PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15321787-10 2004 IFN-gamma- and TNF-alpha-induced JNK phosphorylation remained unaltered in the presence of TGF-beta but was inhibited by dexamethasone, indicating that JNK is not involved in TGF-beta- or dexamethasone-mediated regulation of FKN production. Dexamethasone 121-134 mitogen-activated protein kinase 8 Homo sapiens 33-36 17391526-7 2007 Treatments 1-3 in combination with dexamethasone alter the intracellular balance of phospho-MAPKs by lowering JNK phosphorylation and increasing the level of glucocorticoid receptor phosphorylated at serine 211, a modification known to enhance receptor activity. Dexamethasone 35-48 mitogen-activated protein kinase 8 Homo sapiens 110-113 16934508-12 2007 Slow activation of JNK in constitutive apoptosis as well as a similar tendency in dexamethasone-induced eosinophil apoptosis could be observed by Western blot analyses. Dexamethasone 82-95 mitogen-activated protein kinase 8 Homo sapiens 19-22 15590693-8 2005 Blocking Dex-induced MKP-1 induction using small interfering RNA increased ERK1/2 and JNK phosphorylation and decreased cell survival. Dexamethasone 9-12 mitogen-activated protein kinase 8 Homo sapiens 86-89 9343388-7 1997 Furthermore, we demonstrate that dexamethasone, which inhibits the production of cytokines, including TNF-alpha, significantly inhibits LPS induction of JNK/SAPK activity but not that of p38, ERK1 and ERK2, or MEK3, MEK4, or MEK6. Dexamethasone 33-46 mitogen-activated protein kinase 8 Homo sapiens 153-156 15476200-9 2004 Dexamethasone rapidly and sustainably up-regulated MKP-1, and this also coincided with down-regulation of ERK, JNK, and p38 MAPK phosphorylation. Dexamethasone 0-13 mitogen-activated protein kinase 8 Homo sapiens 111-114 15476200-10 2004 In addition, dexamethasone augmented IL-1beta-induced up-regulation of MKP-1, and this was associated with inhibition of ERK, JNK, and p38 MAPK phosphorylation and IL-6 expression. Dexamethasone 13-26 mitogen-activated protein kinase 8 Homo sapiens 126-129 14688340-8 2004 Studies conducted to understand the regulation of AP-1 and NF-kappaB activation by JNK MAPK revealed that both DXM and SP600125 inhibited IL-12p40 gene transcription by inhibiting the activation of AP-1 and NF-kappaB transcription factors as revealed by luciferase reporter and gel mobility shift assays. Dexamethasone 111-114 mitogen-activated protein kinase 8 Homo sapiens 83-86 14688340-9 2004 Taken together, our results suggest that DXM may inhibit IL-12p40 production in LPS-stimulated human monocytic cells by down-regulating the activation of JNK MAPK, the AP-1, and NF-kappaB transcription factors. Dexamethasone 41-44 mitogen-activated protein kinase 8 Homo sapiens 154-157 12351702-3 2002 Here we demonstrate that activated JNK phosphorylates human GR at Ser226 and enhances its nuclear export after withdrawal of a ligand for GR, dexamethasone. Dexamethasone 142-155 mitogen-activated protein kinase 8 Homo sapiens 35-38 11012613-0 2000 Role of caspases in dexamethasone-induced apoptosis and activation of c-Jun NH2-terminal kinase and p38 mitogen-activated protein kinase in human eosinophils. Dexamethasone 20-33 mitogen-activated protein kinase 8 Homo sapiens 70-95 11012613-3 2000 In the present study, we investigated the effect of dexamethasone on three mitogen-activated protein kinases (MAPK) involved in the intracellular signalling pathway: c-Jun NH2-terminal kinase (JNK), p38 MAPK and extracellular signal-regulated kinase (ERK). Dexamethasone 52-65 mitogen-activated protein kinase 8 Homo sapiens 166-191 11012613-4 2000 We found that dexamethasone could activate JNK and p38 MAPK in a time-dependent manner but not ERK. Dexamethasone 14-27 mitogen-activated protein kinase 8 Homo sapiens 43-46 10974006-3 2000 Here, we show by confocal laser microscopy, enzymatic assays, and immunoblotting that the synthetic glucocorticoid dexamethasone inhibited tumor necrosis factor alpha (TNF-alpha)-induced phosphorylation and activation of JNK in the cytoplasm and nucleus of intact HeLa cells. Dexamethasone 115-128 mitogen-activated protein kinase 8 Homo sapiens 221-224 14688340-0 2004 Dexamethasone inhibits IL-12p40 