PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20542332-0 2010 The effect of immobilized RGD peptide in macroporous alginate scaffolds on TGFbeta1-induced chondrogenesis of human mesenchymal stem cells. Alginates 53-61 transforming growth factor beta 1 Homo sapiens 75-83 20542332-3 2010 In this study, the effects of RGD peptide immobilization onto macro-porous alginate scaffolds on TGF-beta1-induced hMSC chondrogenesis were evaluated. Alginates 75-83 transforming growth factor beta 1 Homo sapiens 97-106 20542332-6 2010 By contrast, in the un-modified alginate scaffolds, the cells aggregated into compacted clusters resulting in lesser effects of TGF-beta1. Alginates 32-40 transforming growth factor beta 1 Homo sapiens 128-137 19662133-5 2007 The addition of the growth factors IGF-I (100 ng/mL) and TGF-beta1 (10 ng/mL) during the alginate culture and the absence of any growth factors during the high-density cell culture led to significantly higher GAG to DNA ratios and Young"s Moduli of the constructs compared to other combinations. Alginates 89-97 transforming growth factor beta 1 Homo sapiens 57-66 18839189-5 2009 At the same time using mosaicplasty to repair the defects on the medial femoral condyle, the dead space between the cylindrical grafts were filled with the gels of hTGF-beta1 gene transduced BMSCs in alginate. Alginates 200-208 transforming growth factor beta 1 Homo sapiens 164-174 17428192-3 2007 The hMSCs/alginate layer was cultured in a chondrogenic defined medium and treated with transforming growth factor-beta1 (TGF-beta1) and/or LIUS for 2 weeks. Alginates 10-18 transforming growth factor beta 1 Homo sapiens 88-120 18277681-6 2007 RESULTS: DNA quantitation in the variant culture systems indicated that in monolayers the NP cells at Passage 3 transfected with Ad/hTGF-beta1 had a much higher cell viability and more DNA synthesis (P < 0.05); however, in the alginate 3-D culture system, the NP cells transfected with Ad/hTGF-bea1 did not have any significant difference from the controls (P > 0.05). Alginates 230-238 transforming growth factor beta 1 Homo sapiens 132-142 18277681-11 2007 The NP cells transfected with Ad/ hTGF-beta1 cultured in the 3-D alginate bead systems can show a nearly native phenotype. Alginates 65-73 transforming growth factor beta 1 Homo sapiens 34-44 17428192-3 2007 The hMSCs/alginate layer was cultured in a chondrogenic defined medium and treated with transforming growth factor-beta1 (TGF-beta1) and/or LIUS for 2 weeks. Alginates 10-18 transforming growth factor beta 1 Homo sapiens 122-131 16846338-0 2006 Mesenchymal stem cells maintain TGF-beta-mediated chondrogenic phenotype in alginate bead culture. Alginates 76-84 transforming growth factor beta 1 Homo sapiens 32-40 16013059-8 2005 Accordingly, 1-week exposure to TGF-beta1 in vitro before transplantation is appropriate for neocartilage formation of human MSCs in alginate. Alginates 133-141 transforming growth factor beta 1 Homo sapiens 32-41 16156303-0 2005 In vitro characterization of TGF-beta1 release from genetically modified fibroblasts in Ca(2+)-alginate microcapsules. Alginates 95-103 transforming growth factor beta 1 Homo sapiens 29-38 11523034-7 2001 Histological and immunohistochemical analysis of the TGF-beta 1-treated PLA/alginate amalgam and PLA constructs showed development of a cartilaginous phenotype from day 7 to day 21 as demonstrated by colocalization of Alcian blue staining with collagen type II and cartilage proteoglycan link protein. Alginates 76-84 transforming growth factor beta 1 Homo sapiens 53-63 12489186-1 2002 The objective of this study was to investigate the use of alginate hydrogels to present either exogenous or endogenous transforming growth factor (TGF)-beta 1 to the dentin-pulp complex to signal reparative processes. Alginates 58-66 transforming growth factor beta 1 Homo sapiens 119-158 12489186-5 2002 Alginate hydrogels provide an appropriate matrix in which dental regeneration can take place and may also be useful for delivery of growth factors, including TGF-beta s, to enhance the natural regenerative capacity of the dental pulp. Alginates 0-8 transforming growth factor beta 1 Homo sapiens 158-166 10458407-3 1999 MATERIALS AND METHODS: A time release method of delivery was developed using sodium alginate microspheres containing recombinant human (rh) TGF-beta1. Alginates 77-92 transforming growth factor beta 1 Homo sapiens 140-149 32867602-3 2020 The objective of this study was to determine the possible mechanism about how the microencapsulated hUCMSCs made by alginate-poly-lysine-alginate (A-P-A) transfected with HGF could ameliorate liver fibrosis through TGF-beta1/Smad signaling pathway. Alginates 116-124 transforming growth factor beta 1 Homo sapiens 215-224 29873069-2 2018 Since cartilage is not spontaneously regenerated, our group has recently developed a strategy of injecting bioactive alginate hydrogel into the defect for promoting endogenous regeneration of cartilage via presentation of affinity-bound transforming growth factor beta1 (TGF-beta1). Alginates 117-125 transforming growth factor beta 1 Homo sapiens 237-269 30485631-2 2019 In this study, we used a blend of alginate sulfate (ALG-S) and polyvinyl alcohol (PVA) to fabricate electrospun scaffolds capable of delivering a heparin-like growth factor, transforming growth factor-beta1 (TGF-beta1). Alginates 52-57 transforming growth factor beta 1 Homo sapiens 174-206 30485631-2 2019 In this study, we used a blend of alginate sulfate (ALG-S) and polyvinyl alcohol (PVA) to fabricate electrospun scaffolds capable of delivering