PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15479233-2 2004 Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (<1 microm) was a poor inhibitor, but was able to efficiently antagonize the effects of dexamethasone and budesonide. Dexamethasone 20-33 mitochondrially encoded cytochrome c oxidase II Homo sapiens 177-182 16354411-7 2005 Dexamethasone (100 nM) not only inhibited PGE2, PGF(2alpha), IL-6 and IL-8 production but also strongly suppressed the expression of COX-2 mRNA and protein. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 133-138 16432508-7 2006 Dexamethasone (DEX) inhibited SP-mediated COX-2 expression. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 16432508-7 2006 Dexamethasone (DEX) inhibited SP-mediated COX-2 expression. Dexamethasone 15-18 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 16516813-6 2006 Dexamethasone suppresses almost completely the LPS-induced effects on COX-2 and mPGES-1. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-75 16352870-4 2006 Coincubation of DEX-treated arteries with INDO for 4 h reversed this DEX-induced attenuation in 5-HT contractile efficacy, although DEX had no significant effects on cyclooxygenase (COX)-1 and COX-2 protein abundance. Dexamethasone 16-19 mitochondrially encoded cytochrome c oxidase II Homo sapiens 193-198 16255020-8 2005 The addition of either TNF blockers or dexamethasone suppressed lipopolysaccharide-induced mPGES-1 and COX-2 expression in synovial fluid monocyte/macrophages in vitro and decreased the production of PGE(2). Dexamethasone 39-52 mitochondrially encoded cytochrome c oxidase II Homo sapiens 103-108 16247187-3 2005 Dexamethasone, that decreases the expression of COX-2 and mucosal generation of PGE(2), delays ulcer healing that can be reversed by the addition of small dose of exogenous PGE(2). Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 48-53 15167967-9 2004 The induction of both COX-1 and COX-2 was inhibited by dexamethasone. Dexamethasone 55-68 mitochondrially encoded cytochrome c oxidase II Homo sapiens 32-37 15038780-5 2003 Dexamethasone significantly reduced IL-1 beta, IL-6, COX-2, and MMP-1 expression at high cell density. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 53-58 12832284-7 2003 Dexamethasone inhibited COX-2 gene transcription. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 24-29 12468269-6 2002 Dexamethasone enhanced leptin release by adipocytes while inhibiting PGE(2) release and COX-2 up-regulation. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 88-93 12925150-8 2003 DEX inhibited HGF mRNA and COX-2 mRNA. Dexamethasone 0-3 mitochondrially encoded cytochrome c oxidase II Homo sapiens 27-32 12517972-8 2003 Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination. Dexamethasone 18-31 mitochondrially encoded cytochrome c oxidase II Homo sapiens 43-48 12468269-7 2002 The mechanisms involved in up-regulation of COX-2 activity during primary culture of adipocytes and the inhibition of this by dexamethasone do not appear to involve p38 MAPK or p42-44 MAPK. Dexamethasone 126-139 mitochondrially encoded cytochrome c oxidase II Homo sapiens 44-49 12432912-8 2002 The induction of COX-2 is suppressed by dexamethasone and PGJ2. Dexamethasone 40-53 mitochondrially encoded cytochrome c oxidase II Homo sapiens 17-22 12225948-7 2002 Dexamethasone and cycloheximide prevented COX-2 induction. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 42-47 11892711-6 2002 Dexamethasone markedly inhibited this peroxynitrite-mediated COX-2 expression at therapeutic concentrations. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 61-66 10678579-8 2000 Dexamethasone, antioxidants, and tumor-suppressor protein p53 suppress COX-2 expression. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 71-76 11159047-7 2001 Preventing the expression of Cox-2 by dexamethasone or blocking Cox-2 activity with the selective Cox-2 inhibitor NS398 attenuated both thromboxane formation and bronchoconstriction. Dexamethasone 38-51 mitochondrially encoded cytochrome c oxidase II Homo sapiens 29-34 10971474-13 2000 Dexamethasone and IL-10 abrogated cytokine-induced COX-2 mRNA and protein expression. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 51-56 10679307-6 2000 Dexamethasone at therapeutic concentrations markedly inhibited this NO-mediated COX-2 expression in synovial cells. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 80-85 10701683-4 2000 Combined treatment of FK506 and a low concentration of dexamethasone (DEX) (10(-9) M) down-regulated synovial COX-2 mRNA and protein expression. Dexamethasone 55-68 mitochondrially encoded cytochrome c oxidase II Homo sapiens 110-115 10701683-4 2000 Combined treatment of FK506 and a low concentration of dexamethasone (DEX) (10(-9) M) down-regulated synovial COX-2 mRNA and protein expression. Dexamethasone 70-73 mitochondrially encoded cytochrome c oxidase II Homo sapiens 110-115 10476899-11 1999 Treatment of IL-1alpha-stimulated PDL cells with dexamethasone, known to inhibit COX-2 expression, prevented PGE2 production and COX-2 mRNA expression. Dexamethasone 49-62 mitochondrially encoded cytochrome c oxidase II Homo sapiens 81-86 10484519-6 1999 Expression of COX-2 protein in unstimulated MTAL cells was attenuated by preincubation for 2 h with dexamethasone (Dex, 2 microM); however, Dex had little or no effect on COX-2 expression in cells challenged with either PMA or TNF. Dexamethasone 100-113 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-19 10484519-6 1999 Expression of COX-2 protein in unstimulated MTAL cells was attenuated by preincubation for 2 h with dexamethasone (Dex, 2 microM); however, Dex had little or no effect on COX-2 expression in cells challenged with either PMA or TNF. Dexamethasone 115-118 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-19 10484519-6 1999 Expression of COX-2 protein in unstimulated MTAL cells was attenuated by preincubation for 2 h with dexamethasone (Dex, 2 microM); however, Dex had little or no effect on COX-2 expression in cells challenged with either PMA or TNF. Dexamethasone 140-143 mitochondrially encoded cytochrome c oxidase II Homo sapiens 14-19 10476899-11 1999 Treatment of IL-1alpha-stimulated PDL cells with dexamethasone, known to inhibit COX-2 expression, prevented PGE2 production and COX-2 mRNA expression. Dexamethasone 49-62 mitochondrially encoded cytochrome c oxidase II Homo sapiens 129-134 10217524-21 1999 The induction of COX-2 protein by the cytokine mixture was attenuated by dexamethasone (100 nM), whereas the level of COX-1 protein was unaffected by either the cytokines or by dexamethasone. Dexamethasone 73-86 mitochondrially encoded cytochrome c oxidase II Homo sapiens 17-22 10383598-8 1999 Pretreatment with dexamethasone abolished IL-1beta- and BK-stimulated COX-2 induction in all cells studied. Dexamethasone 18-31 mitochondrially encoded cytochrome c oxidase II Homo sapiens 70-75 10383598-10 1999 Both IL-1beta and BK induced COX-2 expression in all cells studied and this induction was blocked by dexamethasone. Dexamethasone 101-114 mitochondrially encoded cytochrome c oxidase II Homo sapiens 29-34 10395693-9 1999 Only when LPS or IL-1 beta was removed did COX-2 mRNA decay with a t1/2 of >/=5 h. In contrast, dexamethasone promoted a faster decay of the LPS-induced COX-2 transcripts (t1/2 = 2.5 h). Dexamethasone 99-112 mitochondrially encoded cytochrome c oxidase II Homo sapiens 156-161 10381057-8 1999 Dexamethasone inhibited COX-2 mRNA expression induced by IL-1. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 24-29 10381057-10 1999 Dexamethasone was the strongest drug inhibitor of COX-2 (IC50 = 0.0073 microM). Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 50-55 10381057-15 1999 Among all drugs tested dexamethasone showed the greatest selectivity for COX-2 and meloxicam was the NSAID with the best COX-2/COX-1 ratio (r = 0.12). Dexamethasone 23-36 mitochondrially encoded cytochrome c oxidase II Homo sapiens 73-78 10381057-15 1999 Among all drugs tested dexamethasone showed the greatest selectivity for COX-2 and meloxicam was the NSAID with the best COX-2/COX-1 ratio (r = 0.12). Dexamethasone 23-36 mitochondrially encoded cytochrome c oxidase II Homo sapiens 121-126 10229670-4 1999 PGE generation by goldfish macrophages was similarly inhibited by the glucocorticoid, dexamethasone, and an inhibitor of protein synthesis, cycloheximide, suggesting that this stimulation may be due to an inducible enzyme equivalent to mammalian COX-2. Dexamethasone 86-99 mitochondrially encoded cytochrome c oxidase II Homo sapiens 246-251 9179403-15 1997 The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction. Dexamethasone 24-37 mitochondrially encoded cytochrome c oxidase II Homo sapiens 222-227 10065757-5 1999 Dexamethasone inhibited COX-2 mRNA expression, COX activity and PGE2 production in IL-1beta-stimulated cells. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 24-29 9822711-2 1998 Up-regulation of COX-2 is responsible for increased PG production in inflammation and is antagonized by corticosteriods such as dexamethasone. Dexamethasone 128-141 mitochondrially encoded cytochrome c oxidase II Homo sapiens 17-22 9822711-3 1998 In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2. Dexamethasone 108-121 mitochondrially encoded cytochrome c oxidase II Homo sapiens 145-150 9822711-4 1998 Nuclear run-off assays showed that COX-2 transcription rate was repressed 25-40% by dexamethasone, while PGE2 release, COX activity, and COX-2 protein were totally repressed. Dexamethasone 84-97 mitochondrially encoded cytochrome c oxidase II Homo sapiens 35-40 9822711-6 1998 Preinduced COX-2 mRNA was also potently repressed by dexamethasone, yet suppression of transcription by actinomycin D showed little effect. Dexamethasone 53-66 mitochondrially encoded cytochrome c oxidase II Homo sapiens 11-16 9822711-7 1998 This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486. Dexamethasone 5-18 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-64 9822711-9 1998 Following dexamethasone treatment, shortening of the average length of COX-2 mRNA poly(A) tails was observed. Dexamethasone 10-23 mitochondrially encoded cytochrome c oxidase II Homo sapiens 71-76 9822711-11 1998 In conclusion, these data indicate a major role for post-transcriptional mechanisms in the dexamethasone-dependent repression of COX-2 that require de novo glucocorticoid receptor-dependent transcription and translation. Dexamethasone 91-104 mitochondrially encoded cytochrome c oxidase II Homo sapiens 129-134 9690866-10 1998 Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved. Dexamethasone 168-181 mitochondrially encoded cytochrome c oxidase II Homo sapiens 115-118 9690866-10 1998 Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved. Dexamethasone 168-181 mitochondrially encoded cytochrome c oxidase II Homo sapiens 268-271 9690866-10 1998 Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved. Dexamethasone 168-181 mitochondrially encoded cytochrome c oxidase II Homo sapiens 273-278 9570560-7 1998 The release of PGE2 was blocked by a selective nonsteroidal inhibitor of COX-2, indicating that the enzyme is responsible for the prostanoids produced, and was inhibited by dexamethasone. Dexamethasone 173-186 mitochondrially encoded cytochrome c oxidase II Homo sapiens 73-78 9440135-8 1997 TNF-alpha-stimulated COX-2 expression and the subsequent formation of PGE2 were inhibited by dexamethasone (0.1 microM). Dexamethasone 93-106 mitochondrially encoded cytochrome c oxidase II Homo sapiens 21-26 9722548-10 1998 Finally, SC-58125 and dexamethasone reduced the growth inhibitory effect of ET-1 and TNF-alpha, indicating that activation of COX-2 is required for inhibition of HSC proliferation. Dexamethasone 