PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15975484-13	2005	However, plasma PLP was significantly associated with immune responses after adjustment for age, sex, high-sensitivity C-reactive protein, and the other four vitamin B6 indicators.	Vitamin B 6	158-168	pyridoxal phosphatase	Homo sapiens	16-19	
17045461-8	2006	CONCLUSIONS: A borderline vitamin B6 deficiency (plasma PLP concentration <30 nmol/L) is strongly associated with the risk of CAD.	Vitamin B 6	26-36	pyridoxal phosphatase	Homo sapiens	56-59	
16336786-8	2005	We believe that these PLP phosphatase mAbs could be used as valuable immunodiagnostic reagents for the detection, identification, and characterization of various neurological diseases related to vitamin B6 abnormalities.	Vitamin B 6	195-205	pyridoxal phosphatase	Homo sapiens	22-37	
15975484-7	2005	Vitamin B6 status was assessed by direct measures (plasma pyridoxal 5"-phosphate [PLP] and 4-pyridoxic acid) and indirect measures (erythrocyte alanine and aspartate aminotransferase activity coefficients).	Vitamin B 6	0-10	pyridoxal phosphatase	Homo sapiens	82-85	
15985434-2	2005	This constitutes an essential step in the synthesis of pyridoxal 5"-phosphate (PLP), the active form of vitamin B6, a cofactor for over 140 enzymes.	Vitamin B 6	104-114	pyridoxal phosphatase	Homo sapiens	79-82	
16054880-1	2005	The sensitivity of fluorescent detection of the biologically active form of Vitamin B-6, pyridoxal 5"-phosphate (PLP), in biological samples has been improved approximately four-fold by adopting chlorite as a post-column derivatization reagent (instead of bisulfite) in high-performance liquid chromatography (HPLC) separation.	Vitamin B 6	76-87	pyridoxal phosphatase	Homo sapiens	113-116	
15911615-1	2005	Pyridoxal 5"-phosphate (PLP, vitamin B6), a cofactor in many enzymatic reactions, has two distinct biosynthetic routes, which do not coexist in any organism.	Vitamin B 6	29-39	pyridoxal phosphatase	Homo sapiens	24-27	
14522954-14	2003	Obtaining the molecular properties for the human PLP phosphatase may provide new direction for investigating metabolic pathway involving vitamin B6.	Vitamin B 6	137-147	pyridoxal phosphatase	Homo sapiens	49-64	
10771253-3	2000	Blood concentrations of homocysteine, folate, vitamin B-12 and pyridoxal-5"-phosphate (PLP, a coenzyme form of vitamin B-6) were measured, and thermolabile genotypes of 5, 10-methylenetetrahydrofolate reductase (MTHFR) were also determined.	Vitamin B 6	111-122	pyridoxal phosphatase	Homo sapiens	87-90	
11236096-1	2001	Vitamin B6, measured as pyridoxal 5"-phosphate (PLP), is a co-enzyme in the transsulfuration pathway of homocysteine metabolism.	Vitamin B 6	0-10	pyridoxal phosphatase	Homo sapiens	48-51	
9350682-6	1997	Erythrocyte vitamin B6 was determined by an indirect method, that is, by measuring the effect of pyridoxal-5-phosphate (PLP).	Vitamin B 6	12-22	pyridoxal phosphatase	Homo sapiens	120-123	
9536930-17	1998	Vitamin B6 is used therapeutically in a number of conditions with monitoring of PLP levels.	Vitamin B 6	0-10	pyridoxal phosphatase	Homo sapiens	80-83	
9598766-5	1997	Direct biomarkers of vitamin B6 intake (plasma PLP and 4-pyridoxic acid excretion) were significantly related to more functional parameters (EAST, EALT and alpha-EAST).	Vitamin B 6	21-31	pyridoxal phosphatase	Homo sapiens	47-50	
9350682-8	1997	In addition, an indirect relationship between the effect of PLP and plasma vitamin B6 was found.	Vitamin B 6	75-85	pyridoxal phosphatase	Homo sapiens	60-63	
2619068-7	1989	The method can be used for the determination of PLP in serum, even in vitamin B6 deficient patients.	Vitamin B 6	70-80	pyridoxal phosphatase	Homo sapiens	48-51	
8914491-6	1996	Plasma PLP was positively associated with vitamin B-6 intake, alcohol intake, and serum albumin, and was weakly negatively associated with body mass index.	Vitamin B 6	42-53	pyridoxal phosphatase	Homo sapiens	7-10	
