PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2801311-0	1989	Inhibitory effect of SK&F 86002 on monocyte IL-1 production.	amicloral	21-27	interleukin 1 alpha	Homo sapiens	48-52	
2678952-2	1989	SK&F 86002, a dual inhibitor of the arachidonate metabolism, has been shown to inhibit LPS induced IL-1 production in human monocytes.	amicloral	0-6	interleukin 1 alpha	Homo sapiens	103-107	
2678952-6	1989	Taken together these data indicate that the inhibitory effect of SK&F 86002 on IL-1 production is selective and the production of cytokines in drug treated monocytes can be differentially affected.	amicloral	65-71	interleukin 1 alpha	Homo sapiens	83-87	
2801311-6	1989	Thus, SK&F 86002 may serve as a useful reagent in the understanding of the synthetic, processing and/or secretory pathways of interleukin-1, and may provide important insight into the treatment of disease states where aberrant IL-1 production is implicated.	amicloral	6-12	interleukin 1 alpha	Homo sapiens	231-235	
2801311-2	1989	SK&F 86002-A2 was shown to be a potent inhibitor of IL-1 production with a 50% inhibitory concentration (IC50) of 1.3 +/- 0.5 microM.	amicloral	0-6	interleukin 1 alpha	Homo sapiens	56-60	
3148560-0	1988	Inhibition of monocyte IL-1 production by the anti-inflammatory compound, SK&F 86002.	amicloral	74-80	interleukin 1 alpha	Homo sapiens	23-27	
3148560-2	1988	SK&F 86002, a novel dihydroimidazo thiazoline which inhibits both 5-lipoxygenase- and cyclooxygenase-mediated arachidonate metabolism was shown to be a potent inhibitor of IL-1 production by LPS-stimulated human monocytes.	amicloral	0-6	interleukin 1 alpha	Homo sapiens	176-180	
3148560-7	1988	The inhibition of IL-1 production by SK&F 86002 adds another facet of drug action contributing to its spectrum of anti-inflammatory activities.	amicloral	37-43	interleukin 1 alpha	Homo sapiens	18-22