PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22450127-0 2012 Pyrazolopyrimidines as dual Akt/p70S6K inhibitors. pyrazolopyrimidines 0-19 AKT serine/threonine kinase 1 Homo sapiens 28-31 19584280-5 2009 Unlike the inhibitors of PI3K or dual-pan PI3K/mTOR, cellular inhibition of P-S6K1(T389) and P-AKT(S473) by the pyrazolopyrimidines occurred at significantly lower inhibitor concentrations than those of P-AKT(T308) (PI3K-PDK1 readout), showing mTOR selectivity in cellular setting. pyrazolopyrimidines 112-131 AKT serine/threonine kinase 1 Homo sapiens 95-98 19584280-5 2009 Unlike the inhibitors of PI3K or dual-pan PI3K/mTOR, cellular inhibition of P-S6K1(T389) and P-AKT(S473) by the pyrazolopyrimidines occurred at significantly lower inhibitor concentrations than those of P-AKT(T308) (PI3K-PDK1 readout), showing mTOR selectivity in cellular setting. pyrazolopyrimidines 112-131 AKT serine/threonine kinase 1 Homo sapiens 205-208