22-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 126-131 9138698-13 1997 However, a mixture of cytokines (interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) each at 10 ng ml-1) induced COX-2 mRNA expression, which was maximal at 12 h and inhibited by dexamethasone (1 microM; added 30 min before the cytokines). Dexamethasone 233-246 mitochondrially encoded cytochrome c oxidase II Homo sapiens 167-172 9138096-10 1997 Dexamethasone, an inhibitor of cyclooxygenase (COX-2) expression and PGE2 synthesis, down-regulated control, constitutive levels of IGFBP-4 mRNA and protein, eliminating the previously demonstrated possibility of cross-talk between glucocorticoid receptor (GR) and PGE2-receptor signalling pathways. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 47-52 9117018-4 1997 COX-2 expression and PGE2 formation were inhibited by dexamethasone (2 microM), cycloheximide (10 microM), and IL-1-receptor antagonist (IL-1 ra) (250 ng/ml), independently. Dexamethasone 54-67 mitochondrially encoded cytochrome c oxidase II Homo sapiens 0-5 9138698-14 1997 Furthermore, COX-2 protein was detected 24 h after the cytokine treatment and the expression of this protein was also inhibited by dexamethasone (1 microM) and cyclohexamide (10 micrograms ml-1; added 30 min before the cytokines). Dexamethasone 131-144 mitochondrially encoded cytochrome c oxidase II Homo sapiens 13-18 9032453-10 1997 In addition, Dex (0.1 microM) was only partly effective at preventing EGF-induced COX-2 mRNA and protein expression de novo, whereas Dex completely inhibited TNF-alpha-promoted COX-2 mRNA and protein expression. Dexamethasone 13-16 mitochondrially encoded cytochrome c oxidase II Homo sapiens 82-87 9032453-10 1997 In addition, Dex (0.1 microM) was only partly effective at preventing EGF-induced COX-2 mRNA and protein expression de novo, whereas Dex completely inhibited TNF-alpha-promoted COX-2 mRNA and protein expression. Dexamethasone 133-136 mitochondrially encoded cytochrome c oxidase II Homo sapiens 177-182 8882591-4 1996 The exaggerated release of PGE2 was attenuated by cycloheximide, an inhibitor of protein synthesis or by dexamethasone, a steroid known to inhibit the induction of cyclo-oxygenase (COX-2). Dexamethasone 105-118 mitochondrially encoded cytochrome c oxidase II Homo sapiens 181-186 8995534-9 1997 In addition dexamethasone pretreatment significantly reduced both cPLA2 and COX-2 mRNA levels as well as PGE2 release following cytokine stimulation. Dexamethasone 12-25 mitochondrially encoded cytochrome c oxidase II Homo sapiens 76-81 7608556-4 1995 Dexamethasone completely inhibited IL-1-induced COX-2 mRNA expression. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 48-53 8543370-6 1995 The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA. Dexamethasone 31-44 mitochondrially encoded cytochrome c oxidase II Homo sapiens 88-93 8543370-6 1995 The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA. Dexamethasone 46-49 mitochondrially encoded cytochrome c oxidase II Homo sapiens 88-93 26028848-12 2015 An enhancement of phagocytic cells was observed following the pre exposure of cells to 1 muM dexamethasone, a glucocorticoids, In this study, histologic evidence is presented which supports the finding that COX-2 expression is upregulated in OSF specimens compared to normal oral submucosal cells. Dexamethasone 93-106 mitochondrially encoded cytochrome c oxidase II Homo sapiens 207-212 7706493-4 1995 In F-nl, incubation with the agonists PMA, LPS, or IL-1 increased COX activity and protein expression of the inducible form of COX, COX-2, and these responses were inhibited by coincubation with dexamethasone. Dexamethasone 195-208 mitochondrially encoded cytochrome c oxidase II Homo sapiens 132-137 7858842-16 1994 The glucocorticosteroid, dexamethasone (1 micro M; 30 min prior to cytokines) completely suppressed the cytokine-induced expression of COX-2 protein and activity in both