production in lipopolysaccharide-stimulated human monocytic cells by down-regulating the activity of c-Jun N-terminal kinase, the activation protein-1, and NF-kappa B transcription factors. Dexamethasone 0-13 mitogen-activated protein kinase 8 Homo sapiens 133-156 12421945-9 2002 This conclusion was based on results derived by transfection of THP-1 cells with a dominant-negative mutant of stress-activated protein/extracellular signal-regulated kinase kinase 1, and by exposure of cells to JNK inhibitors dexamethasone and SP600125. Dexamethasone 227-240 mitogen-activated protein kinase 8 Homo sapiens 212-215 11823508-8 2002 To ascertain the role of the c-Jun N-terminal kinase (JNK) MAPK, dexamethasone, an inhibitor of JNK activation, was used, which inhibited LPS-induced B7.2 expression. Dexamethasone 65-78 mitogen-activated protein kinase 8 Homo sapiens 29-52 11823508-8 2002 To ascertain the role of the c-Jun N-terminal kinase (JNK) MAPK, dexamethasone, an inhibitor of JNK activation, was used, which inhibited LPS-induced B7.2 expression. Dexamethasone 65-78 mitogen-activated protein kinase 8 Homo sapiens 54-57 11823508-8 2002 To ascertain the role of the c-Jun N-terminal kinase (JNK) MAPK, dexamethasone, an inhibitor of JNK activation, was used, which inhibited LPS-induced B7.2 expression. Dexamethasone 65-78 mitogen-activated protein kinase 8 Homo sapiens 96-99 11012613-6 2000 These suggest that dexamethasone-induced JNK1/2 and p38 MAPK activation are not crucial to the induction of apoptosis. Dexamethasone 19-32 mitogen-activated protein kinase 8 Homo sapiens 41-47 11012613-8 2000 Moreover, Z-VAD.FMK partially inhibited dexamethasone-activated JNK and p38 MAPK activities. Dexamethasone 40-53 mitogen-activated protein kinase 8 Homo sapiens 64-67 11012613-10 2000 We therefore conclude that dexamethasone-induced apoptosis and activation of JNK and p38 MAPK activity in eosinophils are regulated by caspases but not through the common apoptosis-related caspase-3, -8 as in other cell types. Dexamethasone 27-40 mitogen-activated protein kinase 8 Homo sapiens 77-80 10518034-3 1999 Here we show that the synthetic glucocorticoid dexamethasone (Dex) and retinoic acid (RA) inhibit the activation of c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) signalling pathways by the pro-angiogenic agents tumor necrosis factor and vascular endothelial growth factor in endothelial cells. Dexamethasone 47-60 mitogen-activated protein kinase 8 Homo sapiens 116-139 10518034-3 1999 Here we show that the synthetic glucocorticoid dexamethasone (Dex) and retinoic acid (RA) inhibit the activation of c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) signalling pathways by the pro-angiogenic agents tumor necrosis factor and vascular endothelial growth factor in endothelial cells. Dexamethasone 47-60 mitogen-activated protein kinase 8 Homo sapiens 141-144 10518034-3 1999 Here we show that the synthetic glucocorticoid dexamethasone (Dex) and retinoic acid (RA) inhibit the activation of c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) signalling pathways by the pro-angiogenic agents tumor necrosis factor and vascular endothelial growth factor in endothelial cells. Dexamethasone 62-65 mitogen-activated protein kinase 8 Homo sapiens 116-139 10518034-3 1999 Here we show that the synthetic glucocorticoid dexamethasone (Dex) and retinoic acid (RA) inhibit the activation of c-Jun N-terminal kinase (JNK) and extracellular-regulated kinase (ERK) signalling pathways by the pro-angiogenic agents tumor necrosis factor and vascular endothelial growth factor in endothelial cells. Dexamethasone 62-65 mitogen-activated protein kinase 8 Homo sapiens 141-144 9343388-8 1997 Dexamethasone also blocks the sorbitol but not anisomycin stimulation of JNK/SAPK activity. Dexamethasone 0-13 mitogen-activated protein kinase 8 Homo sapiens 73-81 30897501-11 2019 Dexamethasone induced the dephosphorylation of both p38 and JNK, whereas mPGES-1 expression was downregulated by selective inhibitors of p38 only. Dexamethasone 0-13 mitogen-activated protein kinase 8 Homo sapiens 60-63 9266970-0 1997 Dexamethasone induces apoptosis of multiple myeloma cells in a JNK/SAP kinase independent