PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7926002-1	1994	Interleukin-1 alpha and beta induced the production of large amounts of nitric oxide by normal, human articular chondrocytes in alginate culture; at the same time the biosynthesis of proteoglycan was strongly suppressed.	Alginates	128-136	interleukin 1 alpha	Homo sapiens	0-19	
8602469-2	1996	The authors earlier demonstrated that alginates enriched in mannuronic acid stimulate human monocytes to produce high levels of cytokines such as tumour necrosis factor (TNF), IL-1 IL-6.	Alginates	38-47	interleukin 1 alpha	Homo sapiens	176-185	
11859379-4	1996	IL-1 treatment of chondrocytes cultured in alginate resulted in increased synthesis of IL-6 and prostaglandins, but not leukotrienes.	Alginates	43-51	interleukin 1 alpha	Homo sapiens	0-4	
32252155-3	2020	METHODS: NP cells cultured in alginate beads were activated with IL-1beta +- the COX-2 inhibitor Sc-58125.	Alginates	30-38	interleukin 1 alpha	Homo sapiens	65-73	
8155608-3	1993	Since macrophages are present in this reaction and interleukin-1 (IL-1), a cytokine released by activated macrophages, may induce fibrosis, we tested the capacity of alginate-polylysine microcapsules to activate macrophages.	Alginates	166-174	interleukin 1 alpha	Homo sapiens	51-64	
8155608-3	1993	Since macrophages are present in this reaction and interleukin-1 (IL-1), a cytokine released by activated macrophages, may induce fibrosis, we tested the capacity of alginate-polylysine microcapsules to activate macrophages.	Alginates	166-174	interleukin 1 alpha	Homo sapiens	66-70	
8155608-8	1993	IL-1 beta release and intracellular IL-1 beta and IL-1 alpha production were significantly higher when macrophages were cultured with alginate-polylysine microcapsules than when macrophages were cultured alone.	Alginates	134-142	interleukin 1 alpha	Homo sapiens	50-60	
1931864-3	1991	In this study, we have examined the ability of alginates and their components to stimulate human monocytes to produce tumor necrosis factor-alpha, interleukin-6, and interleukin-1.	Alginates	47-56	interleukin 1 alpha	Homo sapiens	166-179	
32419390-7	2020	In vitro cultures revealed that alginate can dose dependently induce macrophages to secrete TNFalpha, IL-6, IL-1beta, and GM-CSF.	Alginates	32-40	interleukin 1 alpha	Homo sapiens	108-116	
17945515-13	2008	CONCLUSION: Our work shows chondrocytes in osteoarthritic cartilage exhibit DNA damage, and that IL-1 induces DNA damage and reactive oxygen and nitrogen species in non-OA chondrocytes in alginate.	Alginates	188-196	interleukin 1 alpha	Homo sapiens	97-101	
17630143-4	2007	STUDY DESIGN: A short-term in vitro study using normal and interleukin (IL)-1alpha stimulated porcine disc cells cultured in alginate gel to evaluate the biochemical effects of electrosurgical ablation.	Alginates	125-133	interleukin 1 alpha	Homo sapiens	59-82