primary cells and A549 cells.6. Dexamethasone 25-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 135-140 8132748-6 1994 De novo synthesis of Cox-2 polypeptide was enhanced by IL-1 beta or PMA, and dramatically suppressed by dexamethasone (dex). Dexamethasone 104-117 mitochondrially encoded cytochrome c oxidase II Homo sapiens 21-26 8132748-6 1994 De novo synthesis of Cox-2 polypeptide was enhanced by IL-1 beta or PMA, and dramatically suppressed by dexamethasone (dex). Dexamethasone 104-107 mitochondrially encoded cytochrome c oxidase II Homo sapiens 21-26 8132748-10 1994 dex markedly suppressed the induction of Cox-2 mRNA. Dexamethasone 0-3 mitochondrially encoded cytochrome c oxidase II Homo sapiens 41-46 30580627-3 2020 Among these BE derivatives, two (2a e 2c) were able to significantly decrease IFN-g (*p = 0.0391; **p = 0.0156) and 2c modulated the expression of COX-2 better than Dexamethasone (DEXA). Dexamethasone 180-184 mitochondrially encoded cytochrome c oxidase II Homo sapiens 147-152 30580627-6 2020 The presence of chorine in BE seems to be important for the ability of modulate COX-2 expression, since the ester chloride derivative 2c at 100 muM is more powerful inhibitor of COX-2 than DEXA. Dexamethasone 189-193 mitochondrially encoded cytochrome c oxidase II Homo sapiens 80-85 7792388-5 1995 Progesterone (10(-7)-10(-6) M) and dexamethasone (10(-7)-10(-6) M) inhibited basal and interleukin-1 beta-stimulated prostaglandin production, and decreased the numbers of COX-2 positive cells. Dexamethasone 35-48 mitochondrially encoded cytochrome c oxidase II Homo sapiens 172-177 8038702-5 1994 In support of this hypothesis, expression of the inducible COX-2 enzyme is selectively blocked by the potent anti-inflammatory drug dexamethasone. Dexamethasone 132-145 mitochondrially encoded cytochrome c oxidase II Homo sapiens 59-64 12907132-4 2003 The LPS-enhanced PGE2 synthesis and the expression of cPLA2 and COX-2 mRNAs were inhibited by clarithromycin, azithromycin and dexamethasone in PMNLs and MNLs. Dexamethasone 127-140 mitochondrially encoded cytochrome c oxidase II Homo sapiens 64-69 34206129-11 2021 Combined fotemustine and dexamethasone therapy showed anti-inflammatory effects by inducing the synthesis of anti-inflammatory mediators at the transcriptional and post-transcriptional levels (Western blot analysis of NFkappaB, COX-2 and PGE2 expression). Dexamethasone 25-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 228-233 33596205-14 2021 In sharp contrast, dexamethasone was able to control the capacity of pro-inflammatory cytokines, IL-1beta as well as TNFalpha, to stimulate mRNA levels of cPLA2alpha, COX-2 and mPGES-1. Dexamethasone 19-32 mitochondrially encoded cytochrome c oxidase II Homo sapiens 167-172 29059216-10 2017 DEX (1 mg/kg) also reduced the immunoexpression of cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-2, transforming growth factor (TGF)-beta, MIF, Smad 2/3, Smad 2/3 phosphorylated and NFkappaB p65 in the jugal mucosa. Dexamethasone 0-3 mitochondrially encoded cytochrome c oxidase II Homo sapiens 51-73 21664353-11 2011 A further proof was achieved by DEX inhibition for IL1-beta-stimulated IL-6 and COX-2 gene expression. Dexamethasone 32-35 mitochondrially encoded cytochrome c oxidase II Homo sapiens 80-85 22676065-5 2012 Moreover, we also found that dexamethasone combined with PEMF upregulated the mRNA expression of IGF-1 at the early stage after the stimulation of PEMF and improved the decrease of COX-2 mRNA expression induced by dexamethasone at the late stage after the stimulation of PEMF. Dexamethasone 29-42 mitochondrially encoded cytochrome c oxidase II Homo sapiens 181-186 22676065-5 2012 Moreover, we also found that dexamethasone combined with PEMF upregulated the mRNA expression of IGF-1 at the early stage after the stimulation of PEMF and improved the decrease of COX-2 mRNA expression induced by dexamethasone at the late