34097127-4	2021	Inorganic pyrophosphate, pyridoxal 5-phosphate, the activated form of vitamin B6 (PLP), and phosphoethanolamine (PEA), are natural substrates of ALPs.	Vitamin B 6	70-80	pyridoxal phosphatase	Homo sapiens	82-85	
2243296-8	1990	Evaluation of erythrocyte transaminase activity and stimulation with PLP provide an estimate of vitamin B-6 intake over an extended period of time.	Vitamin B 6	96-107	pyridoxal phosphatase	Homo sapiens	69-72	
3940277-2	1986	Adrenalectomy resulted in decreased conversion of dietary vitamin B6 to PLP.	Vitamin B 6	58-68	pyridoxal phosphatase	Homo sapiens	72-75	
3189217-4	1988	Increased serum alkaline phosphatase (AP) and decreased dietary vitamin B-6 intake were correlated with decreased base-line plasma PLP and total vitamin B-6.	Vitamin B 6	64-75	pyridoxal phosphatase	Homo sapiens	131-134	
2756921-7	1989	Vitamin B-6 status was low (PLP less than 32 nmol/L) in 32% of this elderly population (n = 198) and could be attributed to low dietary vitamin B-6 intakes and/or the presence of health problems reported to alter vitamin B-6 status.	Vitamin B 6	0-11	pyridoxal phosphatase	Homo sapiens	28-31	
7319721-1	1981	A sensitive and reliable method for the determination of vitamin B6 as pyridoxal-5"-phosphate (PLP) in whole blood is described.	Vitamin B 6	57-67	pyridoxal phosphatase	Homo sapiens	95-98	
3591725-6	1987	This observation will aid in verifying data concerning the vitamin B-6 status assessment of individuals as determined by capillary blood plasma PLP concentrations.	Vitamin B 6	59-70	pyridoxal phosphatase	Homo sapiens	144-147	
3576625-1	1987	Pyridoxal 5"-phosphate (PLP), the active form of vitamin B6, readily forms complexes with a wide variety of potentially toxic substances, including cyanide (KCN), spermine (SPM), gentamicin (GM), and dopamine (DOP).	Vitamin B 6	49-59	pyridoxal phosphatase	Homo sapiens	24-27	
4056565-0	1985	Relationship between body store of vitamin B6 and plasma pyridoxal-P clearance: metabolic balance studies in humans.	Vitamin B 6	35-45	pyridoxal phosphatase	Homo sapiens	50-68	
4056565-12	1985	Plasma clearance of PLP, therefore, is dependent on the vitamin B6 status of an individual.	Vitamin B 6	56-66	pyridoxal phosphatase	Homo sapiens	20-23	
4055950-1	1985	The determination of pyridoxal-5-phosphate (PLP) and pyridoxal (PL) in plasma requires the availability of dark room facilities, due to the photosensitivity of these vitamin B6 vitamers.	Vitamin B 6	166-176	pyridoxal phosphatase	Homo sapiens	44-47	
4031070-4	1985	In four affected children, urinary excretion of the PLP degradation product, 4-pyridoxic acid, was unremarkable during consumption of normal quantities of dietary vitamin B6.	Vitamin B 6	163-173	pyridoxal phosphatase	Homo sapiens	52-55	
3177812-1	1988	Pyridoxal 5"-phosphate (PLP), the major coenzyme form of vitamin B6, is known to have antisickling properties in vitro.	Vitamin B 6	57-67	pyridoxal phosphatase	Homo sapiens	24-27	
3175340-5	1988	The present study may come to the following conclusions: 1) The relative activation rate of plasma AST-m activity by PLP may be a reliable index of vitamin B6 nutritional status during pregnancy.	Vitamin B 6	148-158	pyridoxal phosphatase	Homo sapiens	117-120	
3350970-4	1988	Our findings help to explain the general absence of symptoms of vitamin B6 excess or deficiency in hypophosphatasia, and provide evidence that TNSALP acts as an ectoenzyme to regulate extracellular rather than intracellular concentrations of PLP (the cofactor form of vitamin B6) and perhaps other phosphate compounds.	Vitamin B 6	268-278	pyridoxal phosphatase	Homo sapiens	242-245	
3737304-1	1986	To determine the effect of cystic fibrosis on the regulation of plasma pyridoxal 5"-phosphate (PLP), the biologically active form of vitamin B6, we measured this compound in plasma from 56 patients with cystic fibrosis.	Vitamin B 6	133-143	pyridoxal phosphatase	Homo sapiens	95-98	
