PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10354960-0	1999	Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs.	Nortriptyline	0-13	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96	
17662092-9	2008	As a representative TCA, nortriptyline fulfilled the in vitro MBI criteria using recombinant CYP2C19 and CYP3A4 (K(I) and k(inact) values of 4 microm and 0.19 min(-1), and 70 microm and 0.06 min(-1)), but not with the human liver microsomal enzymes.	Nortriptyline	25-38	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	105-111	
21854846-10	2011	The results point towards the combination of low CYP3A4 activity and CYP2D6 PM status of major importance for attaining possibly toxic nortriptyline concentrations.	Nortriptyline	135-148	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-55	
21854846-12	2011	In a clinical context, the simulations suggest that precise individual dose adjustment of nortriptyline requires information regarding the activity of both CYP3A4 and CYP2D6.	Nortriptyline	90-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	156-162	
10354960-7	1999	A simulation of the relative contribution of CYPs 2D6 and 3A4 to net nortriptyline hydroxylation rate suggested that the relative contribution of CYP3A4 is only 20% even at the higher end of the therapeutic range.	Nortriptyline	69-82	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	146-152	
10354960-9	1999	The identification of CYP3A4 as a low-affinity nortriptyline E-10-hydroxylase explains the ability of poor metabolizers of debrisoquin to hydroxylate nortriptyline, as well as the increased in vivo clearance via this pathway caused by CYP3A4-inducing drugs such as pentobarbital, carbamazepine, and rifampin.	Nortriptyline	47-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	22-28	
10354960-9	1999	The identification of CYP3A4 as a low-affinity nortriptyline E-10-hydroxylase explains the ability of poor metabolizers of debrisoquin to hydroxylate nortriptyline, as well as the increased in vivo clearance via this pathway caused by CYP3A4-inducing drugs such as pentobarbital, carbamazepine, and rifampin.	Nortriptyline	47-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	235-241