PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31853327-16 2020 In conclusion, dexamethasone inhibited AKT/ERK phosphorylation and lenvatinib antagonism bound VEGF leading to the limitation of migration and invasion of cancer cells in NSCLC. Dexamethasone 15-28 mitogen-activated protein kinase 1 Homo sapiens 43-46 33035699-12 2020 Overexpressed ORMDL3 enhanced migration and viability, decreased E-cadherin level, increased the levels of IL-33and Vimentin, and promoted the phosphorylation of NF-kappaB and MAPK/ERK in Dex-treated 16HBE-14o cells, thus reversing the effect of Dex treatment. Dexamethasone 188-191 mitogen-activated protein kinase 1 Homo sapiens 181-184 33148907-6 2020 Dexamethasone suppressed basal levels of H1R mRNA, and histamine-induced up-regulation of H1R mRNA and ERK phosphorylation in HeLa cells. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 103-106 26693911-0 2016 Dexamethasone Inhibits TGF-beta1-Induced Cell Migration by Regulating the ERK and AKT Pathways in Human Colon Cancer Cells Via CYR61. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 74-77 27486749-9 2016 p38 MAPK (p38), c-Jun NH2-terminal kinase (JNK) and NFkB inhibitors, CsA and Dex induced a partial inhibition of HO-induced CCL2, while Dox and extracellular signal-regulated kinase (ERK) inhibitor did not. Dexamethasone 77-80 mitogen-activated protein kinase 1 Homo sapiens 144-181 27486749-9 2016 p38 MAPK (p38), c-Jun NH2-terminal kinase (JNK) and NFkB inhibitors, CsA and Dex induced a partial inhibition of HO-induced CCL2, while Dox and extracellular signal-regulated kinase (ERK) inhibitor did not. Dexamethasone 77-80 mitogen-activated protein kinase 1 Homo sapiens 183-186 31328390-5 2019 Ligand (dexamethasone or triamcinolone acetonide)-activated GR induced dual specificity phosphatase (DUSP)1 expression via the glucocorticoid response element and attenuated IL-1beta-induced galectin-1/LGALS1 expression by reducing phosphorylation of these AP-1 subunits following AKT and extracellular signal-regulated kinase (ERK)1/2 deactivation. Dexamethasone 8-21 mitogen-activated protein kinase 1 Homo sapiens 289-335 26693911-10 2016 ERK and AKT signaling pathways were found to mediate TGF-beta1-induced migration, which was inhibited by dexamethasone. Dexamethasone 105-118 mitogen-activated protein kinase 1 Homo sapiens 0-3 26693911-14 2016 CONCLUSION: These findings suggested that dexamethasone inhibits AKT and ERK phosphorylation, leading to decreased CYR61 expression, which in turn blocks TGF-beta1-induced migration. Dexamethasone 42-55 mitogen-activated protein kinase 1 Homo sapiens 73-76 26784020-3 2016 In this study, we mapped the activity of Connexin 43 to ERK and Runx2 by extracting longitudinal ligament cell for culture and silencing Connexin expression in addition to dexamethasone treatment in vitro. Dexamethasone 172-185 mitogen-activated protein kinase 1 Homo sapiens 56-59 26399569-1 2016 BACKGROUND: The effects of glucocorticoids (GCs) on the repair of the airway epithelium in asthma are controversial, and we previously reported that the GC dexamethasone (Dex) inhibits the repair of human airway epithelial cells and that this process is mediated by glucocorticoid-induced leucine zipper (GILZ) through MAPK-ERK signaling in vitro. Dexamethasone 156-169 mitogen-activated protein kinase 1 Homo sapiens 319-323 26399569-1 2016 BACKGROUND: The effects of glucocorticoids (GCs) on the repair of the airway epithelium in asthma are controversial, and we previously reported that the GC dexamethasone (Dex) inhibits the repair of human airway epithelial cells and that this process is mediated by glucocorticoid-induced leucine zipper (GILZ) through MAPK-ERK signaling in vitro. Dexamethasone 156-169 mitogen-activated protein kinase 1 Homo sapiens 324-327 26399569-1 2016 BACKGROUND: The effects of glucocorticoids (GCs) on the repair of the airway epithelium in asthma are controversial, and we previously reported that the GC dexamethasone (Dex) inhibits the repair of human airway epithelial cells and that this process is mediated by glucocorticoid-induced leucine zipper (GILZ) through MAPK-ERK signaling in vitro. Dexamethasone 171-174 mitogen-activated protein kinase 1 Homo sapiens 319-323 26399569-1 2016 BACKGROUND: The effects of glucocorticoids (GCs) on the