3737304-6	1986	This study demonstrated that a deficiency of plasma PLP is a common abnormality in cystic fibrosis and that the low PLP level may be a reflection of impaired vitamin B6 metabolism associated with this disorder.	Vitamin B 6	158-168	pyridoxal phosphatase	Homo sapiens	116-119	
3008634-1	1986	In vitro supplementation with the active form of vitamin B6, pyridoxal-phosphate (PLP), increases measurements of both serum aminotransferase enzymes, L-aspartate: 2-oxoglutarate amino transferase, EC 2.6.1.1 (AST) and L-alanine: 2-oxoglutarate aminotransferase, EC 2.6.1.2 (ALT).	Vitamin B 6	49-59	pyridoxal phosphatase	Homo sapiens	82-85	
465370-6	1979	Treatment with PLP also effectively increased erythrocyte vitamin B6 activity.	Vitamin B 6	58-68	pyridoxal phosphatase	Homo sapiens	15-18	
834965-1	1977	Plasma concentrations of pyridoxal-5"-phosphate (PLP), the active coenzyme form of vitamin B6, were found to be markedly raised in patients with fulminant hepatic failure, when estimated within one week of the onset of symptoms.	Vitamin B 6	83-93	pyridoxal phosphatase	Homo sapiens	49-52	
675385-3	1978	The enzyme AST requires pyridoxal-5-phosphate (PLP) (active vitamin B6) as a co-enzyme to express its activity.	Vitamin B 6	60-70	pyridoxal phosphatase	Homo sapiens	47-50	
34000433-1	2021	Pyridoxal 5"-phosphate (PLP), the principal circulating form of vitamin B6 (B6), is elevated in the plasma of individuals with hypophosphatasia (HPP).	Vitamin B 6	64-74	pyridoxal phosphatase	Homo sapiens	24-27	
992265-1	1976	UNLABELLED: Pyridoxal 5"-phosphate (PLP), the coenzyme form of vitamin B6, is essential for many biochemical reactions in the body.	Vitamin B 6	63-73	pyridoxal phosphatase	Homo sapiens	36-39	
33937101-3	2021	This pathogen is unable to synthesize vitamin B6 via de-novo pathway and relies on the uptake of vitamin B6 vitamers from the host which are then phosphorylated by the enzyme pyridoxal kinase to produce PLP, the active form of vitamin B6.	Vitamin B 6	97-107	pyridoxal phosphatase	Homo sapiens	203-206	
33937101-3	2021	This pathogen is unable to synthesize vitamin B6 via de-novo pathway and relies on the uptake of vitamin B6 vitamers from the host which are then phosphorylated by the enzyme pyridoxal kinase to produce PLP, the active form of vitamin B6.	Vitamin B 6	97-107	pyridoxal phosphatase	Homo sapiens	203-206	
33318193-4	2020	Here, we report the crystal structure of the central metabolic enzyme pyridoxal kinase (PDXK), which catalyzes the production of the active form of vitamin B6 (also known as pyridoxal 5"-phosphate [PLP]), in complex with artesunate at 2.4-A resolution.	Vitamin B 6	148-158	pyridoxal phosphatase	Homo sapiens	198-201	
32788630-5	2020	Our study reveals that human PNPO has an allosteric PLP binding site that plays a crucial role in the enzyme regulation and therefore in the regulation of vitamin B6 metabolism in humans.	Vitamin B 6	155-165	pyridoxal phosphatase	Homo sapiens	52-55	
33045383-1	2020	Pyridoxal 5"-phosphate (PLP) is the active form of vitamin B6 and a cofactor for more than 140 enzymes.	Vitamin B 6	51-61	pyridoxal phosphatase	Homo sapiens	24-27	
31261385-1	2019	Pyridox (am) ine 5"-phosphate oxidase (PNPO) is a rate-limiting enzyme in converting dietary vitamin B6 (VB6) to pyridoxal 5"-phosphate (PLP), the biologically active form of VB6 and involved in the synthesis of neurotransmitters including gamma-aminobutyric acid (GABA), dopamine, and serotonin.	Vitamin B 6	93-103	pyridoxal phosphatase	Homo sapiens	137-140	
31578392-1	2019	In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5"-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions.	Vitamin B 6	47-57	pyridoxal phosphatase	Homo sapiens	109-112	
