens 29-34 6378806-5 1984 Such a stimulation of the renin-angiotensin-aldosterone system was greater with azosemide than with furosemide. Furosemide 100-110 renin Homo sapiens 26-31 6388913-0 1984 Synchronous changes in active and inactive renin secretion after furosemide in patients with primary aldosteronism. Furosemide 65-75 renin Homo sapiens 43-48 6328073-6 1984 Plasma renin activity was normal but responded to a greater extent to furosemide plus upright posture. Furosemide 70-80 renin Homo sapiens 7-12 6345362-6 1983 A positive correlation (r = + 0.425; p less than 0.05) was found between plasma renin activity after intravenous furosemide and Lii-Nao countertransport in essential hypertension. Furosemide 113-123 renin Homo sapiens 80-85 6668785-5 1983 The patients with an excessive response to lasix had a significantly lower baseline urine excretion of stable sodium, a higher sodium concentration in the red blood cells and, in cases of stable hypertension, a higher activity of plasma renin as well. Furosemide 43-48 renin Homo sapiens 237-242 6361711-0 1983 [Intra-erythrocytic sodium and plasma renin activity in primary arterial hypertension before and after furosemide therapy]. Furosemide 103-113 renin Homo sapiens 38-43 6363244-1 1983 We examined the renin-angiotensin-aldosterone system in seven patients with Shy-Drager syndrome by studying their response to the stimulation of 1 mg/kg furosemide injection followed by sitting for 1 hour. Furosemide 153-163 renin Homo sapiens 16-21 6195464-6 1983 Twenty minutes after administration of furosemide, plasma renin activity was increased and remained elevated during the following 8 h. Heart rate and plasma noradrenaline concentration were unchanged after 20 min, but both increased gradually as blood pressure started to fall. Furosemide 39-49 renin Homo sapiens 58-63 6345888-4 1983 Intravenous or prolonged furosemide administration was shown to be the test of choice for the diagnosis of renin suppression. Furosemide 25-35 renin Homo sapiens 107-112 6339312-11 1983 The diuretic response to furosemide and spironolactone was related to the activity of the renin-aldosterone system. Furosemide 25-35 renin Homo sapiens 90-95 6339312-13 1983 These results indicate that (a) at the dosages used in the study, spironolactone is more effective than furosemide in nonazotemic cirrhosis with ascites, and (b) the activity of the renin-aldosterone system influences the diuretic response to furosemide and spironolactone in these patients. Furosemide 243-253 renin Homo sapiens 182-187 6354727-0 1983 Sequential changes in plasma renin activity and plasma catecholamines in mildly hypertensive patients during acute, furosemide-induced body-fluid loss. Furosemide 116-126 renin Homo sapiens 29-34 6343667-0 1983 Contributions of central sympathetic neural activity to furosemide-induced increases in plasma renin activity and noradrenaline. Furosemide 56-66 renin Homo sapiens 95-100 6354727-1 1983 To evaluate the role of adrenergic mechanisms in the acute response of renin to furosemide, plasma renin activity (PRA) and plasma catecholamine concentrations were measured for 3 h after i.v. Furosemide 80-90 renin Homo sapiens 71-76 6354727-3 1983 Furosemide induced a prompt and long-lasting increase in renin, with PRA more than doubled at all times. Furosemide 0-10 renin Homo sapiens 57-62 7045443-0 1982 Renin response to furosemide differs with the routes of administration in health men. Furosemide 18-28 renin Homo sapiens 0-5 6755768-5 1982 There is a tendency for furosemide to elevate serum aldosterone levels and renin activity regardless of the time of administration. Furosemide 24-34 renin Homo sapiens 75-80 6757970-2 1982 In each renin subgroup, the administration of furosemide and 2 hours upright posture induced marked increases in urinary excretion of PGE and sodium, and in plasma renin activity. Furosemide 46-56 renin Homo sapiens 8-13 6757970-2 1982 In each renin subgroup, the administration of furosemide and 2 hours upright posture induced marked increases in urinary excretion of PGE and sodium, and in plasma renin activity. Furosemide 46-56 renin Homo sapiens 164-169 7043184-4 1982 While the mean plasma aldosterone concentrations were normal, the mean plasma renin activity in response to furosemide stimulation was subnormal in subjects with hyperparathyroidism. Furosemide 108-118 renin Homo sapiens 78-83 6282524-0 1982 Canrenoate reversal of inhibitory effects of digoxin on basal and furosemide-stimulated renin secretion. Furosemide 66-76 renin Homo sapiens 88-93 6282524-7 1982 This result indicates that furosemide stimulates renin release by affecting a biochemical system other than that affected by digoxin. Furosemide 27-37 renin Homo sapiens 49-54 6125538-1 1982 It has been demonstrated that somatostatin (SRIF) can suppress hypophyseal and extrahypophyseal hormones; moreover, many studies have shown that SRIF inhibits frusemide-induced hyperreninemia in normal man, and renin and aldosterone in renovascular hypertension, possibly through a beta-adrenergic block. Furosemide 159-168 renin Homo sapiens 182-187 7045443-12 1982 These findings suggest that the response of renin release to furosemide in healthy men differs with the routes of administration and renin release with p.o. Furosemide 61-71 renin Homo sapiens 44-49 7045443-12 1982 These findings suggest that the response of renin release to furosemide in healthy men differs with the routes of administration and renin release with p.o. Furosemide 61-71 renin Homo sapiens 133-138 7031155-12 1981 We conclude that prostaglandins mediate baseline renin secretion and renin stimulation in response to furosemide. Furosemide 102-112 renin Homo sapiens 69-74 6281634-11 1982 Potassium delays the increase of plasma renin activity after furosemide and propranolol inhibits the furosemide-induced renin