repair of the airway epithelium in asthma are controversial, and we previously reported that the GC dexamethasone (Dex) inhibits the repair of human airway epithelial cells and that this process is mediated by glucocorticoid-induced leucine zipper (GILZ) through MAPK-ERK signaling in vitro. Dexamethasone 171-174 mitogen-activated protein kinase 1 Homo sapiens 324-327 24141118-0 2013 Lactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signal-regulated kinase 1/2 and suppression of FASL, FAS, and Caspase 3. Dexamethasone 21-34 mitogen-activated protein kinase 1 Homo sapiens 121-162 26469526-3 2016 Pretreatment with basic fibroblast growth factor alone or in combination with dexamethasone 10(-9) M for 48 hr induced an enhancement of glial fibrillary acidic protein, vimetin, and ERK2 expression. Dexamethasone 78-91 mitogen-activated protein kinase 1 Homo sapiens 183-187 24647471-8 2014 The functional relevance of this in vitro data was demonstrated by neutrophil chemotaxis assays where S1P-induced effects can be significantly attenuated by pretreatment with dexamethasone, pharmacological inhibition of p38 MAPK- or ERK-mediated pathways, or by knocking down MSK-1 with siRNA. Dexamethasone 175-188 mitogen-activated protein kinase 1 Homo sapiens 224-228 24647471-8 2014 The functional relevance of this in vitro data was demonstrated by neutrophil chemotaxis assays where S1P-induced effects can be significantly attenuated by pretreatment with dexamethasone, pharmacological inhibition of p38 MAPK- or ERK-mediated pathways, or by knocking down MSK-1 with siRNA. Dexamethasone 175-188 mitogen-activated protein kinase 1 Homo sapiens 233-236 26517722-8 2015 Dexamethasone suppression of the LPS-induced IL-8 mRNA production by steroid resistant asthmatics PBMC in the presence of p38 and ERK inhibitors was evaluated by real time PCR. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 130-133 25770462-6 2015 TGF-beta-activated p38MAPK and ERK pathways cross-talked with GR pathway to augment the expression of PAI-1 through enhancing DEX-induced GR phosphorylation at Ser211 in ovarian cancer cells. Dexamethasone 126-129 mitogen-activated protein kinase 1 Homo sapiens 31-34 24917907-0 2014 Dexamethasone Induces Apoptosis of Nasal Polyp-Derived Tissue Cultures Through JNK and p38 MAPK Activation. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 87-90 24917907-9 2014 In the conventional MAPKs, JNK, and the phospho-p38 MAPK were significantly higher, but phospho-extracellular signal-regulated kinase (ERK)1/2 was significantly lower in DEX-treated polyps (P<0.01). Dexamethasone 170-173 mitogen-activated protein kinase 1 Homo sapiens 96-142 24917907-10 2014 CONCLUSION: DEX induces apoptosis of nasal polyp via caspase cascades, Fas-FasL signaling pathway, mitochondrial pathway and p38 MAPK/JNK pathway. Dexamethasone 12-15 mitogen-activated protein kinase 1 Homo sapiens 125-128 24335929-11 2014 Hubs of these networks were as follows: P38 mitogen-activated protein kinases (P38 MAPK), p42/p44 MAP kinase (ERK1/2) and glutathione for Network 1; protein kinase B (Akt), nuclear factor kappa B (NFkB) and ERK for Network 2; and dexamethasone, tretinoin, and cyclosporin A for Network 3. Dexamethasone 230-243 mitogen-activated protein kinase 1 Homo sapiens 110-113 24141118-12 2013 In addition, rhLF significantly prevented Dex-induced down-regulation of ERK and up-regulation of FAS, FASL, and CASP3. Dexamethasone 42-45 mitogen-activated protein kinase 1 Homo sapiens 73-76 21698455-2 2011 Employing mouse (MBA-15.4) and human (MG-63) osteoblast cell lines, we previously found that the glucocorticoid (GC) dexamethasone (Dex) inhibits cellular proliferation as well as activation of the MAPK/ERK signaling pathway, essential for mitogenesis in these cells, and that both these effects could be reversed by the protein tyrosine phosphatase (PTP) inhibitor vanadate. Dexamethasone 117-130 mitogen-activated protein kinase 1 Homo sapiens 198-202 21946312-2 2011 We previously found that dexamethasone (DEX, a synthetic GC) repressed brain-derived neurotrophic factor (BDNF)-induced synaptic proteins via suppressing extracellular signal-regulated protein kinase (ERK) signaling. Dexamethasone 25-38 mitogen-activated protein kinase 1 Homo sapiens 154-199 21946312-2 2011 We previously found