30061626-0	2018	Protective role of vitamin B6 (PLP) against DNA damage in Drosophila models of type 2 diabetes.	Vitamin B 6	19-29	pyridoxal phosphatase	Homo sapiens	31-34	
30704032-0	2019	Lactoferrin Induces the Synthesis of Vitamin B6 and Protects HUVEC Functions by Activating PDXP and the PI3K/AKT/ERK1/2 Pathway.	Vitamin B 6	37-47	pyridoxal phosphatase	Homo sapiens	91-95	
30704032-6	2019	Results showed that lactoferrin inhibited the expression of TXA2 and activated expression of PGI2, as well as activated expression of PDXP, which significantly up-regulated the synthesis of vitamin B6 (VB6) and the phosphoinositide 3-kinase (PI3K)/ serine/threonine-protein kinase (AKT)/ extracellular regulated protein kinases (ERK) 1/2 pathway.	Vitamin B 6	190-200	pyridoxal phosphatase	Homo sapiens	134-138	
30271425-1	2018	Pyridoxal 5"-phosphate (PLP), the active form of vitamin B6, works as cofactor in numerous enzymatic reactions and it behaves as antioxidant molecule.	Vitamin B 6	49-59	pyridoxal phosphatase	Homo sapiens	24-27	
30928491-1	2019	BACKGROUND: Pyridoxal 5"-phosphate (PLP) is the active form of vitamin B6.	Vitamin B 6	63-73	pyridoxal phosphatase	Homo sapiens	36-39	
29974999-4	2018	MocR-TFs control different metabolic processes involving vitamin B6 and amino acids, which are canonical ligands of PLP-dependent enzymes.	Vitamin B 6	57-67	pyridoxal phosphatase	Homo sapiens	116-119	
29724193-0	2018	Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions.	Vitamin B 6	28-38	pyridoxal phosphatase	Homo sapiens	0-10	
29689137-1	2018	Vitamin B6 -dependent genetic epilepsy was recently associated to mutations in PLPBP (previously PROSC), the human version of the widespread COG0325 gene that encodes TIM-barrel-like pyridoxal phosphate (PLP)-containing proteins of unclear function.	Vitamin B 6	0-10	pyridoxal phosphatase	Homo sapiens	79-82	
29724193-10	2018	Of note, in both cell lines CIN knockdown increased active vitamin B6 levels with vitamin B6 being known to be important for S-adenosylmethionine biosynthesis.	Vitamin B 6	59-69	pyridoxal phosphatase	Homo sapiens	28-31	
29724193-10	2018	Of note, in both cell lines CIN knockdown increased active vitamin B6 levels with vitamin B6 being known to be important for S-adenosylmethionine biosynthesis.	Vitamin B 6	82-92	pyridoxal phosphatase	Homo sapiens	28-31	
29238081-1	2017	Pyridoxine 5"-phosphate oxidase (PNPO) is an enzyme that converts pyridoxine 5"-phosphate into pyridoxal 5"-phosphate (PLP), an active form of vitamin B6 implicated in several types of cancer.	Vitamin B 6	143-153	pyridoxal phosphatase	Homo sapiens	119-122	
29098339-1	2018	This communication focusses on the synthesis of red fluorescent lysozyme cocooned gold nanoclusters (Lyso-AuNCs) that have been successfully applied for the selective and specific recognition of the vitamin B6 cofactor pyridoxal-5"-phosphate (PLP).	Vitamin B 6	199-209	pyridoxal phosphatase	Homo sapiens	243-246	
29098339-7	2018	Graphical abstract Applications of red emitting lysozyme cocooned gold nanoclusters (Lyso-AuNCs) for the selective recognition of the vitamin B6 cofactor pyridoxal-5"-phosphate (PLP) and the conjugated nano-assembly PLP_Lyso-AuNCs for turn-on detection of Zn2+ ions in various environmental and biological samples.	Vitamin B 6	134-144	pyridoxal phosphatase	Homo sapiens	178-181	
29098339-7	2018	Graphical abstract Applications of red emitting lysozyme cocooned gold nanoclusters (Lyso-AuNCs) for the selective recognition of the vitamin B6 cofactor pyridoxal-5"-phosphate (PLP) and the conjugated nano-assembly PLP_Lyso-AuNCs for turn-on detection of Zn2+ ions in various environmental and biological samples.	Vitamin B 6	134-144	pyridoxal phosphatase	Homo sapiens	216-219	
29110180-5	2018	Thus, variants showing a destabilized dimeric structure should, in principle, be responsive to vitamin B6, a precursor of PLP.	Vitamin B 6	95-105	pyridoxal phosphatase	Homo sapiens	122-125	