release, both without impairing aldosterone secretion. Furosemide 101-111 renin Homo sapiens 40-45 6281634-11 1982 Potassium delays the increase of plasma renin activity after furosemide and propranolol inhibits the furosemide-induced renin release, both without impairing aldosterone secretion. Furosemide 101-111 renin Homo sapiens 120-125 6120716-5 1982 4 Intravenous frusemide caused immediate rises in plasma active, total and inactive renin, angiotensin II, and aldosterone, which then declined over 2 h despite increasing cumulative sodium losses. Furosemide 14-23 renin Homo sapiens 84-89 6120716-6 1982 5 Intravenous propranolol or metoprolol attenuated, without abolishing, these early increases in the components of the renin-angiotensin-aldosterone system after frusemide. Furosemide 162-171 renin Homo sapiens 119-124 6120716-9 1982 8 Also in contrast to earlier work, we found attenuation by both intravenous propranolol and metoprolol of the immediate rise in renin after intravenous frusemide. Furosemide 153-162 renin Homo sapiens 129-134 6749346-8 1982 The mechanism of this sustained renin response several days after cessation of diuretic therapy may be best explained by a prolonged action of furosemide or by partial ongoing volume depletion with reduced sodium load to the distal nephron. Furosemide 143-153 renin Homo sapiens 32-37 6750183-0 1982 [Urinary electrolyte excretion and plasma corticoid level at the furosemide administration test in low renin hypertension]. Furosemide 65-75 renin Homo sapiens 103-108 6120716-0 1982 Response of the renin-angiotensin-aldosterone system to upright tilting and to intravenous frusemide: effect of prior metoprolol and propranolol. Furosemide 91-100 renin Homo sapiens 16-21 7033708-3 1982 Renin classification was determined after furosemide (80 mg) stimulation; control measurements were made after each patient had been off all medications for at least 1 week. Furosemide 42-52 renin Homo sapiens 0-5 7033292-8 1982 The intravenous infusion of furosemide, which is known to stimulate renin release via a cyclooxygenase-dependent mechanism, caused a three-to fourfold increase of urinary 6-keto-PGF(1alpha) excretion rate, concomitant with the elevation of plasma renin activity levels, in six healthy women. Furosemide 28-38 renin Homo sapiens 68-73 7033292-8 1982 The intravenous infusion of furosemide, which is known to stimulate renin release via a cyclooxygenase-dependent mechanism, caused a three-to fourfold increase of urinary 6-keto-PGF(1alpha) excretion rate, concomitant with the elevation of plasma renin activity levels, in six healthy women. Furosemide 28-38 renin Homo sapiens 247-252 7029027-4 1981 Following stimulation with furosemide and ambulation, the levels of active renin increased but its responsiveness to the stimulus decreased with age in both groups. Furosemide 27-37 renin Homo sapiens 75-80 7029027-6 1981 These data show that an acute stimulation with furosemide and ambulation affects mainly the active form of plasma renin, and that the effect of age on inactive plasma renin in normal subjects may be different from that in patients with essential hypertension. Furosemide 47-57 renin Homo sapiens 114-119 7021994-0 1981 Renin release after furosemide and ethacrynic acid in man. Furosemide 20-30 renin Homo sapiens 0-5 7021646-4 1981 Following stimulation with furosemide and ambulation, the levels of active renin increased but the responsiveness to stimulus decreased with age in both groups. Furosemide 27-37 renin Homo sapiens 75-80 7021646-5 1981 In contrast, inactive renin levels slightly increased after furosemide administration and ambulation, resulting in increased proportion of active to total renin. Furosemide 60-70 renin Homo sapiens 22-27 7021646-5 1981 In contrast, inactive renin levels slightly increased after furosemide administration and ambulation, resulting in increased proportion of active to total renin. Furosemide 60-70 renin Homo sapiens 155-160 7021646-6 1981 These data show that an acute stimulation with furosemide and ambulation affects mainly the active form of plasma renin, and the effect of age on inactive plasma renin in normal subjects may be different from that in patients with essential hypertension. Furosemide 47-57 renin Homo sapiens 114-119 7023561-0 1981 Renin responsiveness to furosemide in the homotransplanted kidney. Furosemide 24-34 renin Homo sapiens 0-5 7023561-1 1981 Plasma renin activity (PRA) was measured after repetitive furosemide stimulations in 16 normotensive homotransplanted patients who previously had bilateral nephrectomies. Furosemide 58-68 renin Homo sapiens 7-12 7023561-4 1981 These data indicate that the juxtaglomerular cell responsiveness to furosemide is quantitatively time dependent after transplantation, and it is a factor that should be considered in the evaluation of renin-angiotensin system in such patients. Furosemide 68-78 renin Homo sapiens 201-206 7021994-2 1981 The mechanisms of renin release after furosemide (F) and ethacrynic acid (EA) in man were examined. Furosemide 38-48 renin Homo sapiens 18-23 6785094-4 1981 In normal men, furosemide (n = 9) within 15 min increased active renin from 29.9 +/- 5.8 to 82.4 +/- 14.8 microunits/ml (P less than 0.001), while inactive renin slightly but not significantly decreased from 136.3 +/- 29.9 to 121.1 +/- 19.2 microunits/ml; orthostasis (n = 15) within 4 h stimulated active renin (P less than 0.001) and slightly raised inactive renin (P less than 0.05). Furosemide 15-25 renin Homo sapiens 65-70 6785094-4 1981 In normal men, furosemide (n = 9) within 15 min increased active renin from 29.9 +/- 5.8 to 82.4 +/- 14.8 microunits/ml (P less than 0.001), while inactive renin slightly but not significantly decreased from 136.3 +/- 29.9 to 121.1 +/- 19.2 microunits/ml; orthostasis (n = 15) within 4 h stimulated active renin (P less than 0.001) and slightly raised inactive renin (P less than 0.05). Furosemide 15-25 renin Homo sapiens 156-161 6785094-4 1981 In normal men, furosemide (n = 9) within 15 min increased active renin from 29.9 +/- 5.8 to 82.4 +/- 14.8 microunits/ml (P less than 0.001), while inactive renin slightly but not significantly decreased from 136.3 +/- 29.9 to 121.1 +/- 19.2 microunits/ml; orthostasis (n = 15) within 4 h stimulated active renin (P less than 0.001) and slightly raised inactive renin (P less than 0.05). Furosemide 15-25 renin Homo sapiens 156-161 6785094-4 1981 In normal men, furosemide (n = 9) within 15 min increased active renin from 29.9 +/- 5.8 to 82.4 +/- 14.8 microunits/ml (P less than 0.001), while inactive renin slightly but not significantly decreased from 136.3 +/- 29.9 to 121.1 +/- 19.2 microunits/ml; orthostasis (n = 15) within 4 h stimulated active renin (P less than 0.001) and slightly raised inactive renin (P less than 0.05). Furosemide 15-25 renin Homo sapiens 156-161 6785094-5 1981 Both furosemide and orthostasis increased (P less than 0.001 each) the proportion of active renin in normal persons. Furosemide 5-15 renin Homo sapiens 92-97 6785094-9 1981 The stimulation of active renin by furosemide and orthostasis is bound to the presence of the kidney. Furosemide 35-45 renin Homo sapiens 26-31 6258416-3 1981 Plasma renin activity increased with sodium depletion (30 mEq sodium intake for 3 days after furosemide treatment) from 1.26 +/- 0.07 to 3.26 +/- 0.48 ng/ml/hr (p less than 0.001). Furosemide 93-103 renin Homo sapiens 7-12 7010287-5 1980 Furosemide increased cryorenin and trypsin-activated renin in parallel to active renin from 2.9 +/- 1.1 ng/ml/hr and a6.9 +/- 1.5 of PRA to 5.0 +/- 1.0 and 11.2 +/- 1.5 at 65 min, respectively (P less than 0.05). Furosemide 0-10 renin Homo sapiens 25-30 7026261-1 1981 The role of the sympathetic nervous system in furosemide-induced renin release was investigated in six normal subjects. Furosemide 46-56 renin Homo sapiens 65-70 7026261-2 1981 After intravenous administration of furosemide, plasma renin concentrations increased more than two-fold within 15 min. Furosemide 36-46 renin Homo sapiens 55-60 6459589-0 1981 Response of peripheral plasma renin activity (PRA) to furosemide stimulation; reduction of the renal parenchyma as a limiting factor. Furosemide 54-64 renin Homo sapiens 30-35 7010287-5 1980 Furosemide increased cryorenin and trypsin-activated renin in parallel to active renin from 2.9 +/- 1.1 ng/ml/hr and a6.9 +/- 1.5 of PRA to 5.0 +/- 1.0 and 11.2 +/- 1.5 at 65 min, respectively (P less than 0.05). Furosemide 0-10 renin Homo sapiens 53-58 6108811-2 1980 The response of plasma renin activity to frusemide 40 mg given intravenously, was examined before and after oral propranolol 160 mg daily for 7 days in normal and hypertensive subjects. Furosemide 41-50 renin Homo sapiens 23-28 7005123-0 1980 Response of renin, aldosterone and antidiuretic hormone to furosemide and furosemide-triamterene combination. Furosemide 59-69 renin Homo sapiens 12-17 7005123-0 1980 Response of renin, aldosterone and antidiuretic hormone to furosemide and furosemide-triamterene combination. Furosemide 74-84 renin Homo sapiens 12-17 7005123-8 1980 The results show a fast but transient response of the renin-aldosterone system after furosemide and the furosemide-triamterene combination which could not be correlated with the natriuretic effects. Furosemide 85-95 renin Homo sapiens 54-59 7005123-8 1980 The results show a fast but transient response of the renin-aldosterone system after furosemide and the furosemide-triamterene combination which could not be correlated with the natriuretic effects. Furosemide 104-114 renin Homo sapiens 54-59 7017323-0 1980 [Plasma renin activity in patients with acute renal failure treated with furosemide (author"s transl)]. Furosemide 73-83 renin Homo sapiens 8-13 6996896-6 1980 A rise in plasma renin activity was observed 2 hr after an 80-mg dose of furosemide but not after indacrinone. Furosemide 73-83 renin Homo sapiens 17-22 6108811-9 1980 Preservation of the renin stimulatory effect of frusemide during beta blockade confirms the value of this procedure in the investigation of mineralocorticoid and renovascular hypertension were discontinuation of treatment may be undesirable. Furosemide 48-57 renin Homo sapiens 20-25 6996879-6 1980 This was in contrast to the rapid rise seen in normal humans thus indicating a dissociation between the diuretic and renin-releasing activities of frusemide in acute nephritis. Furosemide 147-156 renin Homo sapiens 117-122 6987097-6 1980 3) In low renin EH, the response of PNE to the stimulation of standing with furosemide was significantly greater than in normal renin EH (p less than 0.05). Furosemide 76-86 renin Homo sapiens 10-15 6992087-4 1980 Furosemide administration also resulted in a significant increase from 4.41 +/- 2.00 to 9.70 +/- 2.32 ng/ml/hr (P less than 0.02) in plasma renin activity, from 1.17 +/- 0.22 to 1.68 +/- 0.36 ng/ml (P less than 0.025) in plasma aldosterone, from 0.93 +/- 0.16 to 1.53 +/- 0.35 microgram/12 hr (P less than 0.025) in urinary aldosterone, from 17.53 +/- 3.37 to 23.73 +/- 3.16 ng/12 hr (P less than 0.025) in prostaglandin E, and from 16.48 +/- 4.12 to 26.27 +/- 4.12 ng/12 hr (P less than 0.05) in prostaglandin F2 alpha. Furosemide 0-10 renin Homo sapiens 140-145 6992087-5 1980 It is concluded that the renin-angiotensin-aldosterone system of the neonate responds to acute furosemide challenge in spite of its high baseline activity, and its response may be mediated by increased renal prostaglandin production. Furosemide 95-105 renin Homo sapiens 25-30 7004092-1 1980 The furosemide-induced increase in protein excretion, and its relations to 1) the size of protein molecules as reflected by three enzymes, and 2) glomerular