PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30988257-16 2019 Nonetheless, the structure of the PDX1.2-PDX1.3 complex highlights enhanced flexibility in key catalytic regions for the initial steps of vitamin B6 biosynthesis. Vitamin B 6 138-148 Aldolase-type TIM barrel family protein Arabidopsis thaliana 34-38 32670323-15 2020 Functional characterization of Arabidopsis pdx1.3 mutants challenged with R. solani provided evidence into the role of the vitamin B6 pathway in the maintenance of plant tolerance during disease progression. Vitamin B 6 123-133 Aldolase-type TIM barrel family protein Arabidopsis thaliana 43-47 30988257-2 2019 In the eudicot plant lineage, the pseudoenzyme PDX1.2 and its cognate enzyme PDX1.3 interact to regulate vitamin B6 biosynthesis. Vitamin B 6 105-115 Aldolase-type TIM barrel family protein Arabidopsis thaliana 77-83 30988257-4 2019 PDX1.2 increases the catalytic activity of PDX1.3, with an overall increase in vitamin B6 biosynthesis. Vitamin B 6 79-89 Aldolase-type TIM barrel family protein Arabidopsis thaliana 0-4 30988257-4 2019 PDX1.2 increases the catalytic activity of PDX1.3, with an overall increase in vitamin B6 biosynthesis. Vitamin B 6 79-89 Aldolase-type TIM barrel family protein Arabidopsis thaliana 43-47 31684863-1 2019 BACKGROUND: PDX1.2 has recently been shown to be a regulator of vitamin B6 biosynthesis in plants and is implicated in biotic and abiotic stress resistance. Vitamin B 6 64-74 Aldolase-type TIM barrel family protein Arabidopsis thaliana 12-16 30988257-16 2019 Nonetheless, the structure of the PDX1.2-PDX1.3 complex highlights enhanced flexibility in key catalytic regions for the initial steps of vitamin B6 biosynthesis. Vitamin B 6 138-148 Aldolase-type TIM barrel family protein Arabidopsis thaliana 41-47 25475669-9 2015 Interestingly, Suc specifically represses PDX1.1 expression, accounting for the stronger vitamin B6 deficit in pdx1.3 compared with pdx1.1. Vitamin B 6 89-99 Aldolase-type TIM barrel family protein Arabidopsis thaliana 42-46 27647886-0 2016 Structural definition of the lysine swing in Arabidopsis thaliana PDX1: Intermediate channeling facilitating vitamin B6 biosynthesis. Vitamin B 6 109-119 Aldolase-type TIM barrel family protein Arabidopsis thaliana 66-70 25475669-9 2015 Interestingly, Suc specifically represses PDX1.1 expression, accounting for the stronger vitamin B6 deficit in pdx1.3 compared with pdx1.1. Vitamin B 6 89-99 Aldolase-type TIM barrel family protein Arabidopsis thaliana 111-117 21241390-3 2011 The de novo vitamin B6 biosynthesis pathway in plants has recently been unraveled and involves only two proteins, PDX1 and PDX2. Vitamin B 6 12-22 Aldolase-type TIM barrel family protein Arabidopsis thaliana 114-118 24748553-3 2014 While PDX1.1 and PDX1.3 have been extensively described and are well established to function in vitamin B6 biosynthesis, the biological role of PDX1.2 still remains elusive. Vitamin B 6 96-106 Aldolase-type TIM barrel family protein Arabidopsis thaliana 17-23 24748553-3 2014 While PDX1.1 and PDX1.3 have been extensively described and are well established to function in vitamin B6 biosynthesis, the biological role of PDX1.2 still remains elusive. Vitamin B 6 96-106 Aldolase-type TIM barrel family protein Arabidopsis thaliana 6-10 24505140-0 2014 The pseudoenzyme PDX1.2 boosts vitamin B6 biosynthesis under heat and oxidative stress in Arabidopsis. Vitamin B 6 31-41 Aldolase-type TIM barrel family protein Arabidopsis thaliana 17-21 24505140-6 2014 Analysis of pdx1.2 knockdown lines demonstrates that boosting vitamin B6 content is dependent on PDX1.2, revealing that this pseudoenzyme acts as a positive regulator of vitamin B6 biosynthesis during such stress conditions in plants. Vitamin B 6 62-72 Aldolase-type TIM barrel family protein Arabidopsis thaliana 12-16 24505140-6 2014 Analysis of pdx1.2 knockdown lines demonstrates that boosting vitamin B6 content is dependent on PDX1.2, revealing that this pseudoenzyme acts as a positive regulator of vitamin B6 biosynthesis during such stress conditions in plants. Vitamin B 6 170-180 Aldolase-type TIM barrel family protein Arabidopsis thaliana 12-16 21241390-5 2011 Interestingly, it was possible to increase the level of only one of the two catalytically active PDX1 proteins at the protein level, providing insight into the mechanism of vitamin B6 homeostasis in planta. Vitamin B 6 173-183 Aldolase-type TIM barrel family protein Arabidopsis thaliana 97-101 21288732-0 2011 The role of the pyridoxine (vitamin B6) biosynthesis enzyme PDX1 in ultraviolet-B radiation responses in plants. Vitamin B 6 28-38 Aldolase-type TIM barrel family protein Arabidopsis thaliana 60-64 20675613-1 2010 In plants, vitamin B6 biosynthesis requires the activity of PDX1 and PDX2 proteins. Vitamin B 6 11-21 Aldolase-type TIM barrel family protein Arabidopsis thaliana 60-64 20675613-4 