PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21932165-1 2012 1,25-dihydroxyvitamin D (1,25D), through association with the nuclear vitamin D receptor (VDR), exerts control over a novel endocrine axis consisting of the bone-derived hormone FGF23, and the kidney-expressed klotho, CYP27B1, and CYP24A1 genes, which together prevent hyperphosphatemia/ectopic calcification and govern the levels of 1,25D to maintain bone mineral integrity while promoting optimal function of other vital tissues. 1,25-dihydroxyvitamin D 0-23 klotho Homo sapiens 210-216 23431388-5 2013 RESULTS: The serum Klotho level significantly correlated with the 1,25-dihydroxyvitamin D level and inversely correlated with the parathyroid hormone level and the fractional excretion of phosphate. 1,25-dihydroxyvitamin D 66-89 klotho Homo sapiens 19-25 21982773-7 2011 The phosphatemic actions of 1,25-dihydroxyvitamin D(3) are thus opposed via the combined phosphaturic effects of FGF23 and klotho, both of which are upregulated by the liganded vitamin D receptor. 1,25-dihydroxyvitamin D 28-51 klotho Homo sapiens 123-129 20798257-0 2010 Reciprocal control of 1,25-dihydroxyvitamin D and FGF23 formation involving the FGF23/Klotho system. 1,25-dihydroxyvitamin D 22-45 klotho Homo sapiens 86-92 19483274-2 2009 FGF23 is a humoral factor that is produced by osteocytes and reduces serum phosphate and 1,25-dihydroxyvitamin D levels by binding to a complex comprised of Klotho and some FGF receptor in kidney. 1,25-dihydroxyvitamin D 89-112 klotho Homo sapiens 157-163 19329831-2 2009 Fibroblast growth factor 23 (FGF23) is a hormone which is produced by osteocytes and lowers serum phosphate and 1,25-dihydroxyvitamin D levels by binding to Klotho-FGF receptor complex in kidney. 1,25-dihydroxyvitamin D 112-135 klotho Homo sapiens 157-163 18660670-4 2008 A key protein in this regulatory pathway is FGF23, which is made by osteocytes and activates renal KLOTHO/FGFR1 receptor heterodimers to inhibit renal phosphate reabsorption and 1,25-dihydroxyvitamin D synthesis. 1,25-dihydroxyvitamin D 178-201 klotho Homo sapiens 99-105