filtration rate (GFR), plasma renin activity (PRA) and prostaglandin (PG) E2 and F2 alpha excretions were studied in 14 outpatients with normal renal function and 13 healthy males. Furosemide 4-14 renin Homo sapiens 187-192 6992754-4 1980 The concomitant rise in plasma renin level after furosemide was also blocked by indomethacin. Furosemide 49-59 renin Homo sapiens 31-36 6996661-0 1980 Effect of propranolol on the renin response to frusemide in man. Furosemide 47-56 renin Homo sapiens 29-34 6996661-1 1980 The response of plasma renin activity (PRA) to frusemide, 40 mg given intravenously, was examined before and after oral propranolol 160 mg daily for seven days in normal and hypertensive subjects. Furosemide 47-56 renin Homo sapiens 23-28 6996661-5 1980 Stimulation of renin release by oral frusemide, examined in one subject, was also unaltered by propranolol therapy. Furosemide 37-46 renin Homo sapiens 15-20 6996661-8 1980 The fact that the renin stimulating effect of frusemide is preserved during beta blockade indicates that this procedure can be used in the investigation of hypertension even in those patients in whom discontinuation of beta blocking treatment may be undesirable. Furosemide 46-55 renin Homo sapiens 18-23 6993779-1 1980 Dissociation between plasma renin and catecholamines or aldosterone following furosemide. Furosemide 78-88 renin Homo sapiens 28-33 6992087-0 1980 Furosemide-induced alterations in the electrolyte status, the function of renin-angiotensin-aldosterone system, and the urinary excretion of prostaglandins in newborn infants. Furosemide 0-10 renin Homo sapiens 74-79 6992087-1 1980 To assess the responsiveness of the renin-angiotensin-aldosterone system of the neonate to acute furosemide stimulation and the role of renal prostaglandins in mediating the response of the renin-angiotensin-aldosterone system, this study was carried out to determine simultaneously plasma renin activity, plasma aldosterone concentration, urinary aldosterone, prostaglandin E, and prostaglandin F2 alpha excretion along with determination of plasma electrolyte concentration and urinary electrolyte excretion. Furosemide 97-107 renin Homo sapiens 36-41 6987415-7 1980 Of the 16 patients (all normotensive) who had 6-month followup tests 5 had elevated peripheral renin activity, probably owing to furosemide stimulation. Furosemide 129-139 renin Homo sapiens 95-100 7014055-0 1980 Peripheral renin activity before and after furosemide in normotensives and hypertensives. Furosemide 43-53 renin Homo sapiens 11-16 449254-2 1979 In essential hypertension mean basal (supine) and stimulated plasma renin activity (2 h upright posture + 40 mg furosemide intraveneously) decreased progressively with age. Furosemide 112-122 renin Homo sapiens 68-73 393525-4 1979 It is concluded that furosemide induces a generalized activation of the renal PG system temporally related to the increase of renin release and natriuresis. Furosemide 21-31 renin Homo sapiens 126-131 518220-3 1979 Renin status was categorized by (1) the intravenous furosemide test, (2) ambulation during placebo, and (3) ambulation during spironolactone and hydrochlorothiazide treatment. Furosemide 52-62 renin Homo sapiens 0-5 518124-3 1979 In the present study, plasma renin concentration following intravenous administration of frusemide was measured in eleven subjects with moderate or severe lead poisoning of industrial origin. Furosemide 89-98 renin Homo sapiens 29-34 474601-3 1979 High plasma renin substrate concentrations, and normal basal and furosemide-stimulated plasma renin activities and plasma renin concentrations which were present before surgery, decreased after adrenalectomy, and the hypertension diminished. Furosemide 65-75 renin Homo sapiens 94-99 474601-3 1979 High plasma renin substrate concentrations, and normal basal and furosemide-stimulated plasma renin activities and plasma renin concentrations which were present before surgery, decreased after adrenalectomy, and the hypertension diminished. Furosemide 65-75 renin Homo sapiens 94-99 503889-0 1979 [Evaluation of the effect of intravenous furosemide on the plasma renin activity of renal vein blood in patients with renovascular hypertension]. Furosemide 41-51 renin Homo sapiens 66-71 396070-5 1979 Plasma noradrenaline concentration and plasma renin concentration at rest supine and after acute stimulation, as induced by frusemide intravenously and ambulation, did not differ from reference values in the 40-year-old normotensive controls. Furosemide 124-133 renin Homo sapiens 46-51 489926-12 1979 Intravenous injection of furosemide (50 mg) in a female volunteer was followed by an immediate rise of urinary sodium, PGE2, PGF2 alpha and PGE2/PGF2 alpha ratio and plasma renin activity. Furosemide 25-35 renin Homo sapiens 173-178 763247-1 1979 In 10 healthy and 27 diabetic children aged 11--17 years plasma renin activity was determined in horizontal position (PRA-I) and after stimulation by furosemid and upright position (PRA-II). Furosemide 150-159 renin Homo sapiens 64-69 449049-0 1979 Change in plasma renin substrate level after the intravenous furosemide administration. Furosemide 61-71 renin Homo sapiens 17-22 424524-0 1979 Effects of furosemide on renal venous plasma renin activity. Furosemide 11-21 renin Homo sapiens 45-50 424524-4 1979 Acute stimulation of renin by furosemide does not increase the predictive value of renal venous renin measurements and may actually result in a higher percentage of false-negatives. Furosemide 30-40 renin Homo sapiens 21-26 761310-0 1979 Effects of digoxin and digoxin plus furosemide on plasma renin activity of hypertensive patients. Furosemide 36-46 renin Homo sapiens 57-62 517244-6 1979 The present data show that basal level of urinary excretion of PGE and kallikrein was lower in essential hypertension than in normal subjects and