PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22910222-0	2012	The use of anti-COX2 siRNA coated onto PLGA nanoparticles loading dexamethasone in the treatment of rheumatoid arthritis.	Dexamethasone	66-79	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	16-20	
33596205-14	2021	In sharp contrast, dexamethasone was able to control the capacity of pro-inflammatory cytokines, IL-1beta as well as TNFalpha, to stimulate mRNA levels of cPLA2alpha, COX-2 and mPGES-1.	Dexamethasone	19-32	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172	
29059216-10	2017	DEX (1 mg/kg) also reduced the immunoexpression of cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-2, transforming growth factor (TGF)-beta, MIF, Smad 2/3, Smad 2/3 phosphorylated and NFkappaB p65 in the jugal mucosa.	Dexamethasone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-73	
24172143-6	2014	KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486.	Dexamethasone	116-129	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50	
24172143-6	2014	KEY RESULTS: The hypoxia-induced increase in COX-2 protein and mRNA levels and promoter activity were suppressed by dexamethasone, and this effect of dexamethasone was antagonized by the GR antagonist RU486.	Dexamethasone	150-163	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	45-50	
24172143-7	2014	Overexpression of GILZ in A549 cells also inhibited hypoxia-induced COX-2 expression levels and knockdown of GILZ reduced the glucocorticoid-mediated inhibition of hypoxia-induced COX-2 expression, indicating that the inhibitory effects of dexamethasone on hypoxia-induced COX-2 are mediated by GILZ.	Dexamethasone	240-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185	
24172143-7	2014	Overexpression of GILZ in A549 cells also inhibited hypoxia-induced COX-2 expression levels and knockdown of GILZ reduced the glucocorticoid-mediated inhibition of hypoxia-induced COX-2 expression, indicating that the inhibitory effects of dexamethasone on hypoxia-induced COX-2 are mediated by GILZ.	Dexamethasone	240-253	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	180-185	
24172143-10	2014	CONCLUSION AND IMPLICATIONS: Dexamethasone-induced upregulation of GILZ not only inhibits the hypoxic-evoked induction of COX-2 expression and cell invasion but further blocks the HIF-1 pathway by destabilizing HIF-1alpha expression.	Dexamethasone	29-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	122-127	
22676065-5	2012	Moreover, we also found that dexamethasone combined with PEMF upregulated the mRNA expression of IGF-1 at the early stage after the stimulation of PEMF and improved the decrease of COX-2 mRNA expression induced by dexamethasone at the late stage after the stimulation of PEMF.	Dexamethasone	29-42	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186	
22676065-5	2012	Moreover, we also found that dexamethasone combined with PEMF upregulated the mRNA expression of IGF-1 at the early stage after the stimulation of PEMF and improved the decrease of COX-2 mRNA expression induced by dexamethasone at the late stage after the stimulation of PEMF.	Dexamethasone	214-227	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186	
30580627-3	2020	Among these BE derivatives, two (2a e 2c) were able to significantly decrease IFN-g (*p = 0.0391; **p = 0.0156) and 2c modulated the expression of COX-2 better than Dexamethasone (DEXA).	Dexamethasone	180-184	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	147-152	
30580627-6	2020	The presence of chorine in BE seems to be important for the ability of modulate COX-2 expression, since the ester chloride derivative 2c at 100 muM is more powerful inhibitor of COX-2 than DEXA.	Dexamethasone	189-193	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85	
26028848-12	2015	An enhancement of phagocytic cells was observed following the pre exposure of cells to 1 muM dexamethasone, a glucocorticoids, In this study, histologic evidence is presented which supports the finding that COX-2 expression is upregulated in OSF specimens compared to normal oral submucosal cells.	Dexamethasone	93-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	207-212	
22103778-9	2012	CONCLUSION: The combination of a COX-2 inhibitor and dexamethasone results in better pain relief 24 h after surgery in patients undergoing outpatient ACL surgery, compared to COX-2 inhibitor alone or dexamethasone alone.	Dexamethasone	53-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	175-180	
22103778-9	2012	CONCLUSION: The combination of a COX-2 inhibitor and dexamethasone results in better pain relief 24 h after surgery in patients undergoing outpatient ACL surgery, compared to COX-2 inhibitor alone or dexamethasone alone.	Dexamethasone	200-213	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	33-38	