29070616-2	2018	The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation.	Vitamin B 6	91-101	pyridoxal phosphatase	Homo sapiens	66-69	
28238808-7	2017	In infants with severe HPP, blocked entry of minerals into the skeleton can cause hypercalcemia, and insufficient hydrolysis of pyridoxal 5"-phosphate (PLP), the major circulating form of vitamin B6, can cause pyridoxine-dependent seizures.	Vitamin B 6	188-198	pyridoxal phosphatase	Homo sapiens	152-155	
28801717-1	2017	Pyridoxal 5"-phosphate (PLP), the metabolically active form of vitamin B6, plays an essential role in brain metabolism as a cofactor in numerous enzyme reactions.	Vitamin B 6	63-73	pyridoxal phosphatase	Homo sapiens	24-27	
29038582-1	2017	Enzymes dependent on pyridoxal 5"-phosphate (PLP, the active form of vitamin B6) perform a myriad of diverse chemical transformations.	Vitamin B 6	69-79	pyridoxal phosphatase	Homo sapiens	45-48	
28081293-4	2017	Of these molecules, the surface immobilization of pyridoxal 5"-phosphate (PLP), an active form of vitamin B6 , dramatically increases the hemophilic property of the surface and accelerated osteointegration in vivo.	Vitamin B 6	98-108	pyridoxal phosphatase	Homo sapiens	74-77	
27865135-1	2017	Vitamin B6 cofactor pyridoxal 5"-phosphate (PLP) and PLP crowned gold nanoparticles (PLP-AuNPs) was applied for the optical chemosensing of metal ions in aqueous medium.	Vitamin B 6	0-10	pyridoxal phosphatase	Homo sapiens	44-47	
27865135-1	2017	Vitamin B6 cofactor pyridoxal 5"-phosphate (PLP) and PLP crowned gold nanoparticles (PLP-AuNPs) was applied for the optical chemosensing of metal ions in aqueous medium.	Vitamin B 6	0-10	pyridoxal phosphatase	Homo sapiens	53-56	
27865135-1	2017	Vitamin B6 cofactor pyridoxal 5"-phosphate (PLP) and PLP crowned gold nanoparticles (PLP-AuNPs) was applied for the optical chemosensing of metal ions in aqueous medium.	Vitamin B 6	0-10	pyridoxal phosphatase	Homo sapiens	53-56	
28089883-1	2017	Vitamin B6 comprises six interconvertible pyridine compounds, among which pyridoxal 5"-phosphate (PLP) is a coenzyme for over 140 enzymes.	Vitamin B 6	0-10	pyridoxal phosphatase	Homo sapiens	98-101	
28758913-1	2017	Pyridoxal 5"-phosphate (PLP) is the most important cofactor of vitamin B6-dependent enzymes, which catalyses a wide range of essential body functions (e.g., metabolism) that could be exploited to specifically target highly metabolic cells, such as tumour metastatic cells.	Vitamin B 6	63-73	pyridoxal phosphatase	Homo sapiens	24-27	
27733681-3	2016	Several lines of evidence demonstrate that blood levels of PLP are significantly lower in patients with inflammation than in control subjects and that vitamin B6 has anti-inflammatory effects, with therapeutic potential for a variety of inflammatory diseases.	Vitamin B 6	151-161	pyridoxal phosphatase	Homo sapiens	59-62	
28376200-9	2017	There was a statistically significant inverse linear relationship between cancer risk and both vitamin B6 dietary intake and PLP levels.	Vitamin B 6	95-105	pyridoxal phosphatase	Homo sapiens	125-128	
27912044-1	2016	Pyridoxal 5"-phosphate (PLP), the active form of vitamin B6, functions as a cofactor in humans for more than 140 enzymes, many of which are involved in neurotransmitter synthesis and degradation.	Vitamin B 6	49-59	pyridoxal phosphatase	Homo sapiens	24-27	
26199318-1	2015	Vitamin B6 in the form of pyridoxine (PN) is one of the most widespread pharmacological therapies for inherited diseases involving pyridoxal phosphate (PLP)-dependent enzymes, including primary hyperoxaluria type I (PH1).	Vitamin B 6	0-10	pyridoxal phosphatase	Homo sapiens	152-155	
26835452-3	2015	Pyridoxal 5"-phosphate (PLP), the active form of vitamin B6, is involved in amino acid metabolisms in the body as a cofactor.	Vitamin B 6	49-59	pyridoxal phosphatase	Homo sapiens	24-27	
