PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33495943-7 2021 Among hepatocytic differentiation-inducing factors, dexamethasone (DEX) and insulin-transferrin-sodium selenite (ITS) seemed to be involved in elevation of expression of CYP3A4 mRNA. Dexamethasone 52-65 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 170-176 33495943-7 2021 Among hepatocytic differentiation-inducing factors, dexamethasone (DEX) and insulin-transferrin-sodium selenite (ITS) seemed to be involved in elevation of expression of CYP3A4 mRNA. Dexamethasone 67-70 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 170-176 31127319-8 2019 RESULTS: Dexamethasone was the most commonly used CYP3A inducer (30.4%). Dexamethasone 9-22 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 50-55 32240873-10 2020 Similarly, the mRNA level of CYP3A4 significantly decreased in presence of DEX. Dexamethasone 75-78 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 29-35 31527544-9 2019 Specifically, DEX significantly decreased the concentration of the LOX active metabolite formed by CR, which corresponded to an increased concentration of OH-LOX formed by CYP3A4. Dexamethasone 14-17 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 172-178 30072626-6 2018 Based on the results for the formation of metabolites when incubated in dexamethasone-induced microsomes, incubation with ketoconazole, and human recombinant cDNA-expressed cytochrome P450s, we identified CYP3A4 and CYP3A5 as the major CYP isoforms involved in the hydroxylation of loxoprofen (M3 and M4). Dexamethasone 72-85 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 205-211 30919109-3 2019 Cortisol, at plasma concentrations observed during the third trimester (~ 800 nM), either alone or in combination with other pregnancy-related hormones, induces CYP3A activity in SCHH and HepaRG cells when cultured in dexamethasone-free media. Dexamethasone 218-231 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 161-166 27226420-10 2017 CYP3A4-related drug-drug interactions with panobinostat have been documented with ketoconazole (inhibitor) and dexamethasone (inducer). Dexamethasone 111-124 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 25434721-7 2015 However, overexpression of CYP3A5 attenuated the inducibility of CYP3A4 in response to dexamethasone. Dexamethasone 87-100 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 65-71 28194109-8 2017 All of the neurokinin-1 receptor antagonists with the exception of rolapitant inhibit or induce cytochrome P450 3A4 (CYP3A4), and a reduced dose of dexamethasone (a CYP3A4 substrate) should be administered with aprepitant or netupitant; by contrast, this is not necessary with rolapitant. Dexamethasone 148-161 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 165-171 26966071-7 2016 Treatment with dexamethasone, phenobarbital, rifampicin, or 1alpha,25-dihydroxyvitamin D3 resulted in 5.8-fold, 13.4-fold, 9.8-fold, or 95.0-fold induction of CYP3A4 expression relative to that in the untreated controls, respectively. Dexamethasone 15-28 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 159-165 26301745-7 2015 This effect disappeared in the presence of a CYP3A4 inducer dexamethasone. Dexamethasone 60-73 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 45-51 26330331-12 2015 RESULTS: Administration of erlotinib with CYP3A4 inducers (dexamethasone) and inhibitors (ketoconazole and ritonavir) resulted in significant alterations in erlotinib exposure. Dexamethasone 59-72 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 42-48 25915157-7 2015 Moreover, clarithromycin overcame stromal-mediated MM resistance to dexamethasone, suggesting that CYP3A4 inhibition plays a role in its ability to augment the activity of lenalidomide and dexamethasone as part of the BiRd regimen. Dexamethasone 68-81 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 99-105 25915157-7 2015 Moreover, clarithromycin overcame stromal-mediated MM resistance to dexamethasone, suggesting that CYP3A4 inhibition plays a role in its ability to augment the activity of lenalidomide and dexamethasone as part of the BiRd regimen. Dexamethasone 189-202 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 99-105 24191259-3 2014 A recent clinical study reported that concomitant use of lapatinib with dexamethasone increased the incidence of hepatotoxicity in metastatic breast cancer patients treated with lapatinib, and so we hypothesized that induction of CYP3A enhances the bioactivation of lapatinib to reactive intermediates that contribute to hepatotoxicity. Dexamethasone 72-85 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 230-235 24191259-7 2014 Induction of CYP3A4 by dexamethasone or rifampicin enhanced lapatinib-induced cytotoxicity, compared with treatment with lapatinib alone. Dexamethasone 23-36 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 13-19 24492672-4 2014 Intravenous administration of Ad-E4-122aT-hCYP3A4 at a dose of 2 x 10(11) virus particles/mouse produced a mouse exhibiting human CYP3A4 activity at a level similar to that in the human liver, as shown in the dexamethasone metabolic experiment using liver microsomes. Dexamethasone 209-222 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 42-49 24492672-4 2014 Intravenous administration of Ad-E4-122aT-hCYP3A4 at a dose of 2 x 10(11) virus particles/mouse produced a mouse exhibiting human CYP3A4 activity at a level similar to that in the human liver, as shown in the dexamethasone metabolic experiment using liver