a heparin-like growth factor, transforming growth factor-beta1 (TGF-beta1). Alginates 52-57 transforming growth factor beta 1 Homo sapiens 208-217 30485631-7 2019 The results showed that the binding and entrapment of TGF-beta1 to the nanofibrous scaffolds are improved by the addition of sulfate group to alginate. Alginates 142-150 transforming growth factor beta 1 Homo sapiens 54-63 29873069-2 2018 Since cartilage is not spontaneously regenerated, our group has recently developed a strategy of injecting bioactive alginate hydrogel into the defect for promoting endogenous regeneration of cartilage via presentation of affinity-bound transforming growth factor beta1 (TGF-beta1). Alginates 117-125 transforming growth factor beta 1 Homo sapiens 271-280 23675280-1 2012 OBJECTIVE: Using the alginate bead three-dimensional culturing method, which is considered to be advantageous for the in vitro study of chondrocytes, we confirmed earlier reports concerning the inhibitory effect of TGF-beta on IL-1beta-induced cartilage destruction and serially evaluated changes in proteinases and their inhibitors in cartilage destruction. Alginates 21-29 transforming growth factor beta 1 Homo sapiens 215-223 23891740-4 2013 The objectives of this study were to: (1) develop a novel co-delivery system based on TGF-beta1 loaded RGD-coupled alginate microspheres encapsulating periodontal ligament stem cells (PDLSCs) or gingival mesenchymal stem cells (GMSCs); and (2) investigate dental MSC viability and chondrogenic differentiation in alginate microspheres. Alginates 115-123 transforming growth factor beta 1 Homo sapiens 86-95 23891740-4 2013 The objectives of this study were to: (1) develop a novel co-delivery system based on TGF-beta1 loaded RGD-coupled alginate microspheres encapsulating periodontal ligament stem cells (PDLSCs) or gingival mesenchymal stem cells (GMSCs); and (2) investigate dental MSC viability and chondrogenic differentiation in alginate microspheres. Alginates 313-321 transforming growth factor beta 1 Homo sapiens 86-95 23891740-5 2013 The results revealed the sustained release of TGF-beta1 from the alginate microspheres. Alginates 65-73 transforming growth factor beta 1 Homo sapiens 46-55 29285239-6 2017 Meanwhile, in order to improve the release properties of LDL-RSG complexes, we structured slow release system of LDL-RSG/chitosan-calcium alginate - nanoparticles (CSNP), which effectively inhibited TGF-beta1-induced HTFs proliferation, synthesis of extracellular matrix and activation of TGF-beta1/SMAD pathway. Alginates 130-146 transforming growth factor beta 1 Homo sapiens 199-208 29285239-6 2017 Meanwhile, in order to improve the release properties of LDL-RSG complexes, we structured slow release system of LDL-RSG/chitosan-calcium alginate - nanoparticles (CSNP), which effectively inhibited TGF-beta1-induced HTFs proliferation, synthesis of extracellular matrix and activation of TGF-beta1/SMAD pathway. Alginates 130-146 transforming growth factor beta 1 Homo sapiens 289-298 27523029-0 2016 TGF-beta affinity-bound to a macroporous alginate scaffold generates local and peripheral immunotolerant responses and improves allocell transplantation. Alginates 41-49 transforming growth factor beta 1 Homo sapiens 0-8 27523029-2 2016 Here, we investigated the feasibility of generating an immunoregulatory environment in a highly vascularized macroporous alginate scaffold by affinity-binding of the transforming growth factor-beta (TGF-beta) in a manner mimicking its binding to heparan sulfate. Alginates 121-129 transforming growth factor beta 1 Homo sapiens 166-197 27523029-2 2016 Here, we investigated the feasibility of generating an immunoregulatory environment in a highly vascularized macroporous alginate scaffold by affinity-binding of the transforming growth factor-beta (TGF-beta) in a manner mimicking its binding to heparan sulfate. Alginates 121-129 transforming growth factor beta 1 Homo sapiens 199-207 26743836-2 2016 With the aim of producing a bioactive material for orthopedic applications, a transforming growth factor-beta (TGF- beta1)/hydroxyapatite (HA) association within an alginate-based scaffold was investigated. Alginates 165-173 transforming growth factor beta 1 Homo sapiens 111-121 23251248-0 2013 Bone marrow mesenchymal stem cells combined with calcium alginate gel modified by hTGF-beta1 for the construction of tissue-engineered cartilage in three-dimensional conditions. Alginates 49-65 transforming growth factor beta 1 Homo sapiens 82-92 22241609-4 2012 To promote chondrogenic differentiation, we used lentivirus to transduce iPSCs seeded in alginate matrix with transforming growth factor-beta1 (TGF-beta1) and then in vitro co-cultured these iPSCs with chondrocytes. Alginates 89-97 transforming growth factor beta 1 Homo sapiens 110-142 22241609-4 2012 To promote chondrogenic differentiation, we used lentivirus to transduce iPSCs seeded in alginate matrix with transforming growth factor-beta1 (TGF-beta1) and then in vitro co-cultured these iPSCs with chondrocytes. Alginates 89-97 transforming growth factor beta 1 Homo sapiens 144-153 22241609-7 2012 The histological results revealed a dense sulphated extracellular matrix in the co-culture of TGF-beta1-transfected iPSCs with chondrocytes in alginate matrix. Alginates 143-151 transforming growth factor beta 1 Homo sapiens 94-103 22241609-9 2012 Histological examination revealed that more new cartilage was formed in the co-culture of TGF-beta1-transfected iPSCs with chondrocytes in alginate matrix. Alginates 139-147 transforming growth factor beta 1 Homo sapiens 90-99