PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30768359-0	2019	Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine beta-synthase-deficient homocystinuria.	Taurine	0-7	cystathionine beta-synthase	Mus musculus	165-192	
30768359-10	2019	Collectively, our findings indicate that adjuvantial taurine treatment has the potential to significantly improve clinical outcomes in HCU.-Maclean, K. N., Jiang, H, Phinney, W. N., Keating, A. K., Hurt, K. J., Stabler, S. P. Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine beta-synthase-deficient homocystinuria.	Taurine	53-60	cystathionine beta-synthase	Mus musculus	391-418	
19932868-0	2009	Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygous cystathionine beta-synthase knockout mice.	Taurine	0-7	cystathionine beta-synthase	Mus musculus	36-63	
19932868-0	2009	Taurine-deficient diet up-regulated cystathionine beta-synthase monoallele in hemizygous cystathionine beta-synthase knockout mice.	Taurine	0-7	cystathionine beta-synthase	Mus musculus	89-116	
19932868-2	2009	Reduced CBS activity could decrease cysteine and taurine biosyntheses (metabolites of homocysteine degradation) and lead to less taurocholic acid production with a resultant increased cholesterol content.	Taurine	49-56	cystathionine beta-synthase	Mus musculus	8-11	
19932868-3	2009	We hypothesized that a deficiency in CBS genetic material and enzyme activity would reduce taurine synthesis, which would lead to an elevated cholesterol concentration.	Taurine	91-98	cystathionine beta-synthase	Mus musculus	37-40	
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Taurine	237-244	cystathionine beta-synthase	Mus musculus	104-107	
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Taurine	237-244	cystathionine beta-synthase	Mus musculus	104-107	
19932868-9	2009	Three important findings were a differential sex response of CBS mRNA to feeding the vitamin B(6) diet; CBS (+/-) mice had a significantly lower plasma cholesterol concentration, contrary to what was anticipated; and during feeding, the taurine- and cysteine-deficient diet, CBS mRNA levels in CBS (+/-) mice were reduced only 13% rather than the expected 50%.	Taurine	237-244	cystathionine beta-synthase	Mus musculus	104-107	
19932868-10	2009	We conclude that the remaining CBS monoallele is up-regulated in mice when fed a taurine-deficient diet to produce additional CBS mRNA.	Taurine	81-88	cystathionine beta-synthase	Mus musculus	31-34	
19932868-10	2009	We conclude that the remaining CBS monoallele is up-regulated in mice when fed a taurine-deficient diet to produce additional CBS mRNA.	Taurine	81-88	cystathionine beta-synthase	Mus musculus	126-129