21069571-9	2011	Dexamethasone attenuated LPS-induced IL-1 beta (IC(50) = 70 nM), IL-6 (IC(50) = 58 nM) and TNF-alpha (IC(50) = 44 nM) release, whereas celecoxib, a specific COX-2 inhibitor showed marked reduction in LPS-induced PGE(2) (IC(50) = 23 nM) production.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	157-162	
21664353-11	2011	A further proof was achieved by DEX inhibition for IL1-beta-stimulated IL-6 and COX-2 gene expression.	Dexamethasone	32-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85	
16352870-4	2006	Coincubation of DEX-treated arteries with INDO for 4 h reversed this DEX-induced attenuation in 5-HT contractile efficacy, although DEX had no significant effects on cyclooxygenase (COX)-1 and COX-2 protein abundance.	Dexamethasone	16-19	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	193-198	
19470170-13	2009	The cox-2 inhibitor Etoricoxib was found to negate or increase the action of two other drugs (Leflunomide and Dexamethasone).	Dexamethasone	110-123	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	4-9	
16516813-6	2006	Dexamethasone suppresses almost completely the LPS-induced effects on COX-2 and mPGES-1.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75	
16988013-2	2006	In A549 pulmonary cells, dexamethasone and the prototypical dissociated ligand RU24858 (Mol Endocrinol 11:1245-1255, 1997) repress interleukin (IL)-1beta-induced expression of cyclooxygenase (COX)-2 and IL-8.	Dexamethasone	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	176-198	
16988013-6	2006	Analysis of IL-1beta-induced steady-state mRNA levels for IL-8 and COX-2 show that dexamethasone- and RU24858-dependent repression of these genes is attenuated by inhibitors of transcription and protein synthesis.	Dexamethasone	83-96	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	67-72	
16956425-11	2006	CONCLUSION: We found dexamethasone to inhibit the [Ca2+]i increase in MG-63 cells following stimulation and to reduce considerably COX-2 expression via the genomic pathway.	Dexamethasone	21-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	131-136	
16432508-7	2006	Dexamethasone (DEX) inhibited SP-mediated COX-2 expression.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47	
16432508-7	2006	Dexamethasone (DEX) inhibited SP-mediated COX-2 expression.	Dexamethasone	15-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47	
15479233-2	2004	Conversely, whereas dexamethasone and budesonide were highly effective inhibitors of interleukin-1beta-induced cyclooxygenase (COX)/prostaglandin E synthase (PGES) activity and COX-2 expression, RU486 (<1 microm) was a poor inhibitor, but was able to efficiently antagonize the effects of dexamethasone and budesonide.	Dexamethasone	20-33	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182	
16354411-7	2005	Dexamethasone (100 nM) not only inhibited PGE2, PGF(2alpha), IL-6 and IL-8 production but also strongly suppressed the expression of COX-2 mRNA and protein.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	133-138	
16255020-8	2005	The addition of either TNF blockers or dexamethasone suppressed lipopolysaccharide-induced mPGES-1 and COX-2 expression in synovial fluid monocyte/macrophages in vitro and decreased the production of PGE(2).	Dexamethasone	39-52	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	103-108	
16247187-3	2005	Dexamethasone, that decreases the expression of COX-2 and mucosal generation of PGE(2), delays ulcer healing that can be reversed by the addition of small dose of exogenous PGE(2).	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53	
12517972-8	2003	Pretreatment with dexamethasone suppressed COX-2 expression, PGE(2) release, and COX activity induced by NS-398, Cig, IL-1beta, alone or in combination.	Dexamethasone	18-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	43-48	
12925150-8	2003	DEX inhibited HGF mRNA and COX-2 mRNA.	Dexamethasone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	27-32	
15167967-9	2004	The induction of both COX-1 and COX-2 was inhibited by dexamethasone.	Dexamethasone	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37	
12832284-7	2003	Dexamethasone inhibited COX-2 gene transcription.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29	
15038780-5	2003	Dexamethasone significantly reduced IL-1 beta, IL-6, COX-2, and MMP-1 expression at high cell density.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58	
12432912-8	2002	The induction of COX-2 is suppressed by dexamethasone and PGJ2.	Dexamethasone	40-53	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22	
12468269-6	2002	Dexamethasone enhanced leptin release by adipocytes while inhibiting PGE(2) release and COX-2 up-regulation.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93	