that the release of renal kallikrein and PGE after the furosemide administration was also suppressed in patients with essential hypertension compared with that in normal subjects, suggesting that there exists, in this disease, an impaired defense mechanism against the renin-angiotensin-aldosterone system resulting in sodium retention. Furosemide 201-211 renin Homo sapiens 415-420 282041-7 1978 An acute stimulation induced by frusemide and ambulation led to a considerable rise in active renin and a slight, but significant, rise of inactive renin. Furosemide 32-41 renin Homo sapiens 94-99 397653-5 1979 Likewise, furosemide will stimulate renin release. Furosemide 10-20 renin Homo sapiens 36-41 545821-7 1979 Of the 16 patients (all normotensive) who had 6-month followup tests 5 had elevated peripheral renin activity, probably owing to furosemide stimulation. Furosemide 129-139 renin Homo sapiens 95-100 282044-2 1978 The response of active and inactive plasma renin to orthostasis and frusemide and to inhibition of prostaglandin synthesis by indomethacin was tested in normal human volunteers. Furosemide 68-77 renin Homo sapiens 43-48 282044-4 1978 Active renin increased by orthostasis and frusemide and decreased by indomethacin. Furosemide 42-51 renin Homo sapiens 7-12 741062-1 1978 The effects of orthostatism and furosemide tests on different parameters of renin-angiotensin system have been studied in 14 normal human subjects. Furosemide 32-42 renin Homo sapiens 76-81 282041-7 1978 An acute stimulation induced by frusemide and ambulation led to a considerable rise in active renin and a slight, but significant, rise of inactive renin. Furosemide 32-41 renin Homo sapiens 148-153 713284-3 1978 The rise in plasma renin activity on standing or after frusemide was proportional to the resting level, and it was generally less in hypertensives, but small or absent responses were also seen in those with normal blood pressure. Furosemide 55-64 renin Homo sapiens 19-24 712172-0 1978 [Plasma renin activity in essential hypertension with respect to aging, hypertension severity and furosemide test (author"s transl)]. Furosemide 98-108 renin Homo sapiens 8-13 713174-0 1978 [The influence of aging on renin release stimulated by furosemide and upright posture in essential hypertension (author"s transl)]. Furosemide 55-65 renin Homo sapiens 27-32 720703-0 1978 [The responsiveness of plasma renin activity to furosemide administration in diabetic patients (author"s transl)]. Furosemide 48-58 renin Homo sapiens 30-35 722978-0 1978 [Renin-angiotensin-aldosterone system and electrolytes metabolism on furosemide stimulation test (author"s transl)]. Furosemide 69-79 renin Homo sapiens 1-6 844016-3 1977 The furosemide screening test for renovascular hypertension revealed elevated plasma renin activity (PRA) but an intravenous pyelogram revealed a right suprarenal mass and no evidence of renovascular compression. Furosemide 4-14 renin Homo sapiens 85-90 637637-1 1978 Seventy-nine patients with essential hypertension were evaluated for peripheral renin activity in response to injection of 60 mg of furosemide and to upright posture. Furosemide 132-142 renin Homo sapiens 80-85 398707-0 1978 [Reliability and diagnostic use of the furosemide test in the study of the renin-angiotensin-aldosterone system]. Furosemide 39-49 renin Homo sapiens 75-80 599795-2 1977 Renin activity proved to be higher in double stimulation (in orthostatism after furosemide intake) than in orthostatism before the intake of the drug. Furosemide 80-90 renin Homo sapiens 0-5 874065-0 1977 Inhibition of the renin-aldosterone response to furosemide by indomethacin. Furosemide 48-58 renin Homo sapiens 18-23 874065-2 1977 The increases in plasma renin activity and plasma and urinary aldosterone following acute furosemide challenge were markedly blunted in the presence of indomethacin. Furosemide 90-100 renin Homo sapiens 24-29 637637-4 1978 Aldosterone responses in relation to changes in peripheral renin activity were found to be nearly random with both furosemide and with posture. Furosemide 115-125 renin Homo sapiens 59-64 591619-1 1977 Plasma renin activity (PRA) was stimulated by oral frusemide (60 mg) in 4 normal male subjects. Furosemide 51-60 renin Homo sapiens 7-12 599792-3 1977 Decrease of the renin-angiotensin-aldosterone system compensatory reaction and the prostaglandin F level in patients with stable, high arterial pressur in response to furosemide administration may be among the causes of the hypotensive and natriuretic effect of this preparation. Furosemide 167-177 renin Homo sapiens 16-21 599795-0 1977 [Change in plasma renin activity in patients with hypertension and healthy persons after furosemide intake]. Furosemide 89-99 renin Homo sapiens 18-23 599795-1 1977 Blood plasma renin activity was studied by the radioimmune method in clino- and orthostatism in 36 males with hypertensive disease and in 15 healthy males before and after 3-day medication with furosemide in a daily dose of 120 mg under in-patient conditions. Furosemide 194-204 renin Homo sapiens 13-18 328540-4 1977 A significant increase in plasma renin activity and a significantly greater increase in aldosterone excretion were found in the spironolactone/thiazide group compared to the furosemide group. Furosemide 174-184 renin Homo sapiens 33-38 1027472-0 1976 [Behavior of sodium and water excretion and of plasma renin activity (PRA) after administration of furosemide in patients with glomerulonephritis with various degrees of functional deficiency and arterial pressure levels]. Furosemide 99-109 renin Homo sapiens 54-59 1071603-2 1976 Supine plasma renin activity and its responsiveness to erect posture and frusemide were reduced in fifty-one patients with essential hypertension, compared with fifty-one age- and sex-matched control subjects. Furosemide 73-82 