2010 Metabolic profiling of plants ectopically expressing the different PDX proteins indicates a negative influence of PDX1.2 on vitamin B6 biosynthesis and a correlation between aberrant vitamin B6 content, PDX1 gene expression, and light sensitivity specifically for PDX1.3. Vitamin B 6 124-134 Aldolase-type TIM barrel family protein Arabidopsis thaliana 114-118 20675613-4 2010 Metabolic profiling of plants ectopically expressing the different PDX proteins indicates a negative influence of PDX1.2 on vitamin B6 biosynthesis and a correlation between aberrant vitamin B6 content, PDX1 gene expression, and light sensitivity specifically for PDX1.3. Vitamin B 6 124-134 Aldolase-type TIM barrel family protein Arabidopsis thaliana 264-270 19903353-5 2009 RESULTS: The pdx1.3 mutation affects the vitamin B6 biosynthesis enzyme, pyridoxal synthase (PDX1), and leads to a reduction of the vitamin B6 concentration in Arabidopsis thaliana leaves. Vitamin B 6 41-51 Aldolase-type TIM barrel family protein Arabidopsis thaliana 13-17 19903353-5 2009 RESULTS: The pdx1.3 mutation affects the vitamin B6 biosynthesis enzyme, pyridoxal synthase (PDX1), and leads to a reduction of the vitamin B6 concentration in Arabidopsis thaliana leaves. Vitamin B 6 41-51 Aldolase-type TIM barrel family protein Arabidopsis thaliana 93-97 19903353-5 2009 RESULTS: The pdx1.3 mutation affects the vitamin B6 biosynthesis enzyme, pyridoxal synthase (PDX1), and leads to a reduction of the vitamin B6 concentration in Arabidopsis thaliana leaves. Vitamin B 6 132-142 Aldolase-type TIM barrel family protein Arabidopsis thaliana 13-17 19903353-5 2009 RESULTS: The pdx1.3 mutation affects the vitamin B6 biosynthesis enzyme, pyridoxal synthase (PDX1), and leads to a reduction of the vitamin B6 concentration in Arabidopsis thaliana leaves. Vitamin B 6 132-142 Aldolase-type TIM barrel family protein Arabidopsis thaliana 93-97 17227548-0 2006 PDX1 is essential for vitamin B6 biosynthesis, development and stress tolerance in Arabidopsis. Vitamin B 6 22-32 Aldolase-type TIM barrel family protein Arabidopsis thaliana 0-4 18298794-7 2008 Furthermore, we prove the function of GbPDX1 in vitamin B6 biosynthesis by complementation of an Arabidopsis AtPDX1.3 mutant rsr4-1, at the phenotypical level and increasing vitamin B6 levels caused by ectopic GbPDX1 expression in the mutant background. Vitamin B 6 48-58 Aldolase-type TIM barrel family protein Arabidopsis thaliana 109-115 19306104-0 2009 The short-rooted vitamin B6-deficient mutant pdx1 has impaired local auxin biosynthesis. Vitamin B 6 17-27 Aldolase-type TIM barrel family protein Arabidopsis thaliana 45-49 19306104-5 2009 We previously reported that the Arabidopsis vitamin B(6) biosynthesis mutant pdx1 has stunted root growth although the underlying cause is unknown. Vitamin B 6 44-56 Aldolase-type TIM barrel family protein Arabidopsis thaliana 77-81 17227548-3 2006 The de novo pathway of vitamin B6 biosynthesis has only been described recently and involves the protein PDX1 (pyridoxal phosphate synthase protein). Vitamin B 6 23-33 Aldolase-type TIM barrel family protein Arabidopsis thaliana 105-109 17227548-4 2006 Arabidopsis thaliana has three homologs of PDX1, two of which, PDX1.1 and PDX1.3, have been demonstrated as functional in vitamin B6 biosynthesis in vitro and by yeast complementation. Vitamin B 6 122-132 Aldolase-type TIM barrel family protein Arabidopsis thaliana 43-47 17227548-4 2006 Arabidopsis thaliana has three homologs of PDX1, two of which, PDX1.1 and PDX1.3, have been demonstrated as functional in vitamin B6 biosynthesis in vitro and by yeast complementation. Vitamin B 6 122-132 Aldolase-type TIM barrel family protein Arabidopsis thaliana 63-67 16766694-0 2006 Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis. Vitamin B 6 138-148 Aldolase-type TIM barrel family protein Arabidopsis thaliana 35-39 16766694-0 2006 Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis. Vitamin B 6 138-148 Aldolase-type TIM barrel family protein Arabidopsis thaliana 86-90 16766694-4 2006 Cloning of the mutated gene revealed that rsr4-1 carries a point mutation in a member of the PDX1/SOR1/SNZ (for Pyridoxine biosynthesis protein 1/Singlet oxygen resistant 1/Snooze) family that leads to reduced vitamin B6 content. Vitamin B 6 210-220 Aldolase-type TIM barrel family protein Arabidopsis thaliana 93-97 16766694-8 2006 In summary, our results demonstrate the critical function of the PDX1 protein family for metabolism, whole-plant development, and vitamin B6 biosynthesis in higher plants. Vitamin B 6 130-140 Aldolase-type TIM barrel family protein Arabidopsis thaliana 65-69 16236150-6 2005 The PDX1 protein was mainly associated with the plasma membrane and endomembranes, implying a potential involvement of vitamin B6 in membrane function. Vitamin B 6 119-129 Aldolase-type TIM barrel family protein Arabidopsis thaliana 4-8