mechanism. Dexamethasone 0-13 mitogen-activated protein kinase 8 Homo sapiens 63-66 9266970-8 1997 Taken together, our findings suggest that SAPK/JNK activation is not required for apoptosis in MM cells, and that there are at least two distinct apoptotic signaling pathways: (i) SAPK/JNK-associated, which is induced by IR and unaffected by IL-6; and (ii) SAPK/JNK-independent, which is induced by Dex, associated with downregulation of MAPK and p70S6K and inhibited by IL-6. Dexamethasone 299-302 mitogen-activated protein kinase 8 Homo sapiens 185-188 9266970-8 1997 Taken together, our findings suggest that SAPK/JNK activation is not required for apoptosis in MM cells, and that there are at least two distinct apoptotic signaling pathways: (i) SAPK/JNK-associated, which is induced by IR and unaffected by IL-6; and (ii) SAPK/JNK-independent, which is induced by Dex, associated with downregulation of MAPK and p70S6K and inhibited by IL-6. Dexamethasone 299-302 mitogen-activated protein kinase 8 Homo sapiens 185-188 28398098-8 2018 RESULTS: ASC mineralization in dexamethasone or vitamin D3-induced ASCs correlated with both increased ERK1/2 and JNK1/2 activation. Dexamethasone 31-44 mitogen-activated protein kinase 8 Homo sapiens 114-118 33115754-0 2020 Therapeutic targeting of pancreatic cancer stem cells by dexamethasone modulation of the MKP-1-JNK axis. Dexamethasone 57-70 mitogen-activated protein kinase 8 Homo sapiens 95-98 33115754-4 2020 Using in vitro models of CSCs and in vivo models of tumor initiation in which CSCs give rise to xenograft tumors, we show that dexamethasone induces expression of MKP-1, a MAPK phosphatase, via glucocorticoid receptor activation, thereby inactivating JNK, which is required for self-renewal and tumor-initiation by pancreatic CSCs as well as for their expression of survivin, an anti-apoptotic protein implicated in multi-drug resistance. Dexamethasone 127-140 mitogen-activated protein kinase 8 Homo sapiens 251-254 24597985-0 2014 Low-dose anisomycin sensitizes glucocorticoid-resistant T-acute lymphoblastic leukemia CEM-C1 cells to dexamethasone-induced apoptosis through activation of glucocorticoid receptor and p38-MAPK/JNK. Dexamethasone 103-116 mitogen-activated protein kinase 8 Homo sapiens 194-197 28981109-0 2017 Dexamethasone mediates pancreatic cancer progression by glucocorticoid receptor, TGFbeta and JNK/AP-1. Dexamethasone 0-13 mitogen-activated protein kinase 8 Homo sapiens 93-96 28981109-7 2017 Inhibition of each TGFbeta receptor-I, glucocorticoid receptor or JNK signaling partially reversed the dexamethasone-mediated effects, suggesting a complex signaling network. Dexamethasone 103-116 mitogen-activated protein kinase 8 Homo sapiens 66-69 24597985-6 2014 We conclude that low-dose anisomycin sensitizes GC-resistant CEM-C1 cells to DEX and this effect is mediated, at least in part, by activation of the GR-p38-MAPK/JNK signaling pathway. Dexamethasone 77-80 mitogen-activated protein kinase 8 Homo sapiens 161-164 26101183-5 2015 Furthermore, the Akt inhibitor, LY294002, partly eliminated the protective effect of puerarin on DEX-induced apoptosis, and puerarin combined with the JNK inhibitor, SP600125, suppressed DEX-induced apoptosis to a lesser extent than in the cells treated with SP600125 alone. Dexamethasone 187-190 mitogen-activated protein kinase 8 Homo sapiens 151-154 26101183-7 2015 In conclusion, puerarin prevented DEX-induced apoptosis of hFOB1.19 cells via inhibition of the JNK pathway and activation of the PI3K/Akt signaling pathway in the cells, dependent on the mitochondrial apoptotic pathway. Dexamethasone 34-37 mitogen-activated protein kinase 8 Homo sapiens 96-99 23152905-11 2012 It inhibited c-Jun N-terminal kinase (JNK) activation induced by dexamethasone and/or TNF-alpha and increased levels of GR localized to the nucleus. Dexamethasone 65-78 mitogen-activated protein kinase 8 Homo sapiens 13-36 23871663-10 2013 In rhinovirus-infected cells the combination of JNK and IKK2 inhibitors totally restored dexamethasone suppression of CXCL8 release, induction of mitogen-activated protein kinase phosphatase 1 gene expression, and GRalpha nuclear translocation. Dexamethasone 89-102 mitogen-activated