12468269-7	2002	The mechanisms involved in up-regulation of COX-2 activity during primary culture of adipocytes and the inhibition of this by dexamethasone do not appear to involve p38 MAPK or p42-44 MAPK.	Dexamethasone	126-139	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	44-49	
12225948-7	2002	Dexamethasone and cycloheximide prevented COX-2 induction.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	42-47	
11159047-7	2001	Preventing the expression of Cox-2 by dexamethasone or blocking Cox-2 activity with the selective Cox-2 inhibitor NS398 attenuated both thromboxane formation and bronchoconstriction.	Dexamethasone	38-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34	
11892711-6	2002	Dexamethasone markedly inhibited this peroxynitrite-mediated COX-2 expression at therapeutic concentrations.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	61-66	
10484519-6	1999	Expression of COX-2 protein in unstimulated MTAL cells was attenuated by preincubation for 2 h with dexamethasone (Dex, 2 microM); however, Dex had little or no effect on COX-2 expression in cells challenged with either PMA or TNF.	Dexamethasone	100-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19	
10971474-13	2000	Dexamethasone and IL-10 abrogated cytokine-induced COX-2 mRNA and protein expression.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	51-56	
10701683-4	2000	Combined treatment of FK506 and a low concentration of dexamethasone (DEX) (10(-9) M) down-regulated synovial COX-2 mRNA and protein expression.	Dexamethasone	55-68	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115	
10701683-4	2000	Combined treatment of FK506 and a low concentration of dexamethasone (DEX) (10(-9) M) down-regulated synovial COX-2 mRNA and protein expression.	Dexamethasone	70-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115	
10678579-8	2000	Dexamethasone, antioxidants, and tumor-suppressor protein p53 suppress COX-2 expression.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76	
10679307-6	2000	Dexamethasone at therapeutic concentrations markedly inhibited this NO-mediated COX-2 expression in synovial cells.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	80-85	
10484519-6	1999	Expression of COX-2 protein in unstimulated MTAL cells was attenuated by preincubation for 2 h with dexamethasone (Dex, 2 microM); however, Dex had little or no effect on COX-2 expression in cells challenged with either PMA or TNF.	Dexamethasone	115-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19	
10484519-6	1999	Expression of COX-2 protein in unstimulated MTAL cells was attenuated by preincubation for 2 h with dexamethasone (Dex, 2 microM); however, Dex had little or no effect on COX-2 expression in cells challenged with either PMA or TNF.	Dexamethasone	140-143	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19	
9822711-2	1998	Up-regulation of COX-2 is responsible for increased PG production in inflammation and is antagonized by corticosteriods such as dexamethasone.	Dexamethasone	128-141	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22	
10476899-11	1999	Treatment of IL-1alpha-stimulated PDL cells with dexamethasone, known to inhibit COX-2 expression, prevented PGE2 production and COX-2 mRNA expression.	Dexamethasone	49-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	81-86	
10476899-11	1999	Treatment of IL-1alpha-stimulated PDL cells with dexamethasone, known to inhibit COX-2 expression, prevented PGE2 production and COX-2 mRNA expression.	Dexamethasone	49-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134	
10395693-9	1999	Only when LPS or IL-1 beta was removed did COX-2 mRNA decay with a t1/2 of >/=5 h. In contrast, dexamethasone promoted a faster decay of the LPS-induced COX-2 transcripts (t1/2 = 2.5 h).	Dexamethasone	99-112	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	156-161	
10383598-8	1999	Pretreatment with dexamethasone abolished IL-1beta- and BK-stimulated COX-2 induction in all cells studied.	Dexamethasone	18-31	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-75	
10383598-10	1999	Both IL-1beta and BK induced COX-2 expression in all cells studied and this induction was blocked by dexamethasone.	Dexamethasone	101-114	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	29-34	
10381057-8	1999	Dexamethasone inhibited COX-2 mRNA expression induced by IL-1.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29	
10381057-10	1999	Dexamethasone was the strongest drug inhibitor of COX-2 (IC50 = 0.0073 microM).	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	50-55	
10381057-15	1999	Among all drugs tested dexamethasone showed the greatest selectivity for COX-2 and meloxicam was the NSAID with the best COX-2/COX-1 ratio (r = 0.12).	Dexamethasone	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78	
10381057-15	1999	Among all drugs tested dexamethasone showed the greatest selectivity for COX-2 and meloxicam was the NSAID with the best COX-2/COX-1 ratio (r = 0.12).	Dexamethasone	23-36	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	121-126	
