PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34428833-0 2021 Tetrahydrocurcumin Downregulates MAPKs/cPLA2 Signaling and Attenuates Platelet Thromboxane A2 Generation, Granule Secretion, and Thrombus Growth. tetrahydrocurcumin 0-18 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 39-44 34428833-5 2021 These inhibitory effects of THC were partially mediated by the attenuation of cytosolic phospholipase A2 (cPLA2) phosphorylation, leading to a decrease in thromboxane A2 (TxA2) generation. tetrahydrocurcumin 28-31 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 78-104 34428833-5 2021 These inhibitory effects of THC were partially mediated by the attenuation of cytosolic phospholipase A2 (cPLA2) phosphorylation, leading to a decrease in thromboxane A2 (TxA2) generation. tetrahydrocurcumin 28-31 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 106-111 34428833-6 2021 Moreover, the MAPK (Erk1/2, JNK1/2, and p38 MAPK) signaling pathways were downregulated by THC treatment, resulting in reduced cPLA2 activation, TxA2 generation, and granule secretion. tetrahydrocurcumin 91-94 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 127-132 34428833-10 2021 Thus, through inhibiting MAPKs/cPLA2 signaling, and attenuating platelet TxA2 generation, granule secretion, and thrombus formation, THC may be a potent cardioprotective agent. tetrahydrocurcumin 133-136 phospholipase A2, group IVA (cytosolic, calcium-dependent) Mus musculus 31-36