PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21932165-1	2012	1,25-dihydroxyvitamin D (1,25D), through association with the nuclear vitamin D receptor (VDR), exerts control over a novel endocrine axis consisting of the bone-derived hormone FGF23, and the kidney-expressed klotho, CYP27B1, and CYP24A1 genes, which together prevent hyperphosphatemia/ectopic calcification and govern the levels of 1,25D to maintain bone mineral integrity while promoting optimal function of other vital tissues.	1,25-dihydroxyvitamin D	0-23	klotho	Homo sapiens	210-216	
23431388-5	2013	RESULTS: The serum Klotho level significantly correlated with the 1,25-dihydroxyvitamin D level and inversely correlated with the parathyroid hormone level and the fractional excretion of phosphate.	1,25-dihydroxyvitamin D	66-89	klotho	Homo sapiens	19-25	
21982773-7	2011	The phosphatemic actions of 1,25-dihydroxyvitamin D(3) are thus opposed via the combined phosphaturic effects of FGF23 and klotho, both of which are upregulated by the liganded vitamin D receptor.	1,25-dihydroxyvitamin D	28-51	klotho	Homo sapiens	123-129	
19483274-2	2009	FGF23 is a humoral factor that is produced by osteocytes and reduces serum phosphate and 1,25-dihydroxyvitamin D levels by binding to a complex comprised of Klotho and some FGF receptor in kidney.	1,25-dihydroxyvitamin D	89-112	klotho	Homo sapiens	157-163	
20798257-0	2010	Reciprocal control of 1,25-dihydroxyvitamin D and FGF23 formation involving the FGF23/Klotho system.	1,25-dihydroxyvitamin D	22-45	klotho	Homo sapiens	86-92	
19329831-2	2009	Fibroblast growth factor 23 (FGF23) is a hormone which is produced by osteocytes and lowers serum phosphate and 1,25-dihydroxyvitamin D levels by binding to Klotho-FGF receptor complex in kidney.	1,25-dihydroxyvitamin D	112-135	klotho	Homo sapiens	157-163	
18660670-4	2008	A key protein in this regulatory pathway is FGF23, which is made by osteocytes and activates renal KLOTHO/FGFR1 receptor heterodimers to inhibit renal phosphate reabsorption and 1,25-dihydroxyvitamin D synthesis.	1,25-dihydroxyvitamin D	178-201	klotho	Homo sapiens	99-105