10065757-5	1999	Dexamethasone inhibited COX-2 mRNA expression, COX activity and PGE2 production in IL-1beta-stimulated cells.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	24-29	
10229670-4	1999	PGE generation by goldfish macrophages was similarly inhibited by the glucocorticoid, dexamethasone, and an inhibitor of protein synthesis, cycloheximide, suggesting that this stimulation may be due to an inducible enzyme equivalent to mammalian COX-2.	Dexamethasone	86-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	246-251	
10217524-21	1999	The induction of COX-2 protein by the cytokine mixture was attenuated by dexamethasone (100 nM), whereas the level of COX-1 protein was unaffected by either the cytokines or by dexamethasone.	Dexamethasone	73-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	17-22	
9822711-3	1998	In human pulmonary A549 cells, interleukin-1beta (IL-1beta) increases prostaglandin E2 (PGE2) synthesis via dexamethasone-sensitive induction of COX-2.	Dexamethasone	108-121	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	145-150	
9822711-4	1998	Nuclear run-off assays showed that COX-2 transcription rate was repressed 25-40% by dexamethasone, while PGE2 release, COX activity, and COX-2 protein were totally repressed.	Dexamethasone	84-97	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40	
9822711-6	1998	Preinduced COX-2 mRNA was also potently repressed by dexamethasone, yet suppression of transcription by actinomycin D showed little effect.	Dexamethasone	53-66	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-16	
9822711-7	1998	This dexamethasone-dependent repression involved a reduced COX-2 mRNA half-life, was blocked by actinomycin D or cycloheximide, and was antagonized by the steroid antagonist RU38486.	Dexamethasone	5-18	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64	
9822711-9	1998	Following dexamethasone treatment, shortening of the average length of COX-2 mRNA poly(A) tails was observed.	Dexamethasone	10-23	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	71-76	
9822711-11	1998	In conclusion, these data indicate a major role for post-transcriptional mechanisms in the dexamethasone-dependent repression of COX-2 that require de novo glucocorticoid receptor-dependent transcription and translation.	Dexamethasone	91-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	129-134	
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Dexamethasone	168-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-118	
9722548-10	1998	Finally, SC-58125 and dexamethasone reduced the growth inhibitory effect of ET-1 and TNF-alpha, indicating that activation of COX-2 is required for inhibition of HSC proliferation.	Dexamethasone	22-35	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	126-131	
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Dexamethasone	168-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	268-271	
9690866-10	1998	Furthermore, the release of PGE2 in cytokine-treated astroglial cells was inhibited by indomethacin (10 microM), a COX inhibitor as well as by preincubating cells with dexamethasone (20 microM), an inhibitor of inducible enzymes, showing that the inducible isoform of COX (COX-2) was involved.	Dexamethasone	168-181	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	273-278	
9138698-13	1997	However, a mixture of cytokines (interleukin-1 beta (IL-1 beta), tumour necrosis factor alpha (TNF alpha) and interferon gamma (IFN gamma) each at 10 ng ml-1) induced COX-2 mRNA expression, which was maximal at 12 h and inhibited by dexamethasone (1 microM; added 30 min before the cytokines).	Dexamethasone	233-246	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	167-172	
9440135-8	1997	TNF-alpha-stimulated COX-2 expression and the subsequent formation of PGE2 were inhibited by dexamethasone (0.1 microM).	Dexamethasone	93-106	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26	
9179403-15	1997	The glucocorticosteroid dexamethasone and protein synthesis inhibitors, cycloheximide and actinomycin D, not only markedly inhibited IL-1 beta-stimulated PGE2 release and COX activity but also suppressed IL-1 beta-induced COX-2 induction.	Dexamethasone	24-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	222-227	
9138096-10	1997	Dexamethasone, an inhibitor of cyclooxygenase (COX-2) expression and PGE2 synthesis, down-regulated control, constitutive levels of IGFBP-4 mRNA and protein, eliminating the previously demonstrated possibility of cross-talk between glucocorticoid receptor (GR) and PGE2-receptor signalling pathways.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52	
