PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
3350970-4	1988	Our findings help to explain the general absence of symptoms of vitamin B6 excess or deficiency in hypophosphatasia, and provide evidence that TNSALP acts as an ectoenzyme to regulate extracellular rather than intracellular concentrations of PLP (the cofactor form of vitamin B6) and perhaps other phosphate compounds.	Vitamin B 6	268-278	alkaline phosphatase, biomineralization associated	Homo sapiens	143-149	
30576866-1	2019	Hypophosphatasia (HPP) features low tissue-nonspecific alkaline phosphatase (TNSALP) isoenzyme activity resulting in extracellular accumulation of its substrates including pyridoxal 5"-phosphate (PLP), the principal circulating form of vitamin B6, and inorganic pyrophosphate (PPi), a potent inhibitor of mineralization.	Vitamin B 6	236-246	alkaline phosphatase, biomineralization associated	Homo sapiens	36-75	
32912883-6	2020	Subsequent workup revealed a low bone-specific AP and elevated vitamin B6 Subsequently, genetic testing confirmed the diagnosis of adult-onset HPP caused by a heterozygous mutation c.407G>A in the ALPL gene.	Vitamin B 6	63-73	alkaline phosphatase, biomineralization associated	Homo sapiens	197-201	
32158059-2	2020	TNSALP is expressed in the liver, kidney and bone, and its substrates include TNSALP inorganic pyrophosphate, pyridoxal-5"-phosphate (PLP)/vitamin B6 and phosphoethanolamine (PEA).	Vitamin B 6	139-149	alkaline phosphatase, biomineralization associated	Homo sapiens	0-6	
30576866-1	2019	Hypophosphatasia (HPP) features low tissue-nonspecific alkaline phosphatase (TNSALP) isoenzyme activity resulting in extracellular accumulation of its substrates including pyridoxal 5"-phosphate (PLP), the principal circulating form of vitamin B6, and inorganic pyrophosphate (PPi), a potent inhibitor of mineralization.	Vitamin B 6	236-246	alkaline phosphatase, biomineralization associated	Homo sapiens	77-83	
28391250-1	2017	Vitamin-B6-dependent epilepsies are a heterogenous group of treatable disorders due to mutations in several genes (ALDH7A1, PNPO, ALPL or ALDH4A1).	Vitamin B 6	0-10	alkaline phosphatase, biomineralization associated	Homo sapiens	130-134	
30583557-5	2018	Based on a multivariate joint analysis of all B6 vitamers and their ratios, we identified a genome-wide significant association at a locus on chromosome 1 containing the ALPL (alkaline phosphatase) gene (minimal p = 7.89 x 10-10, rs1106357, minor allele frequency (MAF) = 0.46), previously associated with vitamin B6 levels in blood.	Vitamin B 6	306-316	alkaline phosphatase, biomineralization associated	Homo sapiens	170-174	
29360619-3	2018	Thus, the natural substrates of TNSALP accumulate extracellularly in HPP including inorganic pyrophosphate (PPi), a potent inhibitor of mineralization, and pyridoxal 5"-phosphate (PLP), the principal circulating form of vitamin B6.	Vitamin B 6	220-230	alkaline phosphatase, biomineralization associated	Homo sapiens	32-38	
25147783-8	2014	For baseline measures of Vitamin B6, we identified genome-wide significant associations for SNPs at the ALPL locus (rs1697421; P = 7.06 x 10(-10) and rs1780316; P = 2.25 x 10(-08)).	Vitamin B 6	25-35	alkaline phosphatase, biomineralization associated	Homo sapiens	104-108	
25972531-13	2015	CONCLUSIONS: In healthy adults, common variants in ALPL influence plasma PLP concentration, the most frequently used biomarker for vitamin B-6 status.	Vitamin B 6	131-142	alkaline phosphatase, biomineralization associated	Homo sapiens	51-55	
19303062-5	2009	Polymorphisms in the ALPL gene (rs4654748, p = 8.30 x 10(-18)) were associated with vitamin B6 and FUT2 (rs602662, [corrected] p = 2.83 x 10(-20)) with vitamin B12 serum levels.	Vitamin B 6	84-94	alkaline phosphatase, biomineralization associated	Homo sapiens	21-25	
23479201-3	2013	TNSALP is also necessary for proper vitamin B6 metabolism and its participation as a cofactor for neurotransmitters in the central nervous system.	Vitamin B 6	36-46	alkaline phosphatase, biomineralization associated	Homo sapiens	0-6	
19303062-7	2009	The ALPL gene likely influences the catabolism of vitamin B6 while FUT2 interferes with absorption of vitamin B12.	Vitamin B 6	50-60	alkaline phosphatase, biomineralization associated	Homo sapiens	4-8	
34547524-3	2022	In HPP, diminished TNSALP activity leads to extracellular accumulation of its natural substrates including inorganic pyrophosphate (PPi), an inhibitor of mineralization, and pyridoxal 5"-phosphate (PLP), the principal circulating form of vitamin B6 (B6).	Vitamin B 6	238-248	alkaline phosphatase, biomineralization associated	Homo sapiens	19-25	
34515659-4	2021	A low serum alkaline phosphatase (ALP) and increased serum vitamin B6 level signalled the diagnosis, which was later confirmed by identification of two recessive mutations of the ALPL gene.	Vitamin B 6	59-69	alkaline phosphatase, biomineralization associated	Homo sapiens	179-183