microsomes. Dexamethasone 209-222 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 43-49 22370628-1 2012 Concomitant usage of lapatinib, a cytochrome P450 (CYP) 3A4 substrate and dexamethasone, a CYP3A4 inducer, is a pharmacokinetic drug-drug interaction. Dexamethasone 74-87 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 91-97 24674673-8 2014 Multiple factors may affect CYP3A expression and activity, such as inducers like rifampicin, phenobarbital, 3-methylcholantrene, beta-naphtoflavone, and dexamethasone. Dexamethasone 153-166 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 28-33 22253426-8 2012 Glucocorticoids, including dexamethasone, cortisol, corticosterone, and cortisone all induced the expression of CYP3A7 mRNA, whereas rifampicin, an activator of PXR and an inducer of CYP3A4 in adult liver, had no effect on CYP3A7 expression. Dexamethasone 27-40 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 183-189 21952236-4 2011 Using primary hepatocyte cultures derived from men and women exposed to physiologic-like levels of continuous GH (the feminine circulating profile) alone, dexamethasone alone, and the combined regimen, we observed a dramatic inherent CYP3A4 sexual dimorphism (women more than men) with all treatments. Dexamethasone 155-168 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 234-240 22333269-2 2012 CYP3A4 was induced by rifampicin (RIF), mifepristone (RU486), clotrimazole (CTZ), and dexamethasone (DEX) in HepG2 cells, while these PXR ligands with the exception of DEX did not induce CYP3A4 mRNA expression in HFL cells. Dexamethasone 86-99 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 22333269-2 2012 CYP3A4 was induced by rifampicin (RIF), mifepristone (RU486), clotrimazole (CTZ), and dexamethasone (DEX) in HepG2 cells, while these PXR ligands with the exception of DEX did not induce CYP3A4 mRNA expression in HFL cells. Dexamethasone 101-104 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 22333269-2 2012 CYP3A4 was induced by rifampicin (RIF), mifepristone (RU486), clotrimazole (CTZ), and dexamethasone (DEX) in HepG2 cells, while these PXR ligands with the exception of DEX did not induce CYP3A4 mRNA expression in HFL cells. Dexamethasone 101-104 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 187-193 22333269-2 2012 CYP3A4 was induced by rifampicin (RIF), mifepristone (RU486), clotrimazole (CTZ), and dexamethasone (DEX) in HepG2 cells, while these PXR ligands with the exception of DEX did not induce CYP3A4 mRNA expression in HFL cells. Dexamethasone 168-171 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 22673009-2 2012 In the fetal hepatocytes, betamethasone and dexamethasone (DEX) markedly enhanced the expression levels of CYP3A4 and CYP3A7 mRNAs and slightly increased the expression level of CYP3A5 mRNA. Dexamethasone 44-57 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 107-113 22673009-2 2012 In the fetal hepatocytes, betamethasone and dexamethasone (DEX) markedly enhanced the expression levels of CYP3A4 and CYP3A7 mRNAs and slightly increased the expression level of CYP3A5 mRNA. Dexamethasone 59-62 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 107-113 22673009-4 2012 Human glucocorticoid receptor (GR)-small interfering RNA clearly attenuated the expression level of GR mRNA, and diminished the DEX-stimulated CYP3A4, CYP3A5 and CYP3A7 expression in HFL cells. Dexamethasone 128-131 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 143-149 20798939-11 2011 CONCLUSIONS: We show here a markedly reduced docetaxel exposure followed by CYP3A induction by, most likely, dexamethasone. Dexamethasone 109-122 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 76-81 19429418-5 2009 In human ileum and liver, 1,25(OH)(2)D(3) and DEX induced CYP3A4 expression, whereas CDCA induced CYP3A4 expression in liver only. Dexamethasone 46-49 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 58-64 21219911-9 2011 Further experiments revealed that both diterpenoids were also capable of attenuating the ability of dexamethasone to induce CYP3A4 expression, and 14-Deoxy-11, 12-Didehydroandrographolide tended to bind to the PXR-LBD site in a concentration-dependent manner. Dexamethasone 100-113 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 124-130 21436605-5 2011 Furthermore, CYP3A4 protein levels were significantly increased by the addition of rifampicin and dexamethasone to the culture media, indicating that the induction potential was maintained. Dexamethasone 98-111 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 13-19 19022227-0 2009 Effects of dexamethasone, administered for growth promoting purposes, upon the hepatic cytochrome P450 3A expression in the veal calf. Dexamethasone 11-24 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 87-105 19022227-2 2009 In human liver, DEX is metabolized by cytochrome P450 3A (CYP3A); moreover, it is among those xenobiotics which induce CYP3A itself. Dexamethasone 16-19 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 38-56 19022227-2 2009 In human liver, DEX is metabolized by cytochrome P450 3A (CYP3A); moreover, it is among those xenobiotics which induce CYP3A itself. Dexamethasone 16-19 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 58-63 19022227-2 2009 In human liver, DEX is metabolized by cytochrome P450 3A (CYP3A); moreover, it is among those xenobiotics which induce CYP3A itself. Dexamethasone 16-19 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 119-124 19022227-4 2009 In cattle, DEX is used