9570560-7	1998	The release of PGE2 was blocked by a selective nonsteroidal inhibitor of COX-2, indicating that the enzyme is responsible for the prostanoids produced, and was inhibited by dexamethasone.	Dexamethasone	173-186	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	73-78	
9117018-4	1997	COX-2 expression and PGE2 formation were inhibited by dexamethasone (2 microM), cycloheximide (10 microM), and IL-1-receptor antagonist (IL-1 ra) (250 ng/ml), independently.	Dexamethasone	54-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5	
9138698-14	1997	Furthermore, COX-2 protein was detected 24 h after the cytokine treatment and the expression of this protein was also inhibited by dexamethasone (1 microM) and cyclohexamide (10 micrograms ml-1; added 30 min before the cytokines).	Dexamethasone	131-144	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	13-18	
9032453-10	1997	In addition, Dex (0.1 microM) was only partly effective at preventing EGF-induced COX-2 mRNA and protein expression de novo, whereas Dex completely inhibited TNF-alpha-promoted COX-2 mRNA and protein expression.	Dexamethasone	13-16	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87	
9032453-10	1997	In addition, Dex (0.1 microM) was only partly effective at preventing EGF-induced COX-2 mRNA and protein expression de novo, whereas Dex completely inhibited TNF-alpha-promoted COX-2 mRNA and protein expression.	Dexamethasone	133-136	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	177-182	
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dexamethasone	31-44	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93	
8882591-4	1996	The exaggerated release of PGE2 was attenuated by cycloheximide, an inhibitor of protein synthesis or by dexamethasone, a steroid known to inhibit the induction of cyclo-oxygenase (COX-2).	Dexamethasone	105-118	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	181-186	
8995534-9	1997	In addition dexamethasone pretreatment significantly reduced both cPLA2 and COX-2 mRNA levels as well as PGE2 release following cytokine stimulation.	Dexamethasone	12-25	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81	
8543370-6	1995	The anti-inflammatory steroid, dexamethasone (DEX) abolished the enhanced expression of COX-2 mRNA as well as PGE2 formation induced by IL-1 beta, PMA or the combination of IL-1 beta and PMA.	Dexamethasone	46-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	88-93	
7706493-4	1995	In F-nl, incubation with the agonists PMA, LPS, or IL-1 increased COX activity and protein expression of the inducible form of COX, COX-2, and these responses were inhibited by coincubation with dexamethasone.	Dexamethasone	195-208	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137	
7608556-4	1995	Dexamethasone completely inhibited IL-1-induced COX-2 mRNA expression.	Dexamethasone	0-13	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	48-53	
7792388-5	1995	Progesterone (10(-7)-10(-6) M) and dexamethasone (10(-7)-10(-6) M) inhibited basal and interleukin-1 beta-stimulated prostaglandin production, and decreased the numbers of COX-2 positive cells.	Dexamethasone	35-48	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	172-177	
7858842-16	1994	The glucocorticosteroid, dexamethasone (1 micro M; 30 min prior to cytokines) completely suppressed the cytokine-induced expression of COX-2 protein and activity in both primary cells and A549 cells.6.	Dexamethasone	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	135-140	
34206129-11	2021	Combined fotemustine and dexamethasone therapy showed anti-inflammatory effects by inducing the synthesis of anti-inflammatory mediators at the transcriptional and post-transcriptional levels (Western blot analysis of NFkappaB, COX-2 and PGE2 expression).	Dexamethasone	25-38	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	228-233	
8038702-5	1994	In support of this hypothesis, expression of the inducible COX-2 enzyme is selectively blocked by the potent anti-inflammatory drug dexamethasone.	Dexamethasone	132-145	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64	
8132748-6	1994	De novo synthesis of Cox-2 polypeptide was enhanced by IL-1 beta or PMA, and dramatically suppressed by dexamethasone (dex).	Dexamethasone	104-117	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26	
8132748-6	1994	De novo synthesis of Cox-2 polypeptide was enhanced by IL-1 beta or PMA, and dramatically suppressed by dexamethasone (dex).	Dexamethasone	104-107	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26	
8132748-10	1994	dex markedly suppressed the induction of Cox-2 mRNA.	Dexamethasone	0-3	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	41-46	
12907132-4	2003	The LPS-enhanced PGE2 synthesis and the expression of cPLA2 and COX-2 mRNAs were inhibited by clarithromycin, azithromycin and dexamethasone in PMNLs and MNLs.	Dexamethasone	127-140	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69