27465373-3	2016	OBJECTIVE: We prospectively evaluated the relation between plasma folate, pyridoxal 5"-phosphate (PLP; the biologically active form of vitamin B-6), and vitamin B-12 and breast cancer risk in women with a BRCA1/2 mutation.	Vitamin B 6	135-146	pyridoxal phosphatase	Homo sapiens	98-101	
26666246-2	2016	In a previous HD study, we identified several carbonylated proteins, including pyridoxal kinase and antiquitin, both of which are involved in the metabolism of pyridoxal 5 -phosphate (PLP), the active form of vitamin B6.	Vitamin B 6	209-219	pyridoxal phosphatase	Homo sapiens	184-187	
27419045-1	2016	Pyridoxal 5"-phosphate (PLP) is a cofactor for many vitamin B6-requiring enzymes that are important for the synthesis of neurotransmitters.	Vitamin B 6	52-62	pyridoxal phosphatase	Homo sapiens	24-27	
25381637-4	2015	We speculated that the key factor might be the coenzyme pyridoxal 5"-phosphate (PLP), an active form of vitamin B6 (VB6), because media used in cell-based assays usually contain an excess amount of VB6 which leads to the activation of SPL.	Vitamin B 6	104-114	pyridoxal phosphatase	Homo sapiens	80-83	
25972531-2	2015	Variants in the genes for these enzymes [tissue nonspecific alkaline phosphatase (ALPL), pyridoxamine 5"-phosphate oxidase, pyridoxal kinase, and pyridoxal phosphatase] could affect enzyme function and vitamin B-6 status.	Vitamin B 6	202-213	pyridoxal phosphatase	Homo sapiens	146-167	
25972531-13	2015	CONCLUSIONS: In healthy adults, common variants in ALPL influence plasma PLP concentration, the most frequently used biomarker for vitamin B-6 status.	Vitamin B 6	131-142	pyridoxal phosphatase	Homo sapiens	73-76	
24808485-1	2014	BACKGROUND: Plasma concentrations of PL 5"-phosphate (PLP), which is the active coenzyme form of vitamin B-6, are reduced during inflammation.	Vitamin B 6	97-108	pyridoxal phosphatase	Homo sapiens	37-52	
26219714-5	2015	Cytosolic pyridoxal phosphatase/chronophin may interact with vitamin B-6 metabolism and neuronal development and function.	Vitamin B 6	61-72	pyridoxal phosphatase	Homo sapiens	10-31	
26219714-5	2015	Cytosolic pyridoxal phosphatase/chronophin may interact with vitamin B-6 metabolism and neuronal development and function.	Vitamin B 6	61-72	pyridoxal phosphatase	Homo sapiens	32-42	
24808485-1	2014	BACKGROUND: Plasma concentrations of PL 5"-phosphate (PLP), which is the active coenzyme form of vitamin B-6, are reduced during inflammation.	Vitamin B 6	97-108	pyridoxal phosphatase	Homo sapiens	54-57	
24808485-8	2014	RESULTS: PA:(PL + PLP) had the highest ICC of all vitamin B-6 metabolites and ratios tested.	Vitamin B 6	50-61	pyridoxal phosphatase	Homo sapiens	18-21	
24601602-1	2014	Pyridoxal 5"-phosphate (PLP) is the active vitamer of vitamin B6 and acts as an essential cofactor in many aspects of amino acid and sugar metabolism.	Vitamin B 6	54-64	pyridoxal phosphatase	Homo sapiens	24-27	
23550784-1	2013	A variety of inflammatory disease conditions have been found to be associated with low levels of plasma pyridoxal 5"-phosphate (PLP), the active form of vitamin B6 , without any indication of a lower dietary intake of vitamin B6 , excessive catabolism of the vitamin, or congenital defects in its metabolism.	Vitamin B 6	153-163	pyridoxal phosphatase	Homo sapiens	128-131	
24651653-1	2014	Pyridoxal 5"-phosphate (PLP), the active form of vitamin B6, has been implicated in preventing human pathologies, such as diabetes and cancer.	Vitamin B 6	49-59	pyridoxal phosphatase	Homo sapiens	24-27	
24651653-3	2014	Using Drosophila as a model system, we show that PLP deficiency, caused either by mutations in the pyridoxal kinase-coding gene (dPdxk) or by vitamin B6 antagonists, results in chromosome aberrations (CABs).	Vitamin B 6	142-152	pyridoxal phosphatase	Homo sapiens	49-52	