protein kinase 8 Homo sapiens 48-51 22401993-7 2012 Formoterol restored Dex sensitivity by inhibiting phosphorylation of GR-Ser226 and JNK1. Dexamethasone 20-23 mitogen-activated protein kinase 8 Homo sapiens 83-87 24917907-0 2014 Dexamethasone Induces Apoptosis of Nasal Polyp-Derived Tissue Cultures Through JNK and p38 MAPK Activation. Dexamethasone 0-13 mitogen-activated protein kinase 8 Homo sapiens 79-82 24917907-10 2014 CONCLUSION: DEX induces apoptosis of nasal polyp via caspase cascades, Fas-FasL signaling pathway, mitochondrial pathway and p38 MAPK/JNK pathway. Dexamethasone 12-15 mitogen-activated protein kinase 8 Homo sapiens 134-137 23152905-11 2012 It inhibited c-Jun N-terminal kinase (JNK) activation induced by dexamethasone and/or TNF-alpha and increased levels of GR localized to the nucleus. Dexamethasone 65-78 mitogen-activated protein kinase 8 Homo sapiens 38-41 18403484-5 2008 Using Western blot analysis, we found that dexamethasone rapidly activates ERK, c-jun N-terminal kinase (JNK), and p38 MAPK in human umbilical vein endothelial cells. Dexamethasone 43-56 mitogen-activated protein kinase 8 Homo sapiens 80-103 18441094-7 2008 Dexamethasone decreased TNF-alpha-induced phosphorylation of the major MAPKs, i.e., ERK, p38, and JNK, and decreased the activation of NF-kappaB and AP-1. Dexamethasone 0-13 mitogen-activated protein kinase 8 Homo sapiens 98-101 22276160-11 2012 In addition, RITA in combination with dexamethasone, known as a JNK activator, displays synergistic cytotoxic responses in MM cell lines and patient samples. Dexamethasone 38-51 mitogen-activated protein kinase 8 Homo sapiens 64-67 18403484-5 2008 Using Western blot analysis, we found that dexamethasone rapidly activates ERK, c-jun N-terminal kinase (JNK), and p38 MAPK in human umbilical vein endothelial cells. Dexamethasone 43-56 mitogen-activated protein kinase 8 Homo sapiens 105-108 18403484-7 2008 Using EMSA and a decoy oligonucleotide approach, the transcription factors activator protein-1 (activated by ERK and JNK) and cAMP response element-binding protein (activated by ERK) were found to be involved in the up-regulation of MKP-1 by dexamethasone. Dexamethasone 242-255 mitogen-activated protein kinase 8 Homo sapiens 117-120 18403484-8 2008 Interestingly, dexamethasone induces the generation of reactive oxygen species (measured by dihydrofluorescein assay), which participate in the signaling process by triggering JNK activation. Dexamethasone 15-28 mitogen-activated protein kinase 8 Homo sapiens 176-179 17645739-6 2007 Interestingly, Dex attenuated IL-1beta-mediated activation of p38 MAPK and JNK, but not of AKT. Dexamethasone 15-18 mitogen-activated protein kinase 8 Homo sapiens 75-78 18437985-4 2008 RESULTS: Dexamethasone could induce apoptosis of fibroblasts from keloids, hypertrophic scars and normal skins through activating (phospho-) ERK1/2 and JNK pathways; IFN alpha-2b could not induce apoptosis of fibroblasts from different sources. Dexamethasone 9-22 mitogen-activated protein kinase 8 Homo sapiens 141-155 17645739-9 2007 These results suggest that Dex acts to inhibit IL-1beta-induced HBD-2 mRNA expression through blockage of the nuclear transcriptional activation of p65 NF-kappaB as well as through inactivation of p38 MAPK and JNK. Dexamethasone 27-30 mitogen-activated protein kinase 8 Homo sapiens 210-213 17568772-8 2007 Moreover, such SGK1 depletion prevented the dexamethasone-induced increase in SGK1 expression, as well as the inhibitory effects of dexamethasone on paclitaxel-induced SEK1-JNK signaling and apoptosis in MDA-MB-231 breast cancer cells. Dexamethasone 132-145 mitogen-activated protein kinase 8 Homo sapiens 173-176 17581824-10 2007 Furthermore, induction of apoptosis as well as cell detachment by dexamethasone is abolished by inhibiting the activity of JNK, a recognized downstream target of Pyk2 activation. Dexamethasone 66-79 mitogen-activated protein kinase 8 Homo sapiens 123-126 17513787-6 2007 Using MKP-1 small interfering RNA (siRNA) to block the expression of IL-1beta- and dexamethasone-induced MKP-1 by 50%, JNK phosphorylation was doubled. Dexamethasone 83-96 mitogen-activated protein kinase 8 Homo sapiens 119-122