PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12695351-4 2003 In contrast, treatment with 0.1 microM DEX enhanced CYP2B6 induction by different pregnane X receptor (PXR) activators, including rifampin, phenytoin, clotrimazole, and phenobarbital. Dexamethasone 39-42 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 52-58 16135659-7 2005 All 23 single assays were validated by assessing the effects (induction or repression) of known inducers (ethanol, 3-methylcholanthrene, rifampicin, dexamethasone, phenobarbital) on P450 expression in human primary hepatocytes. Dexamethasone 149-162 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 182-186 20307138-6 2010 Female livers and livers exposed to inducers (phenobarbital and/or dexamethasone) were associated with higher CYP2B6. Dexamethasone 67-80 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 110-116 25409894-0 2015 Characterization of CYP2B6 in a CYP2B6-humanized mouse model: inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivo. Dexamethasone 109-122 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 20-26 12485953-4 2003 Microsomes prepared from dexamethasone-pretreated rats metabolized clopidogrel at a rate of 3.8 nmol min(-1) nmol of p450(-1), which is 65 and 1270% faster than the rate of metabolism by microsomes from control and beta-napthoflavone-treated rats, respectively. Dexamethasone 25-38 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 117-121 12065440-1 2002 The purpose of this study was to characterize the concentration-response effects of cyclophosphamide (CPA) with and without dexamethasone (DEX; 10 microM) on the expression of CYP3A4 and CYP2B6 in cultured human hepatocytes at concentrations representative of standard- and high-dose CPA therapy (25 to 750 microM). Dexamethasone 124-137 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 187-193 12065440-1 2002 The purpose of this study was to characterize the concentration-response effects of cyclophosphamide (CPA) with and without dexamethasone (DEX; 10 microM) on the expression of CYP3A4 and CYP2B6 in cultured human hepatocytes at concentrations representative of standard- and high-dose CPA therapy (25 to 750 microM). Dexamethasone 139-142 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 187-193 12065440-3 2002 The inductive effect of CPA alone and in combination with DEX was greater in magnitude for CYP2B6 compared with CYP3A4. Dexamethasone 58-61 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 91-97 11093784-4 2000 We show that submicromolar concentrations of dexamethasone enhance phenobarbital-mediated induction of CYP3A4, CYP2B6, and CYP2C8 mRNA in cultured human hepatocytes. Dexamethasone 45-58 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 111-117 8055971-10 1994 Liver microsomes from rats pretreated with dexamethasone, a specific inducer of P450 3A, were found to be particularly active for the hydroxylation of bromocriptine, which occurs at the level of its tripeptide moiety. Dexamethasone 43-56 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 80-84 3654968-2 1987 In rat enterocytes, we found two dexamethasone-inducible proteins related to the steroid-inducible liver cytochromes P-450. Dexamethasone 33-46 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 117-122 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Dexamethasone 53-66 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 20-26 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Dexamethasone 53-66 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 92-98 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Dexamethasone 53-66 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 92-98 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Dexamethasone 68-71 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 20-26 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Dexamethasone 68-71 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 92-98 25409894-2 2015 The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. Dexamethasone 68-71 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 92-98 25409894-3 2015 Hepatic expression of CYP2B6 mRNA and protein was greatly induced by PB or DEX treatment in both TG and TG/Cyp2abfgs-null mice. Dexamethasone 75-78 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 22-28