at low dosages as a growth promoter; besides, CYP3A is expressed in the liver. Dexamethasone 11-14 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 69-74 19022227-7 2009 In summary, DEX modulates cattle liver CYP3A at pre- and post-translational level. Dexamethasone 12-15 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 39-44 18490434-0 2008 The influence of CYP3A5 genotype on dexamethasone induction of CYP3A activity in African Americans. Dexamethasone 36-49 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 17-22 18490434-3 2008 We have previously noted a correlation between basal CYP3A activity and the inductive effects of dexamethasone using the erythromycin breath test (ERBT). Dexamethasone 97-110 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 53-58 18094037-10 2008 Dexamethasone (glucocorticoid receptor and PXR ligand) induced CYP3A4 mRNA (3.5-fold) and activity (5-fold) in proximal jejunum. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 63-69 18332045-8 2008 Coexposure to phthalates and dexamethasone (Dex) resulted in enhanced CYP3A4 promoter activity; furthermore, this induction was abrogated by both the GR antagonist RU486 and GR small interfering ribonucleic acid. Dexamethasone 29-42 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 70-76 18332045-8 2008 Coexposure to phthalates and dexamethasone (Dex) resulted in enhanced CYP3A4 promoter activity; furthermore, this induction was abrogated by both the GR antagonist RU486 and GR small interfering ribonucleic acid. Dexamethasone 44-47 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 70-76 18332045-10 2008 CYP3A4 protein was highly induced by Dex and DEHP coadministration in human hepatocyte cultures. Dexamethasone 37-40 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 18332045-11 2008 Finally, enhanced 6beta-hydroxytestosterone formation in Dex and phthalate cotreated human hepatocytes confirmed CYP3A4 enzyme induction. Dexamethasone 57-60 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 113-119 17826359-3 2008 In the present study, we determined the in vivo and in vitro effects of typical mammalian CYP3A inducers (rifampicin, phenobarbital and dexamethasone) on CYP3A-related enzyme activities in a freshwater teleost, the grass carp (Ctenopharyngodon idellus). Dexamethasone 136-149 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 90-95 18037906-4 2008 KEY RESULTS: Dexamethasone significantly up-regulated PXR, CYP3A4 and ABCB1 expression in HepG2 and Caco-2 cells. Dexamethasone 13-26 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 59-65 17826359-3 2008 In the present study, we determined the in vivo and in vitro effects of typical mammalian CYP3A inducers (rifampicin, phenobarbital and dexamethasone) on CYP3A-related enzyme activities in a freshwater teleost, the grass carp (Ctenopharyngodon idellus). Dexamethasone 136-149 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 154-159 17207564-1 2007 Alachlor is cytotoxic to human hepatoblastoma HepG2s, a cell line that expresses constitutive CYP3A7 and dexamethasone (DEX)-inducible CYP3A4 and CYP3A7. Dexamethasone 105-118 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 135-141 17978482-6 2007 In HFL cells, CYP3A4 and CYP3A7 mRNA expression levels were markedly up-regulated by dexamethasone (DEX), but not by rifampicin (RIF). Dexamethasone 85-98 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 14-20 17978482-6 2007 In HFL cells, CYP3A4 and CYP3A7 mRNA expression levels were markedly up-regulated by dexamethasone (DEX), but not by rifampicin (RIF). Dexamethasone 100-103 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 14-20 17978482-8 2007 On the other hand, CYP3A4, CYP3A5, and CYP3A7 mRNA expression levels in HepG2 cells were increased from 2- to 3-fold by treatment with DEX and RIF. Dexamethasone 135-138 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 19-25 17124593-0 2007 Dexamethasone as a probe for CYP3A4 metabolism: evidence of gender effect. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 29-35 16160083-4 2006 In this study, we have examined the effects of physiologic-like exposure doses to dexamethasone and/or pulsatile (masculine) or constant (feminine) human growth hormone on expression levels of CYP3A4, 1A2, 2D6, and 2E1 and the glucocorticoid and growth hormone receptors in hepatocyte cultures obtained from men and women donors. Dexamethasone 82-95 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 193-199 16713641-1 2006 In this study we describe an alligator hepatic CYP3A gene, CYP3A77, which is inducible by dexamethasone and toxaphene. Dexamethasone 90-103 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 47-52 16713641-5 2006 We used real time PCR to examine whether known and suspected CYP3A inducers (dexamethasone, metyrapone, rifampicin, and toxaphene) up-regulate steady state levels of hepatic CYP3A77 transcript to determine if induction patterns in female juvenile alligators are similar to those reported in other vertebrates and whether toxaphene, an organochlorine compound found in high concentrations in Lake Apopka alligators, induces this gene. Dexamethasone 77-90 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 61-66 16160083-6 2006 The masculine-like pulsatile growth hormone profile suppresses dexamethasone-induced CYP3A4, 1A2, and 2D6, whereas the feminine-like constant profile is permissive allowing isoform expression to be equal to or greater than glucocorticoid induction alone. Dexamethasone 63-76 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 85-91 15922010-5 2005 Like the human CYP3A genes, CYP3A65 transcription in the foregut region was enhanced by treatment of the zebrafish larvae with the steroid dexamethasone and the macrocyclic antibiotic rifampicin. Dexamethasone 139-152 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 15-20 15963093-8 2005 Dexamethasone merits further evaluation as a probe of CYP3A metabolism. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 54-59 15081938-2 2004 So, the 6 beta-hydroxydexamethasone/dexamethasone urinary ratio could be a specific marker for human CYP3A4 activity. Dexamethasone 22-35 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 101-107 15832810-6 2005 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Dexamethasone 340-353 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 256-261 15656694-14 2005 Similarly, dexamethasone is both a substrate and concentration-dependent inducer of CYP3A4; enhanced corticosteroid pharmacodynamics may result with CYP3A4 inhibitors, while the efficacy of concomitant HAART may be compromised with prolonged dexamethasone coadministration. Dexamethasone 11-24 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 84-90 15656694-14 2005 Similarly, dexamethasone is both a substrate and concentration-dependent inducer of CYP3A4; enhanced corticosteroid pharmacodynamics may result with CYP3A4 inhibitors, while the efficacy of concomitant HAART may be compromised with prolonged dexamethasone coadministration. Dexamethasone 11-24 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 149-155 15656694-14 2005 Similarly, dexamethasone is both a substrate and concentration-dependent inducer of CYP3A4; enhanced corticosteroid pharmacodynamics may result with CYP3A4 inhibitors, while the efficacy of concomitant HAART may be compromised with prolonged dexamethasone coadministration. Dexamethasone 242-255 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 84-90 15133628-2 2004 Dexamethasone is mainly 6-beta hydroxylated by CYP3A4, and is regularly used as standard docetaxel premedication. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 47-53 15120618-1 2004 CYP3A4 and CYP3A7 mRNA expression levels were markedly up-regulated by dexamethasone (DEX), but not by rifampicin (RIF). Dexamethasone 71-84 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 15120618-1 2004 CYP3A4 and CYP3A7 mRNA expression levels were markedly up-regulated by dexamethasone (DEX), but not by rifampicin (RIF). Dexamethasone 86-89 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 15120618-5 2004 DEX-mediated induction of CYP3A mRNA was suppressed in a dose-dependent manner by RU486, a glucocorticoid receptor (GR) antagonist. Dexamethasone 0-3 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 26-31 15120618-6 2004 At 5microM RU486, DEX-mediated induction of CYP3A4, CYP3A5, and CYP3A7 mRNA expression was inhibited almost completely. Dexamethasone 18-21 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 44-50 12843151-0 2003 Troglitazone induces CYP3A4 activity leading to falsely abnormal dexamethasone suppression test. Dexamethasone 65-78 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 21-27 15055869-2 2004 Its main pathway of elimination is by the cytochrome p450 isozyme CYP3A4, which is the basis for drug interactions with dexamethasone and oral contraceptives. Dexamethasone 120-133 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 66-72 12781341-4 2003 Since this heterodimer then binds to xenobiotic response elements to activate transcription of CYP3A4, we examined a 13kb promoter region of CYP3A4 for responsiveness to dexamethasone and rifampicin. Dexamethasone 170-183 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 141-147 12781341-9 2003 Co-injection of an antisense murine PXR construct with the CYP3A4-luc reduced both the dexamethasone- and rifampicin-induced responses, thus demonstrating that the murine PXR receptor can participate in the regulation of the human CYP3A4 promoter in mice. Dexamethasone 87-100 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 59-65 12781341-9 2003 Co-injection of an antisense murine PXR construct with the CYP3A4-luc reduced both the dexamethasone- and rifampicin-induced responses, thus demonstrating that the murine PXR receptor can participate in the regulation of the human CYP3A4 promoter in mice. Dexamethasone 87-100 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 231-237 12679136-4 2003 All CYP3A mRNAs were induced by dexamethasone. Dexamethasone 32-45 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 4-9 12538830-1 2003 CYP3A5 is the major CYP3A form in the human lung, and it is inducible by dexamethasone in the human A549 lung adenocarcinoma cell line. Dexamethasone 73-86 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-5 12538830-4 2003 About 4-fold induction was detected by nanomolar concentrations of dexamethasone and also by budenoside and beclomethasone dipropionate, glucocorticoids used for the inhalation treatment of bronchial asthma, whereas the CYP3A4 inducers mifepristone (RU486), rifampicin, clotrimazole, and nifedipine were without effect. Dexamethasone 67-80 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 220-226 12369894-10 2002 Similarly, the steroid family of orphan receptors, the constitutive androstane receptor (CAR) and pregnane X receptors (PXR), heterodimerize with the retinoid X receptor (RXR), transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Dexamethasone 315-328 