PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 9658196-1 1998 In the current study, the potential blocking ability of K+ channels encoded by the human ether-a-go-go related gene (HERG) by the piperazine H1 receptor antagonist cetirizine has been examined and compared with that of other second-generation antihistamines (astemizole, terfenadine, and loratadine). Loratadine 288-298 potassium voltage-gated channel subfamily H member 2 Homo sapiens 117-121 10604956-10 2000 However, both drugs potently blocked HERG current amplitude, with a mean IC(50) of 173 nM for loratadine and 204 nM for terfenadine (pacing rate, 0.1 Hz). Loratadine 94-104 potassium voltage-gated channel subfamily H member 2 Homo sapiens 37-41