PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34093211-3 2021 Here, the impact of OCT1 genetic variation on the pharmacokinetics of amitriptyline and its active metabolite nortriptyline was studied in vitro as well as in healthy volunteers and in depressive disorder patients. Nortriptyline 110-123 solute carrier family 22 member 1 Homo sapiens 20-24 34093211-4 2021 Amitriptyline and nortriptyline were found to inhibit OCT1 in recombinant cells with IC50 values of 28.6 and 40.4 microM. Nortriptyline 18-31 solute carrier family 22 member 1 Homo sapiens 54-58