that dexamethasone (DEX, a synthetic GC) repressed brain-derived neurotrophic factor (BDNF)-induced synaptic proteins via suppressing extracellular signal-regulated protein kinase (ERK) signaling. Dexamethasone 25-38 mitogen-activated protein kinase 1 Homo sapiens 201-204 21946312-2 2011 We previously found that dexamethasone (DEX, a synthetic GC) repressed brain-derived neurotrophic factor (BDNF)-induced synaptic proteins via suppressing extracellular signal-regulated protein kinase (ERK) signaling. Dexamethasone 40-43 mitogen-activated protein kinase 1 Homo sapiens 154-199 21946312-2 2011 We previously found that dexamethasone (DEX, a synthetic GC) repressed brain-derived neurotrophic factor (BDNF)-induced synaptic proteins via suppressing extracellular signal-regulated protein kinase (ERK) signaling. Dexamethasone 40-43 mitogen-activated protein kinase 1 Homo sapiens 201-204 21946312-5 2011 NSC87877, a Shp2 inhibitor, mimicked DEX, and Shp2 overexpression reversed the effect of DEX, suggesting that GCs suppress ERK signaling through inhibiting the interaction of Shp2 with TrkB. Dexamethasone 89-92 mitogen-activated protein kinase 1 Homo sapiens 123-126 22205500-8 2013 Furthermore, azithromycin and dexamethasone significantly reduced both the VEGF release and the activation of p38(MAPK) pathway in response to FGF-1 or FGF-2 treatment. Dexamethasone 30-43 mitogen-activated protein kinase 1 Homo sapiens 110-113 22205500-10 2013 Both azithromycin and dexamethasone elicited their anti-angiogenic effects via p38(MAPK) pathway in vitro, thereby suggesting a possible therapeutic approach to tackle VEGF-mediated vascular remodeling. Dexamethasone 22-35 mitogen-activated protein kinase 1 Homo sapiens 79-82 23667643-7 2013 Pre-treatment of DCs with the extracellular signal-regulated kinase (ERK) inhibitor U0126 abolished cooperative induction of IL-10 by DEX and NDV. Dexamethasone 134-137 mitogen-activated protein kinase 1 Homo sapiens 69-72 22406872-6 2012 In cultured HLE-B3 cells, DEX largely inhibited TGF-beta2-induced cell migration and MMP activity, probably by inhibiting the ERK/MAPK pathway. Dexamethasone 26-29 mitogen-activated protein kinase 1 Homo sapiens 126-129 22406872-6 2012 In cultured HLE-B3 cells, DEX largely inhibited TGF-beta2-induced cell migration and MMP activity, probably by inhibiting the ERK/MAPK pathway. Dexamethasone 26-29 mitogen-activated protein kinase 1 Homo sapiens 130-134 21493783-6 2011 Moreover, TNF-alpha led to up-regulation of the ERK1/ERK2 and p38 MAPKs pathways, with only the latter being sensitive to pretreatment with the glucocorticoid dexamethasone. Dexamethasone 159-172 mitogen-activated protein kinase 1 Homo sapiens 53-57 21493783-6 2011 Moreover, TNF-alpha led to up-regulation of the ERK1/ERK2 and p38 MAPKs pathways, with only the latter being sensitive to pretreatment with the glucocorticoid dexamethasone. Dexamethasone 159-172 mitogen-activated protein kinase 1 Homo sapiens 62-65 21698455-2 2011 Employing mouse (MBA-15.4) and human (MG-63) osteoblast cell lines, we previously found that the glucocorticoid (GC) dexamethasone (Dex) inhibits cellular proliferation as well as activation of the MAPK/ERK signaling pathway, essential for mitogenesis in these cells, and that both these effects could be reversed by the protein tyrosine phosphatase (PTP) inhibitor vanadate. Dexamethasone 117-130 mitogen-activated protein kinase 1 Homo sapiens 203-206 21698455-2 2011 Employing mouse (MBA-15.4) and human (MG-63) osteoblast cell lines, we previously found that the glucocorticoid (GC) dexamethasone (Dex) inhibits cellular proliferation as well as activation of the MAPK/ERK signaling pathway, essential for mitogenesis in these cells, and that both these effects could be reversed by the protein tyrosine phosphatase (PTP) inhibitor vanadate. Dexamethasone 132-135 mitogen-activated protein kinase 1 Homo sapiens 198-202 21698455-2 2011 Employing mouse (MBA-15.4) and human (MG-63) osteoblast cell lines, we previously found that the glucocorticoid (GC) dexamethasone (Dex) inhibits cellular proliferation as well as activation of the MAPK/ERK signaling pathway, essential for mitogenesis in these cells, and that both these effects could be reversed by the protein tyrosine phosphatase (PTP) inhibitor vanadate. Dexamethasone 132-135 