PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15365998-0 2004 The cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype. Vitamin B 6 81-91 cystathionine beta-synthase Homo sapiens 4-31 15365998-0 2004 The cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype. Vitamin B 6 81-91 cystathionine beta-synthase Homo sapiens 33-36 15365998-7 2004 In summary, the data of this study suggest that the CBS c.1224-2A>C allele confers vitamin B6 nonresponsiveness and that this mutant allele came from a common ancestor. Vitamin B 6 86-96 cystathionine beta-synthase Homo sapiens 52-55 15280798-2 2004 H2S is synthesized from L-cysteine by either cystathionine beta-synthase (CBS) or cystathionin gamma--lyase (CSE), both using pyridoxal 5"-phosphate (vitamin B6) as a cofactor. Vitamin B 6 150-160 cystathionine beta-synthase Homo sapiens 45-72 11481906-2 2001 Hyperhomocysteinemia may be induced by failure or decreased enzyme activity of the cystathionine-beta-synthase and methylenetetrahydrofolate reductase due to genetic mutation or deficiency of folic acid, vitamin B12 and vitamin B6. Vitamin B 6 220-230 cystathionine beta-synthase Homo sapiens 83-110 15181872-2 2004 The majority of Hcy undergoes transsulfuration to cysteine by cystathionine beta-synthase (CBS), of which vitamin B6 (pyridoxine) is an essential cofactor. Vitamin B 6 106-116 cystathionine beta-synthase Homo sapiens 62-89 9928444-2 1998 Pyridoxine, vitamin B6, is a cofactor for cystathionine beta synthase, which mediates the transformation of homocysteine to cystathionine, the initial step in the transsulfuration pathway and the urinary excretion of sulfur. Vitamin B 6 12-22 cystathionine beta-synthase Homo sapiens 42-69 33179601-4 2020 The trans-sulphuration reaction depends on the enzyme cystathionine beta synthase and its cofactor vitamin B6. Vitamin B 6 99-109 cystathionine beta-synthase Homo sapiens 54-81 23981774-3 2013 Here, we characterized a novel CBS mutation (c.260C>A (p.T87N)) and a previously reported variant (c.700G>A (p.D234N)) found in Venezuelan homocystinuric patients, one nonresponsive and one responsive to vitamin B6. Vitamin B 6 210-220 cystathionine beta-synthase Homo sapiens 31-34 10215408-4 1998 RT-PCR and direct sequence analyses were used to define mutations in the cystathionine beta-synthase (CBS) gene in two unrelated male patients with vitamin B6 nonresponsive homocystinuria. Vitamin B 6 148-158 cystathionine beta-synthase Homo sapiens 73-100 10215408-4 1998 RT-PCR and direct sequence analyses were used to define mutations in the cystathionine beta-synthase (CBS) gene in two unrelated male patients with vitamin B6 nonresponsive homocystinuria. Vitamin B 6 148-158 cystathionine beta-synthase Homo sapiens 102-105 9395725-1 1997 We present two siblings with vitamin B6-nonresponsive homocystinuria due to a deficiency of cystathionine beta-synthase who had different levels of methionine in the blood during the neonatal period, even though they had the same genetic defect. Vitamin B 6 29-39 cystathionine beta-synthase Homo sapiens 92-119 732830-0 1978 Cystathionine beta-synthase deficiency: observations on the biochemical lesion in a vitamin B6 non-responsive patient. Vitamin B 6 84-94 cystathionine beta-synthase Homo sapiens 0-27 32487371-3 2020 Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy). Vitamin B 6 80-90 cystathionine beta-synthase Homo sapiens 157-184 32487371-3 2020 Interestingly, both heme biosynthesis and sulphur amino acid metabolism require vitamin B6, (Pyridoxal-phosphate, PLP) an important cofactor of ALAS1 and of cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) enzymes that catabolize homocysteine (Hcy). Vitamin B 6 80-90 cystathionine beta-synthase Homo sapiens 186-189