PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35517877-0	2022	Fibronectin within Sodium Alginate Microcapsules Improved Osteogenic Differentiation of BMMSCs in Dose Dependent Manner by Targeting SP7, OCN, CDK1, ZBTB16, and Twist1 Expression.	Alginates	19-34	bone gamma-carboxyglutamate protein	Homo sapiens	138-141	
34297530-5	2021	Moreover, the alginate-WHMP hydrogels upregulate the mitogen-activated protein kinase (MAPK) pathway, which in turn orchestrates several osteogenic markers, such as RUNX2 and OCN, in the encapsulated GMSCs.	Alginates	14-22	bone gamma-carboxyglutamate protein	Homo sapiens	175-178	
30590908-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	Alginates	16-24	bone gamma-carboxyglutamate protein	Homo sapiens	214-225	
26090086-5	2015	Enamel matrix derivative-enriched alginate hydrogel significantly increased the expression of osteoblast markers COL1A1, TNFRSF11B, and BGLAP and secretion of osteopontin in human osteoblasts, whereas osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells seemed unaffected by enamel matrix derivative.	Alginates	34-42	bone gamma-carboxyglutamate protein	Homo sapiens	136-141	
21409753-8	2011	The protein levels were effective in inducing osteogenic differentiation in vitro, as seen by elevated alkaline phosphatase (ALP) production and in vivo, as demonstrated by the production of collagen I and osteocalcin in a mineralised alginate matrix.	Alginates	235-243	bone gamma-carboxyglutamate protein	Homo sapiens	206-217	
17532040-5	2007	Cells within RGD-modified alginate microspheres were able to establish more interactions with the synthetic extracellular matrix as visualized by confocal laser scanning microscope and transmission electron microscopy imaging, and presented a much higher level of differentiation (more intense ALP and mineralization stainings and higher levels of osteocalcin secretion) when compared to cells immobilized within unmodified alginate microspheres.	Alginates	26-34	bone gamma-carboxyglutamate protein	Homo sapiens	348-359	
30396234-6	2018	Augmentation of alginate is necessary, and we showed that a few rationally selected small proteins from the basement membrane (BM) compartment of the ECM were sufficient to upregulate cell expression of Runx-2 and osteocalcin for osteoid formation, resulting in Alizarin red-positive mineral nodules.	Alginates	16-24	bone gamma-carboxyglutamate protein	Homo sapiens	214-225