mitogen-activated protein kinase 1 Homo sapiens 203-206 21209015-10 2011 Ameliorating the Dex-induced reduction in ERK or Akt activity by cotreatment with vitamin C or insulin protected against the Dex-induced reduction in cell number. Dexamethasone 17-20 mitogen-activated protein kinase 1 Homo sapiens 42-45 21209015-10 2011 Ameliorating the Dex-induced reduction in ERK or Akt activity by cotreatment with vitamin C or insulin protected against the Dex-induced reduction in cell number. Dexamethasone 125-128 mitogen-activated protein kinase 1 Homo sapiens 42-45 20605057-0 2010 Dexamethasone enhances the norepinephrine-induced ERK/MAPK intracellular pathway possibly via dysregulation of the alpha2-adrenergic receptor: implications for antidepressant drug mechanism of action. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 50-53 20605057-3 2010 To investigate the interaction between GCs and NE, the plasticity-relevant ERK/MAPK pathway was studied in SH-SY5Y neuroblastoma cells treated with dexamethasone (DEX), a synthetic GC, NE, or both. Dexamethasone 148-161 mitogen-activated protein kinase 1 Homo sapiens 75-78 20363256-9 2010 We demonstrate rimexolone and dexamethasone to impair T-cell signalling pathways by rapid non-genomic suppression of the phosphorylation of Akt, p38 and ERK. Dexamethasone 30-43 mitogen-activated protein kinase 1 Homo sapiens 153-156 17513787-4 2007 Dexamethasone (10(-8)-10(-5) M) partially inhibited GRO-alpha expression and release induced by IL-1beta and TNF-alpha; this was associated with an inhibition of JNK, but not of p38 or ERK phosphorylation. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 185-188 20448266-7 2010 In contrast, dexamethasone (DEX) binding was increased in HH at the beginning of the treatment, with following transient activation of extracellular signal-regulated kinase (ERK). Dexamethasone 13-26 mitogen-activated protein kinase 1 Homo sapiens 135-172 20448266-7 2010 In contrast, dexamethasone (DEX) binding was increased in HH at the beginning of the treatment, with following transient activation of extracellular signal-regulated kinase (ERK). Dexamethasone 13-26 mitogen-activated protein kinase 1 Homo sapiens 174-177 20448266-7 2010 In contrast, dexamethasone (DEX) binding was increased in HH at the beginning of the treatment, with following transient activation of extracellular signal-regulated kinase (ERK). Dexamethasone 28-31 mitogen-activated protein kinase 1 Homo sapiens 135-172 20448266-7 2010 In contrast, dexamethasone (DEX) binding was increased in HH at the beginning of the treatment, with following transient activation of extracellular signal-regulated kinase (ERK). Dexamethasone 28-31 mitogen-activated protein kinase 1 Homo sapiens 174-177 19438323-6 2009 Blockage of ERK phosphorylation in osteo-induced hASCs by PD98059 supplemented with dexamethasone (Dex) led to adipogenic differentiation, as confirmed by Nile Red staining to detect intracellular lipid droplets and real-time PCR analysis for expression of adipogenesis-relative genes: peroxisome proliferator-activated receptor gamma 2 and fatty acid-binding protein. Dexamethasone 84-97 mitogen-activated protein kinase 1 Homo sapiens 12-15 19438323-6 2009 Blockage of ERK phosphorylation in osteo-induced hASCs by PD98059 supplemented with dexamethasone (Dex) led to adipogenic differentiation, as confirmed by Nile Red staining to detect intracellular lipid droplets and real-time PCR analysis for expression of adipogenesis-relative genes: peroxisome proliferator-activated receptor gamma 2 and fatty acid-binding protein. Dexamethasone 99-102 mitogen-activated protein kinase 1 Homo sapiens 12-15 18097517-0 2008 Dexamethasone suppresses DU145 cell proliferation and cell cycle through inhibition of the extracellular signal-regulated kinase 1/2 pathway and cyclin D1 expression. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 91-130 18097517-3 2008 Western blot analysis was carried out to evaluate the effects of dexamethasone on phosphorylation of extracellular signal-regulated kinase (ERK)1/2 and expression of cyclin D1 in DU145 cells with or without glucocorticoid receptor (GR) antagonist RU486. Dexamethasone 65-78 mitogen-activated protein kinase 1 Homo sapiens 101-147 20100175-8 2010 Dexamethasone and RU24858 both reduced IL-1beta-induced ERK phosphorylation and increased MKP-1 (MAPK phosphatase-1) expression. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 56-59 18403484-5 2008 Using Western blot analysis, we found that dexamethasone rapidly activates ERK, c-jun N-terminal kinase (JNK), and p38 MAPK in human umbilical vein endothelial cells. Dexamethasone 43-56 mitogen-activated protein kinase 1 Homo sapiens 75-78 18403484-7 2008 Using EMSA and a decoy oligonucleotide approach, the transcription factors activator protein-1 (activated by ERK and JNK) and cAMP response element-binding protein (activated by ERK) were found to be involved in the up-regulation of MKP-1 by dexamethasone. Dexamethasone 242-255 mitogen-activated protein kinase 1 Homo sapiens 109-112 18403484-7 2008 Using EMSA and a decoy oligonucleotide approach, the transcription factors activator protein-1 (activated by ERK and JNK) and cAMP response element-binding protein (activated by ERK) were found to be involved in the up-regulation of MKP-1 by dexamethasone. Dexamethasone 242-255 mitogen-activated protein kinase 1 Homo sapiens 178-181 17692313-5 2007 In serum-treated cells, nucleus residing Sgk and Erk/MAPK were both hyperphosphorylated, indicative of their active states, whereas, in dexamethasone-treated cells Erk/MAPK, but not Sgk, was in its inactive hypophosphorylated state. Dexamethasone 136-149 mitogen-activated protein kinase 1 Homo sapiens 164-167 16164824-8 2005 Both the immune complex inhibitory activity and dexamethasone stimulatory properties depend on NF-kappaB/XIAP and Ras/MEK/ERK/CD95 pathways. Dexamethasone 48-61 mitogen-activated protein kinase 1 Homo sapiens 122-125 16949835-0 2006 Roles of p38 and ERK MAP kinases in IL-8 expression in TNF-alpha- and dexamethasone-stimulated human periodontal ligament cells. Dexamethasone 70-83 mitogen-activated protein kinase 1 Homo sapiens 17-20 16949835-8 2006 In addition, dexamethasone inhibited TNF-alpha-induced phosphorylation of p38 MAP kinase and extracellular-regulated kinases (ERKs), IkappaB degradation, and NF-kappaB activation. Dexamethasone 13-26 mitogen-activated protein kinase 1 Homo sapiens 126-130 17391526-5 2007 RESULTS: The glucocorticoid-resistant clone CEM-C1-15 displays a combination of high constitutive JNK activity and dexamethasone-induced ERK activity with a weak induction of p38 upon glucocorticoid treatment. Dexamethasone 115-128 mitogen-activated protein kinase 1 Homo sapiens 137-140 17143528-5 2007 Pretreatment with 10 microM of dexamethasone inhibited ERK activation and subsequent retinoblastoma protein (pRB) phosphorylation, and reduced sensitivity to paclitaxel in A549 cells. Dexamethasone 31-44 mitogen-activated protein kinase 1 Homo sapiens 55-58 17143528-8 2007 Dexamethasone (10 microM) suppressed ERK activity as well as PD98059, although it did not affect AKT activity. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 37-40 17143528-10 2007 Our observation in this study raised the possibility that dexamethasone pretreatment antagonizes paclitaxel-induced cytotoxicity through ERK suppression and pRB dephosphorylation. Dexamethasone 58-71 mitogen-activated protein kinase 1 Homo sapiens 137-140 15817653-4 2005 We show that Dex and DAC stimulate p38 MAPK phosphorylation and increase the mRNA of MAPK kinase 3, a specific immediate upstream activator of p38 MAPK. Dexamethasone 13-16 mitogen-activated protein kinase 1 Homo sapiens 39-43 16091124-10 2005 Furthermore, Dex-DC sustained the capability of high phosphorylation of ERK and IL-10 production 5 days after Dex removal. Dexamethasone 13-16 mitogen-activated protein kinase 1 Homo sapiens 72-75 15817653-4 2005 We show that Dex and DAC stimulate p38 MAPK phosphorylation and increase the mRNA of MAPK kinase 3, a specific immediate upstream activator of p38 MAPK. Dexamethasone 13-16 mitogen-activated protein kinase 1 Homo sapiens 85-89 15266821-11 2004 Using Western blot analysis, we found that dexamethasone resulted in decreased activity of ERK, but had no effects on JNK and p38. Dexamethasone 43-56 mitogen-activated protein kinase 1 Homo sapiens 91-94 15733153-11 2005 In addition, NS-398, dexamethasone, OTZ, herbimycin A, and curcumin were found to inhibit the nicotine-induced ERK expression (p<0.05). Dexamethasone 21-34 mitogen-activated protein kinase 1 Homo