renin Homo sapiens 14-19 12404-0 1976 [Cyclic AMP and plasma renin activity in renal vein blood after amitryptiline, theophylline, furosemide and beta adrenergic blocking substances (author"s transl)]. Furosemide 93-103 renin Homo sapiens 23-28 12404-1 1976 The influence of amitryptiline, theophylline and furosemide on the concentration of cyclic-AMP and plasma renin activity (PRA) was investigated in renal vein plasma. Furosemide 49-59 renin Homo sapiens 106-111 987428-1 1976 Response of plasma renin activity to furosemide]. Furosemide 37-47 renin Homo sapiens 19-24 937875-0 1976 The intravenous furosemide test: a simple way to evaluate renin responsiveness. Furosemide 16-26 renin Homo sapiens 58-63 937875-1 1976 To identify patients with low-renin hypertension, we measured plasma renin activity after the administration of 40 mg of furosemide intravenously and 30 minutes of upright posture in 127 normotensive subjects and 363 patients with essential hypertension. Furosemide 121-131 renin Homo sapiens 69-74 937875-2 1976 Plasma renin activity 30 minutes after intravenous furosemide was found to be closely correlated to the level found after either 2 or 4 h of standing or 3 days of a low-salt diet plus 2 h of upright posture. Furosemide 51-61 renin Homo sapiens 7-12 1264120-0 1976 Letter: Furosemide stimulation of peripheral renin in men and women. Furosemide 8-18 renin Homo sapiens 45-50 1053468-1 1976 Changes in arterial blood pressure, renal electrolyte excretion, and plasma renin activity in response to repeated doses of furosemide were measured in 12 patients with essential hypertension admitted to the medical service for electrolyte balance studies. Furosemide 124-134 renin Homo sapiens 76-81 1053468-7 1976 However, the average increase in plasma renin activity after repeated doses of furosemide was not statistically significant and no correlation was demonstrated between the level of plasma renin activity after furosemide and the blood pressure lowering effect of the drug. Furosemide 79-89 renin Homo sapiens 40-45 56589-3 1976 Injection of frusemide alone produced hyperreninaemia; but, under somatostatin, renin release was inhibited by 45%. Furosemide 13-22 renin Homo sapiens 43-48 1263402-2 1976 Stimulation of the renin activity was achieved by orthostasis or by furosemide. Furosemide 68-78 renin Homo sapiens 19-24 938983-0 1976 Effects of furosemide and chlorothiazide on blood pressure and plasma renin activity. Furosemide 11-21 renin Homo sapiens 70-75 1022409-0 1976 The effect of furosemide stimulation on renin secretion and its application in examining activity of the renin-angiotensin system. Furosemide 14-24 renin Homo sapiens 40-45 1022409-0 1976 The effect of furosemide stimulation on renin secretion and its application in examining activity of the renin-angiotensin system. Furosemide 14-24 renin Homo sapiens 105-110 1022409-1 1976 The response of plasma renin concentration [PRC] to Furosemide administration and orthostasis stimulation was studied in 9 healthy volunteers and in 30 patients with essential hypertension. Furosemide 52-62 renin Homo sapiens 23-28 1192694-0 1975 Effect of intravenous frusemide on plasma renin concentration: suppression of response in hypertension. Furosemide 22-31 renin Homo sapiens 42-47 1257693-0 1976 Unimpeded plasma renin increase after intravenous furosemide during saline replacement. Furosemide 50-60 renin Homo sapiens 17-22 1257693-1 1976 The effect on plasma renin activity of intravenous furosemide combined with saline replacement of the volume depletion was studied in twelve patients with insignificant heart disease. Furosemide 51-61 renin Homo sapiens 21-26 1105697-3 1975 Furosemide alone resulted in a significant blood pressure fall with a rise in plasma renin and urinary aldosterone with a marked increase in urinary sodium loss. Furosemide 0-10 renin Homo sapiens 85-90 1179572-2 1975 Peripheral plasma renin activity was elevated following furosemide challenge, and there was increased renal vein renin activity on the affected side with suppression of renin secretion from the contralateral kidney. Furosemide 56-66 renin Homo sapiens 18-23 1192694-2 1975 Intravenous frusemide produced in normal subjects a prompt rise of plasma renin concentration which correlated with urinary sodium. Furosemide 12-21 renin Homo sapiens 74-79 1192694-4 1975 The renin response to frusemide was suppressed in patients with primary hyperaldosteronism. Furosemide 22-31 renin Homo sapiens 4-9 1192694-6 1975 In patients with low-renin hypertension and normal renin essential hypertension, the renin response to frusemide was similarly suppressed. Furosemide 103-112 renin Homo sapiens 21-26 1192694-8 1975 Suppression of the renin response to frusemide is therefore a feature of hypertension not confined to patients with primary hyperaldosteronism and low-renin hypertension. Furosemide 37-46 renin Homo sapiens 19-24 1192694-8 1975 Suppression of the renin response to frusemide is therefore a feature of hypertension not confined to patients with primary hyperaldosteronism and low-renin hypertension. Furosemide 37-46 renin Homo sapiens 151-156 1233219-0 1975 Effects of metoprolol and propranolol on furosemide-stimulated renin release in healthy subjects. Furosemide 41-51 renin Homo sapiens 63-68 1138585-1 1975 A standardized test for renin responsiveness, employing the dual stimulus of upright posture and the loop diuretic furosemide, was applied to 19 hypertensive patients in the untreated state and during therapy with the antihypertensive agents guanethidine and methyldopa. Furosemide 115-125 renin Homo sapiens 24-29 802648-11 1975 Oxprenolol suppressed the response of noradrenaline and plasma renin activity to frusemide in all cases. Furosemide 81-90 renin Homo sapiens 63-68 172005-0 1975 [Effect of furosemide and ACTH on plasma renin, aldosterone