23334322-1	2013	Pyridoxal-5"-phosphate (PLP), the bioactive form of vitamin B6, reportedly functions as a prosthetic group for >4% of classified enzymatic activities of the cell.	Vitamin B 6	52-62	pyridoxal phosphatase	Homo sapiens	24-27	
23334322-9	2013	Moreover, elevated levels of pyridoxal kinase (PDXK), the enzyme that converts pyridoxine and other vitamin B6 precursors into PLP, have been shown to constitute a good, therapy-independent prognostic marker in patients affected by non-small cell lung carcinoma (NSCLC).	Vitamin B 6	100-110	pyridoxal phosphatase	Homo sapiens	127-130	
23966327-1	2013	Suboptimal vitamin B-6 status, as reflected by low plasma pyridoxal 5"-phosphate (PLP) concentration, is associated with increased risk of vascular disease.	Vitamin B 6	11-22	pyridoxal phosphatase	Homo sapiens	82-85	
23342087-7	2013	RESULTS: The enzymatic system involved in vitamin B6 metabolism (PK, PNPO and PLP-phosphatase) is fully expressed in Caco-2 cells as well as in human intestine.	Vitamin B 6	42-52	pyridoxal phosphatase	Homo sapiens	78-93	
23342087-1	2013	BACKGROUND: Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6.	Vitamin B 6	12-22	pyridoxal phosphatase	Homo sapiens	126-129	
23342087-1	2013	BACKGROUND: Vitamin B6 is present in various forms (vitamers) in the diet that need to be metabolized to pyridoxal phosphate (PLP), the active cofactor form of vitamin B6.	Vitamin B 6	160-170	pyridoxal phosphatase	Homo sapiens	126-129	
21704546-15	2011	The differential diagnosis of pyridoxine or PLP responsive seizure disorders includes PLP-responsive epileptic encephalopathy due to PNPO deficiency, neonatal/infantile hypophosphatasia (TNSALP deficiency), familial hyperphosphatasia (PIGV deficiency), as well as yet unidentified conditions and nutritional vitamin B6 deficiency.	Vitamin B 6	308-318	pyridoxal phosphatase	Homo sapiens	44-47	
22646918-1	2012	Pyridoxal 5-phosphate (PLP), the phosphorylated and the oxidized form of vitamin B6 is an organic cofactor.	Vitamin B 6	73-83	pyridoxal phosphatase	Homo sapiens	23-26	
22088923-5	2012	Pyridoxal 5"-phosphate (PLP) is formed from vitamin B6 by the action of pyridoxal kinase.	Vitamin B 6	44-54	pyridoxal phosphatase	Homo sapiens	24-27	
22879864-2	2012	The neurotoxic effects of some of these compounds, including theophylline and ginkgotoxin, have been traced to their inhibitory activity against human pyridoxal kinase (hPL kinase), resulting in deficiency of the active cofactor form of vitamin B6, pyridoxal 5"-phosphate (PLP).	Vitamin B 6	237-247	pyridoxal phosphatase	Homo sapiens	273-276	
22879864-3	2012	Pyridoxal (PL), an inactive form of vitamin B6 is converted to PLP by PL kinase.	Vitamin B 6	36-46	pyridoxal phosphatase	Homo sapiens	63-66	
21827189-1	2011	Pyridoxal 5"-phosphate (PLP; vitamin B(6))-catalyzed reactions have been well studied, both on enzymes and in solution, due to the variety of important reactions this cofactor catalyzes in nitrogen metabolism.	Vitamin B 6	29-41	pyridoxal phosphatase	Homo sapiens	24-27	
22879204-2	2012	METHODS: We examined the association of prediagnostic plasma concentrations of pyridoxal-5"-phosphate (PLP), an active form of vitamin B6, with postmenopausal breast cancer risk in a case-control study nested in the multiethnic cohort in Hawaii and Southern California, including 706 cases and 706 controls matched on date of birth, ethnicity, study site, date of blood draw, time of blood draw, hours of fasting before blood draw, and use of menopausal hormones.	Vitamin B 6	127-137	pyridoxal phosphatase	Homo sapiens	103-106	
22623384-1	2012	Low vitamin B-6 status, based on plasma concentrations of pyridoxal-5-phosphate (PLP), has been identified in inflammatory diseases, including cardiovascular disease, rheumatoid arthritis, inflammatory bowel disease, and diabetes.	Vitamin B 6	4-15	pyridoxal phosphatase	Homo sapiens	81-84	