sapiens 111-114 15733153-13 2005 In addition, nicotine-induced ERK expression was down-regulated by NS-398, dexamethasone, OTZ, herbimycin A, and curcumin. Dexamethasone 75-88 mitogen-activated protein kinase 1 Homo sapiens 30-33 15536411-16 2004 CONCLUSIONS: These data are compatible with the hypothesis that superantigen-induced corticosteroid resistance involves the Raf-MEK-ERK1/ERK2 pathway of T-cell receptor signaling, which leads to GCRalpha phosphorylation and inhibition of dexamethasone-induced GCRalpha nuclear translocation. Dexamethasone 238-251 mitogen-activated protein kinase 1 Homo sapiens 137-141 15266821-12 2004 CONCLUSIONS: Dexamethasone may suppresses the proliferation of lung fibroblast cells, which is partly resulted from the facts that it can inhibit ERK activation in MAPK-signaling pathway but has little effect on JNK and p38 pathway. Dexamethasone 13-26 mitogen-activated protein kinase 1 Homo sapiens 146-149 15266821-12 2004 CONCLUSIONS: Dexamethasone may suppresses the proliferation of lung fibroblast cells, which is partly resulted from the facts that it can inhibit ERK activation in MAPK-signaling pathway but has little effect on JNK and p38 pathway. Dexamethasone 13-26 mitogen-activated protein kinase 1 Homo sapiens 164-168 14717776-7 2004 Interestingly, simultaneous inhibition of p38 and ERK1/2 strongly sensitized PCL cells for dexamethasone-induced apoptosis. Dexamethasone 91-104 mitogen-activated protein kinase 1 Homo sapiens 42-45 12478895-0 2002 [Rapid inhibition of extracellular signal-regulated kinase 1/2 in a human ovarian cancer cell line by dexamethasone]. Dexamethasone 102-115 mitogen-activated protein kinase 1 Homo sapiens 21-62 14966571-5 2004 The amount of signaling through the MAPK pathway was critical in determining the effect of Dex on T cell activation. Dexamethasone 91-94 mitogen-activated protein kinase 1 Homo sapiens 36-40 14966571-6 2004 In particular, costimulatory signaling via MAPK kinase (MEK) and extracellular signal-regulated kinase (ERK) was essential for the development of T cell resistance to Dex. Dexamethasone 167-170 mitogen-activated protein kinase 1 Homo sapiens 65-102 14966571-6 2004 In particular, costimulatory signaling via MAPK kinase (MEK) and extracellular signal-regulated kinase (ERK) was essential for the development of T cell resistance to Dex. Dexamethasone 167-170 mitogen-activated protein kinase 1 Homo sapiens 104-107 14623288-2 2003 We demonstrated that dexamethasone, which enhances steroidogenesis by up-regulation of the p450scc enzyme system, stimulates the MAPK cascade by phosphorylation of ERK1, ERK2 as well as by Akt phosphorylation within 1-5min with no effect on p38 MAPK phosphorylation. Dexamethasone 21-34 mitogen-activated protein kinase 1 Homo sapiens 170-174 14623288-2 2003 We demonstrated that dexamethasone, which enhances steroidogenesis by up-regulation of the p450scc enzyme system, stimulates the MAPK cascade by phosphorylation of ERK1, ERK2 as well as by Akt phosphorylation within 1-5min with no effect on p38 MAPK phosphorylation. Dexamethasone 21-34 mitogen-activated protein kinase 1 Homo sapiens 241-244 12538600-3 2003 Dexamethasone (Dex) rapidly (<2 h) inhibits the sustained phase of ERK activation, required for nuclear shift and mitogenesis. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 70-73 12538600-3 2003 Dexamethasone (Dex) rapidly (<2 h) inhibits the sustained phase of ERK activation, required for nuclear shift and mitogenesis. Dexamethasone 0-3 mitogen-activated protein kinase 1 Homo sapiens 70-73 12538600-5 2003 Phosphatase activity was up-regulated by Dex treatment, and inhibition of ERK activity by Dex was also reversed by the protein tyrosine phosphatase inhibitor, vanadate. Dexamethasone 90-93 mitogen-activated protein kinase 1 Homo sapiens 74-77 12270934-1 2002 We demonstrate that exposure of post-confluent 3T3-L1 preadipocytes to insulin, isobutylmethylxanthine (MIX), dexamethasone (DEX), and fetal bovine serum induces a rapid but transient activation of MEK1 as indicated by extensive phosphorylation of ERK1 and ERK2 during the initial 2 h of adipogenesis. Dexamethasone 125-128 mitogen-activated protein kinase 1 Homo sapiens 257-261 12204894-6 2002 In addition, we found that dexamethasone decreases activity of extracellular signal-related