PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22703557-4 2013 RESULTS: Here, we report that the effects of dexamethasone on mitochondrial function and gluconeogenesis in hepatoma cells are dependent on the mitochondrial fission protein dynamin-related protein 1 (Drp1). Dexamethasone 45-58 dynamin 1-like Mus musculus 174-199 22703557-4 2013 RESULTS: Here, we report that the effects of dexamethasone on mitochondrial function and gluconeogenesis in hepatoma cells are dependent on the mitochondrial fission protein dynamin-related protein 1 (Drp1). Dexamethasone 45-58 dynamin 1-like Mus musculus 201-205 22703557-6 2013 Under these conditions, dexamethasone altered mitochondrial morphology, which was paralleled by a large increase in Drp1 expression, and reduced mitofusin 1 (Mfn1) and Mfn2. Dexamethasone 24-37 dynamin 1-like Mus musculus 116-120 22703557-7 2013 In vivo dexamethasone treatment also enhanced Drp1 expression in mouse liver. Dexamethasone 8-21 dynamin 1-like Mus musculus 46-50 22703557-8 2013 On the basis of these observations, we analyzed the dependence on the Drp1 function of dexamethasone effects on mitochondrial respiration and gluconeogenesis. Dexamethasone 87-100 dynamin 1-like Mus musculus 70-74 22703557-9 2013 We show that the increase in mitochondrial respiration and gluconeogenesis induced by dexamethasone are hampered by the inhibition of Drp1 function. Dexamethasone 86-99 dynamin 1-like Mus musculus 134-138 22703557-11 2013 CONCLUSION: In summary, we demonstrate that the mitochondrial effects of dexamethasone both on mitochondrial respiration and on the gluconeogenic pathway depend on Drp1. Dexamethasone 73-86 dynamin 1-like Mus musculus 164-168 28942921-7 2017 Mice lacking myeloid Drp1 showed defective efferocytosis and its pathologic consequences in the thymus after dexamethasone treatment and in advanced atherosclerotic lesions in fat-fed Ldlr-/- mice. Dexamethasone 109-122 dynamin 1-like Mus musculus 21-25