PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32530039-0 2020 JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation. Dexamethasone 54-67 Janus kinase 1 Mus musculus 0-3 32530039-6 2020 We recently reported that cytokine-induced JAK/STAT signaling mediates DEX resistance in T cell acute lymphoblastic leukemia (T-ALL) cells, and that this could be effectively reversed by RUX. Dexamethasone 71-74 Janus kinase 1 Mus musculus 43-46 32530039-7 2020 Based on these findings, we hypothesized that cytokine-mediated JAK/STAT signaling might similarly contribute to DEX resistance in HLH and that RUX treatment would overcome this phenomenon. Dexamethasone 113-116 Janus kinase 1 Mus musculus 64-67 18362173-6 2008 Three mutations that were studied promoted JAK1 gain of function and conferred interleukin (IL)-3-independent growth in Ba/F3 cells and/or IL-9-independent resistance to dexamethasone-induced apoptosis in T cell lymphoma BW5147 cells. Dexamethasone 170-183 Janus kinase 1 Mus musculus 43-47