kinase (ERK)/mitogen-activated protein kinase (MAPK). Dexamethasone 27-40 mitogen-activated protein kinase 1 Homo sapiens 63-98 12204894-6 2002 In addition, we found that dexamethasone decreases activity of extracellular signal-related kinase (ERK)/mitogen-activated protein kinase (MAPK). Dexamethasone 27-40 mitogen-activated protein kinase 1 Homo sapiens 100-103 12204894-6 2002 In addition, we found that dexamethasone decreases activity of extracellular signal-related kinase (ERK)/mitogen-activated protein kinase (MAPK). Dexamethasone 27-40 mitogen-activated protein kinase 1 Homo sapiens 139-143 12478895-5 2002 RESULTS: Inhibition of activation of ERK1 and ERK2 by 1 x 10(-7) mol/L Dex occurred synchronously at 5 min, with maximum up to 41% and 54%, respectively at 30 min compared with the control (P < 0.001), and sustained until 4 h. The effect increased with the increasement of concentration of Dex (1 x 10(-10)-1 x 10(-6) mol/L). Dexamethasone 293-296 mitogen-activated protein kinase 1 Homo sapiens 46-50 12875695-1 2003 OBJECTIVE: To investigate the signaling pathway through testing the effects of dexamethasone (Dex) on the activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2) and p38 kinase (p38) in HO-8910 cells. Dexamethasone 79-92 mitogen-activated protein kinase 1 Homo sapiens 187-190 12875695-1 2003 OBJECTIVE: To investigate the signaling pathway through testing the effects of dexamethasone (Dex) on the activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2) and p38 kinase (p38) in HO-8910 cells. Dexamethasone 79-92 mitogen-activated protein kinase 1 Homo sapiens 199-202 12875695-1 2003 OBJECTIVE: To investigate the signaling pathway through testing the effects of dexamethasone (Dex) on the activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2) and p38 kinase (p38) in HO-8910 cells. Dexamethasone 94-97 mitogen-activated protein kinase 1 Homo sapiens 187-190 12875695-1 2003 OBJECTIVE: To investigate the signaling pathway through testing the effects of dexamethasone (Dex) on the activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2) and p38 kinase (p38) in HO-8910 cells. Dexamethasone 94-97 mitogen-activated protein kinase 1 Homo sapiens 199-202 12875695-3 2003 RESULTS: Dex could suppress the activation of ERK1/2, while enhance the activation of p38 rapidly and strongly in a dose- and time- dependent manner. Dexamethasone 9-12 mitogen-activated protein kinase 1 Homo sapiens 86-89 12875695-5 2003 CONCLUSION: Dex has rapid effects on the activation of ERK1/2 and p38, and these effects are not mediated by GR. Dexamethasone 12-15 mitogen-activated protein kinase 1 Homo sapiens 66-69 12697421-8 2003 In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA. Dexamethasone 37-50 mitogen-activated protein kinase 1 Homo sapiens 207-210 12697421-8 2003 In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA. Dexamethasone 37-50 mitogen-activated protein kinase 1 Homo sapiens 215-218 12697421-8 2003 In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA. Dexamethasone 52-55 mitogen-activated protein kinase 1 Homo sapiens 207-210 12697421-8 2003 In addition, anti-inflammatory drugs dexamethasone (DEX) and cyclosporin A (CSA) both blocked activation of JNKS/SAPK and the cell-cell contact induced production of hRPE IL-8 and MCP-1, while activation of p38 and ERK was only inhibited by DEX, but not by CSA. Dexamethasone 52-55 mitogen-activated protein kinase 1 Homo sapiens 215-218 12270934-1 2002 We demonstrate that exposure of post-confluent 3T3-L1 preadipocytes to insulin, isobutylmethylxanthine (MIX), dexamethasone (DEX), and fetal bovine serum induces a rapid but transient activation of MEK1 as indicated by extensive phosphorylation of ERK1 and ERK2 during the initial 2 h of adipogenesis. Dexamethasone 110-123 mitogen-activated protein kinase 1 Homo sapiens 257-261 12478895-5 2002 RESULTS: Inhibition of activation of ERK1 and ERK2 by 1 x 10(-7) mol/L Dex occurred synchronously at 5 min, with maximum up to 41% and 54%, respectively at 30 min compared with the control (P < 0.001), and sustained until 4 h. The effect increased with the increasement of concentration of Dex (1 x 10(-10)-1 x 10(-6) mol/L). Dexamethasone 71-74 mitogen-activated protein kinase 1 Homo sapiens 46-50 11923227-14 2002 Because the LPS-induced p-ERK