PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21928294-0	2011	Tetrahydrocurcumin, a major metabolite of curcumin, induced autophagic cell death through coordinative modulation of PI3K/Akt-mTOR and MAPK signaling pathways in human leukemia HL-60 cells.	tetrahydrocurcumin	0-18	AKT serine/threonine kinase 1	Homo sapiens	122-125	
29436654-0	2018	Tetrahydrocurcumin-induced autophagy via suppression of PI3K/Akt/mTOR in non-small cell lung carcinoma cells.	tetrahydrocurcumin	0-18	AKT serine/threonine kinase 1	Homo sapiens	61-64	
29976400-7	2018	Glucose uptake and insulin signaling impaired in HepG2 cells incubated with OA were abated by THC treatment, including phosphorylation of the insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1) and glycogen synthase kinase 3 beta (GSK3beta), which are involved in gluconeogenesis and glycogen synthesis, respectively.	tetrahydrocurcumin	94-97	AKT serine/threonine kinase 1	Homo sapiens	212-215	
29436654-11	2018	A promising method of enhancing the therapeutic efficacy of THC against NSCLC cells may include inducing autophagy via inhibition of the PI3K/Akt/mTOR signaling pathway.	tetrahydrocurcumin	60-63	AKT serine/threonine kinase 1	Homo sapiens	142-145	
29207631-9	2017	Importantly, HIF-1alpha expression was downregulated by THC by inhibiting Akt/mTOR and p38 MAPK pathways.	tetrahydrocurcumin	56-59	AKT serine/threonine kinase 1	Homo sapiens	74-77