PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27079852-0 2016 Gene Delivery of TGF-beta3 and BMP2 in an MSC-Laden Alginate Hydrogel for Articular Cartilage and Endochondral Bone Tissue Engineering. Alginates 52-60 transforming growth factor beta 3 Homo sapiens 17-26 27079852-10 2016 Together, these results suggest that the developed gene-activated alginate hydrogels were able to support transfection of encapsulated MSCs and directed their phenotype toward either a chondrogenic or an osteogenic phenotype depending on whether TGF-beta3 and BMP2 were delivered in combination or isolation. Alginates 66-74 transforming growth factor beta 3 Homo sapiens 246-255 24397989-4 2014 In the current study, a co-delivery system based on TGF-beta3-loaded RGD-coupled alginate microspheres was developed for encapsulating periodontal ligament stem cells (PDLSCs) or gingival mesenchymal stem cells (GMSCs). Alginates 81-89 transforming growth factor beta 3 Homo sapiens 52-61 25376622-9 2015 In vitro, we observed that alginate-collagen porous scaffolds supported cell proliferation and extracellular matrix deposition (collagen type I), with secretion amplified by the local release of transforming growth factor-beta3. Alginates 27-35 transforming growth factor beta 3 Homo sapiens 195-227 24397989-11 2014 PDLSCs and GMSCs encapsulated in TGF-beta3-loaded RGD-modified alginate microspheres are promising candidates for tendon regeneration. Alginates 63-71 transforming growth factor beta 3 Homo sapiens 33-42 20205160-0 2010 Continuous supply of TGFbeta3 via adenoviral vector promotes type I collagen and viability of fibroblasts in alginate hydrogel. Alginates 109-117 transforming growth factor beta 3 Homo sapiens 21-29 21652067-0 2011 Enhanced MSC chondrogenesis following delivery of TGF-beta3 from alginate microspheres within hyaluronic acid hydrogels in vitro and in vivo. Alginates 65-73 transforming growth factor beta 3 Homo sapiens 50-59 21652067-3 2011 Here, we investigated the co-encapsulation of TGF-beta3 containing alginate microspheres with human MSCs in hyaluronic acid (HA) hydrogels towards the development of implantable constructs for cartilage repair. Alginates 67-75 transforming growth factor beta 3 Homo sapiens 46-55 21652067-4 2011 TGF-beta3 encapsulated in alginate microspheres with nanofilm coatings showed significantly reduced initial burst release compared to uncoated microspheres, with release times extending up to 6 days. Alginates 26-34 transforming growth factor beta 3 Homo sapiens 0-9 21652067-8 2011 To prevent this, the co-delivery of parathyroid hormone-related protein (PTHrP) with TGF-beta3 in alginate microspheres was pursued, resulting in partially reduced calcification. Alginates 98-106 transforming growth factor beta 3 Homo sapiens 85-94 19950204-7 2010 BMP-7 in the presence of TGF-beta3 induced superior chondrocytic proteoglycan accumulation, type II collagen, and SOX9 protein expression in alginate and pellet cultures compared to either factor alone. Alginates 141-149 transforming growth factor beta 3 Homo sapiens 25-34 19683810-8 2009 It was concluded that the CBD-RGD-alginate culture system promoted the chondrogenesis of mesenchymal stem cells coordinated with TGF-beta3 induction in an RGD dose-dependent manner. Alginates 34-42 transforming growth factor beta 3 Homo sapiens 129-138 15250049-6 2004 Chondrogenesis induced by TGF-beta3 in alginate bead system was confirmed by examining cartilage specific type II collagen expression and aggrecan, whereas type I collagen expression was not affected by TGF-beta3. Alginates 39-47 transforming growth factor beta 3 Homo sapiens 26-35 18950289-0 2009 BMP-2 enhances TGF-beta3-mediated chondrogenic differentiation of human bone marrow multipotent mesenchymal stromal cells in alginate bead culture. Alginates 125-133 transforming growth factor beta 3 Homo sapiens 15-24 18950289-2 2009 Human BM MSCs encapsulated in alginate beads were induced to differentiate in serum-free medium containing BMP-2 and TGF-beta3. Alginates 30-38 transforming growth factor beta 3 Homo sapiens 117-126 18950289-9 2009 The combination of BMP-2 and TGF-beta3 in alginate culture is superior to the standard differentiation method using TGF-beta alone. Alginates 42-50 transforming growth factor beta 3 Homo sapiens 29-38 18950289-9 2009 The combination of BMP-2 and TGF-beta3 in alginate culture is superior to the standard differentiation method using TGF-beta alone. Alginates 42-50 transforming growth factor beta 3 Homo sapiens 29-37 35581061-1 2022 Addressing osteochondral defects, the objective of current study was to synthesize bilayered hydrogel, where the cartilage layer was formed by alginate (Alg)-polyacrylamide (PAAm) with and without the addition of TGF-beta3 and bone layer by laponite XLS/Alg-PAAm and characterize by in vitro and in vivo experiments. Alginates 153-156 transforming growth factor beta 3 Homo sapiens 213-222 34883477-3 2022 To this end alginate sulfate, a sulfated glycosaminoglycan (sGAG) mimic, was used to functionalize porous alginate-based scaffolds and to support the sustained release of transforming growth factor-beta3 (TGF-beta3). Alginates 106-114 transforming growth factor beta 3 Homo sapiens 171-203 31826469-0 2020 Promoted chondrogenesis of hMCSs with controlled release of TGF-beta3 via microfluidics synthesized alginate nanogels. Alginates 100-108 transforming growth factor beta 3 Homo sapiens 60-69 31826469-3 2020 Here, we proposed an on-chip hydrodynamic flow focusing microfluidic approach for synthesis of alginate nanogels loaded with the transforming growth factor beta 3 (TGF-beta3) through an ionic gelation method in order to achieve precise release profile of these bioactive agents during chondrogenic differentiation of mesenchymal stem cells (MSCs). Alginates 95-103 transforming growth factor beta 3 Homo sapiens 129-162 31826469-3 2020 Here, we proposed an on-chip hydrodynamic flow focusing microfluidic approach for synthesis of alginate nanogels loaded with the transforming growth factor beta 3 (TGF-beta3) through an ionic gelation method in order to achieve precise release profile of these bioactive agents during chondrogenic differentiation of mesenchymal stem cells (MSCs). Alginates 95-103 transforming growth factor beta 3 Homo sapiens 164-173