and cortisol levels in normal man]. Furosemide 11-21 renin Homo sapiens 41-46 1150481-4 1975 In the patients who were given substitution therapy with hydrocortisone, studies of plasma renin and aldosterone revealed impairment of plasma aldosterone response to salt restriction, orthostatism and furosemide-induced diuresis combined with postural change. Furosemide 202-212 renin Homo sapiens 91-96 802648-0 1975 Effect of oxprenolol on catecholamines and plasma renin activity: acute response to frusemide in hypertensive patients. Furosemide 84-93 renin Homo sapiens 50-55 1168122-2 1975 They were divided into two groups according to the change in plasma-renin activity in response to furosemide administration: those with and those without response to stimulation, and sub-groups with low, normal or high plasma-renin activity (low renin hypertension; normal renin hypertension; high renin hypertension). Furosemide 98-108 renin Homo sapiens 68-73 1233219-1 1975 The effects of single doses of the beta1-receptor antagonist metoprolol (40 mg orally), propranolol (40 mg orally) and placebo were compared on furosemide-stimulated plasma renin activity (PRA) in seven healthy subjects. Furosemide 144-154 renin Homo sapiens 173-178 1223821-1 1975 In 22 patients with chronic cor pulmonale syndrome plasma renin activity (PRA) was determined at rest and after stimulation by means of intravenous injection of furosemide. Furosemide 161-171 renin Homo sapiens 58-63 1135521-0 1975 Marked elevation of plasma renin activity during post diuretic sodium conservation in furosemide stimulated subjects. Furosemide 86-96 renin Homo sapiens 27-32 180717-0 1975 [Cyclic AMP and renin secretion following furosemide, beta-sympathicolysis and amitryptiline]. Furosemide 42-52 renin Homo sapiens 16-21 172003-3 1975 The sodium depletion induced by furosemide during continuous ACTH infusion increases plasma renin activity but does not change PA. Furosemide 32-42 renin Homo sapiens 92-97 4443232-0 1974 Renin response to furosemide and hypertonic saline infusion. Furosemide 18-28 renin Homo sapiens 0-5 1116335-4 1975 Secondly, renin activity was measured after frusemide stimualtion [0.42 mmol (140 mg) in 18 h] and 3 h ambulation. Furosemide 44-53 renin Homo sapiens 10-15 1186924-0 1975 Inhibition of furosemide-induced renin release by vasoconstrictors. Furosemide 14-24 renin Homo sapiens 33-38 4376467-0 1974 [Furosemide action on the liberation of renin in vitro]. Furosemide 1-11 renin Homo sapiens 40-45 5074393-0 1972 Release of renin into the peripheral circulation of the ewe and foetus, following administration of frusemide, a natriuretic agent. Furosemide 100-109 renin Homo sapiens 11-16 4454541-0 1974 [Effect of propranolol on the stimulation of renin secretion due to orthostasis and furosemide]. Furosemide 84-94 renin Homo sapiens 45-50 4354807-0 1973 Effect of propranolol and theophylline on renin release caused by furosemide in the cat. Furosemide 66-76 renin Homo sapiens 42-47 5163370-1 1971 Effects of methylclothiazide and frusemide on blood pressure and plasma renin activity and electrolytes. Furosemide 33-42 renin Homo sapiens 72-77 5642446-0 1968 Acute changes in plasma volume, renin activity, and free aldosterone levels in healthy subjects following Fursemide administration. Furosemide 106-115 renin Homo sapiens 32-37 4318270-0 1970 Effect of furosemide and hydrochlorothiazide on plasma renin activity in man. Furosemide 10-20 renin Homo sapiens 55-60 4159219-0 1965 Effect of angiotensin and of frusemide on plasma aldosterone, corticosterone, cortisol and renin in man. Furosemide 29-38 renin Homo sapiens 91-96 26089029-0 2015 Furosemide stimulation of parathormone in humans: role of the calcium-sensing receptor and the renin-angiotensin system. Furosemide 0-10 renin Homo sapiens 95-100 31274842-6 2019 Furosemide dose-dependently induced plasma renin and angiotensin I levels, while an equiefficient diuretic BAY 1753011 dose did not activate the renin-angiotensin system. Furosemide 0-10 renin Homo sapiens 43-48 27818782-10 2016 Although catecholamine improvements after treatment were not significantly different, plasma renin activity was enhanced in the furosemide group. Furosemide 128-138 renin Homo sapiens 93-98 29212491-5 2017 Load tests of captopril or furosemide in the standing position demonstrated autonomous aldosterone secretion and renin suppression. Furosemide 27-37 renin Homo sapiens 113-118 25627679-7 2015 Plasma renin activity also increased appropriately when the patient was upright and after furosemide-induced volume depletion. Furosemide 90-100 renin Homo sapiens 7-12 15967872-2 2005 Furosemide-induced diuresis and acute oral captopril stimulated the renal vein/contralateral renin ratios to 4.3:1 and 6.5:1 in patients 1 and 2, respectively. Furosemide 0-10 renin Homo sapiens 93-98 16609147-5 2006 The loop diuretic furosemide 2-fold diluted and increased approximately 10-fold the volume of distal tubular fluid, while also causing the release of 20% of juxtaglomerular renin content. Furosemide 18-28 renin Homo sapiens 173-178 18081357-8 2008 A possible explanation for these findings might be activation of the renin-angiotensin system by furosemide. Furosemide 97-107 renin Homo sapiens 69-74 17703139-9 2007 At 24 hours postdose, plasma renin activity was increased after furosemide or HCTZ administered alone or with tolvaptan, but it was unchanged after tolvaptan alone. Furosemide 64-74 renin Homo sapiens 29-34 12432442-7 2002 Responses of both plasma renin activity and serum aldosterone level following the furosemide upright provocation were blunted in the hyperkalemic acute phase, but recovered in the normokalemic convalescent phase. Furosemide 82-92 renin Homo sapiens 25-30 15364336-2 2004 BACKGROUND: Furosemide activates the renin-angiotensin-aldosterone system in patients with congestive