PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25762723-3 2015 Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV infection, 3"-azido-3"-deoxythymidine (AZT). Zidovudine 190-216 ATP binding cassette subfamily C member 4 Homo sapiens 53-83 25762723-3 2015 Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV infection, 3"-azido-3"-deoxythymidine (AZT). Zidovudine 190-216 ATP binding cassette subfamily C member 4 Homo sapiens 85-89 25762723-3 2015 Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV infection, 3"-azido-3"-deoxythymidine (AZT). Zidovudine 218-221 ATP binding cassette subfamily C member 4 Homo sapiens 53-83 25762723-3 2015 Several drugs are either substrates or inhibitors of multidrug resistance protein 4 (MRP4), such as the anti-colon cancer drug irinotecan and an anti-retroviral used to treat HIV infection, 3"-azido-3"-deoxythymidine (AZT). Zidovudine 218-221 ATP binding cassette subfamily C member 4 Homo sapiens 85-89 25762723-6 2015 Importantly, HIV patients on AZT treatment demonstrate augmented MRP4-CFTR complex formation in the colon, which defines a novel paradigm of drug-induced diarrhea. Zidovudine 29-32 ATP binding cassette subfamily C member 4 Homo sapiens 65-69 19837908-7 2010 In conclusion, drugs that are substrates of BCRP and MRP4, like zidovudine, may have an altered efficacy in newborns. Zidovudine 64-74 ATP binding cassette subfamily C member 4 Homo sapiens 53-57 18364470-6 2008 The function of MRP4 variants was compared by measuring the intracellular accumulation of two antiviral agents, azidothymidine (AZT) and adefovir (PMEA). Zidovudine 112-126 ATP binding cassette subfamily C member 4 Homo sapiens 16-20 20032540-11 2009 However, MRP4 expression increased following phytohaemaglutinin and AZT treatment. Zidovudine 68-71 ATP binding cassette subfamily C member 4 Homo sapiens 9-13 18364470-6 2008 The function of MRP4 variants was compared by measuring the intracellular accumulation of two antiviral agents, azidothymidine (AZT) and adefovir (PMEA). Zidovudine 128-131 ATP binding cassette subfamily C member 4 Homo sapiens 16-20 18364470-10 2008 However, two variants (G187W and G487E) showed a significantly reduced function compared to reference with both substrates, as evidenced by higher intracellular accumulation of AZT and PMEA compared to the reference MRP4 (43 and 69% increase in accumulation for G187W compared with the reference MRP4, with AZT and PMEA, respectively). Zidovudine 177-180 ATP binding cassette subfamily C member 4 Homo sapiens 296-300 18364470-10 2008 However, two variants (G187W and G487E) showed a significantly reduced function compared to reference with both substrates, as evidenced by higher intracellular accumulation of AZT and PMEA compared to the reference MRP4 (43 and 69% increase in accumulation for G187W compared with the reference MRP4, with AZT and PMEA, respectively). Zidovudine 307-310 ATP binding cassette subfamily C member 4 Homo sapiens 296-300 15456083-8 2004 RESULTS: Levels of MDR1, mrp4 and mrp5 mRNA were high following AZT treatment. Zidovudine 64-67 ATP binding cassette subfamily C member 4 Homo sapiens 25-29 15456083-15 2004 The cellular efflux of AZT probably involves MRP4 or MRP5. Zidovudine 23-26 ATP binding cassette subfamily C member 4 Homo sapiens 45-49 10944550-7 2000 MRP4 overexpression is associated with high-level resistance to the nucleoside analogues 9-(2-phosphonylmethoxyethyl) adenine and azidothymidine, both of which are used as anti-human immunodeficiency virus drugs. Zidovudine 130-144 ATP binding cassette subfamily C member 4 Homo sapiens 0-4 10470083-7 1999 Overexpression of MRP4 mRNA and MRP4 protein severely impaired the antiviral efficacy of PMEA, azidothymidine and other nucleoside analogs. Zidovudine 95-109 ATP binding cassette subfamily C member 4 Homo sapiens 18-22 10470083-7 1999 Overexpression of MRP4 mRNA and MRP4 protein severely impaired the antiviral efficacy of PMEA, azidothymidine and other nucleoside analogs. Zidovudine 95-109 ATP binding cassette subfamily C member 4 Homo sapiens 32-36 12792791-0 2003 Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine. Zidovudine 114-128 ATP binding cassette subfamily C member 4 Homo sapiens 26-30 12792791-8 2003 Since MRP4 is known to transport azidiothymidine (AZT) and overexpression of MRP4 confers AZT resistance, we have studied growth inhibitory effects of AZT and [3H]-AZT accumulation. Zidovudine 50-53 ATP binding cassette subfamily C member 4 Homo sapiens 6-10 12792791-8 2003 Since MRP4 is known to transport azidiothymidine (AZT) and overexpression of MRP4 confers AZT resistance, we have studied growth inhibitory effects of AZT and [3H]-AZT accumulation. Zidovudine 90-93 ATP binding cassette subfamily C member 4 Homo sapiens 77-81 12792791-8 2003 Since MRP4 is known to transport azidiothymidine (AZT) and overexpression of MRP4 confers AZT resistance, we have studied growth inhibitory effects of AZT and [3H]-AZT accumulation. Zidovudine 90-93 ATP binding cassette subfamily C member 4 Homo sapiens 77-81 12792791-8 2003 Since MRP4 is known to transport azidiothymidine (AZT) and overexpression of MRP4 confers AZT resistance, we have studied growth inhibitory effects of AZT and [3H]-AZT accumulation. Zidovudine 90-93 ATP binding cassette subfamily C member 4 Homo sapiens 77-81 12792791-11 2003 Thus, the increased sensitivity to AZT in SR-2 could not be solely due to mutation of MRP4. Zidovudine 35-38 ATP binding cassette subfamily C member 4 Homo sapiens 86-90