PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17945515-13 2008 CONCLUSION: Our work shows chondrocytes in osteoarthritic cartilage exhibit DNA damage, and that IL-1 induces DNA damage and reactive oxygen and nitrogen species in non-OA chondrocytes in alginate. Alginates 188-196 interleukin 1 alpha Homo sapiens 97-101 8155608-3 1993 Since macrophages are present in this reaction and interleukin-1 (IL-1), a cytokine released by activated macrophages, may induce fibrosis, we tested the capacity of alginate-polylysine microcapsules to activate macrophages. Alginates 166-174 interleukin 1 alpha Homo sapiens 51-64 17630143-4 2007 STUDY DESIGN: A short-term in vitro study using normal and interleukin (IL)-1alpha stimulated porcine disc cells cultured in alginate gel to evaluate the biochemical effects of electrosurgical ablation. Alginates 125-133 interleukin 1 alpha Homo sapiens 59-82 11859379-4 1996 IL-1 treatment of chondrocytes cultured in alginate resulted in increased synthesis of IL-6 and prostaglandins, but not leukotrienes. Alginates 43-51 interleukin 1 alpha Homo sapiens 0-4 7926002-1 1994 Interleukin-1 alpha and beta induced the production of large amounts of nitric oxide by normal, human articular chondrocytes in alginate culture; at the same time the biosynthesis of proteoglycan was strongly suppressed. Alginates 128-136 interleukin 1 alpha Homo sapiens 0-19 8602469-2 1996 The authors earlier demonstrated that alginates enriched in mannuronic acid stimulate human monocytes to produce high levels of cytokines such as tumour necrosis factor (TNF), IL-1 IL-6. Alginates 38-47 interleukin 1 alpha Homo sapiens 176-185 8155608-3 1993 Since macrophages are present in this reaction and interleukin-1 (IL-1), a cytokine released by activated macrophages, may induce fibrosis, we tested the capacity of alginate-polylysine microcapsules to activate macrophages. Alginates 166-174 interleukin 1 alpha Homo sapiens 66-70 8155608-8 1993 IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone. Alginates 134-142 interleukin 1 alpha Homo sapiens 50-60 32252155-3 2020 METHODS: NP cells cultured in alginate beads were activated with IL-1beta +- the COX-2 inhibitor Sc-58125. Alginates 30-38 interleukin 1 alpha Homo sapiens 65-73 1931864-3 1991 In this study, we have examined the ability of alginates and their components to stimulate human monocytes to produce tumor necrosis factor-alpha, interleukin-6, and interleukin-1. Alginates 47-56 interleukin 1 alpha Homo sapiens 166-179 32419390-7 2020 In vitro cultures revealed that alginate can dose dependently induce macrophages to secrete TNFalpha, IL-6, IL-1beta, and GM-CSF. Alginates 32-40 interleukin 1 alpha Homo sapiens 108-116