22201923-1	2012	The biologically active form of vitamin B6, pyridoxal 5"-phosphate (PLP), is a cofactor in over 160 enzyme activities involved in a number of metabolic pathways, including neurotransmitter synthesis and degradation.	Vitamin B 6	32-42	pyridoxal phosphatase	Homo sapiens	68-71	
21704546-15	2011	The differential diagnosis of pyridoxine or PLP responsive seizure disorders includes PLP-responsive epileptic encephalopathy due to PNPO deficiency, neonatal/infantile hypophosphatasia (TNSALP deficiency), familial hyperphosphatasia (PIGV deficiency), as well as yet unidentified conditions and nutritional vitamin B6 deficiency.	Vitamin B 6	308-318	pyridoxal phosphatase	Homo sapiens	86-89	
21430249-6	2011	Vitamin B-6 restriction lowered the plasma PLP concentration from 49 +- 4 nmol/L (mean +- SEM) to 19 +- 2 nmol/L (P < 0.0001).	Vitamin B 6	0-11	pyridoxal phosphatase	Homo sapiens	43-46	
21349613-9	2011	Vitamin B-6 status was assessed by direct measures [plasma and erythrocyte pyridoxal 5"-phosphate (PLP), pyridoxal (PL) and 4-pyridoxic acid (4-PA), and urinary 4-PA] and indirect measures [erythrocyte alanine and aspartate aminotransaminase activity coefficient].	Vitamin B 6	0-11	pyridoxal phosphatase	Homo sapiens	99-102	
21349613-13	2011	There were significantly correlations of relatively higher plasma PLP at admission (day 1) with the reduction of blood glucose concentration (r(s) = 0.72, p = 0.029) on day 7 in the deficient vitamin B-6 group.	Vitamin B 6	192-203	pyridoxal phosphatase	Homo sapiens	66-69	
21349613-16	2011	Higher plasma PLP at admission was a major contributing factor in the reduction of glucose concentration in critically ill surgical patients with deficient vitamin B-6 status.	Vitamin B 6	156-167	pyridoxal phosphatase	Homo sapiens	14-17	
19906811-7	2010	However, plasma PLP > or =20 nmol/L compared with <20 nmol/L was inversely related to serum CRP independently of vitamin B-6 intake (P < 0.001).	Vitamin B 6	119-130	pyridoxal phosphatase	Homo sapiens	16-19	
22335011-7	2011	Direct relationship between plasma oxalic acid and effect of pyridoxal-5-phosphate (PLP), (effect of PLP was in indirect relationship with the concentration of erythrocyte vitamin B6), in AIP patients was found.	Vitamin B 6	172-182	pyridoxal phosphatase	Homo sapiens	84-87	
22335011-7	2011	Direct relationship between plasma oxalic acid and effect of pyridoxal-5-phosphate (PLP), (effect of PLP was in indirect relationship with the concentration of erythrocyte vitamin B6), in AIP patients was found.	Vitamin B 6	172-182	pyridoxal phosphatase	Homo sapiens	101-104	
18241665-9	2008	SOS4 encodes a pyridoxal (PL) kinase that is involved in the biosynthesis of pyridoxal-5-phosphate (PLP), an active form of vitamin B6.	Vitamin B 6	124-134	pyridoxal phosphatase	Homo sapiens	100-103	
18565210-1	2008	BACKGROUND: The pyridoxal-5"-phosphate (PLP)-dependent or vitamin B6-dependent enzymes that catalyze manifold reactions in the metabolism of amino acids belong to no fewer than four evolutionarily independent protein families.	Vitamin B 6	58-68	pyridoxal phosphatase	Homo sapiens	40-43	
18326613-3	2008	OBJECTIVE: We prospectively evaluated plasma concentrations of folate, pyridoxal 5-phosphate (PLP; the principal active form of vitamin B-6), and vitamin B-12 in relation to breast cancer risk.	Vitamin B 6	128-139	pyridoxal phosphatase	Homo sapiens	94-97	
18446746-8	2008	Erythrocyte vitamin B6 was determined by indirect enzymatic method as an effect of pyridoxal-5-phosphate (PLP).	Vitamin B 6	12-22	pyridoxal phosphatase	Homo sapiens	106-109	
17666362-1	2007	Low plasma vitamin B6, measured as pyridoxal-5"-phosphate (PLP), is associated with an increased risk of first venous thromboembolism (VTE).	Vitamin B 6	11-21	pyridoxal phosphatase	Homo sapiens	59-62