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 231-236 12167569-5 2002 CYP3A genes lack a consensus glucocorticoid receptor response element and yet are highly induced by classical glucocorticoids such as hydrocortisone and dexamethasone. Dexamethasone 153-166 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-5 12065440-1 2002 The purpose of this study was to characterize the concentration-response effects of cyclophosphamide (CPA) with and without dexamethasone (DEX; 10 microM) on the expression of CYP3A4 and CYP2B6 in cultured human hepatocytes at concentrations representative of standard- and high-dose CPA therapy (25 to 750 microM). Dexamethasone 124-137 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 176-182 12065440-1 2002 The purpose of this study was to characterize the concentration-response effects of cyclophosphamide (CPA) with and without dexamethasone (DEX; 10 microM) on the expression of CYP3A4 and CYP2B6 in cultured human hepatocytes at concentrations representative of standard- and high-dose CPA therapy (25 to 750 microM). Dexamethasone 139-142 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 176-182 12065440-3 2002 The inductive effect of CPA alone and in combination with DEX was greater in magnitude for CYP2B6 compared with CYP3A4. Dexamethasone 58-61 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 112-118 12065440-7 2002 Induction index was highly correlated with CYP3A4 baseline activity for both CPA (r(2) = 0.75) and CPA plus DEX (r(2) = 0.85). Dexamethasone 108-111 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 43-49 11737189-0 2001 Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Dexamethasone 15-28 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 32-38 12065440-11 2002 These results indicate that CPA alone and in combination with DEX differentially induces the expression of CYP3A4 and 2B in a concentration-dependent manner, which may be mediated partially through activation of PXR. Dexamethasone 62-65 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 107-120 11737189-4 2001 In contrast to rifampicin (monophasic induction), dexamethasone produces a biphasic induction of CYP3A4 mRNA consisting of a low-dexamethasone component (nmol concentrations) of low amplitude (factor of 3-4) followed by a high-dexamethasone component (supramicromolar concentrations) of high amplitude (factor of 15-30). Dexamethasone 50-63 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 97-103 11737189-5 2001 We show that the low-dexamethasone component results from the glucocorticoid receptor-mediated expression of pregnane X receptor and/or constitutively activated receptor which, in turn, are able to transactivate CYP3A4 in a xenobiotic-independent manner. Dexamethasone 21-34 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 212-218 11737189-6 2001 At supramicromolar concentrations (>10 microm), dexamethasone binds to and activates pregnane X receptor thus producing the high-dexamethasone component of CYP3A4 induction. Dexamethasone 51-64 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 159-165 11737189-6 2001 At supramicromolar concentrations (>10 microm), dexamethasone binds to and activates pregnane X receptor thus producing the high-dexamethasone component of CYP3A4 induction. Dexamethasone 132-145 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 159-165 11602520-6 2001 Known ligands for pregnane X receptor (PXR) (rifampin, dexamethasone, and dexamethasone t-butyl acetate) markedly induced CYP3A4 expression in human hepatocytes. Dexamethasone 55-68 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 122-128 11336975-1 2001 Induction of P450 isoforms 1A (CYP1A) and 3A (CYP3A) by model inducers dexamethasone, omeprazole and rifampin was evaluated in primary cultured hepatocytes from man and laboratory animals. Dexamethasone 71-84 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 46-51 11560876-5 2001 Cotransfection experiments showed that the proximal and the distal PXR response elements of the CYP3A4 promoter and hPXR (HepG2 cells) or dexamethasone-induced hPXR (primary hepatocytes) were necessary to obtain full induction. Dexamethasone 138-151 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 96-102 11336975-3 2001 Results with human hepatocytes from six human donors consistently show that both rifampin and dexamethasone were inducers of CYP3A activity (measured as testosterone 6beta-hydroxylase activity), with rifampin being more potent. Dexamethasone 94-107 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 125-130 11231298-5 2001 Methylcholanthrene induced an increase in CYP1A1/2 enzyme activity (eightfold), phenobarbital induced CYP2B6 activity (1.7-fold), and dexamethasone induced CYP3A4 activity (fivefold). Dexamethasone 134-147 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 156-162 11093784-4 2000 We show that submicromolar concentrations of dexamethasone enhance phenobarbital-mediated induction of CYP3A4, CYP2B6, and CYP2C8 mRNA in cultured human hepatocytes. Dexamethasone 45-58 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 103-109 11061575-0 2000 In vivo and in vitro induction of human cytochrome P4503A4 by dexamethasone. Dexamethasone 62-75 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 40-58 11103751-0 2000 The cytochrome P450 3A4 inhibitor itraconazole markedly increases the plasma concentrations of dexamethasone and enhances its adrenal-suppressant effect. Dexamethasone 95-108 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 4-23 