PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9928444-2	1998	Pyridoxine, vitamin B6, is a cofactor for cystathionine beta synthase, which mediates the transformation of homocysteine to cystathionine, the initial step in the transsulfuration pathway and the urinary excretion of sulfur.	Vitamin B 6	12-22	cystathionine beta-synthase	Homo sapiens	42-69	
15280798-2	2004	H2S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionin gamma--lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B6) as a cofactor.	Vitamin B 6	150-160	cystathionine beta-synthase	Homo sapiens	45-72	
11481906-2	2001	Hyperhomocysteinemia may be induced by failure or decreased enzyme activity of the cystathionine-beta-synthase and methylenetetrahydrofolate reductase due to genetic mutation or deficiency of folic acid, vitamin B12 and vitamin B6.	Vitamin B 6	220-230	cystathionine beta-synthase	Homo sapiens	83-110	
15365998-0	2004	The cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype.	Vitamin B 6	81-91	cystathionine beta-synthase	Homo sapiens	4-31	
15365998-0	2004	The cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype.	Vitamin B 6	81-91	cystathionine beta-synthase	Homo sapiens	33-36	
15365998-7	2004	In summary, the data of this study suggest that the CBS c.1224-2A>C allele confers vitamin B6 nonresponsiveness and that this mutant allele came from a common ancestor.	Vitamin B 6	86-96	cystathionine beta-synthase	Homo sapiens	52-55	
15181872-2	2004	The majority of Hcy undergoes transsulfuration to cysteine by cystathionine beta-synthase (CBS), of which vitamin B6 (pyridoxine) is an essential cofactor.	Vitamin B 6	106-116	cystathionine beta-synthase	Homo sapiens	62-89	
10215408-4	1998	RT-PCR and direct sequence analyses were used to define mutations in the cystathionine beta-synthase (CBS) gene in two unrelated male patients with vitamin B6 nonresponsive homocystinuria.	Vitamin B 6	148-158	cystathionine beta-synthase	Homo sapiens	73-100	
10215408-4	1998	RT-PCR and direct sequence analyses were used to define mutations in the cystathionine beta-synthase (CBS) gene in two unrelated male patients with vitamin B6 nonresponsive homocystinuria.	Vitamin B 6	148-158	cystathionine beta-synthase	Homo sapiens	102-105	
33179601-4	2020	The trans-sulphuration reaction depends on the enzyme cystathionine beta synthase and its cofactor vitamin B6.	Vitamin B 6	99-109	cystathionine beta-synthase	Homo sapiens	54-81	
9395725-1	1997	We present two siblings with vitamin B6-nonresponsive homocystinuria due to a deficiency of cystathionine beta-synthase who had different levels of methionine in the blood during the neonatal period, even though they had the same genetic defect.	Vitamin B 6	29-39	cystathionine beta-synthase	Homo sapiens	92-119	
732830-0	1978	Cystathionine beta-synthase deficiency: observations on the biochemical lesion in a vitamin B6 non-responsive patient.	Vitamin B 6	84-94	cystathionine beta-synthase	Homo sapiens	0-27	
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Vitamin B 6	80-90	cystathionine beta-synthase	Homo sapiens	157-184	
32487371-3	2020	Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy).	Vitamin B 6	80-90	cystathionine beta-synthase	Homo sapiens	186-189	
23981774-3	2013	Here, we characterized a novel CBS mutation (c.260C>A (p.T87N)) and a previously reported variant (c.700G>A (p.D234N)) found in Venezuelan homocystinuric patients, one nonresponsive and one responsive to vitamin B6.	Vitamin B 6	210-220	cystathionine beta-synthase	Homo sapiens	31-34