stage after the stimulation of PEMF. Dexamethasone 214-227 mitochondrially encoded cytochrome c oxidase II Homo sapiens 181-186 22910222-0 2012 The use of anti-COX2 siRNA coated onto PLGA nanoparticles loading dexamethasone in the treatment of rheumatoid arthritis. Dexamethasone 66-79 mitochondrially encoded cytochrome c oxidase II Homo sapiens 16-20 22103778-9 2012 CONCLUSION: The combination of a COX-2 inhibitor and dexamethasone results in better pain relief 24 h after surgery in patients undergoing outpatient ACL surgery, compared to COX-2 inhibitor alone or dexamethasone alone. Dexamethasone 53-66 mitochondrially encoded cytochrome c oxidase II Homo sapiens 175-180 22103778-9 2012 CONCLUSION: The combination of a COX-2 inhibitor and dexamethasone results in better pain relief 24 h after surgery in patients undergoing outpatient ACL surgery, compared to COX-2 inhibitor alone or dexamethasone alone. Dexamethasone 200-213 mitochondrially encoded cytochrome c oxidase II Homo sapiens 33-38 24172143-6 2014 KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486. Dexamethasone 116-129 mitochondrially encoded cytochrome c oxidase II Homo sapiens 45-50 24172143-6 2014 KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486. Dexamethasone 150-163 mitochondrially encoded cytochrome c oxidase II Homo sapiens 45-50 24172143-7 2014 Overexpression of GILZ in A549 cells also inhibited hypoxia-induced COX-2 expression levels and knockdown of GILZ reduced the glucocorticoid-mediated inhibition of hypoxia-induced COX-2 expression, indicating that the inhibitory effects of dexamethasone on hypoxia-induced COX-2 are mediated by GILZ. Dexamethasone 240-253 mitochondrially encoded cytochrome c oxidase II Homo sapiens 180-185 24172143-7 2014 Overexpression of GILZ in A549 cells also inhibited hypoxia-induced COX-2 expression levels and knockdown of GILZ reduced the glucocorticoid-mediated inhibition of hypoxia-induced COX-2 expression, indicating that the inhibitory effects of dexamethasone on hypoxia-induced COX-2 are mediated by GILZ. Dexamethasone 240-253 mitochondrially encoded cytochrome c oxidase II Homo sapiens 180-185 24172143-10 2014 CONCLUSION AND IMPLICATIONS: Dexamethasone-induced upregulation of GILZ not only inhibits the hypoxic-evoked induction of COX-2 expression and cell invasion but further blocks the HIF-1 pathway by destabilizing HIF-1alpha expression. Dexamethasone 29-42 mitochondrially encoded cytochrome c oxidase II Homo sapiens 122-127 21069571-9 2011 Dexamethasone attenuated LPS-induced IL-1 beta (IC(50) = 70 nM), IL-6 (IC(50) = 58 nM) and TNF-alpha (IC(50) = 44 nM) release, whereas celecoxib, a specific COX-2 inhibitor showed marked reduction in LPS-induced PGE(2) (IC(50) = 23 nM) production. Dexamethasone 0-13 mitochondrially encoded cytochrome c oxidase II Homo sapiens 157-162 19470170-13 2009 The cox-2 inhibitor Etoricoxib was found to negate or increase the action of two other drugs (Leflunomide and Dexamethasone). Dexamethasone 110-123 mitochondrially encoded cytochrome c oxidase II Homo sapiens 4-9 16956425-11 2006 CONCLUSION: We found dexamethasone to inhibit the [Ca2+]i increase in MG-63 cells following stimulation and to reduce considerably COX-2 expression via the genomic pathway. Dexamethasone 21-34 mitochondrially encoded cytochrome c oxidase II Homo sapiens 131-136 16988013-2 2006 In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 (Mol Endocrinol 11:1245-1255, 1997) repress interleukin (IL)-1beta-induced expression of cyclooxygenase (COX)-2 and IL-8. Dexamethasone 25-38 mitochondrially encoded cytochrome c oxidase II Homo sapiens 176-198 16988013-6 2006 Analysis of IL-1beta-induced steady-state mRNA levels for IL-8 and COX-2 show that dexamethasone- and RU24858-dependent repression of these genes is attenuated by inhibitors of transcription and protein synthesis. Dexamethasone 83-96 mitochondrially encoded cytochrome c oxidase II Homo sapiens 67-72