11103751-10 2000 A careful follow-up is recommended when itraconazole or other potent inhibitors of the cytochrome P450 3A4 are added to the drug regimen of patients receiving dexamethasone. Dexamethasone 159-172 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 87-106 11061575-1 2000 PURPOSE: The aims of these experiments were to determine the effect of a therapeutic regimen of dexamethasone on cytochrome P4503A4 (CYP3A4) activity in healthy volunteers; and the concentration-effect relationship between dexamethasone and CYP3A4 activity in primary human hepatocyte cultures. Dexamethasone 96-109 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 113-131 11061575-1 2000 PURPOSE: The aims of these experiments were to determine the effect of a therapeutic regimen of dexamethasone on cytochrome P4503A4 (CYP3A4) activity in healthy volunteers; and the concentration-effect relationship between dexamethasone and CYP3A4 activity in primary human hepatocyte cultures. Dexamethasone 96-109 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 133-139 11061575-1 2000 PURPOSE: The aims of these experiments were to determine the effect of a therapeutic regimen of dexamethasone on cytochrome P4503A4 (CYP3A4) activity in healthy volunteers; and the concentration-effect relationship between dexamethasone and CYP3A4 activity in primary human hepatocyte cultures. Dexamethasone 223-236 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 133-139 11061575-2 2000 METHODS: The effect of dexamethasone (8 mg administered by mouth two times a day for 5 days) on CYP3A4 activity in 12 healthy volunteers was assessed with the erythromycin breath test and urinary ratio of dextromethorphan to 3-methoxymorphinan. Dexamethasone 23-36 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 96-102 11061575-3 2000 Concentration-effect of dexamethasone on CYP3A4-dependent testosterone 6-beta-hydroxylation was determined in human hepatocytes treated with 2 to 250 micromol/L dexamethasone. Dexamethasone 24-37 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 41-47 10908304-0 2000 Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 129-135 11061575-3 2000 Concentration-effect of dexamethasone on CYP3A4-dependent testosterone 6-beta-hydroxylation was determined in human hepatocytes treated with 2 to 250 micromol/L dexamethasone. Dexamethasone 161-174 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 41-47 11061575-8 2000 In hepatocytes, dexamethasone 2 to 250 micromol/L resulted in an average 1.7-fold to 6.9-fold increase in CYP3A4 activity, respectively. Dexamethasone 16-29 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 106-112 11061575-9 2000 The extent of CYP3A4 induction with dexamethasone in hepatocyte preparations was inversely correlated with baseline activity (r2 = 0.59). Dexamethasone 36-49 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 14-20 11061575-10 2000 CONCLUSIONS: These data demonstrate that dexamethasone at doses used clinically increased CYP3A4 activity with extensive intersubject variability and that the extent of CYP3A4 induction was, in part, predicted by the baseline activity of CYP3A4 in both healthy volunteers and human hepatocyte cultures. Dexamethasone 41-54 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 90-96 10999732-8 2000 The values of the conventional EBT parameter CER20 min obtained on day 1 were comparable for most subjects (0.03-0.06% dose/min), with the exception of an individual receiving the known CYP3A4 inducers dexamethasone and phenytoin who returned a value of 0.14% dose/min. Dexamethasone 202-215 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 186-192 10908304-1 2000 In this report we show that submicromolar concentrations of dexamethasone enhance pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human hepatocytes. Dexamethasone 60-73 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 127-133 10908304-7 2000 Furthermore, dexamethasone induces the accumulation of a RXRalpha-immunoreactive protein and increases the nuclear level of RXRalpha:PXR heterodimer as shown by gel shift assays with a CYP3A4 ER6 PXRE probe. Dexamethasone 13-26 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 185-191 10908304-8 2000 This accumulation of latent PXR and RXRalpha in the nucleus of hepatocytes explains the synergistic effect observed with dexamethasone and PXR activators together on CYP3A4 induction. Dexamethasone 121-134 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 166-172 10752642-8 2000 The capacity of troglitazone to induce CYP3A4 was between that of rifampin (EC50 = 0.8 microM) and dexamethasone (40-50 microM). Dexamethasone 99-112 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 39-45 10828267-8 2000 When blood cell-derived cultures were exposed to the prototypical CYP1A and CYP3A inducers, i.e., beta-naphthoflavone (beta-NF), dexamethasone (DEX) or phenobarbital, generally little or no inductive response was manifested. Dexamethasone 129-142 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 76-81 10923861-9 2000 A 3-day treatment of human hepatocytes with 50 microM dexamethasone was associated with a major induction of both coumarin 7-hydroxylation (9.4 +/- 11.4-fold, n = 49) and nifedipine dehydrogenation (4.7 +/- 3.8-fold, n = 61), markers for CYP2A6 and CYP3A4 respectively. Dexamethasone 54-67 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 249-255 10772626-6 2000 Although the responses to dexamethasone and rifampicin were both increased by both receptors, dexamethasone activation of CYP3A4 was similar for both the hGR and the hPXR, whereas rifampicin-dependent activation favored the hPXR. Dexamethasone 94-107 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 122-128 10548883-11 1999 Many of the PXR activators are widely used drugs such as dexamethasone, lovastatin, and rifampicin, whose induction of CYP3A levels causes them to promote the metabolism of other drugs, often with adverse consequences. Dexamethasone 57-70 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 119-124 10219967-6 1999 Dexamethasone induced CYP3A4-dependent reporter gene expression in a concentration-dependent manner and induction was approximately doubled in the presence of the glucocorticoid receptor. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 22-28 9826540-0 1998 Modulation of MDR1 and CYP3A expression by dexamethasone: evidence for an inverse regulation in adrenals. Dexamethasone 43-56 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 23-28 9337077-2 1997 CYP3A4 is responsible for 6alpha- and 6beta-hydroxylation of DEX and CYP17 is thought to mediate side-chain cleavage to generate 9alphafluoro-androsta-1,4-diene-11beta-hydroxy-16alpha-methyl-3,17-dione (9alphaF-A). Dexamethasone 61-64 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 0-6 9783333-1 1998 The effects of short-term use of a small dose of dexamethasone on the pharmacokinetics and pharmacodynamics of the CYP3A4 substrate, triazolam, were examined. Dexamethasone 49-62 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 115-121 9783333-9 1998 Although dexamethasone had only small effects on the pharmacokinetics and pharmacodynamics of triazolam in the present study, higher doses or prolonged use of dexamethasone might cause a more pronounced induction of CYP3A4. Dexamethasone 159-172 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 216-222 9783333-10 1998 Further studies on the effects of dexamethasone on the pharmacokinetics of CYP3A4 substrates in man are needed. Dexamethasone 34-47 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 75-81 9661620-0 1998 Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes. Dexamethasone 80-93 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 39-58 9661620-5 1998 Conversely, both dexamethasone and GH treatment substantially increased CYP3A4 gene expression. Dexamethasone 17-30 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 72-78 9536002-8 1998 Enzymatic activity and de novo protein synthesis of 3-methylcholanthrene-induced CYP1A2 and dexamethasone-induced CYP3A4 were also reduced to a much greater extent by oncostatin M than by other cytokines. Dexamethasone 92-105 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 114-120 9468221-2 1998 The induction of CYP3A by dexamethasone has been proposed to be mediated by a mechanism distinct from the glucocorticoid receptor mediated response. Dexamethasone 26-39 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 17-22 9806224-8 1998 The current study demonstrates that the anesthetic effect of MDZ would be reduced in patients treated with dexamethasone or prednisolone, and that the CYP3A induction was greater by dexamethasone than by prednisolone, implying that the potency of CYP3A induction may differ among GCs even when GC activity is the same. Dexamethasone 182-195 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 151-156 9337077-5 1997 Furthermore, molecular models of CYP3A4 and CYP17 (17,20 lyase) have been used to model the enzyme fits of DEX. Dexamethasone 107-110 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 33-39 8619627-5 1996 A putative CYP3A protein is expressed in PLHC-1 cells but its content was not altered by exposure of cultures to the prototypical mammalian CYP3A inducers dexamethasone (DEX), pregnenolone-16 alpha-carbonitrile (PCN), or rifampicin (RIF). Dexamethasone 170-173 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 11-16 9408089-1 1997 Dexamethasone (DEX) is extensively metabolized to 6-hydroxyDEX (6OH-DEX) and side-chain cleaved metabolites in human liver both in vitro and in vivo with CYP3A4 responsible for the formation of 6-hydroxylated products. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 154-160 9408089-1 1997 Dexamethasone (DEX) is extensively metabolized to 6-hydroxyDEX (6OH-DEX) and side-chain cleaved metabolites in human liver both in vitro and in vivo with CYP3A4 responsible for the formation of 6-hydroxylated products. Dexamethasone 15-18 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 154-160 9408089-11 1997 However, 6-hydroxylation was most extensive in the hamster which may therefore be a suitable model to use for further studies on DEX metabolism by CYP3A. Dexamethasone 129-132 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 147-152 8700101-4 1996 When we transfected into cultured rat hepatocytes vectors containing 5"-flanking DNA from CYP3A23, CYP3A4, or CYP3A6 genes, we found that CAT activity was induced on treatment with dexamethasone or pregnenolone-16 alpha-carbonitrile only if consensus II sequences were included. Dexamethasone 181-194 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 99-105 8643461-0 1996 Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 65-70 8643461-1 1996 Elements responsible for dexamethasone responsiveness of CYP3A23, a major glucocorticoid-inducible member of the CYP3A gene family, have been identified. Dexamethasone 25-38 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 57-62 8613906-16 1996 The relatively simple metabolic