PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17951578-1 2007 Class III histone deacetylases (Sir2 or sirtuins) catalyze the NAD+-dependent conversion of acetyl-lysine residues to nicotinamide, 2"-O-acetyl-ADP-ribose (OAADPr), and deacetylated lysine. N(alpha)-acetyllysine 92-105 sirtuin 2 Homo sapiens 32-36 15128440-4 2004 The Sir2 catalytic domain, which is shared among all sirtuins, consists of two distinct domains that bind NAD and the acetyl-lysine substrate, respectively. N(alpha)-acetyllysine 118-131 sirtuin 2 Homo sapiens 4-8