heart failure (CHF). Furosemide 12-22 renin Homo sapiens 37-42 16095054-17 2005 CONCLUSIONS: Furosemide treatment increased U-AQP2, AVP, and the activity of the renin-angiotensin-aldosterone system. Furosemide 13-23 renin Homo sapiens 81-86 11719734-0 2001 Low sodium and furosemide-induced stimulation of the renin system in man is mediated by cyclooxygenase 2. Furosemide 15-25 renin Homo sapiens 53-58 12358151-9 2002 However, peripheral plasma renin activity (PRA) increased normally after the patient resumed an upright posture following furosemide administration. Furosemide 122-132 renin Homo sapiens 27-32 11719734-3 2001 Plasma renin activity increased 2 to 3 times over baseline with a low-sodium diet and 5 times over baseline 30 minutes after intravenous furosemide; it was still elevated nearly 5 times on day 9. Furosemide 137-147 renin Homo sapiens 7-12 11719734-7 2001 We have concluded that low-sodium and furosemide-stimulated renin and aldosterone secretion is completely blocked in healthy volunteers during COX-2 inhibition with rofecoxib, suggesting that intact COX-2 is of major importance for stimulation of the renin system under these conditions in man. Furosemide 38-48 renin Homo sapiens 60-65 11719734-7 2001 We have concluded that low-sodium and furosemide-stimulated renin and aldosterone secretion is completely blocked in healthy volunteers during COX-2 inhibition with rofecoxib, suggesting that intact COX-2 is of major importance for stimulation of the renin system under these conditions in man. Furosemide 38-48 renin Homo sapiens 251-256 11549664-0 2001 Performance of the basal aldosterone to renin ratio and of the renin stimulation test by furosemide and upright posture in screening for aldosterone-producing adenoma in low renin hypertensives. Furosemide 89-99 renin Homo sapiens 63-68 11549664-0 2001 Performance of the basal aldosterone to renin ratio and of the renin stimulation test by furosemide and upright posture in screening for aldosterone-producing adenoma in low renin hypertensives. Furosemide 89-99 renin Homo sapiens 63-68 10910000-2 2000 Furosemide decreased the plasma concentration of hypoxanthine by 39% and increased plasma renin activity (PRA) and the plasma concentration of protein by 3.4-fold and 9%, respectively, at 90 minutes after administration. Furosemide 0-10 renin Homo sapiens 90-95 11095476-3 2000 After repeated EE administration, renin stimulation was induced by a single oral dose of 40 mg furosemide, followed by 50 mg captopril, 12 h later. Furosemide 95-105 renin Homo sapiens 34-39 11046100-5 2000 Furosemide administration increased plasma renin activity from 1.0 +/- 0.2 to 4.5 +/- 1.2 ng of angiotensin I/ml/h and there was no effect of HOE 140 (from 1.1 +/- 0.2 to 3.9 +/- 0.8 ng of angiotensin I/ml/h). Furosemide 0-10 renin Homo sapiens 43-48 11057431-6 2000 RESULTS: Before stimulation with frusemide, the plasma renin in Group A was 0.79 +/- 0.13 ng angiotensin l/ml per h, while in Group B the corresponding figure was 1.73 +/- 0.38 ng angiotensin l/ml per h. This difference was statistically significant (P= 0.0127). Furosemide 33-42 renin Homo sapiens 55-60 11423756-6 2001 Responses of both plasma renin activity and serum aldosterone level to the furosemide-posture challenge were blunted. Furosemide 75-85 renin Homo sapiens 25-30 10577447-8 1999 Frusemide reduced plasma concentrations of atrial natriuretic factor and increased plasma renin activity. Furosemide 0-9 renin Homo sapiens 90-95 10510146-6 1999 L-NMMA completely blocked the renin rise following the bolus of frusemide (1.18+/-0.196 vs 1.96+/-0.333 ng ml-1 h-1 P<0.01). Furosemide 64-73 renin Homo sapiens 30-35 10577572-11 1999 Frusemide significantly increased mean plasma renin activity (days 0 and 42), and the mean aldosterone concentration (day 42) in comparison with placebo, whereas candoxatril caused no significant changes in any of the hormonal parameters assessed. Furosemide 0-9 renin Homo sapiens 46-51 10513831-3 1999 In eight healthy subjects, injection of furosemide increased plasma renin activity (PRA) with little or no change in blood pressure or heart rate. Furosemide 40-50 renin Homo sapiens 68-73 10510146-0 1999 The effect of nitric oxide inhibition on the renin response to frusemide, in man. Furosemide 63-72 renin Homo sapiens 45-50 10510146-7 1999 Phenylephrine 0.5 microg kg-1 min-1 produced very similar haemodynamic effects to L-NMMA, and also suppressed the renin response to frusemide (1.43+/-0.290 vs 2.67+/-0.342 ng ml-1 h-1 P<0. Furosemide 132-141 renin Homo sapiens 114-119 9088586-7 1997 RESULTS: Plasma renin activity (PRA) was significantly (P < 0.01) increased after prior treatment with frusemide compared with placebo at all time points. Furosemide 106-115 renin Homo sapiens 16-21 9735929-0 1998 Renin-aldosterone system can respond to furosemide in patients with hyperkalemic hyporeninism. Furosemide 40-50 renin Homo sapiens 0-5 9737091-3 1998 Therefore, we assessed the effects of meloxicam, a selective inhibitor of COX-2, and indomethacin, an unselective inhibitor of COX-1 and COX-2, on furosemide stimulated plasma renin activity (PRA). Furosemide 147-157 renin Homo sapiens 176-181 9737091-13 1998 CONCLUSION: Meloxicam inhibited furosemide stimulated renin release, suggesting that in man COX-2 is responsible for prostaglandin synthesis mediating renin release. Furosemide 32-42 renin Homo sapiens 54-59 9737091-13 1998 CONCLUSION: Meloxicam inhibited furosemide stimulated renin release, suggesting that in man COX-2 is responsible for prostaglandin synthesis mediating renin release. Furosemide 32-42 renin Homo sapiens 151-156 9247750-5 1997 PRA and PRC respond appropriately to physiologic stimuli in pre-eclampsia except for impaired renin release following frusemide, possibly due to prostacyclin deficiency. Furosemide 118-127 renin Homo sapiens 94-99