profile of dexamethasone compared to other steroids may point to this being a potentially useful in vivo probe for CYP3A4 in humans. Dexamethasone 43-56 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 147-153 8640817-8 1996 Docetaxel metabolism was induced in vitro in human hepatocytes by dexamethasone and rifampicin, both classical CYP3A inducers. Dexamethasone 66-79 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 111-116 7628309-7 1995 In primary cultures of human hepatocytes, dexamethasone and phenobarbital treatments induced CYP3A mRNA (> or = 4.4- and 1.9-fold, respectively, over the amounts of CYP3A mRNA in incubated control cultures). Dexamethasone 42-55 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 93-98 8569713-13 1996 This is the first study to demonstrate that a member of the human CYP3A gene family contains an enhancer that binds the GCR and that this binding is critical to transcriptional activation by dexamethasone. Dexamethasone 191-204 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 66-71 7628309-7 1995 In primary cultures of human hepatocytes, dexamethasone and phenobarbital treatments induced CYP3A mRNA (> or = 4.4- and 1.9-fold, respectively, over the amounts of CYP3A mRNA in incubated control cultures). Dexamethasone 42-55 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 168-173 34791318-2 2022 Dexamethasone is both a substrate and a dose-dependent inducer of cytochrome P450 3A4 (CYP3A4). Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 66-85 8003039-1 1994 The specific binding of the archetypal cytochrome P450 3A subfamily (CYP3A) inducer dexamethasone is examined in microsomal fractions since rat and human liver CYP3A is induced by glucocorticoids through a mechanism which is apparently independent of the cytosolic glucocorticoid receptor. Dexamethasone 84-97 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 160-165 8114683-3 1994 Using a panel of prototypical substrates and inhibitors for specific cytochromes P450, we identified substrates for CYP3A4 (midazolam, erythromycin, cyclosporin, and dexamethasone) as inhibitors of catechol formation from both etoposide and teniposide. Dexamethasone 166-179 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 116-122 33773552-2 2021 Contrarily dexamethasone is metabolized by CYP3A4. Dexamethasone 11-24 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 43-49 34627953-9 2021 In contrast, the CYP3A4 inducer dexamethasone significantly increased GA metabolism and markedly decreased GA toxicity in mice. Dexamethasone 32-45 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 17-23 34791318-2 2022 Dexamethasone is both a substrate and a dose-dependent inducer of cytochrome P450 3A4 (CYP3A4). Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 87-93 34791318-3 2022 As many ARVs are substrates and/or inhibitors or inducers of CYP3A4, there is concern about DDIs with dexamethasone either as a perpetrator or a victim. Dexamethasone 102-115 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 61-67 34337735-5 2021 Dexamethasone is an inducer of CYP3A4 and glycoprotein P, thus coadministration with drugs metabolized by this isoform will lead to their increased clearance. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 31-37 34137279-4 2022 STUDY SELECTION AND DATA EXTRACTION: Included articles describe in vitro or in vivo animal or human data for dexamethasone induction of cytochrome P450 (CYP) 3A4 or P-glycoprotein (P-gp). Dexamethasone 109-122 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 136-161 34137279-5 2022 DATA SYNTHESIS: Dexamethasone has the potential to interact with the DOACs via CYP3A4 and/or P-gp induction. Dexamethasone 16-29 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 79-85 34137279-7 2022 Dexamethasone can increase CYP3A4 activity by up to 70% and reduce the area under the concentration-time curve (AUC) of CYP3A4 substrates by >40%, which is consistent with criteria for a weak CYP inducer. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 27-33 34137279-7 2022 Dexamethasone can increase CYP3A4 activity by up to 70% and reduce the area under the concentration-time curve (AUC) of CYP3A4 substrates by >40%, which is consistent with criteria for a weak CYP inducer. Dexamethasone 0-13 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 120-126 35403851-4 2022 Since Dex is metabolized by CYP3A4, the combined use of Apr and Dex inhibits Dex metabolism. Dexamethasone 6-9 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 28-34 35403851-4 2022 Since Dex is metabolized by CYP3A4, the combined use of Apr and Dex inhibits Dex metabolism. Dexamethasone 64-67 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 28-34 35403851-4 2022 Since Dex is metabolized by CYP3A4, the combined use of Apr and Dex inhibits Dex metabolism. Dexamethasone 77-80 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 28-34 35039908-0 2022 Evaluation of hepatic CYP3A enzyme activity using endogenous markers in lung cancer patients treated with cisplatin, dexamethasone, and aprepitant. Dexamethasone 117-130 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 22-27 35039908-3 2022 In addition, dexamethasone is a CYP3A4 substrate that induces CYP3A4 and CYP3A5 expression. Dexamethasone 13-26 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 32-38 35039908-3 2022 In addition, dexamethasone is a CYP3A4 substrate that induces CYP3A4 and CYP3A5 expression. Dexamethasone 13-26 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 62-68