level was reduced by Dex treatment, its expression seems to be associated with ocular inflammatory stimulus. Dexamethasone 51-54 mitogen-activated protein kinase 1 Homo sapiens 26-29 11012613-3 2000 In the present study, we investigated the effect of dexamethasone on three mitogen-activated protein kinases (MAPK) involved in the intracellular signalling pathway: c-Jun NH2-terminal kinase (JNK), p38 MAPK and extracellular signal-regulated kinase (ERK). Dexamethasone 52-65 mitogen-activated protein kinase 1 Homo sapiens 110-114 11012613-6 2000 These suggest that dexamethasone-induced JNK1/2 and p38 MAPK activation are not crucial to the induction of apoptosis. Dexamethasone 19-32 mitogen-activated protein kinase 1 Homo sapiens 56-60 11012613-10 2000 We therefore conclude that dexamethasone-induced apoptosis and activation of JNK and p38 MAPK activity in eosinophils are regulated by caspases but not through the common apoptosis-related caspase-3, -8 as in other cell types. Dexamethasone 27-40 mitogen-activated protein kinase 1 Homo sapiens 89-93 11739613-7 2001 Indeed, DEX reduced PDGF-induced phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2). Dexamethasone 8-11 mitogen-activated protein kinase 1 Homo sapiens 52-94 7588209-5 1995 Dexamethasone (100 nM) for 24 h decreases by 50-75% GH-induced tyrosyl phosphorylation of mitogen-activated protein kinases ERK1 and ERK2, the transcription factor Stat3/APRF, the GH receptor-associated tyrosine kinase JAK2, and the GH receptor. Dexamethasone 0-13 mitogen-activated protein kinase 1 Homo sapiens 133-137 10722699-9 2000 Taken together, we hypothesize that oxidative stress impairs Na(+) transport activity by inhibiting dexamethasone-dependent alpha-ENaC GRE activation via both ERK-dependent and thioredoxin-sensitive pathways. Dexamethasone 100-113 mitogen-activated protein kinase 1 Homo sapiens 159-162 10518034-3 1999 Here we show that the synthetic glucocorticoid dexamethasone (Dex) and retinoic acid (RA) inhibit the activation of c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) signalling pathways by the pro-angiogenic agents tumor necrosis factor and vascular endothelial growth factor in endothelial cells. Dexamethasone 47-60 mitogen-activated protein kinase 1 Homo sapiens 150-180 10518034-3 1999 Here we show that the synthetic glucocorticoid dexamethasone (Dex) and retinoic acid (RA) inhibit the activation of c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) signalling pathways by the pro-angiogenic agents tumor necrosis factor and vascular endothelial growth factor in endothelial cells. Dexamethasone 47-60 mitogen-activated protein kinase 1 Homo sapiens 182-185 10518034-3 1999 Here we show that the synthetic glucocorticoid dexamethasone (Dex) and retinoic acid (RA) inhibit the activation of c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) signalling pathways by the pro-angiogenic agents tumor necrosis factor and vascular endothelial growth factor in endothelial cells. Dexamethasone 62-65 mitogen-activated protein kinase 1 Homo sapiens 150-180 10518034-3 1999 Here we show that the synthetic glucocorticoid dexamethasone (Dex) and retinoic acid (RA) inhibit the activation of c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) signalling pathways by the pro-angiogenic agents tumor necrosis factor and vascular endothelial growth factor in endothelial cells. Dexamethasone 62-65 mitogen-activated protein kinase 1 Homo sapiens 182-185 34567410-6 2021 DEXA inhibited extracellular-signal-regulated kinase 1/2 (ERK1/2) and cAMP response element binding protein (CREB) phosphorylation, and artemisinin treatment promoted their activation in a concentration-dependent manner. Dexamethasone 0-4 mitogen-activated protein kinase 1 Homo sapiens 15-56 35409154-8 2022 MAPK-ERK pathway inhibitors were demonstrated to enhance the results of dexamethasone therapy in preclinical ALL studies. Dexamethasone 72-85 mitogen-activated protein kinase 1 Homo sapiens 5-8 32253606-6 2021 Furthermore, hesperetin activated ERK signal pathway in DEX-treated BMSCs. Dexamethasone 56-59 mitogen-activated protein kinase 1 Homo sapiens 34-37 32253606-7 2021 ERK inhibitor U0126 could abolish the protective effect of hesperein in DEX-treated BMSCs. Dexamethasone 72-75 mitogen-activated protein kinase 1 Homo sapiens 0-3