PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21199317-4	2011	We conducted a retrospective analysis of a large commercial claims database and a Medicare database to assess the prevalence of DDEs among patients with osteoarthritis taking CYP450-metabolized opioids.	Dichlorodiphenyl Dichloroethylene	128-132	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	175-181	
20807350-3	2011	Using a retrospective analysis of a large commercial claims database and a Medicare database, we evaluated DDEs that have the potential to cause DDIs among chronic low back pain (cLBP) patients on long-term opioid analgesia, which metabolizes through the CYP450 enzyme system, concomitant with other CYP450-metabolized drug(s).	Dichlorodiphenyl Dichloroethylene	107-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	255-261	
20807350-3	2011	Using a retrospective analysis of a large commercial claims database and a Medicare database, we evaluated DDEs that have the potential to cause DDIs among chronic low back pain (cLBP) patients on long-term opioid analgesia, which metabolizes through the CYP450 enzyme system, concomitant with other CYP450-metabolized drug(s).	Dichlorodiphenyl Dichloroethylene	107-111	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	300-306	
21574905-9	2011	CONCLUSION: Since concurrent exposure to DDEs with the potential to cause PK DDIs may be relatively common, policy decisions-makers should consider the use of long-acting opioids that are not metabolized through the CYP450 pathway.	Dichlorodiphenyl Dichloroethylene	41-45	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	216-222	
15135080-7	2004	The barbiturate phenobarbital and the environmental toxicant 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) are among the well characterized inducers for the CYP 2B and 3A enzymes and selected conjugation enzymes.	Dichlorodiphenyl Dichloroethylene	61-105	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	162-165	
15135080-7	2004	The barbiturate phenobarbital and the environmental toxicant 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) are among the well characterized inducers for the CYP 2B and 3A enzymes and selected conjugation enzymes.	Dichlorodiphenyl Dichloroethylene	107-110	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	162-165